Putative membrane-bound acid phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGW8_LEIBR

TriTrypDb:

LbrM.28.2860 , LBRM2903_280035700

Length:

548

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 60

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 35, no: 3
NetGPI	no	yes: 0, no: 38

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	28
GO:0110165	cellular anatomical entity	1	28

Expansion

Sequence features

A4HGW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGW8

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016311	dephosphorylation	5	4
GO:0044237	cellular metabolic process	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0003993	acid phosphatase activity	6	2
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.145
CLV_NRD_NRD_1	14	16	PF00675	0.629
CLV_NRD_NRD_1	393	395	PF00675	0.530
CLV_PCSK_KEX2_1	14	16	PF00082	0.659
CLV_PCSK_KEX2_1	229	231	PF00082	0.566
CLV_PCSK_KEX2_1	393	395	PF00082	0.514
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.578
CLV_PCSK_SKI1_1	336	340	PF00082	0.405
CLV_PCSK_SKI1_1	394	398	PF00082	0.569
DOC_MAPK_MEF2A_6	478	487	PF00069	0.330
DOC_PP1_RVXF_1	392	399	PF00149	0.370
DOC_PP2B_LxvP_1	31	34	PF13499	0.624
DOC_PP4_FxxP_1	162	165	PF00568	0.212
DOC_USP7_MATH_1	117	121	PF00917	0.180
DOC_USP7_MATH_1	228	232	PF00917	0.295
DOC_USP7_MATH_1	290	294	PF00917	0.389
DOC_USP7_MATH_1	35	39	PF00917	0.586
DOC_USP7_MATH_1	457	461	PF00917	0.344
DOC_USP7_MATH_1	479	483	PF00917	0.504
DOC_USP7_MATH_1	488	492	PF00917	0.472
DOC_USP7_MATH_1	57	61	PF00917	0.333
DOC_WW_Pin1_4	352	357	PF00397	0.310
DOC_WW_Pin1_4	4	9	PF00397	0.378
DOC_WW_Pin1_4	67	72	PF00397	0.426
LIG_14-3-3_CanoR_1	119	127	PF00244	0.266
LIG_14-3-3_CanoR_1	292	296	PF00244	0.375
LIG_14-3-3_CanoR_1	393	399	PF00244	0.295
LIG_14-3-3_CanoR_1	91	101	PF00244	0.330
LIG_Actin_WH2_2	506	524	PF00022	0.215
LIG_BRCT_BRCA1_1	262	266	PF00533	0.403
LIG_deltaCOP1_diTrp_1	252	258	PF00928	0.277
LIG_EH_1	263	267	PF12763	0.199
LIG_FHA_1	180	186	PF00498	0.300
LIG_FHA_1	21	27	PF00498	0.508
LIG_FHA_1	292	298	PF00498	0.288
LIG_FHA_1	327	333	PF00498	0.299
LIG_FHA_1	365	371	PF00498	0.357
LIG_FHA_1	381	387	PF00498	0.346
LIG_FHA_1	395	401	PF00498	0.306
LIG_FHA_1	412	418	PF00498	0.385
LIG_FHA_1	426	432	PF00498	0.463
LIG_FHA_2	281	287	PF00498	0.390
LIG_FHA_2	311	317	PF00498	0.308
LIG_FHA_2	337	343	PF00498	0.215
LIG_FHA_2	97	103	PF00498	0.381
LIG_HP1_1	165	169	PF01393	0.199
LIG_LIR_Apic_2	161	165	PF02991	0.353
LIG_LIR_Apic_2	527	533	PF02991	0.601
LIG_LIR_Gen_1	163	174	PF02991	0.340
LIG_LIR_Gen_1	192	201	PF02991	0.357
LIG_LIR_Nem_3	163	169	PF02991	0.289
LIG_LIR_Nem_3	192	196	PF02991	0.355
LIG_LIR_Nem_3	390	395	PF02991	0.284
LIG_LIR_Nem_3	438	443	PF02991	0.328
LIG_PCNA_yPIPBox_3	125	138	PF02747	0.191
LIG_PCNA_yPIPBox_3	181	190	PF02747	0.299
