2OG-FeII_Oxy_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGX4_LEIBR

TriTrypDb:

LbrM.28.2920 , LBRM2903_280036500

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HGX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGX4

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0006996	organelle organization	4	11
GO:0007005	mitochondrion organization	5	11
GO:0007006	mitochondrial membrane organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0033554	cellular response to stress	3	11
GO:0046902	regulation of mitochondrial membrane permeability	4	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0061024	membrane organization	4	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090559	regulation of membrane permeability	3	11
GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	5	11
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.517
CLV_NRD_NRD_1	239	241	PF00675	0.463
CLV_NRD_NRD_1	262	264	PF00675	0.456
CLV_NRD_NRD_1	282	284	PF00675	0.267
CLV_NRD_NRD_1	287	289	PF00675	0.577
CLV_NRD_NRD_1	6	8	PF00675	0.615
CLV_PCSK_KEX2_1	239	241	PF00082	0.463
CLV_PCSK_KEX2_1	262	264	PF00082	0.424
CLV_PCSK_KEX2_1	282	284	PF00082	0.267
CLV_PCSK_KEX2_1	287	289	PF00082	0.573
CLV_PCSK_KEX2_1	6	8	PF00082	0.584
CLV_PCSK_KEX2_1	80	82	PF00082	0.393
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.302
CLV_PCSK_PC7_1	2	8	PF00082	0.648
CLV_PCSK_PC7_1	283	289	PF00082	0.348
CLV_PCSK_SKI1_1	190	194	PF00082	0.340
CLV_PCSK_SKI1_1	44	48	PF00082	0.456
CLV_PCSK_SKI1_1	6	10	PF00082	0.677
DEG_Nend_UBRbox_1	1	4	PF02207	0.639
DOC_CYCLIN_RxL_1	2	12	PF00134	0.566
DOC_MAPK_gen_1	239	247	PF00069	0.512
DOC_MAPK_gen_1	262	271	PF00069	0.320
DOC_PP1_RVXF_1	153	159	PF00149	0.318
DOC_PP4_FxxP_1	33	36	PF00568	0.375
DOC_PP4_FxxP_1	74	77	PF00568	0.380
DOC_WW_Pin1_4	247	252	PF00397	0.378
DOC_WW_Pin1_4	256	261	PF00397	0.377
DOC_WW_Pin1_4	272	277	PF00397	0.240
DOC_WW_Pin1_4	46	51	PF00397	0.459
DOC_WW_Pin1_4	9	14	PF00397	0.531
LIG_14-3-3_CanoR_1	175	181	PF00244	0.365
LIG_14-3-3_CanoR_1	190	195	PF00244	0.329
LIG_14-3-3_CanoR_1	81	85	PF00244	0.531
LIG_14-3-3_CterR_2	287	289	PF00244	0.424
LIG_deltaCOP1_diTrp_1	223	230	PF00928	0.361
LIG_FHA_1	13	19	PF00498	0.541
LIG_FHA_1	265	271	PF00498	0.322
LIG_FHA_1	53	59	PF00498	0.429
LIG_FHA_2	110	116	PF00498	0.567
LIG_FHA_2	62	68	PF00498	0.424
LIG_LIR_Apic_2	32	36	PF02991	0.405
LIG_LIR_Apic_2	55	60	PF02991	0.468
LIG_LIR_Apic_2	73	77	PF02991	0.474
LIG_LIR_Gen_1	102	110	PF02991	0.502
LIG_LIR_Nem_3	258	264	PF02991	0.367
LIG_LIR_Nem_3	76	82	PF02991	0.354
LIG_LIR_Nem_3	98	103	PF02991	0.334
LIG_PALB2_WD40_1	74	82	PF16756	0.348
LIG_PCNA_PIPBox_1	89	98	PF02747	0.396
LIG_Pex14_1	53	57	PF04695	0.446
