Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGZ2_LEIBR

TriTrypDb:

LbrM.28.3100 , LBRM2903_280038600

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGZ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.326
CLV_MEL_PAP_1	254	260	PF00089	0.423
CLV_NRD_NRD_1	181	183	PF00675	0.461
CLV_NRD_NRD_1	274	276	PF00675	0.432
CLV_NRD_NRD_1	293	295	PF00675	0.624
CLV_NRD_NRD_1	99	101	PF00675	0.528
CLV_PCSK_FUR_1	56	60	PF00082	0.585
CLV_PCSK_KEX2_1	126	128	PF00082	0.549
CLV_PCSK_KEX2_1	181	183	PF00082	0.461
CLV_PCSK_KEX2_1	274	276	PF00082	0.432
CLV_PCSK_KEX2_1	293	295	PF00082	0.624
CLV_PCSK_KEX2_1	58	60	PF00082	0.587
CLV_PCSK_KEX2_1	99	101	PF00082	0.589
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.517
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.587
CLV_PCSK_SKI1_1	164	168	PF00082	0.376
CLV_PCSK_SKI1_1	209	213	PF00082	0.600
CLV_PCSK_SKI1_1	70	74	PF00082	0.404
DEG_APCC_DBOX_1	208	216	PF00400	0.586
DEG_APCC_DBOX_1	274	282	PF00400	0.447
DEG_APCC_DBOX_1	58	66	PF00400	0.542
DEG_APCC_DBOX_1	99	107	PF00400	0.419
DOC_CDC14_PxL_1	367	375	PF14671	0.507
DOC_CYCLIN_yCln2_LP_2	369	372	PF00134	0.504
DOC_MAPK_gen_1	99	105	PF00069	0.430
DOC_PP2B_LxvP_1	369	372	PF13499	0.504
DOC_USP7_MATH_1	180	184	PF00917	0.583
DOC_USP7_MATH_1	232	236	PF00917	0.402
DOC_USP7_MATH_1	352	356	PF00917	0.566
DOC_USP7_MATH_1	4	8	PF00917	0.522
DOC_WW_Pin1_4	118	123	PF00397	0.437
DOC_WW_Pin1_4	362	367	PF00397	0.622
DOC_WW_Pin1_4	375	380	PF00397	0.552
LIG_14-3-3_CanoR_1	117	122	PF00244	0.483
LIG_14-3-3_CanoR_1	181	185	PF00244	0.528
LIG_14-3-3_CanoR_1	274	279	PF00244	0.335
LIG_14-3-3_CanoR_1	293	301	PF00244	0.426
LIG_14-3-3_CanoR_1	52	60	PF00244	0.584
LIG_Actin_WH2_2	103	121	PF00022	0.511
LIG_Actin_WH2_2	363	378	PF00022	0.503
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_Clathr_ClatBox_1	147	151	PF01394	0.424
LIG_deltaCOP1_diTrp_1	201	211	PF00928	0.415
LIG_FHA_1	118	124	PF00498	0.518
LIG_FHA_1	132	138	PF00498	0.552
LIG_FHA_1	168	174	PF00498	0.509
LIG_FHA_1	19	25	PF00498	0.431
LIG_FHA_1	282	288	PF00498	0.478
LIG_FHA_1	296	302	PF00498	0.444
LIG_FHA_1	6	12	PF00498	0.505
LIG_FHA_1	93	99	PF00498	0.489
LIG_FHA_2	21	27	PF00498	0.444
LIG_FHA_2	263	269	PF00498	0.532
LIG_FHA_2	302	308	PF00498	0.509
LIG_FHA_2	357	363	PF00498	0.467
LIG_FHA_2	393	399	PF00498	0.572
LIG_LIR_Gen_1	143	150	PF02991	0.510
LIG_LIR_Gen_1	319	329	PF02991	0.407
LIG_LIR_Gen_1	71	79	PF02991	0.473
LIG_LIR_Nem_3	143	147	PF02991	0.512
LIG_LIR_Nem_3	152	158	PF02991	0.408
LIG_LIR_Nem_3	272	276	PF02991	0.484
LIG_LIR_Nem_3	304	308	PF02991	0.485
LIG_LIR_Nem_3	319	325	PF02991	0.327
LIG_LIR_Nem_3	71	76	PF02991	0.525
LIG_Pex14_1	64	68	PF04695	0.400
LIG_RPA_C_Fungi	47	59	PF08784	0.577
LIG_SH2_NCK_1	79	83	PF00017	0.475
LIG_SH2_STAP1	108	112	PF00017	0.375