LIG_PDZ_Class_3	543	548	PF00595	0.533
LIG_Pex14_1	166	170	PF04695	0.348
LIG_Pex14_1	204	208	PF04695	0.419
LIG_Pex14_2	162	166	PF04695	0.354
LIG_Pex14_2	254	258	PF04695	0.258
LIG_Pex14_2	360	364	PF04695	0.390
LIG_SH2_CRK	440	444	PF00017	0.273
LIG_SH2_CRK	530	534	PF00017	0.649
LIG_SH2_NCK_1	173	177	PF00017	0.239
LIG_SH2_NCK_1	447	451	PF00017	0.247
LIG_SH2_STAP1	111	115	PF00017	0.278
LIG_SH2_STAP1	170	174	PF00017	0.317
LIG_SH2_STAP1	212	216	PF00017	0.331
LIG_SH2_STAP1	326	330	PF00017	0.253
LIG_SH2_STAP1	94	98	PF00017	0.190
LIG_SH2_STAT3	320	323	PF00017	0.173
LIG_SH2_STAT5	189	192	PF00017	0.374
LIG_SH2_STAT5	208	211	PF00017	0.327
LIG_SH2_STAT5	395	398	PF00017	0.321
LIG_SH2_STAT5	453	456	PF00017	0.329
LIG_SH2_STAT5	94	97	PF00017	0.235
LIG_SH3_3	26	32	PF00018	0.361
LIG_SH3_3	482	488	PF00018	0.343
LIG_SH3_3	98	104	PF00018	0.298
LIG_SH3_5	107	111	PF00018	0.219
LIG_Sin3_3	130	137	PF02671	0.145
LIG_SUMO_SIM_anti_2	112	118	PF11976	0.367
LIG_SUMO_SIM_anti_2	514	520	PF11976	0.415
LIG_SUMO_SIM_par_1	408	415	PF11976	0.190
LIG_TRAF2_2	352	357	PF00917	0.349
LIG_UBA3_1	221	229	PF00899	0.360
LIG_WRC_WIRS_1	159	164	PF05994	0.363
LIG_WRC_WIRS_1	500	505	PF05994	0.349
MOD_CDK_SPxxK_3	4	11	PF00069	0.356
MOD_CK1_1	118	124	PF00069	0.308
MOD_CK1_1	154	160	PF00069	0.348
MOD_CK1_1	337	343	PF00069	0.341
MOD_CK1_1	460	466	PF00069	0.343
MOD_CK1_1	524	530	PF00069	0.647
MOD_CK2_1	207	213	PF00069	0.412
MOD_CK2_1	336	342	PF00069	0.236
MOD_CK2_1	453	459	PF00069	0.361
MOD_GlcNHglycan	128	131	PF01048	0.459
MOD_GlcNHglycan	300	303	PF01048	0.501
MOD_GlcNHglycan	316	320	PF01048	0.555
MOD_GlcNHglycan	336	339	PF01048	0.525
MOD_GlcNHglycan	414	417	PF01048	0.509
MOD_GlcNHglycan	455	458	PF01048	0.530
MOD_GlcNHglycan	465	468	PF01048	0.533
MOD_GlcNHglycan	503	506	PF01048	0.365
MOD_GlcNHglycan	523	526	PF01048	0.467
MOD_GlcNHglycan	530	533	PF01048	0.482
MOD_GlcNHglycan	55	58	PF01048	0.541
MOD_GSK3_1	111	118	PF00069	0.230
MOD_GSK3_1	147	154	PF00069	0.326
MOD_GSK3_1	207	214	PF00069	0.328
MOD_GSK3_1	322	329	PF00069	0.291
MOD_GSK3_1	360	367	PF00069	0.389
MOD_GSK3_1	431	438	PF00069	0.318
MOD_GSK3_1	453	460	PF00069	0.396
MOD_GSK3_1	479	486	PF00069	0.452
MOD_GSK3_1	524	531	PF00069	0.577
MOD_GSK3_1	53	60	PF00069	0.359
MOD_GSK3_1	92	99	PF00069	0.319
MOD_N-GLC_1	479	484	PF02516	0.716
MOD_N-GLC_1	61	66	PF02516	0.549
MOD_N-GLC_2	385	387	PF02516	0.511
MOD_NEK2_1	158	163	PF00069	0.355
MOD_NEK2_1	169	174	PF00069	0.382
MOD_NEK2_1	298	303	PF00069	0.303
MOD_NEK2_1	334	339	PF00069	0.326
MOD_NEK2_1	433	438	PF00069	0.381
MOD_NEK2_1	521	526	PF00069	0.585
MOD_OGLYCOS	67	72	PF02709	0.482
MOD_PIKK_1	151	157	PF00454	0.399
MOD_PIKK_1	160	166	PF00454	0.358
MOD_PKA_2	118	124	PF00069	0.266
MOD_PKA_2	291	297	PF00069	0.366
MOD_PKA_2	35	41	PF00069	0.628
MOD_PKA_2	460	466	PF00069	0.209
