Beta-lactamase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-lactamase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGY3_LEIBR

TriTrypDb:

LbrM.28.3010 , LBRM2903_280037700

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.531
CLV_C14_Caspase3-7	357	361	PF00656	0.360
CLV_NRD_NRD_1	185	187	PF00675	0.174
CLV_NRD_NRD_1	373	375	PF00675	0.486
CLV_NRD_NRD_1	496	498	PF00675	0.648
CLV_PCSK_KEX2_1	185	187	PF00082	0.174
CLV_PCSK_KEX2_1	318	320	PF00082	0.256
CLV_PCSK_KEX2_1	373	375	PF00082	0.564
CLV_PCSK_KEX2_1	477	479	PF00082	0.717
CLV_PCSK_KEX2_1	481	483	PF00082	0.666
CLV_PCSK_KEX2_1	496	498	PF00082	0.472
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.256
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.717
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.666
CLV_PCSK_SKI1_1	135	139	PF00082	0.267
CLV_PCSK_SKI1_1	162	166	PF00082	0.231
CLV_PCSK_SKI1_1	240	244	PF00082	0.328
CLV_PCSK_SKI1_1	277	281	PF00082	0.335
CLV_PCSK_SKI1_1	319	323	PF00082	0.212
CLV_PCSK_SKI1_1	349	353	PF00082	0.231
CLV_PCSK_SKI1_1	362	366	PF00082	0.231
CLV_PCSK_SKI1_1	394	398	PF00082	0.514
CLV_PCSK_SKI1_1	447	451	PF00082	0.482
CLV_PCSK_SKI1_1	478	482	PF00082	0.558
CLV_PCSK_SKI1_1	53	57	PF00082	0.452
DOC_CDC14_PxL_1	145	153	PF14671	0.256
DOC_CKS1_1	215	220	PF01111	0.174
DOC_CYCLIN_RxL_1	346	357	PF00134	0.231
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.231
DOC_CYCLIN_yCln2_LP_2	120	126	PF00134	0.231
DOC_MAPK_gen_1	11	18	PF00069	0.435
DOC_MAPK_MEF2A_6	11	18	PF00069	0.527
DOC_PP1_RVXF_1	13	19	PF00149	0.506
DOC_PP1_RVXF_1	275	282	PF00149	0.322
DOC_PP2B_LxvP_1	120	123	PF13499	0.231
DOC_PP2B_LxvP_1	340	343	PF13499	0.231
DOC_PP2B_LxvP_1	382	385	PF13499	0.228
DOC_PP4_FxxP_1	280	283	PF00568	0.256
DOC_PP4_FxxP_1	304	307	PF00568	0.231
DOC_PP4_FxxP_1	317	320	PF00568	0.231
DOC_SPAK_OSR1_1	431	435	PF12202	0.317
DOC_USP7_MATH_1	283	287	PF00917	0.246
DOC_USP7_MATH_1	402	406	PF00917	0.271
DOC_USP7_UBL2_3	477	481	PF12436	0.497
DOC_WW_Pin1_4	187	192	PF00397	0.434
DOC_WW_Pin1_4	214	219	PF00397	0.334
DOC_WW_Pin1_4	232	237	PF00397	0.300
LIG_14-3-3_CanoR_1	162	168	PF00244	0.329
LIG_14-3-3_CanoR_1	185	189	PF00244	0.255
LIG_14-3-3_CanoR_1	248	258	PF00244	0.263
LIG_14-3-3_CanoR_1	319	324	PF00244	0.304
LIG_14-3-3_CanoR_1	482	492	PF00244	0.552
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_BIR_III_2	401	405	PF00653	0.391
LIG_Clathr_ClatBox_1	352	356	PF01394	0.326
LIG_eIF4E_1	347	353	PF01652	0.246
LIG_FHA_1	117	123	PF00498	0.330
LIG_FHA_1	166	172	PF00498	0.299
LIG_FHA_1	241	247	PF00498	0.400
LIG_FHA_1	391	397	PF00498	0.460
LIG_FHA_1	398	404	PF00498	0.403
LIG_FHA_2	320	326	PF00498	0.212
LIG_FHA_2	355	361	PF00498	0.360
LIG_FHA_2	488	494	PF00498	0.584
LIG_LIR_Apic_2	187	191	PF02991	0.174
LIG_LIR_Apic_2	278	283	PF02991	0.419
LIG_LIR_Apic_2	289	294	PF02991	0.227
LIG_LIR_Apic_2	295	300	PF02991	0.172
LIG_LIR_Apic_2	302	307	PF02991	0.197
LIG_LIR_Apic_2	315	320	PF02991	0.150
LIG_LIR_Nem_3	17	21	PF02991	0.450
LIG_LIR_Nem_3	345	350	PF02991	0.230
LIG_LIR_Nem_3	378	382	PF02991	0.336
LIG_LIR_Nem_3	486	492	PF02991	0.564
LIG_Pex14_1	184	188	PF04695	0.174
LIG_Pex14_2	485	489	PF04695	0.582
LIG_SH2_CRK	117	121	PF00017	0.231
LIG_SH2_CRK	291	295	PF00017	0.231
LIG_SH2_CRK	347	351	PF00017	0.246
LIG_SH2_NCK_1	202	206	PF00017	0.300
LIG_SH2_NCK_1	341	345	PF00017	0.360
LIG_SH2_SRC	202	205	PF00017	0.350
LIG_SH2_SRC	341	344	PF00017	0.300
LIG_SH2_SRC	383	386	PF00017	0.432
