Spindle pole body component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

gamma-tubulin complex component 3

Species:

Leishmania braziliensis

UniProt:

A4HGX8_LEIBR

TriTrypDb:

LbrM.28.2960 , LBRM2903_280037100

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	11
GO:0005737	cytoplasm	2	11
GO:0005815	microtubule organizing center	2	11
GO:0005874	microtubule	6	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0000923	equatorial microtubule organizing center	3	1
GO:0000930	gamma-tubulin complex	2	1
GO:0005813	centrosome	3	1
GO:0008275	gamma-tubulin small complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HGX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGX8

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	11
GO:0006996	organelle organization	4	11
GO:0007010	cytoskeleton organization	5	11
GO:0007017	microtubule-based process	2	11
GO:0007020	microtubule nucleation	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0000278	mitotic cell cycle	3	1
GO:0007049	cell cycle	2	1
GO:0007051	spindle organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0022607	cellular component assembly	4	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0051225	spindle assembly	4	1
GO:0051321	meiotic cell cycle	2	1
GO:0070925	organelle assembly	5	1
GO:0097435	supramolecular fiber organization	4	1
GO:0140694	non-membrane-bounded organelle assembly	6	1
GO:1904158	axonemal central apparatus assembly	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0043015	gamma-tubulin binding	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.470
CLV_C14_Caspase3-7	587	591	PF00656	0.583
CLV_NRD_NRD_1	385	387	PF00675	0.261
CLV_NRD_NRD_1	72	74	PF00675	0.275
CLV_NRD_NRD_1	88	90	PF00675	0.275
CLV_PCSK_FUR_1	86	90	PF00082	0.275
CLV_PCSK_KEX2_1	103	105	PF00082	0.232
CLV_PCSK_KEX2_1	385	387	PF00082	0.261
CLV_PCSK_KEX2_1	538	540	PF00082	0.313
CLV_PCSK_KEX2_1	72	74	PF00082	0.275
CLV_PCSK_KEX2_1	88	90	PF00082	0.271
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.261
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.313
CLV_PCSK_PC7_1	68	74	PF00082	0.275
CLV_PCSK_SKI1_1	196	200	PF00082	0.305
CLV_PCSK_SKI1_1	325	329	PF00082	0.209
CLV_PCSK_SKI1_1	342	346	PF00082	0.316
CLV_PCSK_SKI1_1	385	389	PF00082	0.261
CLV_PCSK_SKI1_1	492	496	PF00082	0.341
CLV_PCSK_SKI1_1	68	72	PF00082	0.284
CLV_PCSK_SKI1_1	73	77	PF00082	0.294
CLV_Separin_Metazoa	280	284	PF03568	0.561
DEG_Nend_Nbox_1	1	3	PF02207	0.454
DOC_CYCLIN_RxL_1	256	266	PF00134	0.541
DOC_CYCLIN_RxL_1	489	498	PF00134	0.541
DOC_MAPK_gen_1	382	392	PF00069	0.461
DOC_MAPK_gen_1	393	401	PF00069	0.461
DOC_MAPK_gen_1	402	411	PF00069	0.329
DOC_MAPK_HePTP_8	307	319	PF00069	0.541
DOC_MAPK_MEF2A_6	310	319	PF00069	0.541
DOC_MAPK_MEF2A_6	86	95	PF00069	0.538
DOC_MAPK_RevD_3	91	104	PF00069	0.541
DOC_PP1_RVXF_1	219	226	PF00149	0.461
DOC_PP1_RVXF_1	257	264	PF00149	0.541
DOC_PP1_RVXF_1	354	360	PF00149	0.463
DOC_PP1_RVXF_1	387	393	PF00149	0.475
DOC_PP1_RVXF_1	573	579	PF00149	0.461
DOC_USP7_UBL2_3	352	356	PF12436	0.541
DOC_WW_Pin1_4	152	157	PF00397	0.461
DOC_WW_Pin1_4	329	334	PF00397	0.517
DOC_WW_Pin1_4	367	372	PF00397	0.450
