Putative sodium/sulphate symporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Low-affinity phosphate transporter PHO91

Species:

Leishmania braziliensis

UniProt:

A4HGZ6_LEIBR

TriTrypDb:

LbrM.28.3140 , LBRM2903_280039000

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HGZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGZ6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0009987	cellular process	1	5
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055085	transmembrane transport	2	5
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006811	monoatomic ion transport	4	1
GO:0006817	phosphate ion transport	7	1
GO:0006820	monoatomic anion transport	5	1
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0008152	metabolic process	1	1
GO:0015698	inorganic anion transport	6	1
GO:0019725	cellular homeostasis	2	1
GO:0030002	intracellular monoatomic anion homeostasis	5	1
GO:0030643	intracellular phosphate ion homeostasis	7	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0042592	homeostatic process	3	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0055062	phosphate ion homeostasis	8	1
GO:0055081	monoatomic anion homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0072502	obsolete cellular trivalent inorganic anion homeostasis	6	1
GO:0072506	obsolete trivalent inorganic anion homeostasis	7	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	6
GO:0005315	inorganic phosphate transmembrane transporter activity	4	1
GO:0015291	secondary active transmembrane transporter activity	4	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	604	608	PF00656	0.370
CLV_NRD_NRD_1	187	189	PF00675	0.357
CLV_NRD_NRD_1	198	200	PF00675	0.417
CLV_NRD_NRD_1	236	238	PF00675	0.354
CLV_NRD_NRD_1	84	86	PF00675	0.475
CLV_NRD_NRD_1	88	90	PF00675	0.444
CLV_NRD_NRD_1	92	94	PF00675	0.491
CLV_PCSK_KEX2_1	198	200	PF00082	0.433
CLV_PCSK_KEX2_1	23	25	PF00082	0.351
CLV_PCSK_KEX2_1	5	7	PF00082	0.399
CLV_PCSK_KEX2_1	88	90	PF00082	0.446
CLV_PCSK_KEX2_1	92	94	PF00082	0.502
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.351
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.399
CLV_PCSK_PC7_1	88	94	PF00082	0.491
CLV_PCSK_SKI1_1	142	146	PF00082	0.431
CLV_PCSK_SKI1_1	163	167	PF00082	0.434
CLV_PCSK_SKI1_1	189	193	PF00082	0.367
CLV_PCSK_SKI1_1	216	220	PF00082	0.398
CLV_PCSK_SKI1_1	225	229	PF00082	0.408
CLV_PCSK_SKI1_1	23	27	PF00082	0.358
CLV_PCSK_SKI1_1	237	241	PF00082	0.381
CLV_PCSK_SKI1_1	260	264	PF00082	0.351
CLV_PCSK_SKI1_1	701	705	PF00082	0.269
CLV_PCSK_SKI1_1	71	75	PF00082	0.491
DEG_APCC_DBOX_1	213	221	PF00400	0.569
DEG_APCC_DBOX_1	224	232	PF00400	0.574
