Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

receptor for activated C kinase 1

Species:

Leishmania braziliensis

UniProt:

A4HGX7_LEIBR

TriTrypDb:

LbrM.28.2950 , LBRM2903_280037000

Length:

312

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: avilan@ula.ve
Publication title: Leishmania mexicana: LACK (Leishmania homolog of receptors for activated C-kinase) is a plasminogen binding protein
Publication 1st author(s): Gomez-Arreaza
Publication Identifier(s): 21272581
Host organism: -1
Interaction detection method(s): enzymatic linked imunosorbent assay
Interaction type: direct interaction
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: Q7KFG4
ID(s) interactor B: P00747
Taxid interactor A: Leishmania mexicana
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	yes	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0015935	small ribosomal subunit	4	12
GO:0032991	protein-containing complex	1	12
GO:0044391	ribosomal subunit	3	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGX7

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0044237	cellular metabolic process	2	8
GO:0001932	regulation of protein phosphorylation	7	1
GO:0001934	positive regulation of protein phosphorylation	8	1
GO:0006414	translational elongation	5	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010562	positive regulation of phosphorus metabolic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0031401	positive regulation of protein modification process	7	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0042325	regulation of phosphorylation	7	1
GO:0042327	positive regulation of phosphorylation	8	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0045937	positive regulation of phosphate metabolic process	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0072344	rescue of stalled ribosome	6	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	12
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0043021	ribonucleoprotein complex binding	3	12
GO:0043022	ribosome binding	4	12
GO:0044877	protein-containing complex binding	2	12
GO:0005080	protein kinase C binding	6	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.657
CLV_C14_Caspase3-7	32	36	PF00656	0.578
CLV_NRD_NRD_1	100	102	PF00675	0.440
CLV_PCSK_SKI1_1	101	105	PF00082	0.374
CLV_PCSK_SKI1_1	108	112	PF00082	0.330
CLV_PCSK_SKI1_1	188	192	PF00082	0.401
DEG_Kelch_Keap1_1	222	227	PF01344	0.625
DEG_Nend_UBRbox_3	1	3	PF02207	0.661
DEG_SCF_FBW7_1	272	277	PF00400	0.439
DEG_SPOP_SBC_1	29	33	PF00917	0.578
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.553
DOC_MAPK_gen_1	105	115	PF00069	0.640
DOC_MAPK_MEF2A_6	108	115	PF00069	0.565
DOC_USP7_MATH_1	204	208	PF00917	0.546
DOC_USP7_MATH_1	254	258	PF00917	0.483
DOC_USP7_MATH_2	279	285	PF00917	0.604
DOC_WW_Pin1_4	113	118	PF00397	0.553
DOC_WW_Pin1_4	156	161	PF00397	0.544
DOC_WW_Pin1_4	200	205	PF00397	0.553
DOC_WW_Pin1_4	241	246	PF00397	0.418
DOC_WW_Pin1_4	270	275	PF00397	0.587
LIG_14-3-3_CanoR_1	11	20	PF00244	0.565
LIG_14-3-3_CanoR_1	120	130	PF00244	0.640