LIG_Pex14_2	74	78	PF04695	0.378
LIG_SH2_CRK	103	107	PF00017	0.432
LIG_SH2_PTP2	214	217	PF00017	0.416
LIG_SH2_PTP2	57	60	PF00017	0.428
LIG_SH2_STAP1	103	107	PF00017	0.272
LIG_SH2_STAT5	146	149	PF00017	0.365
LIG_SH2_STAT5	214	217	PF00017	0.302
LIG_SH2_STAT5	57	60	PF00017	0.428
LIG_SH3_3	142	148	PF00018	0.342
LIG_SH3_3	15	21	PF00018	0.489
LIG_SH3_3	194	200	PF00018	0.452
LIG_SH3_3	31	37	PF00018	0.459
LIG_SUMO_SIM_anti_2	126	133	PF11976	0.319
LIG_SUMO_SIM_anti_2	202	208	PF11976	0.403
LIG_TRAF2_1	37	40	PF00917	0.530
MOD_CDK_SPxK_1	247	253	PF00069	0.441
MOD_CDK_SPxK_1	256	262	PF00069	0.348
MOD_CDK_SPxxK_3	256	263	PF00069	0.437
MOD_CK1_1	102	108	PF00069	0.491
MOD_CK1_1	12	18	PF00069	0.396
MOD_CK1_1	130	136	PF00069	0.490
MOD_CK1_1	23	29	PF00069	0.415
MOD_CK2_1	61	67	PF00069	0.397
MOD_GlcNHglycan	132	135	PF01048	0.435
MOD_GlcNHglycan	163	166	PF01048	0.390
MOD_GlcNHglycan	176	179	PF01048	0.351
MOD_GSK3_1	102	109	PF00069	0.386
MOD_GSK3_1	9	16	PF00069	0.422
MOD_NEK2_1	118	123	PF00069	0.527
MOD_NEK2_1	161	166	PF00069	0.411
MOD_NEK2_1	192	197	PF00069	0.351
MOD_NEK2_1	264	269	PF00069	0.393
MOD_NEK2_1	99	104	PF00069	0.356
MOD_PKA_1	80	86	PF00069	0.393
MOD_PKA_2	174	180	PF00069	0.407
MOD_PKA_2	80	86	PF00069	0.537
MOD_Plk_1	127	133	PF00069	0.424
MOD_Plk_1	224	230	PF00069	0.234
MOD_Plk_1	264	270	PF00069	0.364
MOD_Plk_2-3	61	67	PF00069	0.429
MOD_Plk_4	102	108	PF00069	0.404
MOD_Plk_4	127	133	PF00069	0.462
MOD_Plk_4	13	19	PF00069	0.643
MOD_Plk_4	20	26	PF00069	0.460
MOD_Plk_4	241	247	PF00069	0.496
MOD_Plk_4	29	35	PF00069	0.460
MOD_ProDKin_1	247	253	PF00069	0.384
MOD_ProDKin_1	256	262	PF00069	0.376
MOD_ProDKin_1	272	278	PF00069	0.245
MOD_ProDKin_1	46	52	PF00069	0.456
MOD_ProDKin_1	9	15	PF00069	0.529
MOD_SUMO_rev_2	39	49	PF00179	0.441
TRG_DiLeu_BaEn_1	202	207	PF01217	0.370
TRG_DiLeu_BaEn_1	67	72	PF01217	0.333
TRG_DiLeu_BaEn_4	67	73	PF01217	0.356
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.676
TRG_ENDOCYTIC_2	103	106	PF00928	0.386
TRG_ENDOCYTIC_2	214	217	PF00928	0.302
TRG_ENDOCYTIC_2	261	264	PF00928	0.366
TRG_ENDOCYTIC_2	96	99	PF00928	0.355
TRG_ER_diArg_1	219	222	PF00400	0.448
TRG_ER_diArg_1	238	240	PF00400	0.425
TRG_ER_diArg_1	261	263	PF00400	0.473
TRG_ER_diArg_1	282	284	PF00400	0.469
TRG_ER_diArg_1	6	8	PF00400	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYL5	Leptomonas seymouri	75%	99%
A0A0S4JCJ0	Bodo saltans	48%	89%
A0A1X0NR19	Trypanosomatidae	60%	100%
A0A3Q8IE10	Leishmania donovani	85%	100%
A4I404	Leishmania infantum	85%	100%
D0A901	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B094	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q7Z1	Leishmania major	84%	100%
V5B945	Trypanosoma cruzi	56%	100%