DEG_APCC_DBOX_1	381	389	PF00400	0.286
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DOC_CYCLIN_RxL_1	160	171	PF00134	0.634
DOC_CYCLIN_RxL_1	222	232	PF00134	0.636
DOC_MAPK_gen_1	237	243	PF00069	0.577
DOC_MAPK_gen_1	5	13	PF00069	0.679
DOC_MAPK_HePTP_8	340	352	PF00069	0.469
DOC_MAPK_MEF2A_6	343	352	PF00069	0.469
DOC_MAPK_MEF2A_6	426	435	PF00069	0.530
DOC_PP1_RVXF_1	641	647	PF00149	0.347
DOC_PP4_FxxP_1	239	242	PF00568	0.629
DOC_PP4_FxxP_1	315	318	PF00568	0.416
DOC_PP4_FxxP_1	646	649	PF00568	0.286
DOC_USP7_MATH_1	114	118	PF00917	0.759
DOC_USP7_MATH_1	331	335	PF00917	0.465
DOC_USP7_MATH_1	399	403	PF00917	0.323
DOC_USP7_MATH_1	588	592	PF00917	0.269
DOC_USP7_MATH_1	677	681	PF00917	0.323
DOC_USP7_MATH_1	689	693	PF00917	0.543
DOC_USP7_UBL2_3	189	193	PF12436	0.567
DOC_WW_Pin1_4	158	163	PF00397	0.611
DOC_WW_Pin1_4	443	448	PF00397	0.307
DOC_WW_Pin1_4	605	610	PF00397	0.310
DOC_WW_Pin1_4	655	660	PF00397	0.266
LIG_14-3-3_CanoR_1	188	194	PF00244	0.589
LIG_14-3-3_CanoR_1	216	221	PF00244	0.551
LIG_14-3-3_CanoR_1	225	235	PF00244	0.544
LIG_14-3-3_CanoR_1	377	385	PF00244	0.269
LIG_BRCT_BRCA1_1	231	235	PF00533	0.630
LIG_deltaCOP1_diTrp_1	254	259	PF00928	0.608
LIG_EH1_1	629	637	PF00400	0.323
LIG_FHA_1	106	112	PF00498	0.798
LIG_FHA_1	113	119	PF00498	0.696
LIG_FHA_1	203	209	PF00498	0.572
LIG_FHA_1	287	293	PF00498	0.309
LIG_FHA_1	294	300	PF00498	0.331
LIG_FHA_1	306	312	PF00498	0.279
LIG_FHA_1	330	336	PF00498	0.482
LIG_FHA_1	46	52	PF00498	0.634
LIG_FHA_1	470	476	PF00498	0.293
LIG_FHA_1	517	523	PF00498	0.489
LIG_FHA_1	528	534	PF00498	0.283
LIG_FHA_1	543	549	PF00498	0.347
LIG_FHA_1	623	629	PF00498	0.351
LIG_FHA_1	718	724	PF00498	0.324
LIG_FHA_2	363	369	PF00498	0.323
LIG_FHA_2	415	421	PF00498	0.469
LIG_FHA_2	507	513	PF00498	0.519
LIG_FHA_2	602	608	PF00498	0.370
LIG_GBD_Chelix_1	525	533	PF00786	0.387
LIG_LIR_Apic_2	236	242	PF02991	0.627
LIG_LIR_Apic_2	417	422	PF02991	0.469
LIG_LIR_Apic_2	532	537	PF02991	0.464
LIG_LIR_Apic_2	720	724	PF02991	0.324
LIG_LIR_Apic_2	726	731	PF02991	0.313
LIG_LIR_Gen_1	244	251	PF02991	0.677
LIG_LIR_Gen_1	289	299	PF02991	0.192
LIG_LIR_Gen_1	41	52	PF02991	0.552
LIG_LIR_Gen_1	494	504	PF02991	0.459
LIG_LIR_Gen_1	55	65	PF02991	0.552
LIG_LIR_Gen_1	565	575	PF02991	0.469
LIG_LIR_Gen_1	608	619	PF02991	0.381
LIG_LIR_Nem_3	14	18	PF02991	0.559
LIG_LIR_Nem_3	21	25	PF02991	0.536
LIG_LIR_Nem_3	244	249	PF02991	0.626
LIG_LIR_Nem_3	289	294	PF02991	0.192
LIG_LIR_Nem_3	41	47	PF02991	0.529
LIG_LIR_Nem_3	494	499	PF02991	0.503
LIG_LIR_Nem_3	55	61	PF02991	0.543
LIG_LIR_Nem_3	565	570	PF02991	0.469
LIG_LIR_Nem_3	608	614	PF02991	0.381
LIG_LIR_Nem_3	679	684	PF02991	0.374
