Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGX6_LEIBR

TriTrypDb:

LbrM.28.2940 , LBRM2903_280036700

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGX6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008233	peptidase activity	3	1
GO:0008236	serine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0017171	serine hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.621
CLV_NRD_NRD_1	208	210	PF00675	0.349
CLV_NRD_NRD_1	458	460	PF00675	0.510
CLV_PCSK_FUR_1	436	440	PF00082	0.421
CLV_PCSK_KEX2_1	148	150	PF00082	0.584
CLV_PCSK_KEX2_1	208	210	PF00082	0.349
CLV_PCSK_KEX2_1	24	26	PF00082	0.703
CLV_PCSK_KEX2_1	438	440	PF00082	0.443
CLV_PCSK_KEX2_1	457	459	PF00082	0.392
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.703
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.576
CLV_PCSK_SKI1_1	150	154	PF00082	0.624
CLV_PCSK_SKI1_1	178	182	PF00082	0.492
CLV_PCSK_SKI1_1	209	213	PF00082	0.305
CLV_PCSK_SKI1_1	25	29	PF00082	0.751
CLV_PCSK_SKI1_1	49	53	PF00082	0.342
CLV_PCSK_SKI1_1	61	65	PF00082	0.438
CLV_PCSK_SKI1_1	9	13	PF00082	0.620
CLV_PCSK_SKI1_1	93	97	PF00082	0.414
DEG_APCC_DBOX_1	177	185	PF00400	0.400
DEG_APCC_DBOX_1	3	11	PF00400	0.591
DEG_Nend_Nbox_1	1	3	PF02207	0.547
DOC_MAPK_DCC_7	97	107	PF00069	0.527
DOC_MAPK_FxFP_2	230	233	PF00069	0.385
DOC_MAPK_gen_1	101	109	PF00069	0.559
DOC_MAPK_gen_1	182	190	PF00069	0.571
DOC_MAPK_gen_1	53	62	PF00069	0.496
DOC_MAPK_MEF2A_6	101	109	PF00069	0.498
DOC_MAPK_MEF2A_6	53	62	PF00069	0.461
DOC_PP1_RVXF_1	373	379	PF00149	0.342
DOC_PP1_RVXF_1	59	65	PF00149	0.491
DOC_PP2B_LxvP_1	74	77	PF13499	0.465
DOC_PP2B_LxvP_1	80	83	PF13499	0.428
DOC_PP4_FxxP_1	230	233	PF00568	0.385
DOC_PP4_FxxP_1	260	263	PF00568	0.474
DOC_PP4_FxxP_1	332	335	PF00568	0.510
DOC_USP7_MATH_1	200	204	PF00917	0.384
DOC_USP7_MATH_1	27	31	PF00917	0.592
DOC_USP7_MATH_1	370	374	PF00917	0.367
DOC_USP7_MATH_1	557	561	PF00917	0.477
DOC_USP7_UBL2_3	16	20	PF12436	0.627
DOC_WW_Pin1_4	158	163	PF00397	0.698
DOC_WW_Pin1_4	214	219	PF00397	0.502
DOC_WW_Pin1_4	319	324	PF00397	0.581
DOC_WW_Pin1_4	33	38	PF00397	0.508
DOC_WW_Pin1_4	400	405	PF00397	0.355
DOC_WW_Pin1_4	442	447	PF00397	0.597
DOC_WW_Pin1_4	484	489	PF00397	0.606
DOC_WW_Pin1_4	498	503	PF00397	0.589
LIG_14-3-3_CanoR_1	148	153	PF00244	0.606
LIG_14-3-3_CanoR_1	236	241	PF00244	0.524
LIG_14-3-3_CanoR_1	25	33	PF00244	0.580
LIG_14-3-3_CanoR_1	371	375	PF00244	0.360
LIG_14-3-3_CanoR_1	382	392	PF00244	0.370
LIG_14-3-3_CanoR_1	4	8	PF00244	0.585
LIG_14-3-3_CanoR_1	489	494	PF00244	0.645
LIG_14-3-3_CanoR_1	87	95	PF00244	0.447
LIG_BRCT_BRCA1_1	402	406	PF00533	0.351
LIG_BRCT_BRCA1_1	480	484	PF00533	0.523
LIG_deltaCOP1_diTrp_1	460	468	PF00928	0.409
LIG_DLG_GKlike_1	148	156	PF00625	0.494
LIG_DLG_GKlike_1	489	496	PF00625	0.570
LIG_EH_1	481	485	PF12763	0.401