LIG_14-3-3_CanoR_1	47	51	PF00244	0.580
LIG_14-3-3_CanoR_1	95	104	PF00244	0.386
LIG_BRCT_BRCA1_1	154	158	PF00533	0.640
LIG_deltaCOP1_diTrp_1	150	158	PF00928	0.556
LIG_FHA_1	105	111	PF00498	0.544
LIG_FHA_1	173	179	PF00498	0.596
LIG_FHA_1	197	203	PF00498	0.615
LIG_FHA_1	63	69	PF00498	0.640
LIG_FHA_2	30	36	PF00498	0.565
LIG_LIR_Apic_2	51	57	PF02991	0.547
LIG_LIR_Gen_1	25	30	PF02991	0.616
LIG_LIR_Nem_3	25	29	PF02991	0.616
LIG_RPA_C_Fungi	6	18	PF08784	0.405
LIG_SH2_CRK	54	58	PF00017	0.658
LIG_SH2_PTP2	26	29	PF00017	0.527
LIG_SH2_STAP1	79	83	PF00017	0.527
LIG_SH2_STAT5	196	199	PF00017	0.405
LIG_SH2_STAT5	26	29	PF00017	0.463
LIG_SUMO_SIM_par_1	163	169	PF11976	0.397
LIG_SUMO_SIM_par_1	198	203	PF11976	0.527
MOD_CDC14_SPxK_1	244	247	PF00782	0.471
MOD_CDK_SPxK_1	241	247	PF00069	0.454
MOD_CDK_SPxxK_3	113	120	PF00069	0.405
MOD_CK1_1	198	204	PF00069	0.497
MOD_CK1_1	40	46	PF00069	0.662
MOD_CK1_1	49	55	PF00069	0.629
MOD_CK1_1	69	75	PF00069	0.224
MOD_CK2_1	221	227	PF00069	0.492
MOD_CK2_1	306	312	PF00069	0.584
MOD_GlcNHglycan	123	126	PF01048	0.405
MOD_GlcNHglycan	168	171	PF01048	0.405
MOD_GlcNHglycan	210	213	PF01048	0.491
MOD_GlcNHglycan	235	238	PF01048	0.348
MOD_GlcNHglycan	287	290	PF01048	0.405
MOD_GlcNHglycan	295	298	PF01048	0.396
MOD_GSK3_1	152	159	PF00069	0.425
MOD_GSK3_1	168	175	PF00069	0.463
MOD_GSK3_1	191	198	PF00069	0.392
MOD_GSK3_1	200	207	PF00069	0.392
MOD_GSK3_1	270	277	PF00069	0.572
MOD_GSK3_1	281	288	PF00069	0.382
MOD_GSK3_1	30	37	PF00069	0.421
MOD_GSK3_1	62	69	PF00069	0.430
MOD_GSK3_1	81	88	PF00069	0.295
MOD_NEK2_1	121	126	PF00069	0.473
MOD_NEK2_1	208	213	PF00069	0.485
MOD_NEK2_2	172	177	PF00069	0.508
MOD_NEK2_2	186	191	PF00069	0.388
MOD_NEK2_2	85	90	PF00069	0.405
MOD_PIKK_1	96	102	PF00454	0.389
MOD_PK_1	256	262	PF00069	0.574
MOD_PK_1	304	310	PF00069	0.440
MOD_PKA_2	46	52	PF00069	0.577
MOD_Plk_1	172	178	PF00069	0.527
MOD_Plk_1	186	192	PF00069	0.471
MOD_Plk_1	254	260	PF00069	0.553
MOD_Plk_1	85	91	PF00069	0.405
MOD_Plk_2-3	46	52	PF00069	0.612
MOD_Plk_4	22	28	PF00069	0.425
MOD_Plk_4	256	262	PF00069	0.540
MOD_Plk_4	290	296	PF00069	0.406
MOD_ProDKin_1	113	119	PF00069	0.405
MOD_ProDKin_1	156	162	PF00069	0.392
MOD_ProDKin_1	200	206	PF00069	0.405
MOD_ProDKin_1	241	247	PF00069	0.421
MOD_ProDKin_1	270	276	PF00069	0.598
MOD_SUMO_rev_2	259	268	PF00179	0.547
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.527
TRG_ENDOCYTIC_2	26	29	PF00928	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X3	Leptomonas seymouri	20%	70%
A0A0N1I307	Leptomonas seymouri	27%	72%
A0A0N1I6C2	Leptomonas seymouri	28%	74%
A0A0N1PB16	Leptomonas seymouri	92%	100%
A0A0S4IWU9	Bodo saltans	60%	99%
A0A0S4JE21	Bodo saltans	30%	76%
A0A0S4JFE0	Bodo saltans	22%	70%
A0A0S4JMG6	Bodo saltans	25%	80%
A0A1X0NQ54	Trypanosomatidae	23%	77%
A0A1X0NQ96	Trypanosomatidae	27%	74%
A0A1X0NQI7	Trypanosomatidae	65%	98%
A0A1X0P0F0	Trypanosomatidae	28%	67%
A0A1X0P2X5	Trypanosomatidae	24%	70%
A0A1X0P551	Trypanosomatidae	23%	70%
A0A1X0P6M9	Trypanosomatidae	29%	83%
A0A3Q8IBR2	Leishmania donovani	25%	74%
