Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGX2_LEIBR

TriTrypDb:

LbrM.28.2900 , LBRM2903_280036300

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HGX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.417
CLV_MEL_PAP_1	139	145	PF00089	0.599
CLV_NRD_NRD_1	3	5	PF00675	0.694
CLV_NRD_NRD_1	331	333	PF00675	0.421
CLV_NRD_NRD_1	347	349	PF00675	0.448
CLV_NRD_NRD_1	359	361	PF00675	0.503
CLV_PCSK_KEX2_1	3	5	PF00082	0.694
CLV_PCSK_KEX2_1	347	349	PF00082	0.484
CLV_PCSK_KEX2_1	358	360	PF00082	0.507
CLV_PCSK_SKI1_1	137	141	PF00082	0.597
CLV_PCSK_SKI1_1	213	217	PF00082	0.603
CLV_PCSK_SKI1_1	373	377	PF00082	0.517
CLV_PCSK_SKI1_1	6	10	PF00082	0.670
DEG_APCC_DBOX_1	347	355	PF00400	0.700
DEG_SPOP_SBC_1	105	109	PF00917	0.427
DEG_SPOP_SBC_1	251	255	PF00917	0.558
DOC_MAPK_gen_1	3	13	PF00069	0.467
DOC_MAPK_MEF2A_6	6	15	PF00069	0.414
DOC_PP4_FxxP_1	380	383	PF00568	0.739
DOC_USP7_MATH_1	100	104	PF00917	0.497
DOC_USP7_MATH_1	105	109	PF00917	0.440
DOC_USP7_MATH_1	267	271	PF00917	0.379
DOC_USP7_MATH_1	281	285	PF00917	0.382
DOC_USP7_MATH_1	374	378	PF00917	0.681
DOC_WW_Pin1_4	313	318	PF00397	0.513
DOC_WW_Pin1_4	83	88	PF00397	0.448
DOC_WW_Pin1_4	98	103	PF00397	0.471
LIG_14-3-3_CanoR_1	142	148	PF00244	0.467
LIG_14-3-3_CanoR_1	227	236	PF00244	0.416
LIG_14-3-3_CanoR_1	348	356	PF00244	0.684
LIG_14-3-3_CanoR_1	359	365	PF00244	0.704
LIG_BRCT_BRCA1_1	269	273	PF00533	0.306
LIG_BRCT_BRCA1_1	376	380	PF00533	0.727
LIG_deltaCOP1_diTrp_1	131	138	PF00928	0.467
LIG_deltaCOP1_diTrp_1	46	52	PF00928	0.497
LIG_EH1_1	9	17	PF00400	0.402
LIG_FHA_1	176	182	PF00498	0.382
LIG_FHA_1	209	215	PF00498	0.474
LIG_FHA_1	228	234	PF00498	0.517
LIG_FHA_1	246	252	PF00498	0.303
LIG_FHA_2	218	224	PF00498	0.532
LIG_FHA_2	61	67	PF00498	0.345
LIG_LIR_Apic_2	377	383	PF02991	0.733
LIG_LIR_Gen_1	310	320	PF02991	0.412
LIG_LIR_Gen_1	66	77	PF02991	0.433
LIG_LIR_Nem_3	152	158	PF02991	0.429
LIG_LIR_Nem_3	310	315	PF02991	0.390
LIG_LIR_Nem_3	66	72	PF02991	0.421
LIG_NRBOX	135	141	PF00104	0.393
LIG_Pex14_1	155	159	PF04695	0.406
LIG_Pex14_1	64	68	PF04695	0.471
LIG_SH2_GRB2like	287	290	PF00017	0.319
LIG_SH2_SRC	287	290	PF00017	0.500
LIG_SH2_STAP1	151	155	PF00017	0.411
LIG_SH2_STAP1	229	233	PF00017	0.453
LIG_SH2_STAT3	151	154	PF00017	0.301
LIG_SH2_STAT5	151	154	PF00017	0.412
LIG_SH2_STAT5	185	188	PF00017	0.334
LIG_SH2_STAT5	229	232	PF00017	0.454
LIG_SH2_STAT5	287	290	PF00017	0.475
LIG_SH2_STAT5	369	372	PF00017	0.704
LIG_SH3_1	368	374	PF00018	0.710
LIG_SH3_2	371	376	PF14604	0.712
