Putative molybdenum cofactor biosynthesis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

molybdenum cofactor biosynthesis protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGW7_LEIBR

TriTrypDb:

LbrM.28.2850 , LBRM2903_280035500

Length:

752

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGW7

Function

Biological processes
Term	Name	Level	Count
GO:0006777	Mo-molybdopterin cofactor biosynthetic process	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009987	cellular process	1	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019637	organophosphate metabolic process	3	6
GO:0019720	Mo-molybdopterin cofactor metabolic process	4	6
GO:0032324	molybdopterin cofactor biosynthetic process	4	6
GO:0043545	molybdopterin cofactor metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0051189	prosthetic group metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:0090407	organophosphate biosynthetic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016829	lyase activity	2	1
GO:0016830	carbon-carbon lyase activity	3	1
GO:0016849	phosphorus-oxygen lyase activity	3	1
GO:0061798	GTP 3',8'-cyclase activity	4	1
GO:0061799	cyclic pyranopterin monophosphate synthase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	639	643	PF00656	0.611
CLV_NRD_NRD_1	106	108	PF00675	0.307
CLV_NRD_NRD_1	242	244	PF00675	0.569
CLV_NRD_NRD_1	277	279	PF00675	0.750
CLV_NRD_NRD_1	318	320	PF00675	0.715
CLV_NRD_NRD_1	399	401	PF00675	0.696
CLV_NRD_NRD_1	497	499	PF00675	0.721
CLV_NRD_NRD_1	528	530	PF00675	0.561
CLV_NRD_NRD_1	571	573	PF00675	0.721
CLV_NRD_NRD_1	600	602	PF00675	0.598
CLV_NRD_NRD_1	659	661	PF00675	0.720
CLV_NRD_NRD_1	674	676	PF00675	0.597
CLV_NRD_NRD_1	694	696	PF00675	0.632
CLV_NRD_NRD_1	736	738	PF00675	0.730
CLV_NRD_NRD_1	740	742	PF00675	0.701
CLV_NRD_NRD_1	76	78	PF00675	0.415
CLV_NRD_NRD_1	96	98	PF00675	0.415
CLV_PCSK_KEX2_1	106	108	PF00082	0.296
CLV_PCSK_KEX2_1	167	169	PF00082	0.415
CLV_PCSK_KEX2_1	242	244	PF00082	0.614
CLV_PCSK_KEX2_1	273	275	PF00082	0.748
CLV_PCSK_KEX2_1	277	279	PF00082	0.707
CLV_PCSK_KEX2_1	310	312	PF00082	0.633
CLV_PCSK_KEX2_1	318	320	PF00082	0.629
CLV_PCSK_KEX2_1	496	498	PF00082	0.729
CLV_PCSK_KEX2_1	521	523	PF00082	0.740
CLV_PCSK_KEX2_1	528	530	PF00082	0.661
CLV_PCSK_KEX2_1	571	573	PF00082	0.633
CLV_PCSK_KEX2_1	582	584	PF00082	0.710
CLV_PCSK_KEX2_1	659	661	PF00082	0.730
CLV_PCSK_KEX2_1	694	696	PF00082	0.675
CLV_PCSK_KEX2_1	738	740	PF00082	0.678
CLV_PCSK_KEX2_1	745	747	PF00082	0.718
CLV_PCSK_KEX2_1	75	77	PF00082	0.415
CLV_PCSK_KEX2_1	750	752	PF00082	0.663
CLV_PCSK_KEX2_1	95	97	PF00082	0.415
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.415
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.748