A0A3R7KUH0	Trypanosoma rangeli	27%	74%
A0A3R7M2T7	Trypanosoma rangeli	63%	98%
A0A3R7M365	Trypanosoma rangeli	24%	74%
A0A3R7MCP0	Trypanosoma rangeli	26%	68%
A0A3S7WR72	Leishmania donovani	28%	74%
A0A3S7WVV8	Leishmania donovani	23%	76%
A0A3S7X9Q7	Leishmania donovani	22%	70%
A0CH87	Paramecium tetraurelia	28%	77%
A0DB19	Paramecium tetraurelia	29%	77%
A1CF18	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	29%	72%
A1CUD6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	30%	67%
A2QP30	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	70%
A4H666	Leishmania braziliensis	28%	74%
A4HBH0	Leishmania braziliensis	24%	76%
A4HN59	Leishmania braziliensis	21%	70%
A4HUJ0	Leishmania infantum	28%	74%
A4HYJ4	Leishmania infantum	23%	76%
A4HZL2	Leishmania infantum	25%	74%
A4IBS6	Leishmania infantum	21%	70%
A4R3M4	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	28%	68%
A7EKM8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	30%	68%
A7RWD2	Nematostella vectensis	26%	95%
A7S338	Nematostella vectensis	27%	76%
A8NEG8	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	29%	72%
A8X8C6	Caenorhabditis briggsae	29%	85%
A8XZJ9	Caenorhabditis briggsae	26%	80%
A9V790	Monosiga brevicollis	28%	76%
B0LSW3	Felis catus	27%	76%
B0XM00	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	31%	67%
B2AEZ5	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	28%	67%
B2B766	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	30%	67%
B2VWG7	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	29%	68%
B3MEY6	Drosophila ananassae	27%	76%
B3NPW0	Drosophila erecta	27%	76%
B3NQR5	Drosophila erecta	26%	93%
B3S4I5	Trichoplax adhaerens	30%	76%
B4GAJ1	Drosophila persimilis	27%	76%
B4GDM7	Drosophila persimilis	25%	93%
B4HRQ6	Drosophila sechellia	25%	93%
B4HSL3	Drosophila sechellia	27%	76%
B4JW81	Drosophila grimshawi	26%	94%
B4JWA1	Drosophila grimshawi	27%	76%
B4KT48	Drosophila mojavensis	27%	76%
B4KTK4	Drosophila mojavensis	26%	94%
B4LQ21	Drosophila virilis	27%	76%
B4MY65	Drosophila willistoni	27%	76%
B4P6P9	Drosophila yakuba	27%	76%
B4P7Q3	Drosophila yakuba	26%	93%
B4QFZ8	Drosophila simulans	25%	93%
B4QHG6	Drosophila simulans	27%	76%
B5X3C4	Salmo salar	26%	76%
B5X3Z6	Salmo salar	26%	76%
B6GZD3	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	25%	67%
B6HP56	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	31%	68%
B6QC06	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	25%	69%
B6QC56	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	26%	68%
B7FNU7	Phaeodactylum tricornutum (strain CCAP 1055/1)	26%	71%
B7PS00	Ixodes scapularis	31%	76%
B8M0Q1	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	28%	68%
B8N9H4	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	28%	69%
B8P4B0	Postia placenta (strain ATCC 44394 / Madison 698-R)	28%	71%
B8PD53	Postia placenta (strain ATCC 44394 / Madison 698-R)	28%	73%
C0NRC6	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	28%	68%
C3XVT5	Branchiostoma floridae	25%	77%
C4JPW9	Uncinocarpus reesii (strain UAMH 1704)	29%	68%
