Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HGX3_LEIBR

TriTrypDb:

LbrM.28.2910 , LBRM2903_280036400

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	404	408	PF00656	0.647
CLV_C14_Caspase3-7	417	421	PF00656	0.558
CLV_NRD_NRD_1	137	139	PF00675	0.593
CLV_NRD_NRD_1	175	177	PF00675	0.730
CLV_NRD_NRD_1	206	208	PF00675	0.606
CLV_NRD_NRD_1	341	343	PF00675	0.575
CLV_NRD_NRD_1	398	400	PF00675	0.654
CLV_NRD_NRD_1	415	417	PF00675	0.515
CLV_PCSK_KEX2_1	137	139	PF00082	0.587
CLV_PCSK_KEX2_1	175	177	PF00082	0.722
CLV_PCSK_KEX2_1	206	208	PF00082	0.606
CLV_PCSK_KEX2_1	233	235	PF00082	0.618
CLV_PCSK_KEX2_1	341	343	PF00082	0.575
CLV_PCSK_KEX2_1	398	400	PF00082	0.654
CLV_PCSK_KEX2_1	415	417	PF00082	0.515
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.573
CLV_PCSK_PC7_1	229	235	PF00082	0.578
CLV_PCSK_SKI1_1	137	141	PF00082	0.681
CLV_PCSK_SKI1_1	328	332	PF00082	0.562
DEG_APCC_DBOX_1	14	22	PF00400	0.575
DEG_APCC_DBOX_1	174	182	PF00400	0.724
DEG_APCC_DBOX_1	398	406	PF00400	0.644
DEG_SPOP_SBC_1	346	350	PF00917	0.722
DOC_ANK_TNKS_1	278	285	PF00023	0.713
DOC_PP2B_LxvP_1	358	361	PF13499	0.558
DOC_USP7_MATH_1	170	174	PF00917	0.592
DOC_USP7_MATH_1	187	191	PF00917	0.674
DOC_USP7_MATH_1	283	287	PF00917	0.688
DOC_USP7_MATH_1	310	314	PF00917	0.583
DOC_USP7_MATH_1	69	73	PF00917	0.692
DOC_USP7_UBL2_3	120	124	PF12436	0.709
DOC_USP7_UBL2_3	233	237	PF12436	0.568
DOC_WW_Pin1_4	113	118	PF00397	0.685
DOC_WW_Pin1_4	124	129	PF00397	0.606
DOC_WW_Pin1_4	137	142	PF00397	0.671
DOC_WW_Pin1_4	250	255	PF00397	0.651
DOC_WW_Pin1_4	393	398	PF00397	0.661
LIG_14-3-3_CanoR_1	175	179	PF00244	0.721
LIG_14-3-3_CanoR_1	188	196	PF00244	0.581
LIG_14-3-3_CanoR_1	65	69	PF00244	0.434
LIG_14-3-3_CanoR_1	83	87	PF00244	0.598
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_BIR_III_2	275	279	PF00653	0.581
LIG_BRCT_MDC1_1	433	437	PF00533	0.533
LIG_FHA_1	226	232	PF00498	0.576
LIG_FHA_1	79	85	PF00498	0.438
LIG_FHA_1	97	103	PF00498	0.521
LIG_FHA_2	371	377	PF00498	0.552
LIG_FHA_2	99	105	PF00498	0.448
LIG_GBD_Chelix_1	94	102	PF00786	0.561
LIG_SH2_STAT5	49	52	PF00017	0.564
LIG_SH2_STAT5	54	57	PF00017	0.512
LIG_SH2_STAT5	77	80	PF00017	0.640
LIG_SH3_3	155	161	PF00018	0.667
LIG_SUMO_SIM_par_1	98	105	PF11976	0.576
LIG_TRAF2_1	11	14	PF00917	0.601
MOD_CDC14_SPxK_1	396	399	PF00782	0.651
MOD_CDK_SPK_2	137	142	PF00069	0.671
MOD_CDK_SPK_2	250	255	PF00069	0.617
MOD_CDK_SPK_2	393	398	PF00069	0.661
MOD_CDK_SPxK_1	393	399	PF00069	0.660
MOD_CDK_SPxxK_3	113	120	PF00069	0.666
