Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGY7_LEIBR

TriTrypDb:

LbrM.28.3050 , LBRM2903_280038100

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.700
CLV_C14_Caspase3-7	405	409	PF00656	0.761
CLV_NRD_NRD_1	151	153	PF00675	0.521
CLV_NRD_NRD_1	172	174	PF00675	0.434
CLV_NRD_NRD_1	260	262	PF00675	0.447
CLV_NRD_NRD_1	269	271	PF00675	0.403
CLV_NRD_NRD_1	297	299	PF00675	0.557
CLV_NRD_NRD_1	321	323	PF00675	0.598
CLV_NRD_NRD_1	356	358	PF00675	0.688
CLV_NRD_NRD_1	478	480	PF00675	0.522
CLV_NRD_NRD_1	52	54	PF00675	0.431
CLV_PCSK_KEX2_1	151	153	PF00082	0.525
CLV_PCSK_KEX2_1	171	173	PF00082	0.330
CLV_PCSK_KEX2_1	269	271	PF00082	0.451
CLV_PCSK_KEX2_1	297	299	PF00082	0.517
CLV_PCSK_KEX2_1	320	322	PF00082	0.556
CLV_PCSK_KEX2_1	358	360	PF00082	0.659
CLV_PCSK_KEX2_1	478	480	PF00082	0.522
CLV_PCSK_KEX2_1	52	54	PF00082	0.424
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.655
CLV_PCSK_PC7_1	474	480	PF00082	0.538
CLV_PCSK_SKI1_1	158	162	PF00082	0.497
CLV_PCSK_SKI1_1	172	176	PF00082	0.365
CLV_PCSK_SKI1_1	310	314	PF00082	0.655
DEG_SPOP_SBC_1	126	130	PF00917	0.549
DEG_SPOP_SBC_1	339	343	PF00917	0.686
DOC_CKS1_1	248	253	PF01111	0.505
DOC_MAPK_gen_1	320	327	PF00069	0.505
DOC_MAPK_gen_1	357	368	PF00069	0.686
DOC_MAPK_MEF2A_6	482	490	PF00069	0.635
DOC_PP2B_LxvP_1	34	37	PF13499	0.382
DOC_USP7_MATH_1	10	14	PF00917	0.538
DOC_USP7_MATH_1	180	184	PF00917	0.375
DOC_USP7_MATH_1	223	227	PF00917	0.684
DOC_USP7_MATH_1	337	341	PF00917	0.773
DOC_USP7_MATH_1	387	391	PF00917	0.666
DOC_USP7_MATH_1	4	8	PF00917	0.591
DOC_USP7_MATH_1	454	458	PF00917	0.711
DOC_USP7_MATH_1	86	90	PF00917	0.631
DOC_WW_Pin1_4	104	109	PF00397	0.416
DOC_WW_Pin1_4	247	252	PF00397	0.488
DOC_WW_Pin1_4	370	375	PF00397	0.652
DOC_WW_Pin1_4	389	394	PF00397	0.696
DOC_WW_Pin1_4	6	11	PF00397	0.539
LIG_14-3-3_CanoR_1	151	161	PF00244	0.566
LIG_14-3-3_CanoR_1	163	168	PF00244	0.503
LIG_14-3-3_CanoR_1	179	185	PF00244	0.391
LIG_14-3-3_CanoR_1	217	225	PF00244	0.580
LIG_14-3-3_CanoR_1	310	316	PF00244	0.609
LIG_14-3-3_CanoR_1	82	86	PF00244	0.539
LIG_Actin_WH2_2	105	120	PF00022	0.494
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BIR_III_3	1	5	PF00653	0.587
LIG_BRCT_BRCA1_1	486	490	PF00533	0.645
LIG_Clathr_ClatBox_1	57	61	PF01394	0.598
LIG_deltaCOP1_diTrp_1	480	490	PF00928	0.629
LIG_eIF4E_1	435	441	PF01652	0.644
LIG_FHA_1	108	114	PF00498	0.501
LIG_FHA_1	227	233	PF00498	0.449
LIG_FHA_1	248	254	PF00498	0.506
LIG_FHA_1	269	275	PF00498	0.583
LIG_FHA_1	282	288	PF00498	0.401
LIG_FHA_1	463	469	PF00498	0.705
LIG_FHA_2	118	124	PF00498	0.583
LIG_FHA_2	144	150	PF00498	0.426
LIG_FHA_2	238	244	PF00498	0.442
LIG_FHA_2	254	260	PF00498	0.454
LIG_FHA_2	403	409	PF00498	0.753
LIG_Integrin_RGD_1	361	363	PF01839	0.658
LIG_LIR_Apic_2	432	438	PF02991	0.656
LIG_LIR_LC3C_4	19	24	PF02991	0.308
LIG_LIR_Nem_3	147	153	PF02991	0.562
LIG_LIR_Nem_3	199	205	PF02991	0.548
LIG_MYND_1	438	442	PF01753	0.646
LIG_PDZ_Class_2	485	490	PF00595	0.642
LIG_SH2_CRK	150	154	PF00017	0.486
LIG_SH2_NCK_1	435	439	PF00017	0.640
LIG_SH2_PTP2	444	447	PF00017	0.623
LIG_SH2_SRC	439	442	PF00017	0.615
LIG_SH2_STAT3	245	248	PF00017	0.500
LIG_SH2_STAT5	116	119	PF00017	0.619
LIG_SH2_STAT5	429	432	PF00017	0.678