LIG_SH2_STAT5	128	131	PF00017	0.246
LIG_SH2_STAT5	147	150	PF00017	0.246
LIG_SH2_STAT5	188	191	PF00017	0.207
LIG_SH2_STAT5	231	234	PF00017	0.208
LIG_SH2_STAT5	383	386	PF00017	0.432
LIG_SH2_STAT5	488	491	PF00017	0.471
LIG_SH3_3	198	204	PF00018	0.237
LIG_SH3_3	212	218	PF00018	0.237
LIG_SH3_3	320	326	PF00018	0.174
LIG_SH3_3	453	459	PF00018	0.629
LIG_SH3_4	142	149	PF00018	0.174
LIG_SH3_5	343	347	PF00018	0.246
LIG_SUMO_SIM_anti_2	254	260	PF11976	0.233
LIG_SUMO_SIM_par_1	319	325	PF11976	0.406
LIG_SUMO_SIM_par_1	349	354	PF11976	0.246
LIG_SUMO_SIM_par_1	54	59	PF11976	0.461
LIG_SUMO_SIM_par_1	98	104	PF11976	0.174
LIG_TYR_ITIM	115	120	PF00017	0.246
LIG_UBA3_1	137	142	PF00899	0.174
LIG_UBA3_1	440	447	PF00899	0.352
LIG_WRC_WIRS_1	164	169	PF05994	0.300
MOD_CDK_SPK_2	232	237	PF00069	0.256
MOD_CK1_1	163	169	PF00069	0.313
MOD_CK1_1	187	193	PF00069	0.242
MOD_CK1_1	252	258	PF00069	0.305
MOD_CK1_1	271	277	PF00069	0.468
MOD_CK1_1	286	292	PF00069	0.246
MOD_CK1_1	354	360	PF00069	0.300
MOD_CK1_1	405	411	PF00069	0.255
MOD_CK1_1	424	430	PF00069	0.326
MOD_CK1_1	487	493	PF00069	0.472
MOD_CK1_1	59	65	PF00069	0.416
MOD_CK2_1	487	493	PF00069	0.545
MOD_CK2_1	51	57	PF00069	0.454
MOD_Cter_Amidation	371	374	PF01082	0.489
MOD_GlcNHglycan	404	407	PF01048	0.372
MOD_GlcNHglycan	437	440	PF01048	0.257
MOD_GlcNHglycan	63	66	PF01048	0.418
MOD_GlcNHglycan	90	93	PF01048	0.258
MOD_GSK3_1	118	125	PF00069	0.307
MOD_GSK3_1	153	160	PF00069	0.352
MOD_GSK3_1	210	217	PF00069	0.271
MOD_GSK3_1	232	239	PF00069	0.298
MOD_GSK3_1	242	249	PF00069	0.264
MOD_GSK3_1	271	278	PF00069	0.280
MOD_GSK3_1	405	412	PF00069	0.341
MOD_GSK3_1	483	490	PF00069	0.482
MOD_N-GLC_1	240	245	PF02516	0.246
MOD_N-GLC_1	334	339	PF02516	0.229
MOD_N-GLC_1	435	440	PF02516	0.443
MOD_NEK2_1	165	170	PF00069	0.353
MOD_NEK2_1	242	247	PF00069	0.325
MOD_NEK2_1	390	395	PF00069	0.440
MOD_NEK2_1	56	61	PF00069	0.425
MOD_OFUCOSY	419	425	PF10250	0.386
MOD_PIKK_1	262	268	PF00454	0.356
MOD_PIKK_1	64	70	PF00454	0.455
MOD_PKA_2	184	190	PF00069	0.234
MOD_PKA_2	236	242	PF00069	0.285
MOD_PKA_2	483	489	PF00069	0.407
MOD_PKA_2	93	99	PF00069	0.256
MOD_PKB_1	482	490	PF00069	0.411
MOD_Plk_1	472	478	PF00069	0.680
MOD_Plk_1	56	62	PF00069	0.510
MOD_Plk_2-3	153	159	PF00069	0.174
MOD_Plk_4	292	298	PF00069	0.331
MOD_Plk_4	354	360	PF00069	0.356
MOD_Plk_4	392	398	PF00069	0.495
MOD_Plk_4	484	490	PF00069	0.492
MOD_ProDKin_1	187	193	PF00069	0.434
MOD_ProDKin_1	214	220	PF00069	0.334
MOD_ProDKin_1	232	238	PF00069	0.300
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.243
TRG_ENDOCYTIC_2	117	120	PF00928	0.231
TRG_ENDOCYTIC_2	202	205	PF00928	0.232
TRG_ENDOCYTIC_2	341	344	PF00928	0.264
TRG_ENDOCYTIC_2	347	350	PF00928	0.228
TRG_ENDOCYTIC_2	376	379	PF00928	0.405
TRG_ER_diArg_1	12	15	PF00400	0.467
TRG_ER_diArg_1	184	186	PF00400	0.410
TRG_ER_diArg_1	198	201	PF00400	0.432
TRG_ER_diArg_1	373	375	PF00400	0.486
TRG_ER_diArg_1	482	485	PF00400	0.420
TRG_ER_diArg_1	496	498	PF00400	0.470
TRG_NLS_MonoExtN_4	478	485	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	98	103	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWQ0	Leptomonas seymouri	71%	96%
A0A0S4J446	Bodo saltans	46%	94%
A0A1X0NQV6	Trypanosomatidae	60%	96%
A0A3Q8IDD8	Leishmania donovani	89%	100%
A4I415	Leishmania infantum	89%	100%
D0A8Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B0A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q7Y2	Leishmania major	89%	100%
V5ATN3	Trypanosoma cruzi	57%	100%