Putative heat-shock protein hsp70

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat-shock protein hsp70, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HGY0_LEIBR

TriTrypDb:

LbrM.28.2980 , LBRM2903_280037300

Length:

246

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HGY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGY0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0044183	protein folding chaperone	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140657	ATP-dependent activity	1	2
GO:0140662	ATP-dependent protein folding chaperone	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	75	77	PF00675	0.526
CLV_PCSK_KEX2_1	71	73	PF00082	0.526
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.526
CLV_PCSK_SKI1_1	113	117	PF00082	0.526
CLV_PCSK_SKI1_1	138	142	PF00082	0.526
CLV_PCSK_SKI1_1	156	160	PF00082	0.211
CLV_PCSK_SKI1_1	195	199	PF00082	0.526
CLV_PCSK_SKI1_1	238	242	PF00082	0.526
CLV_Separin_Metazoa	169	173	PF03568	0.526
DOC_CKS1_1	114	119	PF01111	0.526
DOC_MAPK_gen_1	138	147	PF00069	0.526
DOC_MAPK_gen_1	193	200	PF00069	0.526
DOC_MAPK_HePTP_8	94	106	PF00069	0.526
DOC_MAPK_MEF2A_6	97	106	PF00069	0.526
DOC_PP1_RVXF_1	236	243	PF00149	0.526
DOC_PP2B_PxIxI_1	101	107	PF00149	0.526
DOC_USP7_MATH_2	117	123	PF00917	0.526
DOC_USP7_UBL2_3	138	142	PF12436	0.526
DOC_USP7_UBL2_3	93	97	PF12436	0.526
DOC_WW_Pin1_4	113	118	PF00397	0.526
DOC_WW_Pin1_4	35	40	PF00397	0.526
LIG_14-3-3_CanoR_1	238	243	PF00244	0.526
LIG_Clathr_ClatBox_1	211	215	PF01394	0.526
LIG_FHA_1	204	210	PF00498	0.526
LIG_FHA_2	114	120	PF00498	0.526
LIG_FHA_2	222	228	PF00498	0.526
LIG_FHA_2	43	49	PF00498	0.526
LIG_FHA_2	64	70	PF00498	0.526
LIG_FHA_2	94	100	PF00498	0.356
LIG_LIR_Gen_1	13	20	PF02991	0.526
LIG_LIR_Gen_1	38	48	PF02991	0.526
LIG_LIR_Nem_3	13	18	PF02991	0.526
LIG_LIR_Nem_3	38	44	PF02991	0.526
LIG_SH2_CRK	15	19	PF00017	0.526
LIG_SH2_GRB2like	150	153	PF00017	0.526
LIG_SH2_NCK_1	15	19	PF00017	0.526
LIG_SH2_STAT5	108	111	PF00017	0.495
LIG_SH2_STAT5	135	138	PF00017	0.526
LIG_SH2_STAT5	150	153	PF00017	0.264
LIG_SH2_STAT5	41	44	PF00017	0.526
LIG_SH3_3	142	148	PF00018	0.526
LIG_SUMO_SIM_anti_2	208	213	PF11976	0.526
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.526
LIG_SUMO_SIM_par_1	210	215	PF11976	0.526
LIG_TRAF2_1	116	119	PF00917	0.481
LIG_TYR_ITSM	11	18	PF00017	0.526
LIG_UBA3_1	125	129	PF00899	0.526
LIG_WRC_WIRS_1	239	244	PF05994	0.526
MOD_CK2_1	113	119	PF00069	0.176
MOD_CK2_1	42	48	PF00069	0.351
MOD_CK2_1	93	99	PF00069	0.526
MOD_Cter_Amidation	74	77	PF01082	0.526
MOD_GSK3_1	203	210	PF00069	0.526
MOD_GSK3_1	221	228	PF00069	0.211
MOD_N-GLC_1	151	156	PF02516	0.526
MOD_N-GLC_1	34	39	PF02516	0.526
MOD_NEK2_1	11	16	PF00069	0.526
MOD_NEK2_1	151	156	PF00069	0.526
MOD_NEK2_1	207	212	PF00069	0.526
MOD_NEK2_2	63	68	PF00069	0.526
MOD_PIKK_1	151	157	PF00454	0.526
MOD_Plk_1	118	124	PF00069	0.395
MOD_Plk_1	207	213	PF00069	0.526
MOD_Plk_4	119	125	PF00069	0.526
MOD_Plk_4	207	213	PF00069	0.526
MOD_Plk_4	238	244	PF00069	0.526
MOD_Plk_4	37	43	PF00069	0.526
MOD_Plk_4	63	69	PF00069	0.526
MOD_ProDKin_1	113	119	PF00069	0.526
MOD_ProDKin_1	35	41	PF00069	0.526
MOD_SUMO_rev_2	105	115	PF00179	0.526
MOD_SUMO_rev_2	215	224	PF00179	0.526
TRG_DiLeu_BaEn_1	194	199	PF01217	0.526
TRG_DiLeu_BaEn_3	118	124	PF01217	0.526
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.526
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.526
TRG_ENDOCYTIC_2	15	18	PF00928	0.526
TRG_ENDOCYTIC_2	41	44	PF00928	0.526
TRG_NES_CRM1_1	118	130	PF08389	0.526
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4II73	Bodo saltans	35%	75%
A0A0S4KFF1	Bodo saltans	35%	100%
A4HII1	Leishmania braziliensis	54%	100%
A4HII6	Leishmania braziliensis	52%	100%
C9ZR49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B120	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	72%
P12077	Leishmania major	67%	100%
P22623	Paracentrotus lividus	73%	66%
P48741	Homo sapiens	77%	67%