C4JZS6	Uncinocarpus reesii (strain UAMH 1704)	25%	70%
C5FWH1	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	30%	68%
C5PFX0	Coccidioides posadasii (strain C735)	31%	66%
C6HTE8	Ajellomyces capsulatus (strain H143)	28%	68%
C7Z6H2	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	27%	70%
C9ZL39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	86%
C9ZQJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	71%
C9ZVL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	74%
D0A4F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	70%
D0A8Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	98%
D1ZEB4	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	27%	68%
D3BUN1	Polysphondylium pallidum (strain ATCC 26659 / Pp 5 / PN500)	26%	75%
D3TLL6	Glossina morsitans morsitans	25%	76%
D4AZ50	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	28%	68%
D4DG66	Trichophyton verrucosum (strain HKI 0517)	28%	68%
D5GBI7	Tuber melanosporum (strain Mel28)	30%	69%
E8NHN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AFL2	Leishmania major	21%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	74%
E9AUX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	73%
E9B3I3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	72%
E9B6R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	70%
F4IIK6	Arabidopsis thaliana	24%	100%
F6ZT52	Xenopus tropicalis	28%	66%
G4MQX3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	44%	99%
O14775	Homo sapiens	25%	79%
O18640	Drosophila melanogaster	48%	98%
O24076	Medicago sativa	47%	96%
O24456	Arabidopsis thaliana	47%	95%
O35353	Rattus norvegicus	24%	92%
O42248	Danio rerio	48%	98%
O42249	Oreochromis niloticus	47%	98%
O43017	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	82%
O45040	Homarus americanus	23%	92%
O54927	Mus musculus	30%	74%
O54929	Mus musculus	25%	77%
P0CS42	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	28%	72%
P0CS43	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	28%	72%
P11017	Bos taurus	23%	92%
P16520	Homo sapiens	27%	92%
P17343	Caenorhabditis elegans	22%	92%
P20053	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	67%
P23232	Loligo forbesii	23%	91%
P25387	Chlamydomonas reinhardtii	46%	98%
P26308	Drosophila melanogaster	24%	92%
P29387	Mus musculus	24%	92%
P36408	Dictyostelium discoideum	24%	90%
P38011	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	98%
P41318	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P42841	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	67%
P43033	Bos taurus	27%	76%
P43034	Homo sapiens	27%	76%
P46800	Dictyostelium discoideum	44%	95%
P49026	Nicotiana tabacum	47%	96%
P49027	Oryza sativa subsp. japonica	46%	93%
P49178	Zea mays	26%	82%
P52287	Rattus norvegicus	24%	92%
P54311	Rattus norvegicus	23%	92%
P54313	Rattus norvegicus	23%	92%
P61964	Homo sapiens	30%	93%
P61965	Mus musculus	30%	93%
P62871	Bos taurus	23%	92%
P62872	Canis lupus familiaris	23%	92%
P62873	Homo sapiens	23%	92%
P62874	Mus musculus	23%	92%
P62879	Homo sapiens	23%	92%
P62880	Mus musculus	23%	92%