MOD_CK1_1	159	165	PF00069	0.592
MOD_CK1_1	270	276	PF00069	0.582
MOD_CK1_1	290	296	PF00069	0.710
MOD_CK1_1	313	319	PF00069	0.590
MOD_CK1_1	332	338	PF00069	0.729
MOD_CK1_1	344	350	PF00069	0.609
MOD_CK1_1	352	358	PF00069	0.519
MOD_CK1_1	429	435	PF00069	0.539
MOD_CK2_1	159	165	PF00069	0.578
MOD_CK2_1	67	73	PF00069	0.612
MOD_CMANNOS	386	389	PF00535	0.686
MOD_GlcNHglycan	1	4	PF01048	0.611
MOD_GlcNHglycan	170	173	PF01048	0.736
MOD_GlcNHglycan	185	188	PF01048	0.563
MOD_GlcNHglycan	285	288	PF01048	0.606
MOD_GlcNHglycan	301	304	PF01048	0.697
MOD_GlcNHglycan	308	311	PF01048	0.666
MOD_GlcNHglycan	331	334	PF01048	0.688
MOD_GlcNHglycan	354	357	PF01048	0.645
MOD_GlcNHglycan	69	72	PF01048	0.631
MOD_GSK3_1	124	131	PF00069	0.562
MOD_GSK3_1	170	177	PF00069	0.706
MOD_GSK3_1	183	190	PF00069	0.583
MOD_GSK3_1	283	290	PF00069	0.582
MOD_GSK3_1	306	313	PF00069	0.579
MOD_GSK3_1	341	348	PF00069	0.708
MOD_GSK3_1	366	373	PF00069	0.544
MOD_GSK3_1	69	76	PF00069	0.586
MOD_GSK3_1	78	85	PF00069	0.652
MOD_GSK3_1	98	105	PF00069	0.413
MOD_N-GLC_1	188	193	PF02516	0.562
MOD_N-GLC_1	247	252	PF02516	0.617
MOD_N-GLC_1	370	375	PF02516	0.544
MOD_NEK2_1	102	107	PF00069	0.597
MOD_NEK2_1	4	9	PF00069	0.638
MOD_NEK2_1	78	83	PF00069	0.650
MOD_PIKK_1	128	134	PF00454	0.560
MOD_PIKK_1	267	273	PF00454	0.710
MOD_PIKK_1	349	355	PF00454	0.571
MOD_PK_1	57	63	PF00069	0.612
MOD_PKA_1	341	347	PF00069	0.576
MOD_PKA_2	174	180	PF00069	0.729
MOD_PKA_2	187	193	PF00069	0.585
MOD_PKA_2	341	347	PF00069	0.709
MOD_PKA_2	64	70	PF00069	0.439
MOD_PKA_2	82	88	PF00069	0.566
MOD_PKB_1	297	305	PF00069	0.733
MOD_Plk_1	102	108	PF00069	0.633
MOD_Plk_1	366	372	PF00069	0.544
MOD_Plk_1	375	381	PF00069	0.512
MOD_Plk_4	73	79	PF00069	0.599
MOD_ProDKin_1	113	119	PF00069	0.690
MOD_ProDKin_1	124	130	PF00069	0.606
MOD_ProDKin_1	137	143	PF00069	0.671
MOD_ProDKin_1	250	256	PF00069	0.652
MOD_ProDKin_1	393	399	PF00069	0.660
TRG_DiLeu_BaEn_4	400	406	PF01217	0.482
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.564
TRG_ENDOCYTIC_2	232	235	PF00928	0.735
TRG_ER_diArg_1	136	138	PF00400	0.591
TRG_ER_diArg_1	15	18	PF00400	0.580
TRG_ER_diArg_1	297	300	PF00400	0.716
TRG_ER_diArg_1	341	343	PF00400	0.575
TRG_ER_diArg_1	397	399	PF00400	0.639
TRG_ER_diArg_1	414	416	PF00400	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IID2	Leishmania donovani	59%	94%
A4I403	Leishmania infantum	59%	94%
E9B093	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	94%
Q4Q7Z2	Leishmania major	58%	99%