LIG_EVH1_2	446	450	PF00568	0.631
LIG_FHA_1	132	138	PF00498	0.407
LIG_FHA_1	17	23	PF00498	0.737
LIG_FHA_1	175	181	PF00498	0.538
LIG_FHA_1	192	198	PF00498	0.263
LIG_FHA_1	215	221	PF00498	0.377
LIG_FHA_1	229	235	PF00498	0.339
LIG_FHA_1	263	269	PF00498	0.406
LIG_FHA_1	308	314	PF00498	0.526
LIG_FHA_1	348	354	PF00498	0.360
LIG_FHA_1	383	389	PF00498	0.365
LIG_FHA_1	551	557	PF00498	0.750
LIG_FHA_1	87	93	PF00498	0.526
LIG_FHA_2	16	22	PF00498	0.628
LIG_FHA_2	413	419	PF00498	0.575
LIG_FHA_2	50	56	PF00498	0.279
LIG_FHA_2	505	511	PF00498	0.606
LIG_GBD_Chelix_1	39	47	PF00786	0.420
LIG_LIR_Apic_2	227	233	PF02991	0.364
LIG_LIR_Gen_1	252	263	PF02991	0.456
LIG_LIR_Gen_1	460	470	PF02991	0.347
LIG_LIR_Gen_1	473	478	PF02991	0.364
LIG_LIR_Gen_1	487	498	PF02991	0.522
LIG_LIR_Nem_3	239	244	PF02991	0.469
LIG_LIR_Nem_3	252	258	PF02991	0.354
LIG_LIR_Nem_3	394	400	PF02991	0.410
LIG_LIR_Nem_3	405	410	PF02991	0.413
LIG_LIR_Nem_3	42	47	PF02991	0.366
LIG_LIR_Nem_3	460	466	PF02991	0.346
LIG_LIR_Nem_3	473	477	PF02991	0.367
LIG_LIR_Nem_3	487	493	PF02991	0.503
LIG_PCNA_yPIPBox_3	61	74	PF02747	0.447
LIG_PDZ_Class_3	597	602	PF00595	0.517
LIG_Pex14_2	241	245	PF04695	0.354
LIG_PTAP_UEV_1	581	586	PF05743	0.570
LIG_REV1ctd_RIR_1	150	156	PF16727	0.522
LIG_REV1ctd_RIR_1	404	412	PF16727	0.493
LIG_SH2_CRK	44	48	PF00017	0.367
LIG_SH2_CRK	474	478	PF00017	0.441
LIG_SH2_GRB2like	119	122	PF00017	0.528
LIG_SH2_SRC	119	122	PF00017	0.528
LIG_SH2_STAP1	410	414	PF00017	0.539
LIG_SH2_STAP1	474	478	PF00017	0.496
LIG_SH2_STAP1	88	92	PF00017	0.503
LIG_SH2_STAT5	168	171	PF00017	0.577
LIG_SH2_STAT5	352	355	PF00017	0.360
LIG_SH2_STAT5	361	364	PF00017	0.360
LIG_SH2_STAT5	88	91	PF00017	0.399
LIG_SH3_1	154	160	PF00018	0.512
LIG_SH3_2	173	178	PF14604	0.631
LIG_SH3_3	154	160	PF00018	0.587
LIG_SH3_3	170	176	PF00018	0.585
LIG_SH3_3	332	338	PF00018	0.521
LIG_SH3_3	446	452	PF00018	0.502
LIG_SH3_3	551	557	PF00018	0.765
LIG_SH3_3	579	585	PF00018	0.581
LIG_SH3_3	73	79	PF00018	0.596
LIG_SH3_CIN85_PxpxPR_1	162	167	PF14604	0.572
MOD_CDK_SPK_2	484	489	PF00069	0.606
MOD_CK1_1	139	145	PF00069	0.535
MOD_CK1_1	276	282	PF00069	0.561
MOD_CK1_1	283	289	PF00069	0.736
MOD_CK1_1	292	298	PF00069	0.613
MOD_CK1_1	31	37	PF00069	0.500
MOD_CK1_1	311	317	PF00069	0.491
MOD_CK1_1	413	419	PF00069	0.561
MOD_CK2_1	284	290	PF00069	0.621
MOD_CK2_1	351	357	PF00069	0.368
MOD_CK2_1	383	389	PF00069	0.429
MOD_CMANNOS	296	299	PF00535	0.537
MOD_GlcNHglycan	142	145	PF01048	0.418
MOD_GlcNHglycan	202	205	PF01048	0.601
MOD_GlcNHglycan	221	224	PF01048	0.436
MOD_GlcNHglycan	287	290	PF01048	0.706
MOD_GlcNHglycan	316	319	PF01048	0.688
MOD_GlcNHglycan	393	396	PF01048	0.336
MOD_GlcNHglycan	412	415	PF01048	0.501
MOD_GlcNHglycan	582	585	PF01048	0.642
MOD_GSK3_1	10	17	PF00069	0.620
MOD_GSK3_1	136	143	PF00069	0.462