LIG_SH2_STAT5	439	442	PF00017	0.638
LIG_SH2_STAT5	444	447	PF00017	0.644
LIG_SH3_3	458	464	PF00018	0.568
LIG_SUMO_SIM_anti_2	375	381	PF11976	0.791
LIG_SUMO_SIM_par_1	375	381	PF11976	0.679
LIG_TRAF2_1	381	384	PF00917	0.526
LIG_WRC_WIRS_1	5	10	PF05994	0.430
MOD_CDK_SPxxK_3	104	111	PF00069	0.427
MOD_CK1_1	136	142	PF00069	0.647
MOD_CK1_1	226	232	PF00069	0.555
MOD_CK1_1	3	9	PF00069	0.583
MOD_CK1_1	340	346	PF00069	0.662
MOD_CK1_1	353	359	PF00069	0.738
MOD_CK1_1	466	472	PF00069	0.559
MOD_CK2_1	143	149	PF00069	0.495
MOD_CK2_1	180	186	PF00069	0.579
MOD_CK2_1	237	243	PF00069	0.448
MOD_CK2_1	253	259	PF00069	0.512
MOD_CK2_1	378	384	PF00069	0.718
MOD_CK2_1	430	436	PF00069	0.669
MOD_GlcNHglycan	2	5	PF01048	0.586
MOD_GlcNHglycan	208	211	PF01048	0.584
MOD_GlcNHglycan	221	224	PF01048	0.596
MOD_GlcNHglycan	342	345	PF01048	0.691
MOD_GlcNHglycan	352	355	PF01048	0.702
MOD_GlcNHglycan	380	383	PF01048	0.725
MOD_GlcNHglycan	388	392	PF01048	0.637
MOD_GlcNHglycan	431	435	PF01048	0.706
MOD_GlcNHglycan	452	455	PF01048	0.612
MOD_GlcNHglycan	456	459	PF01048	0.679
MOD_GlcNHglycan	465	468	PF01048	0.778
MOD_GSK3_1	219	226	PF00069	0.648
MOD_GSK3_1	26	33	PF00069	0.325
MOD_GSK3_1	346	353	PF00069	0.589
MOD_GSK3_1	378	385	PF00069	0.621
MOD_GSK3_1	445	452	PF00069	0.654
MOD_GSK3_1	462	469	PF00069	0.502
MOD_GSK3_1	6	13	PF00069	0.478
MOD_GSK3_1	81	88	PF00069	0.551
MOD_N-GLC_1	226	231	PF02516	0.464
MOD_N-GLC_1	448	453	PF02516	0.496
MOD_N-GLC_1	96	101	PF02516	0.614
MOD_NEK2_1	205	210	PF00069	0.583
MOD_NEK2_1	218	223	PF00069	0.511
MOD_NEK2_1	253	258	PF00069	0.456
MOD_NEK2_1	85	90	PF00069	0.663
MOD_NEK2_2	180	185	PF00069	0.376
MOD_OFUCOSY	95	100	PF10250	0.378
MOD_PIKK_1	253	259	PF00454	0.475
MOD_PIKK_1	26	32	PF00454	0.552
MOD_PIKK_1	466	472	PF00454	0.693
MOD_PKA_1	172	178	PF00069	0.491
MOD_PKA_2	117	123	PF00069	0.653
MOD_PKA_2	172	178	PF00069	0.444
MOD_PKA_2	268	274	PF00069	0.539
MOD_PKA_2	30	36	PF00069	0.372
MOD_PKA_2	302	308	PF00069	0.574
MOD_PKA_2	346	352	PF00069	0.582
MOD_PKA_2	445	451	PF00069	0.554
MOD_PKA_2	81	87	PF00069	0.550
MOD_PKA_2	93	99	PF00069	0.439
MOD_Plk_1	430	436	PF00069	0.623
MOD_Plk_2-3	404	410	PF00069	0.532
MOD_Plk_4	30	36	PF00069	0.372
MOD_Plk_4	394	400	PF00069	0.676
MOD_ProDKin_1	104	110	PF00069	0.385
MOD_ProDKin_1	247	253	PF00069	0.490
MOD_ProDKin_1	370	376	PF00069	0.653
MOD_ProDKin_1	389	395	PF00069	0.696
MOD_ProDKin_1	6	12	PF00069	0.538
TRG_DiLeu_BaEn_1	436	441	PF01217	0.642
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.593
TRG_ENDOCYTIC_2	150	153	PF00928	0.491
TRG_ER_diArg_1	150	152	PF00400	0.526
TRG_ER_diArg_1	171	173	PF00400	0.546
TRG_ER_diArg_1	297	299	PF00400	0.436
TRG_ER_diArg_1	320	322	PF00400	0.678
TRG_ER_diArg_1	477	479	PF00400	0.533
TRG_ER_diArg_1	51	53	PF00400	0.463
TRG_NLS_MonoExtC_3	356	361	PF00514	0.682
TRG_NLS_MonoExtN_4	355	362	PF00514	0.682
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYA9	Leptomonas seymouri	50%	100%
A0A1X0NQL1	Trypanosomatidae	28%	100%
A0A3Q8IE22	Leishmania donovani	72%	100%
A0A3R7JYS6	Trypanosoma rangeli	31%	100%
A4I419	Leishmania infantum	71%	100%
E9B0A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q7X8	Leishmania major	72%	99%