LIG_NRBOX	143	149	PF00104	0.652
LIG_NRBOX	223	229	PF00104	0.634
LIG_NRBOX	573	579	PF00104	0.323
LIG_Pex14_1	15	19	PF04695	0.550
LIG_Pex14_1	259	263	PF04695	0.465
LIG_Pex14_1	572	576	PF04695	0.323
LIG_Pex14_2	141	145	PF04695	0.624
LIG_Pex14_2	235	239	PF04695	0.613
LIG_PTB_Apo_2	461	468	PF02174	0.223
LIG_SH2_CRK	22	26	PF00017	0.550
LIG_SH2_CRK	246	250	PF00017	0.638
LIG_SH2_GRB2like	246	249	PF00017	0.688
LIG_SH2_NCK_1	246	250	PF00017	0.691
LIG_SH2_PTP2	261	264	PF00017	0.379
LIG_SH2_PTP2	501	504	PF00017	0.540
LIG_SH2_PTP2	728	731	PF00017	0.393
LIG_SH2_SRC	246	249	PF00017	0.688
LIG_SH2_STAP1	246	250	PF00017	0.652
LIG_SH2_STAP1	370	374	PF00017	0.309
LIG_SH2_STAT5	19	22	PF00017	0.510
LIG_SH2_STAT5	261	264	PF00017	0.379
LIG_SH2_STAT5	386	389	PF00017	0.323
LIG_SH2_STAT5	501	504	PF00017	0.540
LIG_SH2_STAT5	611	614	PF00017	0.323
LIG_SH2_STAT5	697	700	PF00017	0.521
LIG_SH2_STAT5	728	731	PF00017	0.364
LIG_SH3_1	74	80	PF00018	0.729
LIG_SH3_2	80	85	PF14604	0.634
LIG_SH3_3	115	121	PF00018	0.775
LIG_SH3_3	126	132	PF00018	0.653
LIG_SH3_3	319	325	PF00018	0.499
LIG_SH3_3	401	407	PF00018	0.318
LIG_SH3_3	470	476	PF00018	0.346
LIG_SH3_3	489	495	PF00018	0.193
LIG_SH3_3	497	503	PF00018	0.469
LIG_SH3_3	74	80	PF00018	0.645
LIG_SUMO_SIM_anti_2	519	525	PF11976	0.443
LIG_SUMO_SIM_anti_2	613	619	PF11976	0.324
LIG_SUMO_SIM_anti_2	708	714	PF11976	0.379
LIG_SUMO_SIM_par_1	145	152	PF11976	0.711
LIG_SUMO_SIM_par_1	475	481	PF11976	0.379
LIG_SUMO_SIM_par_1	488	494	PF11976	0.379
LIG_SUMO_SIM_par_1	521	527	PF11976	0.328
LIG_SUMO_SIM_par_1	617	622	PF11976	0.267
LIG_SUMO_SIM_par_1	661	666	PF11976	0.299
LIG_TRAF2_1	104	107	PF00917	0.775
LIG_TRAF2_1	510	513	PF00917	0.570
LIG_TYR_ITIM	20	25	PF00017	0.541
LIG_TYR_ITIM	499	504	PF00017	0.540
LIG_UBA3_1	593	602	PF00899	0.340
LIG_UBA3_1	635	643	PF00899	0.325
LIG_Vh1_VBS_1	617	635	PF01044	0.318
LIG_WRC_WIRS_1	624	629	PF05994	0.469
MOD_CDK_SPK_2	158	163	PF00069	0.611
MOD_CK1_1	112	118	PF00069	0.771
MOD_CK1_1	229	235	PF00069	0.598
MOD_CK1_1	334	340	PF00069	0.465
MOD_CK1_1	516	522	PF00069	0.500
MOD_CK1_1	527	533	PF00069	0.267
MOD_CK1_1	600	606	PF00069	0.370
MOD_CK1_1	622	628	PF00069	0.211
MOD_CK2_1	362	368	PF00069	0.305
MOD_CK2_1	414	420	PF00069	0.469
MOD_CK2_1	506	512	PF00069	0.540
MOD_Cter_Amidation	3	6	PF01082	0.401
MOD_GlcNHglycan	189	192	PF01048	0.413
MOD_GlcNHglycan	329	332	PF01048	0.319
MOD_GlcNHglycan	457	460	PF01048	0.540
MOD_GlcNHglycan	516	519	PF01048	0.340
MOD_GlcNHglycan	526	529	PF01048	0.422
MOD_GlcNHglycan	670	673	PF01048	0.318
MOD_GlcNHglycan	97	100	PF01048	0.571
MOD_GSK3_1	105	112	PF00069	0.740
MOD_GSK3_1	212	219	PF00069	0.569
MOD_GSK3_1	293	300	PF00069	0.323