LIG_SH3_3	178	184	PF00018	0.451
LIG_SH3_3	368	374	PF00018	0.686
LIG_SH3_3	380	386	PF00018	0.665
LIG_SH3_3	96	102	PF00018	0.450
LIG_SUMO_SIM_par_1	18	25	PF11976	0.498
LIG_UBA3_1	327	333	PF00899	0.474
MOD_CK1_1	107	113	PF00069	0.471
MOD_CK1_1	122	128	PF00069	0.497
MOD_CK1_1	145	151	PF00069	0.494
MOD_CK1_1	199	205	PF00069	0.406
MOD_CK1_1	206	212	PF00069	0.309
MOD_CK1_1	253	259	PF00069	0.566
MOD_CK1_1	307	313	PF00069	0.238
MOD_CK1_1	98	104	PF00069	0.494
MOD_CK2_1	107	113	PF00069	0.583
MOD_CK2_1	143	149	PF00069	0.391
MOD_CK2_1	252	258	PF00069	0.399
MOD_CK2_1	60	66	PF00069	0.345
MOD_GlcNHglycan	116	119	PF01048	0.629
MOD_GlcNHglycan	121	124	PF01048	0.616
MOD_GlcNHglycan	239	243	PF01048	0.569
MOD_GlcNHglycan	24	27	PF01048	0.682
MOD_GlcNHglycan	283	286	PF01048	0.587
MOD_GlcNHglycan	33	36	PF01048	0.614
MOD_GlcNHglycan	391	394	PF01048	0.559
MOD_GlcNHglycan	90	93	PF01048	0.673
MOD_GSK3_1	100	107	PF00069	0.546
MOD_GSK3_1	119	126	PF00069	0.476
MOD_GSK3_1	141	148	PF00069	0.475
MOD_GSK3_1	149	156	PF00069	0.474
MOD_GSK3_1	199	206	PF00069	0.368
MOD_GSK3_1	213	220	PF00069	0.322
MOD_GSK3_1	250	257	PF00069	0.556
MOD_GSK3_1	304	311	PF00069	0.471
MOD_GSK3_1	360	367	PF00069	0.780
MOD_N-GLC_1	119	124	PF02516	0.663
MOD_N-GLC_1	199	204	PF02516	0.670
MOD_N-GLC_1	217	222	PF02516	0.608
MOD_N-GLC_1	267	272	PF02516	0.696
MOD_N-GLC_1	334	339	PF02516	0.424
MOD_N-GLC_1	349	354	PF02516	0.498
MOD_N-GLC_2	261	263	PF02516	0.526
MOD_NEK2_1	104	109	PF00069	0.427
MOD_NEK2_1	114	119	PF00069	0.402
MOD_NEK2_1	143	148	PF00069	0.505
MOD_NEK2_1	203	208	PF00069	0.335
MOD_NEK2_1	304	309	PF00069	0.520
MOD_NEK2_1	31	36	PF00069	0.538
MOD_NEK2_1	341	346	PF00069	0.747
MOD_NEK2_1	364	369	PF00069	0.786
MOD_NEK2_2	132	137	PF00069	0.390
MOD_NEK2_2	75	80	PF00069	0.356
MOD_PKA_2	141	147	PF00069	0.437
MOD_PKB_1	358	366	PF00069	0.706
MOD_Plk_1	349	355	PF00069	0.699
MOD_Plk_4	177	183	PF00069	0.440
MOD_Plk_4	199	205	PF00069	0.506
MOD_Plk_4	360	366	PF00069	0.696
MOD_ProDKin_1	313	319	PF00069	0.513
MOD_ProDKin_1	83	89	PF00069	0.456
MOD_ProDKin_1	98	104	PF00069	0.471
TRG_ENDOCYTIC_2	369	372	PF00928	0.704
TRG_ER_diArg_1	3	6	PF00400	0.605
TRG_ER_diArg_1	346	348	PF00400	0.690
TRG_ER_diArg_1	358	360	PF00400	0.707
TRG_ER_diArg_1	386	389	PF00400	0.807

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M3	Leptomonas seymouri	46%	100%
A0A3S7X1V5	Leishmania donovani	70%	100%
A4I402	Leishmania infantum	70%	100%
E9B092	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q7Z3	Leishmania major	66%	92%