MOD_PKA_2	521	527	PF00069	0.643
MOD_PKA_2	528	534	PF00069	0.652
MOD_PKA_2	92	98	PF00069	0.328
MOD_PKB_1	373	381	PF00069	0.223
MOD_Plk_1	111	117	PF00069	0.246
MOD_Plk_1	303	309	PF00069	0.281
MOD_Plk_1	315	321	PF00069	0.305
MOD_Plk_1	425	431	PF00069	0.378
MOD_Plk_1	479	485	PF00069	0.492
MOD_Plk_1	96	102	PF00069	0.289
MOD_Plk_4	111	117	PF00069	0.306
MOD_Plk_4	154	160	PF00069	0.322
MOD_Plk_4	326	332	PF00069	0.280
MOD_Plk_4	435	441	PF00069	0.263
MOD_Plk_4	511	517	PF00069	0.325
MOD_Plk_4	78	84	PF00069	0.259
MOD_Plk_4	96	102	PF00069	0.288
MOD_ProDKin_1	352	358	PF00069	0.312
MOD_ProDKin_1	4	10	PF00069	0.368
MOD_ProDKin_1	67	73	PF00069	0.393
MOD_SUMO_rev_2	472	479	PF00179	0.305
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.274
TRG_ENDOCYTIC_2	243	246	PF00928	0.383
TRG_ENDOCYTIC_2	295	298	PF00928	0.359
TRG_ENDOCYTIC_2	440	443	PF00928	0.219
TRG_ER_diArg_1	13	15	PF00400	0.514
TRG_ER_diArg_1	370	373	PF00400	0.207
TRG_ER_diArg_1	392	394	PF00400	0.321
TRG_ER_diArg_1	90	93	PF00400	0.311
TRG_Pf-PMV_PEXEL_1	197	202	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	43%	96%
A0A0N1I756	Leptomonas seymouri	38%	100%
A0A0N1PEH4	Leptomonas seymouri	34%	100%
A0A0S4IRF5	Bodo saltans	23%	82%
A0A0S4IUV8	Bodo saltans	23%	100%
A0A0S4IV77	Bodo saltans	33%	100%
A0A0S4IXN9	Bodo saltans	22%	100%
A0A0S4JEA9	Bodo saltans	23%	100%
A0A0S4JJK3	Bodo saltans	29%	100%
A0A0S4JW09	Bodo saltans	27%	100%
A0A1X0NNY4	Trypanosomatidae	37%	99%
A0A1X0NQL4	Trypanosomatidae	28%	100%
A0A1X0NY34	Trypanosomatidae	25%	100%
A0A1X0P7V5	Trypanosomatidae	38%	100%
A0A3Q8IR23	Leishmania donovani	46%	96%
A0A3R7KSH4	Trypanosoma rangeli	25%	100%
A0A3R7MEN7	Trypanosoma rangeli	40%	100%
A0A3R7MHJ7	Trypanosoma rangeli	29%	100%
A0A3S5H827	Leishmania donovani	36%	100%
A0A3S7WXU0	Leishmania donovani	43%	100%
A0A3S7X1W4	Leishmania donovani	72%	100%
A4HCZ0	Leishmania braziliensis	42%	100%
A4HPC1	Leishmania braziliensis	37%	100%
A4HPC5	Leishmania braziliensis	45%	95%
A4HQG6	Leishmania braziliensis	35%	100%
A4HQG9	Leishmania braziliensis	35%	100%
A4I0H5	Leishmania infantum	43%	100%
A4I3Z8	Leishmania infantum	73%	100%
A4ICA5	Leishmania infantum	34%	82%
A4ICG3	Leishmania infantum	36%	100%
A4ICG5	Leishmania infantum	46%	96%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	96%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
P11117	Homo sapiens	26%	100%
P20611	Rattus norvegicus	26%	100%
P24638	Mus musculus	26%	100%
Q4Q0A9	Leishmania major	26%	100%
Q4Q1G2	Leishmania major	46%	100%
Q4Q1G4	Leishmania major	37%	100%
Q4Q7Z7	Leishmania major	72%	100%
Q4QB35	Leishmania major	42%	100%
Q9USS6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
V5BCI2	Trypanosoma cruzi	26%	100%
V5BIM1	Trypanosoma cruzi	23%	100%
V5BK91	Trypanosoma cruzi	39%	100%
V5BL75	Trypanosoma cruzi	30%	100%