Putative heat-shock protein hsp70

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat-shock protein hsp70, putative

Species:

Leishmania braziliensis

UniProt:

A4HGX9_LEIBR

TriTrypDb:

LbrM.28.2970 , LBRM2903_280037200

Length:

226

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGX9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0005488	binding	1	4
GO:0005524	ATP binding	5	4
GO:0017076	purine nucleotide binding	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0044183	protein folding chaperone	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:0140657	ATP-dependent activity	1	4
GO:0140662	ATP-dependent protein folding chaperone	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.291
CLV_PCSK_KEX2_1	72	74	PF00082	0.466
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.466
CLV_PCSK_SKI1_1	142	146	PF00082	0.291
DEG_Nend_UBRbox_1	1	3	PF02207	0.476
DOC_MAPK_gen_1	72	78	PF00069	0.350
DOC_MAPK_MEF2A_6	44	53	PF00069	0.350
DOC_PP2B_PxIxI_1	46	52	PF00149	0.350
DOC_USP7_MATH_1	144	148	PF00917	0.275
DOC_USP7_MATH_1	201	205	PF00917	0.681
DOC_USP7_MATH_1	214	218	PF00917	0.553
DOC_USP7_UBL2_3	68	72	PF12436	0.350
LIG_BIR_III_4	56	60	PF00653	0.350
LIG_FHA_1	31	37	PF00498	0.319
LIG_FHA_1	50	56	PF00498	0.350
LIG_FHA_2	125	131	PF00498	0.350
LIG_LIR_Gen_1	183	193	PF02991	0.673
LIG_PCNA_yPIPBox_3	172	186	PF02747	0.350
LIG_Pex14_1	14	18	PF04695	0.459
LIG_PTB_Apo_2	116	123	PF02174	0.350
LIG_PTB_Phospho_1	116	122	PF10480	0.350
LIG_SH2_NCK_1	100	104	PF00017	0.291
LIG_SH2_SRC	120	123	PF00017	0.350
LIG_SH2_STAP1	120	124	PF00017	0.466
LIG_SH3_2	12	17	PF14604	0.466
LIG_SH3_3	37	43	PF00018	0.335
LIG_SH3_3	9	15	PF00018	0.470
LIG_TPR	223	226	PF00515	0.769
LIG_TRAF2_1	158	161	PF00917	0.371
LIG_TRAF2_1	163	166	PF00917	0.326
LIG_TRAF2_1	64	67	PF00917	0.350
LIG_WRC_WIRS_1	31	36	PF05994	0.350
MOD_CK1_1	140	146	PF00069	0.300
MOD_CK2_1	155	161	PF00069	0.371
MOD_CK2_1	61	67	PF00069	0.313
MOD_CK2_1	83	89	PF00069	0.308
MOD_CK2_1	95	101	PF00069	0.386
MOD_Cter_Amidation	70	73	PF01082	0.350
MOD_GlcNHglycan	133	136	PF01048	0.371
MOD_GlcNHglycan	141	145	PF01048	0.269
MOD_GlcNHglycan	146	149	PF01048	0.256
MOD_GlcNHglycan	202	206	PF01048	0.711
MOD_GlcNHglycan	217	220	PF01048	0.545
MOD_GlcNHglycan	35	39	PF01048	0.466
MOD_GlcNHglycan	63	66	PF01048	0.350
MOD_GSK3_1	120	127	PF00069	0.350
MOD_GSK3_1	140	147	PF00069	0.344
MOD_GSK3_1	30	37	PF00069	0.380
MOD_N-GLC_1	131	136	PF02516	0.466
MOD_N-GLC_1	61	66	PF02516	0.350
MOD_NEK2_1	124	129	PF00069	0.329
MOD_NEK2_1	174	179	PF00069	0.326
MOD_NEK2_1	185	190	PF00069	0.513
MOD_NEK2_1	34	39	PF00069	0.466
MOD_NEK2_2	120	125	PF00069	0.466
MOD_PKA_2	83	89	PF00069	0.350
MOD_Plk_1	140	146	PF00069	0.350
MOD_Plk_1	49	55	PF00069	0.350
MOD_SUMO_for_1	220	223	PF00179	0.771
MOD_SUMO_rev_2	64	70	PF00179	0.350
TRG_ENDOCYTIC_2	186	189	PF00928	0.658
TRG_ER_diArg_1	18	21	PF00400	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KGT9	Bodo saltans	74%	100%
E9B0A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	69%
P12078	Plasmodium falciparum	55%	100%
P12794	Plasmodium falciparum	52%	81%
P12795	Schistosoma japonicum	58%	100%
P16121	Lupinus polyphyllus	50%	88%
P27894	Leishmania braziliensis	91%	99%
P34935	Sus scrofa	53%	86%
Q03681	Nicotiana tabacum	55%	78%
Q03682	Nicotiana tabacum	55%	77%
Q03686	Nicotiana tabacum	52%	77%