LIG_SH2_STAP1	144	148	PF00017	0.499
LIG_SH2_STAP1	318	322	PF00017	0.392
LIG_SH2_STAP1	35	39	PF00017	0.653
LIG_SH2_STAT3	318	321	PF00017	0.394
LIG_SH2_STAT3	35	38	PF00017	0.545
LIG_SH2_STAT5	280	283	PF00017	0.404
LIG_SH2_STAT5	291	294	PF00017	0.405
LIG_SH2_STAT5	318	321	PF00017	0.316
LIG_SH2_STAT5	35	38	PF00017	0.545
LIG_SH2_STAT5	39	42	PF00017	0.511
LIG_SH2_STAT5	68	71	PF00017	0.468
LIG_SH2_STAT5	79	82	PF00017	0.537
LIG_SH3_1	119	125	PF00018	0.558
LIG_SH3_2	122	127	PF14604	0.731
LIG_SH3_3	119	125	PF00018	0.723
LIG_SH3_3	360	366	PF00018	0.557
LIG_SH3_3	9	15	PF00018	0.518
LIG_SUMO_SIM_anti_2	130	137	PF11976	0.548
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.487
LIG_SUMO_SIM_anti_2	364	371	PF11976	0.493
LIG_SUMO_SIM_par_1	146	152	PF11976	0.440
MOD_CDK_SPxK_1	118	124	PF00069	0.424
MOD_CK1_1	189	195	PF00069	0.425
MOD_CK1_1	365	371	PF00069	0.542
MOD_CK1_1	77	83	PF00069	0.655
MOD_CK1_1	92	98	PF00069	0.459
MOD_CK2_1	262	268	PF00069	0.494
MOD_CK2_1	301	307	PF00069	0.507
MOD_CK2_1	392	398	PF00069	0.571
MOD_GlcNHglycan	80	83	PF01048	0.538
MOD_GlcNHglycan	91	94	PF01048	0.550
MOD_GSK3_1	281	288	PF00069	0.307
MOD_GSK3_1	33	40	PF00069	0.445
MOD_GSK3_1	352	359	PF00069	0.467
MOD_GSK3_1	361	368	PF00069	0.546
MOD_GSK3_1	392	399	PF00069	0.557
MOD_GSK3_1	74	81	PF00069	0.553
MOD_N-GLC_1	5	10	PF02516	0.594
MOD_N-GLC_2	344	346	PF02516	0.375
MOD_NEK2_1	301	306	PF00069	0.436
MOD_NEK2_1	78	83	PF00069	0.545
MOD_PIKK_1	33	39	PF00454	0.547
MOD_PIKK_1	378	384	PF00454	0.533
MOD_PKA_1	274	280	PF00069	0.337
MOD_PKA_1	293	299	PF00069	0.340
MOD_PKA_2	180	186	PF00069	0.540
MOD_PKA_2	274	280	PF00069	0.337
MOD_PKA_2	293	299	PF00069	0.425
MOD_PKA_2	51	57	PF00069	0.567
MOD_Plk_1	316	322	PF00069	0.388
MOD_Plk_1	74	80	PF00069	0.586
MOD_Plk_2-3	264	270	PF00069	0.482
MOD_Plk_4	131	137	PF00069	0.586
MOD_Plk_4	151	157	PF00069	0.406
MOD_Plk_4	345	351	PF00069	0.486
MOD_Plk_4	365	371	PF00069	0.448
MOD_Plk_4	60	66	PF00069	0.473
MOD_Plk_4	74	80	PF00069	0.538
MOD_ProDKin_1	118	124	PF00069	0.435
MOD_ProDKin_1	362	368	PF00069	0.623
MOD_ProDKin_1	375	381	PF00069	0.550
MOD_SUMO_rev_2	13	21	PF00179	0.502
TRG_DiLeu_BaEn_1	143	148	PF01217	0.430
TRG_DiLeu_BaEn_2	150	156	PF01217	0.497
TRG_DiLeu_BaEn_2	306	312	PF01217	0.508
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.371
TRG_ENDOCYTIC_2	144	147	PF00928	0.631
TRG_ENDOCYTIC_2	163	166	PF00928	0.342
TRG_ENDOCYTIC_2	305	308	PF00928	0.443
TRG_ER_diArg_1	273	275	PF00400	0.455
TRG_ER_diArg_1	292	294	PF00400	0.610
TRG_ER_diArg_1	98	100	PF00400	0.631
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J9	Leptomonas seymouri	49%	100%
A0A3S7X1Y7	Leishmania donovani	72%	100%
A4I424	Leishmania infantum	72%	100%
E9B0B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q7X3	Leishmania major	72%	100%