C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGZ8_LEIBR

TriTrypDb:

LbrM.28.3160 , LBRM2903_280039300

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGZ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.584
CLV_NRD_NRD_1	204	206	PF00675	0.443
CLV_NRD_NRD_1	55	57	PF00675	0.551
CLV_NRD_NRD_1	7	9	PF00675	0.612
CLV_PCSK_FUR_1	5	9	PF00082	0.731
CLV_PCSK_KEX2_1	204	206	PF00082	0.505
CLV_PCSK_KEX2_1	39	41	PF00082	0.475
CLV_PCSK_KEX2_1	7	9	PF00082	0.637
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.477
CLV_PCSK_PC7_1	3	9	PF00082	0.729
CLV_PCSK_SKI1_1	135	139	PF00082	0.350
CLV_PCSK_SKI1_1	39	43	PF00082	0.378
CLV_PCSK_SKI1_1	64	68	PF00082	0.495
DEG_COP1_1	230	238	PF00400	0.506
DOC_CYCLIN_RxL_1	36	46	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.665
DOC_MAPK_gen_1	39	45	PF00069	0.473
DOC_PP2B_LxvP_1	214	217	PF13499	0.692
DOC_PP2B_LxvP_1	41	44	PF13499	0.358
DOC_PP2B_LxvP_1	95	98	PF13499	0.317
DOC_USP7_MATH_1	149	153	PF00917	0.566
DOC_USP7_MATH_1	301	305	PF00917	0.690
DOC_USP7_MATH_1	320	324	PF00917	0.453
DOC_USP7_MATH_1	44	48	PF00917	0.414
DOC_USP7_MATH_2	11	17	PF00917	0.706
DOC_WW_Pin1_4	103	108	PF00397	0.366
DOC_WW_Pin1_4	176	181	PF00397	0.596
DOC_WW_Pin1_4	243	248	PF00397	0.755
DOC_WW_Pin1_4	268	273	PF00397	0.566
DOC_WW_Pin1_4	297	302	PF00397	0.592
DOC_WW_Pin1_4	307	312	PF00397	0.617
LIG_14-3-3_CanoR_1	242	247	PF00244	0.515
LIG_14-3-3_CanoR_1	305	311	PF00244	0.573
LIG_BRCT_BRCA1_1	272	276	PF00533	0.534
LIG_BRCT_BRCA1_1	303	307	PF00533	0.709
LIG_EVH1_2	27	31	PF00568	0.521
LIG_FHA_1	114	120	PF00498	0.532
LIG_FHA_1	126	132	PF00498	0.428
LIG_FHA_1	138	144	PF00498	0.397
LIG_FHA_1	164	170	PF00498	0.413
LIG_FHA_1	21	27	PF00498	0.472
LIG_FHA_1	255	261	PF00498	0.594
LIG_FHA_1	269	275	PF00498	0.659
LIG_FHA_1	28	34	PF00498	0.354
LIG_FHA_2	225	231	PF00498	0.652
LIG_FHA_2	232	238	PF00498	0.639
LIG_IBAR_NPY_1	319	321	PF08397	0.559
LIG_LIR_Gen_1	187	198	PF02991	0.352
LIG_LIR_Gen_1	230	239	PF02991	0.578
LIG_LIR_Gen_1	30	37	PF02991	0.272
LIG_LIR_LC3C_4	116	121	PF02991	0.303
LIG_LIR_Nem_3	187	193	PF02991	0.346
LIG_LIR_Nem_3	230	235	PF02991	0.582
LIG_LIR_Nem_3	273	279	PF02991	0.602
LIG_LIR_Nem_3	30	34	PF02991	0.267
LIG_SH3_3	255	261	PF00018	0.721
LIG_SH3_3	30	36	PF00018	0.361
LIG_WRC_WIRS_1	143	148	PF05994	0.280
MOD_CDK_SPxxK_3	176	183	PF00069	0.573
MOD_CDK_SPxxK_3	268	275	PF00069	0.679
MOD_CK1_1	108	114	PF00069	0.483
MOD_CK1_1	306	312	PF00069	0.568
MOD_CK1_1	324	330	PF00069	0.574
MOD_CK2_1	325	331	PF00069	0.579
MOD_GlcNHglycan	109	113	PF01048	0.533
MOD_GlcNHglycan	151	154	PF01048	0.546
MOD_GlcNHglycan	173	176	PF01048	0.460
MOD_GlcNHglycan	264	267	PF01048	0.677
MOD_GlcNHglycan	286	289	PF01048	0.506
MOD_GlcNHglycan	291	294	PF01048	0.508
MOD_GlcNHglycan	311	314	PF01048	0.724
MOD_GSK3_1	237	244	PF00069	0.585
MOD_GSK3_1	249	256	PF00069	0.678
MOD_GSK3_1	297	304	PF00069	0.652
MOD_GSK3_1	305	312	PF00069	0.604
MOD_GSK3_1	320	327	PF00069	0.486
MOD_GSK3_1	44	51	PF00069	0.425
MOD_N-GLC_1	321	326	PF02516	0.629
MOD_NEK2_1	169	174	PF00069	0.321
MOD_NEK2_1	262	267	PF00069	0.684
MOD_NEK2_1	281	286	PF00069	0.649
MOD_NEK2_1	303	308	PF00069	0.578
MOD_NEK2_1	48	53	PF00069	0.394
MOD_PIKK_1	249	255	PF00454	0.744
MOD_PKA_2	241	247	PF00069	0.515
MOD_PKB_1	70	78	PF00069	0.499
MOD_Plk_2-3	231	237	PF00069	0.702
MOD_Plk_4	254	260	PF00069	0.621
MOD_Plk_4	325	331	PF00069	0.579
MOD_Plk_4	44	50	PF00069	0.510
MOD_ProDKin_1	103	109	PF00069	0.368
MOD_ProDKin_1	176	182	PF00069	0.579
MOD_ProDKin_1	243	249	PF00069	0.756
MOD_ProDKin_1	268	274	PF00069	0.565
MOD_ProDKin_1	297	303	PF00069	0.592
MOD_ProDKin_1	307	313	PF00069	0.618
MOD_SUMO_for_1	208	211	PF00179	0.587
TRG_ER_diArg_1	5	8	PF00400	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3L5	Leptomonas seymouri	66%	100%
A0A1X0NQH6	Trypanosomatidae	39%	100%
A0A3S5IR49	Trypanosoma rangeli	40%	100%
A0A3S7X224	Leishmania donovani	83%	99%
A4I430	Leishmania infantum	83%	99%
E9B0B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4Q7W7	Leishmania major	84%	100%
V5BI47	Trypanosoma cruzi	44%	100%