Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGY6_LEIBR

TriTrypDb:

LbrM.28.3040 , LBRM2903_280038000

Length:

944

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.518
CLV_C14_Caspase3-7	889	893	PF00656	0.528
CLV_NRD_NRD_1	145	147	PF00675	0.410
CLV_NRD_NRD_1	237	239	PF00675	0.479
CLV_NRD_NRD_1	315	317	PF00675	0.563
CLV_NRD_NRD_1	328	330	PF00675	0.424
CLV_NRD_NRD_1	335	337	PF00675	0.405
CLV_NRD_NRD_1	367	369	PF00675	0.538
CLV_NRD_NRD_1	710	712	PF00675	0.569
CLV_NRD_NRD_1	742	744	PF00675	0.442
CLV_NRD_NRD_1	780	782	PF00675	0.429
CLV_NRD_NRD_1	94	96	PF00675	0.447
CLV_PCSK_FUR_1	326	330	PF00082	0.477
CLV_PCSK_KEX2_1	237	239	PF00082	0.479
CLV_PCSK_KEX2_1	328	330	PF00082	0.494
CLV_PCSK_KEX2_1	335	337	PF00082	0.496
CLV_PCSK_KEX2_1	367	369	PF00082	0.538
CLV_PCSK_KEX2_1	538	540	PF00082	0.698
CLV_PCSK_KEX2_1	710	712	PF00082	0.569
CLV_PCSK_KEX2_1	780	782	PF00082	0.429
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.698
CLV_PCSK_PC7_1	776	782	PF00082	0.435
CLV_PCSK_SKI1_1	211	215	PF00082	0.478
CLV_PCSK_SKI1_1	248	252	PF00082	0.462
CLV_PCSK_SKI1_1	286	290	PF00082	0.520
CLV_PCSK_SKI1_1	307	311	PF00082	0.589
CLV_PCSK_SKI1_1	328	332	PF00082	0.511
CLV_PCSK_SKI1_1	385	389	PF00082	0.568
CLV_PCSK_SKI1_1	530	534	PF00082	0.720
CLV_PCSK_SKI1_1	630	634	PF00082	0.444
CLV_PCSK_SKI1_1	67	71	PF00082	0.502
CLV_PCSK_SKI1_1	700	704	PF00082	0.559
CLV_PCSK_SKI1_1	711	715	PF00082	0.500
CLV_PCSK_SKI1_1	858	862	PF00082	0.562
DEG_APCC_DBOX_1	129	137	PF00400	0.432
DEG_APCC_DBOX_1	210	218	PF00400	0.479
DEG_APCC_DBOX_1	327	335	PF00400	0.546
DEG_APCC_DBOX_1	471	479	PF00400	0.600
DEG_SPOP_SBC_1	362	366	PF00917	0.496
DEG_SPOP_SBC_1	464	468	PF00917	0.492
DOC_CKS1_1	14	19	PF01111	0.538
DOC_CYCLIN_RxL_1	245	252	PF00134	0.571
DOC_CYCLIN_RxL_1	280	290	PF00134	0.419
DOC_CYCLIN_RxL_1	322	333	PF00134	0.412
DOC_CYCLIN_RxL_1	697	707	PF00134	0.433
DOC_MAPK_DCC_7	211	219	PF00069	0.468
DOC_MAPK_gen_1	167	176	PF00069	0.590
DOC_MAPK_gen_1	367	375	PF00069	0.535
DOC_MAPK_gen_1	755	764	PF00069	0.628
DOC_MAPK_gen_1	935	943	PF00069	0.433
DOC_MAPK_MEF2A_6	167	176	PF00069	0.555
DOC_MAPK_MEF2A_6	211	219	PF00069	0.502
DOC_MAPK_MEF2A_6	755	764	PF00069	0.628
DOC_MAPK_MEF2A_6	902	910	PF00069	0.563
DOC_PP1_RVXF_1	930	937	PF00149	0.557
DOC_PP2B_LxvP_1	762	765	PF13499	0.622
DOC_USP7_MATH_1	213	217	PF00917	0.646
DOC_USP7_MATH_1	362	366	PF00917	0.498
DOC_USP7_MATH_1	389	393	PF00917	0.581
DOC_USP7_MATH_1	4	8	PF00917	0.515
DOC_USP7_MATH_1	418	422	PF00917	0.587
DOC_USP7_MATH_1	463	467	PF00917	0.490
DOC_USP7_MATH_1	518	522	PF00917	0.633
DOC_USP7_MATH_1	562	566	PF00917	0.676
DOC_USP7_MATH_1	571	575	PF00917	0.510
DOC_USP7_MATH_1	606	610	PF00917	0.705