DOC_WW_Pin1_4	87	92	PF00397	0.454
LIG_14-3-3_CanoR_1	141	146	PF00244	0.513
LIG_14-3-3_CanoR_1	247	251	PF00244	0.526
LIG_14-3-3_CanoR_1	413	419	PF00244	0.481
LIG_14-3-3_CanoR_1	53	63	PF00244	0.411
LIG_14-3-3_CanoR_1	72	82	PF00244	0.517
LIG_Actin_WH2_2	254	272	PF00022	0.461
LIG_Actin_WH2_2	387	404	PF00022	0.461
LIG_Actin_WH2_2	453	469	PF00022	0.541
LIG_Actin_WH2_2	78	96	PF00022	0.383
LIG_APCC_ABBAyCdc20_2	492	498	PF00400	0.541
LIG_CAP-Gly_1	587	594	PF01302	0.464
LIG_CORNRBOX	44	52	PF00104	0.541
LIG_EH1_1	278	286	PF00400	0.561
LIG_FHA_1	117	123	PF00498	0.464
LIG_FHA_1	199	205	PF00498	0.536
LIG_FHA_1	218	224	PF00498	0.350
LIG_FHA_1	250	256	PF00498	0.452
LIG_FHA_1	264	270	PF00498	0.475
LIG_FHA_1	312	318	PF00498	0.413
LIG_FHA_1	363	369	PF00498	0.461
LIG_FHA_2	164	170	PF00498	0.475
LIG_FHA_2	205	211	PF00498	0.541
LIG_FHA_2	300	306	PF00498	0.541
LIG_FHA_2	419	425	PF00498	0.492
LIG_FHA_2	555	561	PF00498	0.461
LIG_GBD_Chelix_1	44	52	PF00786	0.261
LIG_KLC1_Yacidic_2	148	152	PF13176	0.541
LIG_LIR_Apic_2	176	181	PF02991	0.541
LIG_LIR_Gen_1	249	257	PF02991	0.454
LIG_LIR_Gen_1	295	304	PF02991	0.492
LIG_LIR_Gen_1	340	351	PF02991	0.461
LIG_LIR_Gen_1	567	576	PF02991	0.463
LIG_LIR_Gen_1	76	85	PF02991	0.492
LIG_LIR_LC3C_4	97	100	PF02991	0.477
LIG_LIR_Nem_3	176	180	PF02991	0.489
LIG_LIR_Nem_3	249	253	PF02991	0.458
LIG_LIR_Nem_3	295	300	PF02991	0.484
LIG_LIR_Nem_3	340	346	PF02991	0.475
LIG_LIR_Nem_3	426	431	PF02991	0.475
LIG_LIR_Nem_3	484	488	PF02991	0.541
LIG_LIR_Nem_3	567	571	PF02991	0.463
LIG_LIR_Nem_3	76	81	PF02991	0.492
LIG_LIR_Nem_3	8	13	PF02991	0.461
LIG_NRBOX	141	147	PF00104	0.461
LIG_NRBOX	522	528	PF00104	0.461
LIG_NRBOX	568	574	PF00104	0.461
LIG_OCRL_FandH_1	342	354	PF00620	0.541
LIG_PCNA_yPIPBox_3	259	272	PF02747	0.463
LIG_PCNA_yPIPBox_3	402	415	PF02747	0.541
LIG_PCNA_yPIPBox_3	514	527	PF02747	0.461
LIG_PDZ_Class_1	589	594	PF00595	0.585
LIG_Pex14_1	193	197	PF04695	0.461
LIG_Pex14_2	388	392	PF04695	0.461
LIG_SH2_CRK	102	106	PF00017	0.541
LIG_SH2_CRK	384	388	PF00017	0.461
LIG_SH2_CRK	541	545	PF00017	0.461
LIG_SH2_CRK	78	82	PF00017	0.461
LIG_SH2_PTP2	178	181	PF00017	0.541
LIG_SH2_SRC	13	16	PF00017	0.513
LIG_SH2_STAP1	297	301	PF00017	0.461
LIG_SH2_STAP1	334	338	PF00017	0.464
LIG_SH2_STAT3	488	491	PF00017	0.541
LIG_SH2_STAT5	10	13	PF00017	0.461
LIG_SH2_STAT5	150	153	PF00017	0.541
LIG_SH2_STAT5	178	181	PF00017	0.541
LIG_SH2_STAT5	197	200	PF00017	0.541
LIG_SH2_STAT5	452	455	PF00017	0.461
LIG_SH2_STAT5	485	488	PF00017	0.461
LIG_SH2_STAT5	516	519	PF00017	0.492
LIG_SH2_STAT5	80	83	PF00017	0.541
LIG_SH3_3	167	173	PF00018	0.492
LIG_SH3_3	365	371	PF00018	0.477
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.477
LIG_SUMO_SIM_par_1	215	220	PF11976	0.541
LIG_TRAF2_1	421	424	PF00917	0.541
LIG_TRAF2_1	558	561	PF00917	0.461
LIG_TRFH_1	20	24	PF08558	0.454
LIG_TYR_ITIM	100	105	PF00017	0.426
LIG_UBA3_1	387	395	PF00899	0.314
MOD_CDK_SPxxK_3	329	336	PF00069	0.392
MOD_CDK_SPxxK_3	87	94	PF00069	0.204
MOD_CK1_1	309	315	PF00069	0.333
MOD_CK1_1	554	560	PF00069	0.331
MOD_CK1_1	66	72	PF00069	0.333
MOD_CK2_1	204	210	PF00069	0.393
MOD_CK2_1	299	305	PF00069	0.426
