Conserved oligomeric Golgi complex subunit 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligomeric golgi complex component 8, putative

Species:

Leishmania braziliensis

UniProt:

A4HGZ3_LEIBR

TriTrypDb:

LbrM.28.3110 , LBRM2903_280038700

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0017119	Golgi transport complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0099023	vesicle tethering complex	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0000139	Golgi membrane	5	3
GO:0031090	organelle membrane	3	3
GO:0098588	bounding membrane of organelle	4	3

Expansion

Sequence features

A4HGZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.307
CLV_PCSK_KEX2_1	170	172	PF00082	0.307
CLV_PCSK_SKI1_1	180	184	PF00082	0.318
CLV_PCSK_SKI1_1	210	214	PF00082	0.344
CLV_PCSK_SKI1_1	384	388	PF00082	0.510
CLV_PCSK_SKI1_1	424	428	PF00082	0.427
DEG_SPOP_SBC_1	523	527	PF00917	0.726
DOC_ANK_TNKS_1	307	314	PF00023	0.201
DOC_CDC14_PxL_1	410	418	PF14671	0.572
DOC_CYCLIN_RxL_1	381	391	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	437	443	PF00134	0.455
DOC_PP1_RVXF_1	422	428	PF00149	0.275
DOC_PP2B_LxvP_1	504	507	PF13499	0.614
DOC_USP7_MATH_1	198	202	PF00917	0.323
DOC_USP7_MATH_1	2	6	PF00917	0.411
DOC_USP7_MATH_1	284	288	PF00917	0.458
DOC_USP7_MATH_1	495	499	PF00917	0.731
DOC_USP7_MATH_1	517	521	PF00917	0.679
DOC_USP7_MATH_1	523	527	PF00917	0.701
DOC_USP7_MATH_1	56	60	PF00917	0.222
DOC_USP7_MATH_1	67	71	PF00917	0.448
DOC_USP7_MATH_1	81	85	PF00917	0.414
DOC_WW_Pin1_4	172	177	PF00397	0.427
DOC_WW_Pin1_4	354	359	PF00397	0.443
DOC_WW_Pin1_4	91	96	PF00397	0.454
LIG_14-3-3_CanoR_1	103	107	PF00244	0.458
LIG_14-3-3_CanoR_1	289	298	PF00244	0.422
LIG_14-3-3_CanoR_1	315	325	PF00244	0.465
LIG_14-3-3_CanoR_1	331	335	PF00244	0.380
LIG_APCC_ABBAyCdc20_2	103	109	PF00400	0.307
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_BIR_III_3	1	5	PF00653	0.427
LIG_Clathr_ClatBox_1	111	115	PF01394	0.307
LIG_Clathr_ClatBox_1	473	477	PF01394	0.529
LIG_EH1_1	443	451	PF00400	0.484
LIG_EH1_1	466	474	PF00400	0.544
LIG_eIF4E_1	163	169	PF01652	0.427
LIG_FHA_1	145	151	PF00498	0.312
LIG_FHA_1	240	246	PF00498	0.453
LIG_FHA_1	290	296	PF00498	0.353
LIG_FHA_1	355	361	PF00498	0.529
LIG_FHA_1	460	466	PF00498	0.578
LIG_FHA_1	479	485	PF00498	0.438
LIG_FHA_1	49	55	PF00498	0.421
LIG_FHA_1	525	531	PF00498	0.503
LIG_FHA_2	239	245	PF00498	0.201
LIG_FHA_2	351	357	PF00498	0.607
LIG_FHA_2	416	422	PF00498	0.324
LIG_FHA_2	489	495	PF00498	0.578
LIG_GBD_Chelix_1	368	376	PF00786	0.378
LIG_LIR_Apic_2	146	151	PF02991	0.201
LIG_LIR_Gen_1	21	31	PF02991	0.409
LIG_LIR_Gen_1	377	387	PF02991	0.367
LIG_LIR_Gen_1	59	67	PF02991	0.454
LIG_LIR_LC3C_4	272	277	PF02991	0.454
LIG_LIR_Nem_3	160	166	PF02991	0.414
LIG_LIR_Nem_3	21	26	PF02991	0.354
LIG_LIR_Nem_3	377	382	PF02991	0.357
LIG_LIR_Nem_3	59	63	PF02991	0.454
LIG_LYPXL_yS_3	439	442	PF13949	0.394
LIG_MAD2	87	95	PF02301	0.454
LIG_Pex14_2	430	434	PF04695	0.353
LIG_Rb_pABgroove_1	414	422	PF01858	0.328
LIG_SH2_CRK	163	167	PF00017	0.427
LIG_SH2_CRK	205	209	PF00017	0.307
LIG_SH2_PTP2	148	151	PF00017	0.201
LIG_SH2_PTP2	211	214	PF00017	0.427
LIG_SH2_STAP1	205	209	PF00017	0.310
LIG_SH2_STAP1	23	27	PF00017	0.276
LIG_SH2_STAT3	190	193	PF00017	0.446
LIG_SH2_STAT5	148	151	PF00017	0.345
LIG_SH2_STAT5	190	193	PF00017	0.346
LIG_SH2_STAT5	211	214	PF00017	0.323
LIG_SH2_STAT5	335	338	PF00017	0.596
LIG_SH2_STAT5	441	444	PF00017	0.415
LIG_SH3_3	472	478	PF00018	0.508
LIG_SH3_3	516	522	PF00018	0.728
