Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGX5_LEIBR

TriTrypDb:

LbrM.28.2930 , LBRM2903_280036600

Length:

122

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGX5

Function

Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	1
GO:0006996	organelle organization	4	1
GO:0007033	vacuole organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1905037	autophagosome organization	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.499
CLV_NRD_NRD_1	39	41	PF00675	0.553
CLV_PCSK_SKI1_1	42	46	PF00082	0.510
CLV_PCSK_SKI1_1	47	51	PF00082	0.573
DEG_Nend_UBRbox_3	1	3	PF02207	0.703
DEG_SPOP_SBC_1	63	67	PF00917	0.518
DOC_MAPK_gen_1	109	115	PF00069	0.470
DOC_MAPK_gen_1	40	51	PF00069	0.590
DOC_MAPK_MEF2A_6	45	53	PF00069	0.636
DOC_SPAK_OSR1_1	16	20	PF12202	0.579
DOC_USP7_MATH_1	22	26	PF00917	0.549
DOC_USP7_MATH_1	52	56	PF00917	0.675
DOC_USP7_MATH_1	63	67	PF00917	0.691
DOC_USP7_UBL2_3	41	45	PF12436	0.518
DOC_WW_Pin1_4	102	107	PF00397	0.594
DOC_WW_Pin1_4	65	70	PF00397	0.693
LIG_FHA_1	3	9	PF00498	0.492
LIG_FHA_1	48	54	PF00498	0.659
LIG_FHA_2	1	7	PF00498	0.639
LIG_FHA_2	102	108	PF00498	0.564
LIG_FHA_2	29	35	PF00498	0.514
LIG_FHA_2	95	101	PF00498	0.545
LIG_LIR_Nem_3	76	80	PF02991	0.522
LIG_NRBOX	94	100	PF00104	0.484
LIG_SH2_PTP2	112	115	PF00017	0.512
LIG_SH2_STAT5	112	115	PF00017	0.512
MOD_CDK_SPxxK_3	102	109	PF00069	0.396
MOD_CK1_1	11	17	PF00069	0.430
MOD_CK1_1	65	71	PF00069	0.659
MOD_CK1_1	73	79	PF00069	0.572
MOD_CK2_1	101	107	PF00069	0.563
MOD_CK2_1	28	34	PF00069	0.514
MOD_GlcNHglycan	54	57	PF01048	0.683
MOD_GlcNHglycan	70	73	PF01048	0.567
MOD_GSK3_1	2	9	PF00069	0.524
MOD_GSK3_1	47	54	PF00069	0.548
MOD_GSK3_1	59	66	PF00069	0.666
MOD_N-GLC_1	1	6	PF02516	0.732
MOD_N-GLC_1	12	17	PF02516	0.325
MOD_N-GLC_1	81	86	PF02516	0.478
MOD_NEK2_1	101	106	PF00069	0.550
MOD_NEK2_1	12	17	PF00069	0.502
MOD_Plk_1	12	18	PF00069	0.630
MOD_Plk_1	28	34	PF00069	0.610
MOD_Plk_1	91	97	PF00069	0.493
MOD_Plk_4	73	79	PF00069	0.578
MOD_Plk_4	94	100	PF00069	0.484
MOD_ProDKin_1	102	108	PF00069	0.593
MOD_ProDKin_1	65	71	PF00069	0.692
TRG_ENDOCYTIC_2	112	115	PF00928	0.512
TRG_NLS_MonoExtN_4	38	44	PF00514	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T6	Leptomonas seymouri	72%	100%
A0A3Q8IGZ6	Leishmania donovani	89%	100%
A4I405	Leishmania infantum	89%	100%
E9B095	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7Z0	Leishmania major	90%	100%
V5B949	Trypanosoma cruzi	30%	100%