Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGY4_LEIBR

TriTrypDb:

LbrM.28.3020 , LBRM2903_280037800

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.457
CLV_NRD_NRD_1	123	125	PF00675	0.474
CLV_NRD_NRD_1	171	173	PF00675	0.692
CLV_PCSK_KEX2_1	125	127	PF00082	0.485
CLV_PCSK_KEX2_1	134	136	PF00082	0.516
CLV_PCSK_KEX2_1	39	41	PF00082	0.646
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.540
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.568
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.724
CLV_PCSK_SKI1_1	114	118	PF00082	0.541
CLV_PCSK_SKI1_1	129	133	PF00082	0.561
CLV_PCSK_SKI1_1	172	176	PF00082	0.708
CLV_PCSK_SKI1_1	26	30	PF00082	0.553
CLV_PCSK_SKI1_1	40	44	PF00082	0.460
CLV_PCSK_SKI1_1	60	64	PF00082	0.556
DOC_CKS1_1	2	7	PF01111	0.519
DOC_MAPK_gen_1	124	133	PF00069	0.508
DOC_PP1_RVXF_1	127	133	PF00149	0.583
DOC_PP1_RVXF_1	93	99	PF00149	0.545
DOC_PP1_SILK_1	147	152	PF00149	0.571
DOC_USP7_MATH_1	145	149	PF00917	0.529
DOC_USP7_MATH_1	42	46	PF00917	0.689
DOC_USP7_MATH_1	80	84	PF00917	0.682
DOC_WW_Pin1_4	1	6	PF00397	0.671
DOC_WW_Pin1_4	88	93	PF00397	0.603
DOC_WW_Pin1_4	98	103	PF00397	0.519
LIG_14-3-3_CanoR_1	8	13	PF00244	0.756
LIG_CaM_IQ_9	149	165	PF13499	0.615
LIG_FHA_1	145	151	PF00498	0.546
LIG_FHA_1	41	47	PF00498	0.524
LIG_FHA_1	91	97	PF00498	0.541
LIG_FHA_2	139	145	PF00498	0.688
LIG_FHA_2	51	57	PF00498	0.660
LIG_Integrin_isoDGR_2	127	129	PF01839	0.613
LIG_LIR_Nem_3	154	159	PF02991	0.386
LIG_PDZ_Class_3	194	199	PF00595	0.769
LIG_Pex14_2	111	115	PF04695	0.582
LIG_SH2_CRK	9	13	PF00017	0.802
LIG_SH3_1	13	19	PF00018	0.702
LIG_SH3_3	13	19	PF00018	0.800
LIG_TRAF2_1	54	57	PF00917	0.627
LIG_UBA3_1	149	157	PF00899	0.533
LIG_UBA3_1	182	189	PF00899	0.579
MOD_CDK_SPK_2	1	6	PF00069	0.671
MOD_CDK_SPxxK_3	1	8	PF00069	0.525
MOD_CDK_SPxxK_3	88	95	PF00069	0.613
MOD_CK1_1	45	51	PF00069	0.622
MOD_CK1_1	83	89	PF00069	0.666
MOD_CK2_1	138	144	PF00069	0.681
MOD_CK2_1	50	56	PF00069	0.627
MOD_CK2_1	75	81	PF00069	0.724
MOD_Cter_Amidation	170	173	PF01082	0.482
MOD_Cter_Amidation	36	39	PF01082	0.794
MOD_GlcNHglycan	40	43	PF01048	0.691
MOD_GlcNHglycan	77	80	PF01048	0.558
MOD_GSK3_1	38	45	PF00069	0.611
MOD_GSK3_1	46	53	PF00069	0.612
MOD_N-GLC_1	88	93	PF02516	0.642
MOD_NEK2_1	138	143	PF00069	0.685
MOD_NEK2_1	185	190	PF00069	0.576
MOD_NEK2_1	46	51	PF00069	0.497
MOD_PK_1	8	14	PF00069	0.799
MOD_PKA_1	38	44	PF00069	0.787
MOD_PKB_1	6	14	PF00069	0.755
MOD_Plk_1	80	86	PF00069	0.694
MOD_Plk_4	145	151	PF00069	0.521
MOD_ProDKin_1	1	7	PF00069	0.675
MOD_ProDKin_1	88	94	PF00069	0.594
MOD_ProDKin_1	98	104	PF00069	0.519
MOD_SUMO_for_1	174	177	PF00179	0.649
MOD_SUMO_for_1	28	31	PF00179	0.666
TRG_ENDOCYTIC_2	9	12	PF00928	0.797
TRG_ER_diArg_1	5	8	PF00400	0.695
TRG_NLS_Bipartite_1	124	138	PF00514	0.525
TRG_NLS_MonoExtC_3	133	139	PF00514	0.552
TRG_NLS_MonoExtC_3	171	177	PF00514	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE59	Leptomonas seymouri	60%	100%
A0A0S4J694	Bodo saltans	42%	97%
A0A1X0NS83	Trypanosomatidae	51%	100%
A0A3S7X1Y4	Leishmania donovani	78%	96%
A4I416	Leishmania infantum	77%	94%
D0A8Z3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B0A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	96%
Q4Q7Y1	Leishmania major	76%	100%