MOD_GSK3_1	327	334	PF00069	0.473
MOD_GSK3_1	443	450	PF00069	0.323
MOD_GSK3_1	597	604	PF00069	0.300
MOD_GSK3_1	619	626	PF00069	0.373
MOD_N-GLC_1	463	468	PF02516	0.423
MOD_NEK2_1	110	115	PF00069	0.777
MOD_NEK2_1	212	217	PF00069	0.598
MOD_NEK2_1	293	298	PF00069	0.338
MOD_NEK2_1	305	310	PF00069	0.290
MOD_NEK2_1	362	367	PF00069	0.347
MOD_NEK2_1	391	396	PF00069	0.341
MOD_NEK2_1	435	440	PF00069	0.211
MOD_NEK2_1	524	529	PF00069	0.408
MOD_NEK2_1	542	547	PF00069	0.180
MOD_NEK2_1	601	606	PF00069	0.269
MOD_NEK2_1	668	673	PF00069	0.323
MOD_PIKK_1	149	155	PF00454	0.672
MOD_PIKK_1	249	255	PF00454	0.684
MOD_PIKK_1	334	340	PF00454	0.535
MOD_PKA_2	187	193	PF00069	0.585
MOD_PKA_2	376	382	PF00069	0.255
MOD_PKB_1	214	222	PF00069	0.568
MOD_Plk_1	229	235	PF00069	0.623
MOD_Plk_1	463	469	PF00069	0.188
MOD_Plk_4	119	125	PF00069	0.730
MOD_Plk_4	216	222	PF00069	0.567
MOD_Plk_4	286	292	PF00069	0.286
MOD_Plk_4	293	299	PF00069	0.291
MOD_Plk_4	370	376	PF00069	0.336
MOD_Plk_4	381	387	PF00069	0.233
MOD_Plk_4	610	616	PF00069	0.345
MOD_Plk_4	619	625	PF00069	0.367
MOD_Plk_4	658	664	PF00069	0.286
MOD_Plk_4	683	689	PF00069	0.514
MOD_Plk_4	717	723	PF00069	0.349
MOD_ProDKin_1	158	164	PF00069	0.606
MOD_ProDKin_1	443	449	PF00069	0.307
MOD_ProDKin_1	605	611	PF00069	0.310
MOD_ProDKin_1	655	661	PF00069	0.266
MOD_SUMO_for_1	52	55	PF00179	0.630
MOD_SUMO_rev_2	230	239	PF00179	0.561
TRG_DiLeu_BaEn_1	106	111	PF01217	0.720
TRG_DiLeu_BaEn_1	68	73	PF01217	0.647
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.323
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.342
TRG_ENDOCYTIC_2	22	25	PF00928	0.538
TRG_ENDOCYTIC_2	246	249	PF00928	0.634
TRG_ENDOCYTIC_2	261	264	PF00928	0.347
TRG_ENDOCYTIC_2	501	504	PF00928	0.540
TRG_ENDOCYTIC_2	611	614	PF00928	0.323
TRG_ER_diArg_1	198	200	PF00400	0.631
TRG_ER_diArg_1	214	217	PF00400	0.494
TRG_ER_diArg_1	222	225	PF00400	0.539
TRG_ER_diArg_1	87	89	PF00400	0.628
TRG_ER_diArg_1	91	93	PF00400	0.647
TRG_NES_CRM1_1	175	185	PF08389	0.599
TRG_NLS_Bipartite_1	5	27	PF00514	0.590
TRG_NLS_MonoExtC_3	191	196	PF00514	0.581
TRG_NLS_MonoExtN_4	189	196	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWP2	Leptomonas seymouri	80%	99%
A0A1X0NQK1	Trypanosomatidae	64%	100%
A0A3Q8IB88	Leishmania donovani	91%	100%
A0A422NG32	Trypanosoma rangeli	71%	100%
A4I428	Leishmania infantum	91%	100%
D0A8X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B0B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P27514	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	82%
Q21339	Caenorhabditis elegans	25%	100%
Q4Q7W9	Leishmania major	91%	100%
Q93655	Caenorhabditis elegans	21%	100%