MOD_CK2_1	418	424	PF00069	0.333
MOD_CK2_1	554	560	PF00069	0.314
MOD_GlcNHglycan	14	18	PF01048	0.407
MOD_GlcNHglycan	325	328	PF01048	0.288
MOD_GlcNHglycan	424	428	PF01048	0.426
MOD_GlcNHglycan	530	533	PF01048	0.386
MOD_GlcNHglycan	68	71	PF01048	0.258
MOD_GSK3_1	306	313	PF00069	0.426
MOD_GSK3_1	358	365	PF00069	0.418
MOD_GSK3_1	414	421	PF00069	0.373
MOD_GSK3_1	477	484	PF00069	0.458
MOD_GSK3_1	490	497	PF00069	0.360
MOD_GSK3_1	5	12	PF00069	0.355
MOD_GSK3_1	528	535	PF00069	0.426
MOD_GSK3_1	54	61	PF00069	0.205
MOD_GSK3_1	550	557	PF00069	0.314
MOD_NEK2_1	116	121	PF00069	0.426
MOD_NEK2_1	217	222	PF00069	0.333
MOD_NEK2_1	261	266	PF00069	0.335
MOD_NEK2_1	299	304	PF00069	0.363
MOD_NEK2_1	3	8	PF00069	0.340
MOD_NEK2_1	311	316	PF00069	0.269
MOD_NEK2_1	362	367	PF00069	0.314
MOD_NEK2_1	414	419	PF00069	0.373
MOD_NEK2_1	522	527	PF00069	0.333
MOD_NEK2_1	63	68	PF00069	0.335
MOD_PIKK_1	116	122	PF00454	0.426
MOD_PIKK_1	487	493	PF00454	0.426
MOD_PIKK_1	5	11	PF00454	0.426
MOD_PIKK_1	516	522	PF00454	0.426
MOD_PIKK_1	73	79	PF00454	0.357
MOD_PKA_2	116	122	PF00069	0.333
MOD_PKA_2	246	252	PF00069	0.405
MOD_PKA_2	528	534	PF00069	0.377
MOD_Plk_1	423	429	PF00069	0.333
MOD_Plk_1	532	538	PF00069	0.409
MOD_Plk_1	550	556	PF00069	0.171
MOD_Plk_2-3	246	252	PF00069	0.418
MOD_Plk_4	141	147	PF00069	0.426
MOD_Plk_4	237	243	PF00069	0.369
MOD_Plk_4	315	321	PF00069	0.314
MOD_Plk_4	358	364	PF00069	0.382
MOD_Plk_4	481	487	PF00069	0.380
MOD_Plk_4	508	514	PF00069	0.409
MOD_Plk_4	522	528	PF00069	0.356
MOD_Plk_4	551	557	PF00069	0.314
MOD_Plk_4	58	64	PF00069	0.423
MOD_Plk_4	80	86	PF00069	0.392
MOD_ProDKin_1	152	158	PF00069	0.314
MOD_ProDKin_1	329	335	PF00069	0.392
MOD_ProDKin_1	367	373	PF00069	0.299
MOD_ProDKin_1	87	93	PF00069	0.304
MOD_SUMO_for_1	351	354	PF00179	0.426
MOD_SUMO_rev_2	349	357	PF00179	0.314
TRG_DiLeu_BaEn_1	280	285	PF01217	0.440
TRG_DiLeu_BaEn_1	551	556	PF01217	0.314
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.314
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.392
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.426
TRG_ENDOCYTIC_2	102	105	PF00928	0.426
TRG_ENDOCYTIC_2	293	296	PF00928	0.329
TRG_ENDOCYTIC_2	297	300	PF00928	0.297
TRG_ENDOCYTIC_2	384	387	PF00928	0.314
TRG_ENDOCYTIC_2	541	544	PF00928	0.314
TRG_ENDOCYTIC_2	78	81	PF00928	0.314
TRG_ER_diArg_1	384	386	PF00400	0.314
TRG_ER_diArg_1	71	73	PF00400	0.333
TRG_NES_CRM1_1	172	186	PF08389	0.454
TRG_NES_CRM1_1	280	295	PF08389	0.454
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P297	Leptomonas seymouri	86%	71%
A0A1X0NQL5	Trypanosomatidae	64%	75%
A0A3S7X1X3	Leishmania donovani	95%	100%
A0A422MYN6	Trypanosoma rangeli	62%	76%
A4I410	Leishmania infantum	95%	100%
D0A8Z7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	74%
E9B098	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q7Y6	Leishmania major	95%	100%
Q95ZG4	Dictyostelium discoideum	22%	73%
Q9C5H9	Arabidopsis thaliana	20%	88%
Q9D4F8	Mus musculus	22%	89%
Q9FG37	Arabidopsis thaliana	24%	71%
Q9UGJ1	Homo sapiens	22%	89%
Q9USQ2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	71%
Q9XYP7	Drosophila melanogaster	21%	70%
V5ATN7	Trypanosoma cruzi	62%	76%