P62881	Mus musculus	26%	79%
P62882	Rattus norvegicus	26%	88%
P62883	Leishmania chagasi	97%	100%
P62884	Leishmania infantum	97%	100%
P63004	Rattus norvegicus	27%	76%
P63005	Mus musculus	27%	76%
P63243	Bos taurus	47%	98%
P63244	Homo sapiens	47%	98%
P63245	Rattus norvegicus	47%	98%
P63246	Sus scrofa	47%	98%
P63247	Gallus gallus	47%	98%
P68040	Mus musculus	47%	98%
P69103	Trypanosoma brucei brucei	62%	98%
P69104	Trypanosoma brucei rhodesiense	62%	98%
P74598	Synechocystis sp. (strain PCC 6803 / Kazusa)	31%	90%
P79147	Canis lupus familiaris	26%	92%
P79959	Xenopus laevis	25%	92%
P83774	Candida albicans (strain SC5314 / ATCC MYA-2876)	42%	98%
P93340	Nicotiana plumbaginifolia	48%	96%
P93563	Solanum tuberosum	25%	83%
Q00664	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	70%
Q01369	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	44%	99%
Q08706	Lymnaea stagnalis	23%	91%
Q0D0X6	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	28%	70%
Q0P593	Bos taurus	26%	75%
Q0U1B1	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	29%	68%
Q0V8J1	Bos taurus	25%	77%
Q10281	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	99%
Q10282	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q12417	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	69%
Q17963	Caenorhabditis elegans	30%	83%
Q17N69	Aedes aegypti	32%	76%
Q1LV15	Danio rerio	32%	75%
Q21215	Caenorhabditis elegans	46%	96%
Q25189	Hydra vulgaris	47%	98%
Q25306	Leishmania major	97%	100%
Q26544	Schistosoma mansoni	25%	100%
Q28I85	Xenopus tropicalis	27%	71%
Q291L9	Drosophila pseudoobscura pseudoobscura	27%	76%
Q292E8	Drosophila pseudoobscura pseudoobscura	25%	93%
Q29RH4	Bos taurus	26%	89%
Q2GT28	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	30%	69%
Q2HBX6	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	27%	69%
Q2HJH6	Bos taurus	30%	87%
Q2KIG2	Bos taurus	30%	93%
Q2TBP4	Bos taurus	26%	77%
Q2UGU1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	28%	69%
Q39336	Brassica napus	47%	95%
Q39836	Glycine max	46%	96%
Q3Y8L7	Chlamydomonas reinhardtii	29%	70%
Q40507	Nicotiana tabacum	26%	83%
Q498M4	Rattus norvegicus	30%	93%
Q4P9P9	Ustilago maydis (strain 521 / FGSC 9021)	28%	69%
Q4Q7Y7	Leishmania major	97%	100%
Q4QCL0	Leishmania major	25%	74%
Q4QHD6	Leishmania major	28%	100%
Q4R7Y4	Macaca fascicularis	47%	98%
Q4R8E7	Macaca fascicularis	26%	75%
Q4RJN5	Tetraodon nigroviridis	26%	76%
Q4V7A0	Rattus norvegicus	26%	100%
Q4V7Z1	Xenopus laevis	29%	67%
Q4V8C4	Rattus norvegicus	29%	95%
Q4WLM7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	67%
Q4WT34	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	69%
Q54KL5	Dictyostelium discoideum	29%	93%
Q55AR8	Dictyostelium discoideum	26%	88%
Q5A7Q3	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	80%
Q5BE22	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	69%
Q5BK30	Rattus norvegicus	26%	75%
Q5FWQ6	Xenopus laevis	26%	75%
Q5GIS3	Pinctada fucata	23%	91%
Q5IS43	Pan troglodytes	27%	76%
Q5JTN6	Homo sapiens	31%	99%
Q5M786	Xenopus tropicalis	30%	93%