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.416
LIG_SUMO_SIM_par_1	87	94	PF11976	0.427
LIG_TRAF2_1	241	244	PF00917	0.427
LIG_TRAF2_1	5	8	PF00917	0.357
LIG_TYR_ITIM	203	208	PF00017	0.364
LIG_TYR_ITIM	209	214	PF00017	0.427
LIG_TYR_ITIM	437	442	PF00017	0.455
LIG_TYR_ITSM	159	166	PF00017	0.427
LIG_UBA3_1	297	305	PF00899	0.415
LIG_WRC_WIRS_1	376	381	PF05994	0.482
LIG_WRC_WIRS_1	427	432	PF05994	0.445
MOD_CK1_1	282	288	PF00069	0.399
MOD_CK1_1	489	495	PF00069	0.675
MOD_CK1_1	498	504	PF00069	0.628
MOD_CK1_1	509	515	PF00069	0.600
MOD_CK2_1	2	8	PF00069	0.573
MOD_CK2_1	238	244	PF00069	0.323
MOD_CK2_1	488	494	PF00069	0.638
MOD_GlcNHglycan	153	156	PF01048	0.350
MOD_GlcNHglycan	284	287	PF01048	0.365
MOD_GlcNHglycan	4	7	PF01048	0.623
MOD_GlcNHglycan	41	44	PF01048	0.232
MOD_GlcNHglycan	486	489	PF01048	0.698
MOD_GlcNHglycan	508	511	PF01048	0.564
MOD_GlcNHglycan	79	82	PF01048	0.415
MOD_GSK3_1	151	158	PF00069	0.410
MOD_GSK3_1	239	246	PF00069	0.438
MOD_GSK3_1	316	323	PF00069	0.470
MOD_GSK3_1	326	333	PF00069	0.451
MOD_GSK3_1	337	344	PF00069	0.519
MOD_GSK3_1	35	42	PF00069	0.410
MOD_GSK3_1	350	357	PF00069	0.414
MOD_GSK3_1	484	491	PF00069	0.562
MOD_GSK3_1	495	502	PF00069	0.703
MOD_GSK3_1	77	84	PF00069	0.376
MOD_N-GLC_1	268	273	PF02516	0.323
MOD_N-GLC_1	337	342	PF02516	0.625
MOD_NEK2_1	183	188	PF00069	0.412
MOD_NEK2_1	297	302	PF00069	0.376
MOD_NEK2_1	325	330	PF00069	0.458
MOD_NEK2_1	342	347	PF00069	0.465
MOD_NEK2_1	415	420	PF00069	0.556
MOD_NEK2_1	50	55	PF00069	0.318
MOD_NEK2_2	330	335	PF00069	0.546
MOD_PIKK_1	459	465	PF00454	0.584
MOD_PIKK_1	58	64	PF00454	0.341
MOD_PKA_2	102	108	PF00069	0.468
MOD_PKA_2	11	17	PF00069	0.405
MOD_PKA_2	238	244	PF00069	0.409
MOD_PKA_2	317	323	PF00069	0.499
MOD_PKA_2	330	336	PF00069	0.387
MOD_Plk_1	198	204	PF00069	0.395
MOD_Plk_1	220	226	PF00069	0.427
MOD_Plk_1	243	249	PF00069	0.412
MOD_Plk_1	337	343	PF00069	0.604
MOD_Plk_4	102	108	PF00069	0.405
MOD_Plk_4	11	17	PF00069	0.427
MOD_Plk_4	144	150	PF00069	0.462
MOD_Plk_4	198	204	PF00069	0.453
MOD_Plk_4	210	216	PF00069	0.293
MOD_Plk_4	243	249	PF00069	0.427
MOD_Plk_4	297	303	PF00069	0.333
MOD_Plk_4	330	336	PF00069	0.544
MOD_Plk_4	343	349	PF00069	0.578
MOD_Plk_4	415	421	PF00069	0.519
MOD_Plk_4	426	432	PF00069	0.361
MOD_ProDKin_1	172	178	PF00069	0.427
MOD_ProDKin_1	354	360	PF00069	0.445
MOD_ProDKin_1	91	97	PF00069	0.454
TRG_DiLeu_BaEn_1	397	402	PF01217	0.468
TRG_DiLeu_BaEn_1	93	98	PF01217	0.427
TRG_DiLeu_BaEn_2	422	428	PF01217	0.527
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.538
TRG_ENDOCYTIC_2	163	166	PF00928	0.427
TRG_ENDOCYTIC_2	205	208	PF00928	0.307
TRG_ENDOCYTIC_2	211	214	PF00928	0.420
TRG_ENDOCYTIC_2	23	26	PF00928	0.323
TRG_ENDOCYTIC_2	439	442	PF00928	0.410
TRG_ER_diArg_1	169	171	PF00400	0.307
TRG_ER_diArg_1	184	187	PF00400	0.307
TRG_NES_CRM1_1	109	122	PF08389	0.427
TRG_NES_CRM1_1	463	477	PF08389	0.449
TRG_Pf-PMV_PEXEL_1	399	404	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS6	Leptomonas seymouri	71%	88%
A0A0S4IRC0	Bodo saltans	34%	100%
A0A1X0NS75	Trypanosomatidae	39%	100%
A0A3R7LW05	Trypanosoma rangeli	38%	100%
A0A3S7X1Y9	Leishmania donovani	85%	100%
A4I425	Leishmania infantum	86%	100%
D0A8Y2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B0B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q2TBH9	Bos taurus	22%	85%
Q4Q7X2	Leishmania major	84%	100%
Q84K25	Arabidopsis thaliana	22%	93%
Q96MW5	Homo sapiens	24%	87%
Q9JJA2	Mus musculus	23%	83%
Q9VKH0	Drosophila melanogaster	22%	93%
V5BI51	Trypanosoma cruzi	39%	100%