DOC_USP7_MATH_1	821	825	PF00917	0.543
DOC_WW_Pin1_4	13	18	PF00397	0.710
DOC_WW_Pin1_4	21	26	PF00397	0.552
DOC_WW_Pin1_4	278	283	PF00397	0.506
DOC_WW_Pin1_4	425	430	PF00397	0.459
DOC_WW_Pin1_4	516	521	PF00397	0.583
DOC_WW_Pin1_4	522	527	PF00397	0.576
DOC_WW_Pin1_4	569	574	PF00397	0.544
DOC_WW_Pin1_4	765	770	PF00397	0.618
LIG_14-3-3_CanoR_1	146	150	PF00244	0.389
LIG_14-3-3_CanoR_1	182	189	PF00244	0.461
LIG_14-3-3_CanoR_1	237	241	PF00244	0.430
LIG_14-3-3_CanoR_1	286	292	PF00244	0.581
LIG_14-3-3_CanoR_1	329	335	PF00244	0.394
LIG_14-3-3_CanoR_1	336	341	PF00244	0.399
LIG_14-3-3_CanoR_1	367	376	PF00244	0.567
LIG_14-3-3_CanoR_1	414	418	PF00244	0.606
LIG_14-3-3_CanoR_1	435	439	PF00244	0.448
LIG_14-3-3_CanoR_1	689	698	PF00244	0.485
LIG_14-3-3_CanoR_1	734	740	PF00244	0.437
LIG_14-3-3_CanoR_1	95	105	PF00244	0.446
LIG_Actin_RPEL_3	895	914	PF02755	0.486
LIG_Actin_WH2_2	718	736	PF00022	0.424
LIG_Actin_WH2_2	81	97	PF00022	0.454
LIG_APCC_ABBAyCdc20_2	238	244	PF00400	0.510
LIG_BIR_II_1	1	5	PF00653	0.490
LIG_Clathr_ClatBox_1	913	917	PF01394	0.552
LIG_deltaCOP1_diTrp_1	420	427	PF00928	0.513
LIG_deltaCOP1_diTrp_1	841	850	PF00928	0.532
LIG_eIF4E_1	235	241	PF01652	0.580
LIG_FHA_1	140	146	PF00498	0.542
LIG_FHA_1	26	32	PF00498	0.563
LIG_FHA_1	344	350	PF00498	0.511
LIG_FHA_1	375	381	PF00498	0.515
LIG_FHA_1	491	497	PF00498	0.467
LIG_FHA_1	543	549	PF00498	0.510
LIG_FHA_1	780	786	PF00498	0.515
LIG_FHA_1	857	863	PF00498	0.562
LIG_FHA_1	929	935	PF00498	0.551
LIG_FHA_1	97	103	PF00498	0.438
LIG_FHA_2	346	352	PF00498	0.411
LIG_FHA_2	369	375	PF00498	0.604
LIG_FHA_2	573	579	PF00498	0.524
LIG_FHA_2	60	66	PF00498	0.556
LIG_GBD_Chelix_1	721	729	PF00786	0.504
LIG_LIR_Apic_2	413	418	PF02991	0.548
LIG_LIR_Gen_1	100	111	PF02991	0.466
LIG_LIR_Gen_1	377	386	PF02991	0.480
LIG_LIR_Gen_1	447	457	PF02991	0.438
LIG_LIR_Gen_1	505	514	PF02991	0.629
LIG_LIR_Gen_1	578	587	PF02991	0.487
LIG_LIR_Gen_1	643	653	PF02991	0.499
LIG_LIR_Gen_1	724	733	PF02991	0.449
LIG_LIR_Gen_1	800	808	PF02991	0.458
LIG_LIR_Gen_1	810	819	PF02991	0.499
LIG_LIR_Nem_3	100	106	PF02991	0.468
LIG_LIR_Nem_3	180	184	PF02991	0.543
LIG_LIR_Nem_3	325	330	PF02991	0.419
LIG_LIR_Nem_3	377	381	PF02991	0.455
LIG_LIR_Nem_3	411	415	PF02991	0.490
LIG_LIR_Nem_3	447	452	PF02991	0.441
LIG_LIR_Nem_3	505	509	PF02991	0.625
LIG_LIR_Nem_3	578	583	PF02991	0.624
LIG_LIR_Nem_3	643	648	PF02991	0.496
LIG_LIR_Nem_3	724	729	PF02991	0.452
LIG_LIR_Nem_3	800	806	PF02991	0.460
LIG_LIR_Nem_3	810	814	PF02991	0.501
LIG_LIR_Nem_3	872	877	PF02991	0.547
LIG_MYND_1	765	769	PF01753	0.619
LIG_PCNA_yPIPBox_3	829	839	PF02747	0.407
LIG_PTAP_UEV_1	16	21	PF05743	0.593
LIG_Rb_pABgroove_1	229	237	PF01858	0.519