Q5R5W8	Pongo abelii	23%	92%
Q5RD06	Pongo abelii	26%	69%
Q5RDY7	Pongo abelii	25%	88%
Q5RE95	Pongo abelii	31%	95%
Q5REG7	Pongo abelii	26%	76%
Q5RF51	Pongo abelii	30%	87%
Q5XGI5	Xenopus tropicalis	25%	99%
Q61011	Mus musculus	24%	92%
Q61ZF6	Caenorhabditis briggsae	22%	92%
Q6BU94	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	75%
Q6C709	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	71%
Q6CG48	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	71%
Q6CKE8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	72%
Q6CP71	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	69%
Q6FJS0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	69%
Q6FJZ9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	73%
Q6GMD2	Xenopus laevis	26%	100%
Q6L4F8	Oryza sativa subsp. japonica	46%	93%
Q6NZH4	Xenopus tropicalis	25%	76%
Q6P1V3	Xenopus tropicalis	29%	74%
Q6P2Y2	Xenopus tropicalis	25%	75%
Q6P5M2	Danio rerio	25%	100%
Q6PBD6	Xenopus tropicalis	26%	100%
Q6PBY0	Danio rerio	24%	79%
Q6PE01	Mus musculus	30%	87%
Q6PH57	Danio rerio	24%	92%
Q6PNB6	Oryctolagus cuniculus	26%	88%
Q6TMK6	Cricetulus griseus	24%	92%
Q6ZMY6	Homo sapiens	24%	66%
Q75AV4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	69%
Q75BY3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	73%
Q76LS6	Leishmania donovani	97%	100%
Q7K1Y4	Drosophila melanogaster	25%	93%
Q7KNS3	Drosophila melanogaster	27%	76%
Q7RY30	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	69%
Q7T0P4	Xenopus laevis	27%	71%
Q7T2F6	Danio rerio	29%	74%
Q7T394	Danio rerio	26%	76%
Q7ZVF0	Danio rerio	27%	75%
Q803D2	Danio rerio	26%	76%
Q80ZD0	Tamias striatus	25%	88%
Q86TI4	Homo sapiens	26%	83%
Q86VZ2	Homo sapiens	31%	95%
Q8HXX0	Macaca fascicularis	26%	76%
Q8I0F4	Dictyostelium discoideum	27%	74%
Q8JZX3	Mus musculus	26%	77%
Q8N136	Homo sapiens	26%	75%
Q8NBT0	Homo sapiens	26%	77%
Q8SRB0	Encephalitozoon cuniculi (strain GB-M1)	26%	93%
Q8VE80	Mus musculus	25%	89%
Q90ZL4	Xenopus laevis	25%	76%
Q93134	Biomphalaria glabrata	49%	99%
Q96DI7	Homo sapiens	30%	87%
Q96J01	Homo sapiens	26%	89%
Q9AYE4	Oryza sativa subsp. japonica	23%	99%
Q9BRX9	Homo sapiens	30%	99%
Q9C1X0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9C4Z6	Arabidopsis thaliana	47%	96%
Q9D7H2	Mus musculus	29%	95%
Q9D994	Mus musculus	31%	100%
Q9DAJ4	Mus musculus	28%	99%
Q9ERF3	Mus musculus	26%	100%
Q9FKT5	Arabidopsis thaliana	26%	99%
Q9GL51	Sus scrofa	27%	76%
Q9GZS3	Homo sapiens	27%	100%
Q9HAV0	Homo sapiens	25%	92%
Q9LV28	Arabidopsis thaliana	46%	96%
Q9M2Z2	Arabidopsis thaliana	29%	98%
Q9NDC9	Caenorhabditis elegans	28%	77%
Q9NYS7	Homo sapiens	25%	77%
Q9PTR5	Gallus gallus	27%	76%
Q9SY00	Arabidopsis thaliana	31%	94%
Q9UTC7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	68%
Q9V3J8	Drosophila melanogaster	30%	86%
Q9VU65	Drosophila melanogaster	25%	80%
Q9W5Z5	Takifugu rubripes	26%	73%
Q9Y6I7	Homo sapiens	31%	74%
V5B4Z8	Trypanosoma cruzi	29%	70%
V5B6G4	Trypanosoma cruzi	27%	84%
V5BDQ2	Trypanosoma cruzi	61%	98%
V5BJG9	Trypanosoma cruzi	24%	70%
V5BP59	Trypanosoma cruzi	28%	74%