F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGY8_LEIBR

TriTrypDb:

LbrM.28.3060 , LBRM2903_280038200

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HGY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGY8

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.536
CLV_NRD_NRD_1	123	125	PF00675	0.583
CLV_NRD_NRD_1	233	235	PF00675	0.459
CLV_NRD_NRD_1	43	45	PF00675	0.566
CLV_NRD_NRD_1	93	95	PF00675	0.458
CLV_PCSK_KEX2_1	123	125	PF00082	0.512
CLV_PCSK_KEX2_1	151	153	PF00082	0.658
CLV_PCSK_KEX2_1	233	235	PF00082	0.459
CLV_PCSK_KEX2_1	432	434	PF00082	0.677
CLV_PCSK_KEX2_1	93	95	PF00082	0.440
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.680
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.710
CLV_PCSK_PC7_1	119	125	PF00082	0.577
CLV_PCSK_SKI1_1	123	127	PF00082	0.555
CLV_PCSK_SKI1_1	148	152	PF00082	0.627
CLV_PCSK_SKI1_1	295	299	PF00082	0.456
CLV_PCSK_SKI1_1	93	97	PF00082	0.577
CLV_Separin_Metazoa	222	226	PF03568	0.545
DEG_APCC_DBOX_1	92	100	PF00400	0.540
DOC_ANK_TNKS_1	224	231	PF00023	0.535
DOC_CDC14_PxL_1	174	182	PF14671	0.529
DOC_CDC14_PxL_1	406	414	PF14671	0.499
DOC_CKS1_1	106	111	PF01111	0.542
DOC_CYCLIN_RxL_1	133	146	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	285	291	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.529
DOC_MAPK_FxFP_2	378	381	PF00069	0.316
DOC_MAPK_gen_1	119	129	PF00069	0.517
DOC_MAPK_gen_1	90	99	PF00069	0.319
DOC_MAPK_MEF2A_6	279	287	PF00069	0.516
DOC_PP1_RVXF_1	68	75	PF00149	0.445
DOC_PP2B_LxvP_1	163	166	PF13499	0.512
DOC_PP2B_LxvP_1	264	267	PF13499	0.449
DOC_PP2B_LxvP_1	285	288	PF13499	0.478
DOC_PP4_FxxP_1	378	381	PF00568	0.316
DOC_PP4_FxxP_1	74	77	PF00568	0.553
DOC_USP7_MATH_1	131	135	PF00917	0.551
DOC_USP7_MATH_1	193	197	PF00917	0.634
DOC_USP7_MATH_1	335	339	PF00917	0.701
DOC_USP7_MATH_1	342	346	PF00917	0.731
DOC_WW_Pin1_4	1	6	PF00397	0.690
DOC_WW_Pin1_4	105	110	PF00397	0.397
DOC_WW_Pin1_4	257	262	PF00397	0.685
DOC_WW_Pin1_4	331	336	PF00397	0.578
DOC_WW_Pin1_4	52	57	PF00397	0.693
LIG_14-3-3_CanoR_1	119	123	PF00244	0.547
LIG_14-3-3_CanoR_1	124	130	PF00244	0.531
LIG_14-3-3_CanoR_1	133	141	PF00244	0.518
LIG_14-3-3_CanoR_1	23	28	PF00244	0.557
LIG_Actin_WH2_2	134	150	PF00022	0.332
LIG_Actin_WH2_2	280	297	PF00022	0.538
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_CSL_BTD_1	285	288	PF09270	0.527
LIG_deltaCOP1_diTrp_1	276	286	PF00928	0.295
LIG_DLG_GKlike_1	23	30	PF00625	0.524
LIG_FHA_1	137	143	PF00498	0.542
LIG_FHA_1	214	220	PF00498	0.270
LIG_FHA_1	331	337	PF00498	0.730
LIG_FHA_1	383	389	PF00498	0.458
LIG_FHA_1	86	92	PF00498	0.435
LIG_FHA_2	179	185	PF00498	0.431
LIG_FHA_2	385	391	PF00498	0.462
LIG_FHA_2	423	429	PF00498	0.759
LIG_LIR_Apic_2	245	250	PF02991	0.615
LIG_LIR_Apic_2	376	381	PF02991	0.546
LIG_LIR_Gen_1	22	30	PF02991	0.559
LIG_LIR_Gen_1	269	278	PF02991	0.418
LIG_LIR_LC3C_4	239	243	PF02991	0.479
LIG_LIR_Nem_3	22	27	PF02991	0.538
LIG_LIR_Nem_3	269	273	PF02991	0.399
LIG_LIR_Nem_3	304	309	PF02991	0.509