LIG_SH2_CRK	181	185	PF00017	0.544
LIG_SH2_CRK	327	331	PF00017	0.398
LIG_SH2_CRK	378	382	PF00017	0.472
LIG_SH2_CRK	415	419	PF00017	0.460
LIG_SH2_CRK	506	510	PF00017	0.603
LIG_SH2_CRK	645	649	PF00017	0.494
LIG_SH2_NCK_1	378	382	PF00017	0.544
LIG_SH2_NCK_1	415	419	PF00017	0.466
LIG_SH2_NCK_1	510	514	PF00017	0.454
LIG_SH2_NCK_1	890	894	PF00017	0.402
LIG_SH2_SRC	242	245	PF00017	0.565
LIG_SH2_SRC	262	265	PF00017	0.387
LIG_SH2_SRC	926	929	PF00017	0.561
LIG_SH2_STAP1	369	373	PF00017	0.512
LIG_SH2_STAP1	376	380	PF00017	0.508
LIG_SH2_STAP1	510	514	PF00017	0.544
LIG_SH2_STAP1	799	803	PF00017	0.396
LIG_SH2_STAP1	926	930	PF00017	0.555
LIG_SH2_STAT3	137	140	PF00017	0.507
LIG_SH2_STAT3	369	372	PF00017	0.590
LIG_SH2_STAT3	641	644	PF00017	0.508
LIG_SH2_STAT5	262	265	PF00017	0.585
LIG_SH2_STAT5	376	379	PF00017	0.488
LIG_SH2_STAT5	645	648	PF00017	0.427
LIG_SH2_STAT5	652	655	PF00017	0.510
LIG_SH2_STAT5	877	880	PF00017	0.552
LIG_SH2_STAT5	890	893	PF00017	0.423
LIG_SH3_3	11	17	PF00018	0.583
LIG_SH3_3	260	266	PF00018	0.505
LIG_SH3_3	468	474	PF00018	0.472
LIG_SH3_3	824	830	PF00018	0.432
LIG_SUMO_SIM_par_1	473	479	PF11976	0.498
LIG_SUMO_SIM_par_1	858	863	PF11976	0.564
LIG_TRAF2_1	115	118	PF00917	0.433
LIG_TRAF2_1	488	491	PF00917	0.551
LIG_TRAF2_1	499	502	PF00917	0.694
LIG_TYR_ITIM	508	513	PF00017	0.453
LIG_UBA3_1	878	883	PF00899	0.545
MOD_CDK_SPxK_1	21	27	PF00069	0.640
MOD_CDK_SPxxK_3	765	772	PF00069	0.615
MOD_CK1_1	18	24	PF00069	0.602
MOD_CK1_1	2	8	PF00069	0.537
MOD_CK1_1	413	419	PF00069	0.478
MOD_CK1_1	444	450	PF00069	0.440
MOD_CK1_1	466	472	PF00069	0.482
MOD_CK1_1	565	571	PF00069	0.815
MOD_CK1_1	572	578	PF00069	0.631
MOD_CK1_1	622	628	PF00069	0.476
MOD_CK1_1	763	769	PF00069	0.475
MOD_CK1_1	886	892	PF00069	0.549
MOD_CK2_1	496	502	PF00069	0.464
MOD_CK2_1	59	65	PF00069	0.649
MOD_CK2_1	799	805	PF00069	0.539
MOD_GlcNHglycan	17	20	PF01048	0.685
MOD_GlcNHglycan	184	187	PF01048	0.464
MOD_GlcNHglycan	322	325	PF01048	0.452
MOD_GlcNHglycan	351	355	PF01048	0.525
MOD_GlcNHglycan	391	394	PF01048	0.449
MOD_GlcNHglycan	550	553	PF01048	0.528
MOD_GlcNHglycan	564	567	PF01048	0.573
MOD_GlcNHglycan	595	598	PF01048	0.567
MOD_GlcNHglycan	600	603	PF01048	0.784
MOD_GlcNHglycan	607	611	PF01048	0.672
MOD_GlcNHglycan	623	627	PF01048	0.468
MOD_GlcNHglycan	823	826	PF01048	0.541
MOD_GlcNHglycan	869	872	PF01048	0.392
MOD_GlcNHglycan	9	12	PF01048	0.506
MOD_GSK3_1	15	22	PF00069	0.639
MOD_GSK3_1	330	337	PF00069	0.565
MOD_GSK3_1	363	370	PF00069	0.441
MOD_GSK3_1	389	396	PF00069	0.447
MOD_GSK3_1	44	51	PF00069	0.438
MOD_GSK3_1	518	525	PF00069	0.583
MOD_GSK3_1	52	59	PF00069	0.461
MOD_GSK3_1	565	572	PF00069	0.651
