Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HGZ0_LEIBR

TriTrypDb:

LbrM.28.3080 , LBRM2903_280038400

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.672
CLV_NRD_NRD_1	122	124	PF00675	0.692
CLV_NRD_NRD_1	21	23	PF00675	0.535
CLV_NRD_NRD_1	74	76	PF00675	0.667
CLV_PCSK_KEX2_1	122	124	PF00082	0.692
CLV_PCSK_KEX2_1	21	23	PF00082	0.535
CLV_PCSK_KEX2_1	74	76	PF00082	0.667
CLV_PCSK_SKI1_1	208	212	PF00082	0.544
CLV_PCSK_SKI1_1	225	229	PF00082	0.488
CLV_PCSK_SKI1_1	75	79	PF00082	0.728
DEG_APCC_DBOX_1	74	82	PF00400	0.731
DOC_CKS1_1	165	170	PF01111	0.445
DOC_MAPK_gen_1	21	29	PF00069	0.526
DOC_USP7_MATH_1	67	71	PF00917	0.565
DOC_WW_Pin1_4	156	161	PF00397	0.636
DOC_WW_Pin1_4	164	169	PF00397	0.654
LIG_14-3-3_CanoR_1	24	28	PF00244	0.591
LIG_14-3-3_CanoR_1	74	78	PF00244	0.460
LIG_Actin_WH2_2	172	189	PF00022	0.385
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_BRCT_BRCA1_1	240	244	PF00533	0.600
LIG_Clathr_ClatBox_1	147	151	PF01394	0.544
LIG_FHA_1	181	187	PF00498	0.622
LIG_FHA_1	24	30	PF00498	0.692
LIG_FHA_1	61	67	PF00498	0.477
LIG_FHA_2	74	80	PF00498	0.456
LIG_FHA_2	95	101	PF00498	0.612
LIG_GBD_Chelix_1	85	93	PF00786	0.482
LIG_LIR_Gen_1	193	203	PF02991	0.354
LIG_LIR_Nem_3	100	106	PF02991	0.560
LIG_LIR_Nem_3	193	198	PF02991	0.438
LIG_LIR_Nem_3	201	207	PF02991	0.476
LIG_LIR_Nem_3	241	247	PF02991	0.456
LIG_REV1ctd_RIR_1	202	212	PF16727	0.489
LIG_SH2_NCK_1	195	199	PF00017	0.444
LIG_SH2_SRC	195	198	PF00017	0.437
LIG_SH3_2	165	170	PF14604	0.445
LIG_SH3_2	17	22	PF14604	0.543
LIG_SH3_3	118	124	PF00018	0.729
LIG_SH3_3	14	20	PF00018	0.529
LIG_SH3_3	147	153	PF00018	0.466
LIG_SH3_3	162	168	PF00018	0.439
LIG_SUMO_SIM_anti_2	143	149	PF11976	0.506
LIG_SUMO_SIM_anti_2	96	103	PF11976	0.560
LIG_SUMO_SIM_par_1	25	31	PF11976	0.548
LIG_TYR_ITIM	101	106	PF00017	0.519
LIG_TYR_ITSM	191	198	PF00017	0.340
MOD_CDK_SPxK_1	164	170	PF00069	0.530
MOD_CK1_1	164	170	PF00069	0.601
MOD_CK1_1	94	100	PF00069	0.614
MOD_CK2_1	174	180	PF00069	0.553
MOD_GlcNHglycan	213	216	PF01048	0.454
MOD_GlcNHglycan	69	72	PF01048	0.682
MOD_GSK3_1	152	159	PF00069	0.597
MOD_GSK3_1	170	177	PF00069	0.585
MOD_GSK3_1	50	57	PF00069	0.547
MOD_GSK3_1	73	80	PF00069	0.501
MOD_GSK3_1	89	96	PF00069	0.588
MOD_N-GLC_1	60	65	PF02516	0.646
MOD_NEK2_1	141	146	PF00069	0.492
MOD_NEK2_1	73	78	PF00069	0.521
MOD_NEK2_1	89	94	PF00069	0.657
MOD_PIKK_1	170	176	PF00454	0.647
MOD_PIKK_1	187	193	PF00454	0.367
MOD_PIKK_1	60	66	PF00454	0.485
MOD_PKA_2	221	227	PF00069	0.588
MOD_PKA_2	23	29	PF00069	0.595
MOD_PKA_2	73	79	PF00069	0.523
MOD_Plk_2-3	54	60	PF00069	0.684
MOD_Plk_4	141	147	PF00069	0.486
MOD_Plk_4	174	180	PF00069	0.440
MOD_Plk_4	190	196	PF00069	0.412
MOD_Plk_4	23	29	PF00069	0.595
MOD_Plk_4	80	86	PF00069	0.465
MOD_ProDKin_1	156	162	PF00069	0.639
MOD_ProDKin_1	164	170	PF00069	0.651
MOD_SUMO_for_1	218	221	PF00179	0.545
MOD_SUMO_rev_2	180	188	PF00179	0.382
TRG_DiLeu_BaEn_1	143	148	PF01217	0.508
TRG_ENDOCYTIC_2	103	106	PF00928	0.563
TRG_ENDOCYTIC_2	195	198	PF00928	0.355
TRG_ER_diArg_1	121	123	PF00400	0.696
TRG_ER_diArg_1	20	22	PF00400	0.536
TRG_ER_diArg_1	73	75	PF00400	0.680
TRG_NES_CRM1_1	137	151	PF08389	0.495
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6I3	Leptomonas seymouri	51%	96%
A0A3Q8IE62	Leishmania donovani	82%	100%
A4I422	Leishmania infantum	82%	100%
E9B0A9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q7X5	Leishmania major	84%	100%