LIG_LYPXL_S_1	379	383	PF13949	0.550
LIG_LYPXL_yS_3	380	383	PF13949	0.523
LIG_NRBOX	198	204	PF00104	0.537
LIG_SH2_STAT5	179	182	PF00017	0.447
LIG_SH2_STAT5	201	204	PF00017	0.419
LIG_SH2_STAT5	247	250	PF00017	0.671
LIG_SH2_STAT5	270	273	PF00017	0.516
LIG_SH3_1	246	252	PF00018	0.530
LIG_SH3_3	103	109	PF00018	0.472
LIG_SH3_3	246	252	PF00018	0.574
LIG_SUMO_SIM_anti_2	103	108	PF11976	0.491
LIG_SUMO_SIM_par_1	103	108	PF11976	0.423
LIG_SUMO_SIM_par_1	138	146	PF11976	0.566
LIG_SUMO_SIM_par_1	387	393	PF11976	0.551
LIG_SUMO_SIM_par_1	4	10	PF11976	0.676
LIG_SUMO_SIM_par_1	59	65	PF11976	0.586
LIG_WRC_WIRS_1	126	131	PF05994	0.431
LIG_WRC_WIRS_1	24	29	PF05994	0.556
MOD_CK1_1	115	121	PF00069	0.479
MOD_CK1_1	254	260	PF00069	0.705
MOD_CK1_1	302	308	PF00069	0.496
MOD_CK1_1	422	428	PF00069	0.756
MOD_CK2_1	259	265	PF00069	0.599
MOD_CK2_1	422	428	PF00069	0.754
MOD_GlcNHglycan	1	4	PF01048	0.629
MOD_GlcNHglycan	11	14	PF01048	0.512
MOD_GlcNHglycan	114	117	PF01048	0.568
MOD_GlcNHglycan	158	161	PF01048	0.415
MOD_GlcNHglycan	301	304	PF01048	0.593
MOD_GlcNHglycan	338	341	PF01048	0.761
MOD_GlcNHglycan	344	347	PF01048	0.739
MOD_GlcNHglycan	421	424	PF01048	0.592
MOD_GSK3_1	1	8	PF00069	0.619
MOD_GSK3_1	132	139	PF00069	0.442
MOD_GSK3_1	19	26	PF00069	0.550
MOD_GSK3_1	250	257	PF00069	0.696
MOD_GSK3_1	30	37	PF00069	0.541
MOD_GSK3_1	331	338	PF00069	0.613
MOD_GSK3_1	342	349	PF00069	0.698
MOD_N-GLC_1	236	241	PF02516	0.521
MOD_N-GLC_2	416	418	PF02516	0.551
MOD_NEK2_1	30	35	PF00069	0.609
MOD_NEK2_1	85	90	PF00069	0.511
MOD_PIKK_1	132	138	PF00454	0.554
MOD_PIKK_1	172	178	PF00454	0.506
MOD_PIKK_1	193	199	PF00454	0.578
MOD_PIKK_1	30	36	PF00454	0.376
MOD_PKA_2	118	124	PF00069	0.581
MOD_PKA_2	132	138	PF00069	0.471
MOD_Plk_1	143	149	PF00069	0.622
MOD_Plk_1	236	242	PF00069	0.519
MOD_Plk_1	254	260	PF00069	0.444
MOD_Plk_4	107	113	PF00069	0.378
MOD_Plk_4	237	243	PF00069	0.524
MOD_Plk_4	259	265	PF00069	0.605
MOD_Plk_4	384	390	PF00069	0.487
MOD_ProDKin_1	1	7	PF00069	0.685
MOD_ProDKin_1	105	111	PF00069	0.401
MOD_ProDKin_1	257	263	PF00069	0.667
MOD_ProDKin_1	331	337	PF00069	0.580
MOD_ProDKin_1	52	58	PF00069	0.687
MOD_SUMO_for_1	150	153	PF00179	0.666
MOD_SUMO_rev_2	46	52	PF00179	0.542
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.415
TRG_ENDOCYTIC_2	270	273	PF00928	0.501
TRG_ENDOCYTIC_2	380	383	PF00928	0.523
TRG_ER_diArg_1	122	124	PF00400	0.564
TRG_ER_diArg_1	232	234	PF00400	0.516
TRG_ER_diArg_1	92	94	PF00400	0.452
TRG_NLS_MonoExtN_4	429	435	PF00514	0.772
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Z3	Leptomonas seymouri	46%	93%
A0A0S4IUX7	Bodo saltans	26%	98%
A0A1X0NQH2	Trypanosomatidae	26%	100%
A0A3S7X213	Leishmania donovani	77%	100%
A0A422N0P3	Trypanosoma rangeli	26%	98%
A4I420	Leishmania infantum	77%	100%
D0A8Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
E9B0A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	94%
Q4Q7X7	Leishmania major	77%	100%
V5ATM8	Trypanosoma cruzi	26%	100%