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.633
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.729
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.740
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.585
CLV_PCSK_PC1ET2_1	738	740	PF00082	0.678
CLV_PCSK_PC1ET2_1	745	747	PF00082	0.718
CLV_PCSK_PC1ET2_1	750	752	PF00082	0.663
CLV_PCSK_PC7_1	741	747	PF00082	0.690
CLV_PCSK_PC7_1	91	97	PF00082	0.415
CLV_PCSK_SKI1_1	2	6	PF00082	0.745
CLV_PCSK_SKI1_1	435	439	PF00082	0.737
CLV_PCSK_SKI1_1	498	502	PF00082	0.651
CLV_PCSK_SKI1_1	742	746	PF00082	0.699
CLV_PCSK_SKI1_1	77	81	PF00082	0.415
CLV_PCSK_SKI1_1	91	95	PF00082	0.253
DEG_APCC_DBOX_1	432	440	PF00400	0.559
DEG_APCC_DBOX_1	527	535	PF00400	0.553
DEG_Nend_UBRbox_1	1	4	PF02207	0.670
DEG_SCF_FBW7_1	7	13	PF00400	0.708
DEG_SPOP_SBC_1	216	220	PF00917	0.562
DEG_SPOP_SBC_1	471	475	PF00917	0.739
DOC_CKS1_1	361	366	PF01111	0.535
DOC_CKS1_1	4	9	PF01111	0.728
DOC_CKS1_1	628	633	PF01111	0.560
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.721
DOC_MAPK_gen_1	582	591	PF00069	0.661
DOC_PP2B_LxvP_1	80	83	PF13499	0.415
DOC_USP7_MATH_1	22	26	PF00917	0.653
DOC_USP7_MATH_1	337	341	PF00917	0.654
DOC_USP7_MATH_1	408	412	PF00917	0.666
DOC_USP7_MATH_1	431	435	PF00917	0.693
DOC_USP7_MATH_1	502	506	PF00917	0.678
DOC_USP7_MATH_1	562	566	PF00917	0.582
DOC_USP7_MATH_1	584	588	PF00917	0.621
DOC_USP7_MATH_1	592	596	PF00917	0.624
DOC_USP7_UBL2_3	373	377	PF12436	0.623
DOC_USP7_UBL2_3	582	586	PF12436	0.584
DOC_USP7_UBL2_3	663	667	PF12436	0.740
DOC_USP7_UBL2_3	738	742	PF12436	0.741
DOC_WW_Pin1_4	220	225	PF00397	0.799
DOC_WW_Pin1_4	277	282	PF00397	0.569
DOC_WW_Pin1_4	3	8	PF00397	0.768
DOC_WW_Pin1_4	328	333	PF00397	0.740
DOC_WW_Pin1_4	360	365	PF00397	0.543
DOC_WW_Pin1_4	427	432	PF00397	0.617
DOC_WW_Pin1_4	514	519	PF00397	0.595
DOC_WW_Pin1_4	520	525	PF00397	0.542
DOC_WW_Pin1_4	61	66	PF00397	0.434
DOC_WW_Pin1_4	627	632	PF00397	0.565
DOC_WW_Pin1_4	731	736	PF00397	0.601
LIG_14-3-3_CanoR_1	326	332	PF00244	0.564
LIG_14-3-3_CanoR_1	583	592	PF00244	0.622
LIG_14-3-3_CanoR_1	69	75	PF00244	0.415
LIG_14-3-3_CanoR_1	95	101	PF00244	0.415
LIG_BIR_III_4	231	235	PF00653	0.659
LIG_BRCT_BRCA1_1	12	16	PF00533	0.691
LIG_BRCT_BRCA1_1	70	74	PF00533	0.415
LIG_deltaCOP1_diTrp_1	686	692	PF00928	0.737
LIG_FHA_1	131	137	PF00498	0.240
LIG_FHA_1	173	179	PF00498	0.627
LIG_FHA_1	235	241	PF00498	0.560
LIG_FHA_1	392	398	PF00498	0.699
LIG_FHA_1	41	47	PF00498	0.415
LIG_FHA_2	139	145	PF00498	0.415
LIG_FHA_2	226	232	PF00498	0.647
LIG_FHA_2	617	623	PF00498	0.556
LIG_FHA_2	628	634	PF00498	0.537
LIG_FHA_2	716	722	PF00498	0.699
LIG_LIR_Gen_1	109	116	PF02991	0.415
LIG_LIR_Gen_1	141	150	PF02991	0.517
LIG_LIR_Gen_1	173	182	PF02991	0.647
LIG_LIR_Nem_3	109	113	PF02991	0.415
LIG_LIR_Nem_3	141	146	PF02991	0.517