MOD_GSK3_1	882	889	PF00069	0.499
MOD_LATS_1	881	887	PF00433	0.544
MOD_N-GLC_1	705	710	PF02516	0.430
MOD_NEK2_1	145	150	PF00069	0.537
MOD_NEK2_1	311	316	PF00069	0.620
MOD_NEK2_1	330	335	PF00069	0.611
MOD_NEK2_1	387	392	PF00069	0.426
MOD_NEK2_1	402	407	PF00069	0.606
MOD_NEK2_1	663	668	PF00069	0.579
MOD_NEK2_1	733	738	PF00069	0.559
MOD_NEK2_1	784	789	PF00069	0.426
MOD_NEK2_1	867	872	PF00069	0.405
MOD_PIKK_1	368	374	PF00454	0.582
MOD_PIKK_1	518	524	PF00454	0.662
MOD_PIKK_1	733	739	PF00454	0.530
MOD_PKA_1	367	373	PF00069	0.458
MOD_PKA_2	145	151	PF00069	0.386
MOD_PKA_2	236	242	PF00069	0.429
MOD_PKA_2	334	340	PF00069	0.499
MOD_PKA_2	367	373	PF00069	0.458
MOD_PKA_2	413	419	PF00069	0.491
MOD_PKA_2	434	440	PF00069	0.475
MOD_PKA_2	491	497	PF00069	0.653
MOD_PKA_2	59	65	PF00069	0.663
MOD_PKA_2	663	669	PF00069	0.591
MOD_PKA_2	696	702	PF00069	0.436
MOD_PKA_2	733	739	PF00069	0.457
MOD_PKA_2	779	785	PF00069	0.429
MOD_PKB_1	54	62	PF00069	0.563
MOD_Plk_1	25	31	PF00069	0.456
MOD_Plk_1	886	892	PF00069	0.549
MOD_Plk_4	376	382	PF00069	0.484
MOD_Plk_4	869	875	PF00069	0.416
MOD_Plk_4	98	104	PF00069	0.464
MOD_ProDKin_1	13	19	PF00069	0.709
MOD_ProDKin_1	21	27	PF00069	0.552
MOD_ProDKin_1	278	284	PF00069	0.502
MOD_ProDKin_1	425	431	PF00069	0.453
MOD_ProDKin_1	516	522	PF00069	0.586
MOD_ProDKin_1	569	575	PF00069	0.532
MOD_ProDKin_1	765	771	PF00069	0.615
MOD_SUMO_for_1	452	455	PF00179	0.443
MOD_SUMO_for_1	537	540	PF00179	0.672
MOD_SUMO_rev_2	224	231	PF00179	0.574
TRG_DiLeu_BaEn_4	65	71	PF01217	0.593
TRG_DiLeu_BaEn_4	680	686	PF01217	0.559
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.570
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.407
TRG_ENDOCYTIC_2	181	184	PF00928	0.541
TRG_ENDOCYTIC_2	327	330	PF00928	0.407
TRG_ENDOCYTIC_2	378	381	PF00928	0.471
TRG_ENDOCYTIC_2	506	509	PF00928	0.600
TRG_ENDOCYTIC_2	510	513	PF00928	0.567
TRG_ENDOCYTIC_2	645	648	PF00928	0.490
TRG_ENDOCYTIC_2	726	729	PF00928	0.512
TRG_ENDOCYTIC_2	803	806	PF00928	0.384
TRG_ER_diArg_1	327	329	PF00400	0.451
TRG_ER_diArg_1	334	336	PF00400	0.385
TRG_ER_diArg_1	367	369	PF00400	0.536
TRG_ER_diArg_1	779	781	PF00400	0.577
TRG_ER_diArg_1	921	924	PF00400	0.567
TRG_ER_diArg_1	938	941	PF00400	0.414
TRG_NES_CRM1_1	724	737	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	700	704	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	743	747	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	858	863	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC11	Leptomonas seymouri	32%	100%
A0A3Q8IIE5	Leishmania donovani	69%	100%
A4I418	Leishmania infantum	69%	100%
E9B0A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q7X9	Leishmania major	69%	100%