MOD_GSK3_1	214	221	PF00069	0.493
MOD_GSK3_1	228	235	PF00069	0.245
MOD_GSK3_1	258	265	PF00069	0.454
MOD_GSK3_1	27	34	PF00069	0.693
MOD_GSK3_1	276	283	PF00069	0.507
MOD_GSK3_1	284	291	PF00069	0.705
MOD_GSK3_1	301	308	PF00069	0.524
MOD_GSK3_1	313	320	PF00069	0.606
MOD_GSK3_1	347	354	PF00069	0.390
MOD_GSK3_1	39	46	PF00069	0.538
MOD_GSK3_1	478	485	PF00069	0.519
MOD_N-GLC_1	281	286	PF02516	0.491
MOD_NEK2_1	136	141	PF00069	0.411
MOD_NEK2_1	2	7	PF00069	0.561
MOD_NEK2_1	228	233	PF00069	0.409
MOD_NEK2_1	351	356	PF00069	0.359
MOD_NEK2_1	381	386	PF00069	0.498
MOD_NEK2_1	43	48	PF00069	0.437
MOD_NEK2_1	550	555	PF00069	0.623
MOD_NEK2_2	370	375	PF00069	0.382
MOD_PIKK_1	131	137	PF00454	0.383
MOD_PIKK_1	253	259	PF00454	0.391
MOD_PIKK_1	383	389	PF00454	0.412
MOD_PKA_1	148	154	PF00069	0.494
MOD_PKA_2	140	146	PF00069	0.578
MOD_PKA_2	148	154	PF00069	0.584
MOD_PKA_2	3	9	PF00069	0.565
MOD_PKA_2	370	376	PF00069	0.360
MOD_PKA_2	381	387	PF00069	0.369
MOD_PKA_2	488	494	PF00069	0.644
MOD_PKA_2	86	92	PF00069	0.562
MOD_Plk_1	131	137	PF00069	0.496
MOD_Plk_1	289	295	PF00069	0.716
MOD_Plk_1	308	314	PF00069	0.475
MOD_Plk_1	49	55	PF00069	0.417
MOD_Plk_1	550	556	PF00069	0.776
MOD_Plk_1	97	103	PF00069	0.560
MOD_Plk_2-3	535	541	PF00069	0.613
MOD_Plk_4	148	154	PF00069	0.587
MOD_Plk_4	191	197	PF00069	0.482
MOD_Plk_4	236	242	PF00069	0.533
MOD_Plk_4	289	295	PF00069	0.639
MOD_Plk_4	3	9	PF00069	0.565
MOD_Plk_4	347	353	PF00069	0.510
MOD_Plk_4	402	408	PF00069	0.387
MOD_Plk_4	550	556	PF00069	0.643
MOD_Plk_4	69	75	PF00069	0.342
MOD_ProDKin_1	158	164	PF00069	0.697
MOD_ProDKin_1	214	220	PF00069	0.501
MOD_ProDKin_1	319	325	PF00069	0.566
MOD_ProDKin_1	33	39	PF00069	0.501
MOD_ProDKin_1	400	406	PF00069	0.354
MOD_ProDKin_1	442	448	PF00069	0.599
MOD_ProDKin_1	484	490	PF00069	0.616
MOD_ProDKin_1	498	504	PF00069	0.590
MOD_SUMO_rev_2	560	568	PF00179	0.757
TRG_DiLeu_BaEn_1	132	137	PF01217	0.327
TRG_DiLeu_BaEn_1	192	197	PF01217	0.330
TRG_DiLeu_BaEn_1	473	478	PF01217	0.382
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.369
TRG_ENDOCYTIC_2	119	122	PF00928	0.528
TRG_ENDOCYTIC_2	44	47	PF00928	0.365
TRG_ENDOCYTIC_2	474	477	PF00928	0.444
TRG_ENDOCYTIC_2	48	51	PF00928	0.367
TRG_ENDOCYTIC_2	88	91	PF00928	0.371
TRG_ER_diArg_1	208	210	PF00400	0.349
TRG_ER_diArg_1	456	459	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	45	50	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F0	Leptomonas seymouri	69%	98%
A0A1X0NQL7	Trypanosomatidae	56%	100%
A0A3Q8IE54	Leishmania donovani	86%	99%
A0A422MYL5	Trypanosoma rangeli	55%	100%
A4I406	Leishmania infantum	86%	99%
D0A900	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B096	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q7Y9	Leishmania major	86%	100%
V5BI69	Trypanosoma cruzi	55%	100%