LIG_LIR_Nem_3	173	177	PF02991	0.604
LIG_NRP_CendR_1	750	752	PF00754	0.731
LIG_Pex14_1	688	692	PF04695	0.745
LIG_SH2_CRK	110	114	PF00017	0.415
LIG_SH2_CRK	143	147	PF00017	0.415
LIG_SH2_CRK	63	67	PF00017	0.240
LIG_SH2_STAP1	110	114	PF00017	0.415
LIG_SH2_STAT5	114	117	PF00017	0.415
LIG_SH2_STAT5	33	36	PF00017	0.415
LIG_SH2_STAT5	530	533	PF00017	0.731
LIG_SH3_1	521	527	PF00018	0.551
LIG_SH3_2	101	106	PF14604	0.240
LIG_SH3_2	524	529	PF14604	0.548
LIG_SH3_2	733	738	PF14604	0.714
LIG_SH3_3	179	185	PF00018	0.763
LIG_SH3_3	358	364	PF00018	0.542
LIG_SH3_3	4	10	PF00018	0.675
LIG_SH3_3	521	527	PF00018	0.577
LIG_SH3_3	558	564	PF00018	0.570
LIG_SH3_3	730	736	PF00018	0.697
LIG_SH3_3	76	82	PF00018	0.447
LIG_SH3_3	98	104	PF00018	0.242
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.641
LIG_TRAF2_1	258	261	PF00917	0.780
LIG_TRAF2_1	482	485	PF00917	0.617
LIG_TRAF2_1	554	557	PF00917	0.650
LIG_TRAF2_1	711	714	PF00917	0.656
LIG_WW_3	734	738	PF00397	0.693
LIG_WW_3	81	85	PF00397	0.415
MOD_CDC14_SPxK_1	430	433	PF00782	0.604
MOD_CDC14_SPxK_1	734	737	PF00782	0.548
MOD_CDK_SPxK_1	427	433	PF00069	0.613
MOD_CDK_SPxK_1	731	737	PF00069	0.548
MOD_CDK_SPxxK_3	514	521	PF00069	0.572
MOD_CDK_SPxxK_3	627	634	PF00069	0.561
MOD_CDK_SPxxK_3	731	738	PF00069	0.548
MOD_CK1_1	223	229	PF00069	0.725
MOD_CK1_1	293	299	PF00069	0.533
MOD_CK1_1	330	336	PF00069	0.659
MOD_CK1_1	376	382	PF00069	0.789
MOD_CK1_1	616	622	PF00069	0.579
MOD_CK1_1	687	693	PF00069	0.685
MOD_CK2_1	155	161	PF00069	0.415
MOD_CK2_1	24	30	PF00069	0.640
MOD_CK2_1	303	309	PF00069	0.648
MOD_CK2_1	584	590	PF00069	0.551
MOD_CK2_1	693	699	PF00069	0.561
MOD_CK2_1	715	721	PF00069	0.700
MOD_Cter_Amidation	519	522	PF01082	0.745
MOD_Cter_Amidation	580	583	PF01082	0.729
MOD_GlcNHglycan	188	191	PF01048	0.731
MOD_GlcNHglycan	192	195	PF01048	0.697
MOD_GlcNHglycan	204	207	PF01048	0.726
MOD_GlcNHglycan	208	211	PF01048	0.709
MOD_GlcNHglycan	231	235	PF01048	0.647
MOD_GlcNHglycan	244	247	PF01048	0.712
MOD_GlcNHglycan	292	295	PF01048	0.798
MOD_GlcNHglycan	339	342	PF01048	0.649
MOD_GlcNHglycan	355	358	PF01048	0.675
MOD_GlcNHglycan	439	442	PF01048	0.736
MOD_GlcNHglycan	476	479	PF01048	0.579
MOD_GlcNHglycan	504	507	PF01048	0.661
MOD_GlcNHglycan	564	567	PF01048	0.688
MOD_GlcNHglycan	586	589	PF01048	0.619
MOD_GlcNHglycan	594	597	PF01048	0.676
MOD_GlcNHglycan	598	601	PF01048	0.709
MOD_GlcNHglycan	615	618	PF01048	0.547
MOD_GSK3_1	186	193	PF00069	0.821
MOD_GSK3_1	202	209	PF00069	0.623
MOD_GSK3_1	215	222	PF00069	0.717
MOD_GSK3_1	223	230	PF00069	0.746
MOD_GSK3_1	286	293	PF00069	0.572
MOD_GSK3_1	326	333	PF00069	0.653
MOD_GSK3_1	351	358	PF00069	0.631
MOD_GSK3_1	359	366	PF00069	0.579
MOD_GSK3_1	427	434	PF00069	0.704
MOD_GSK3_1	470	477	PF00069	0.841
MOD_GSK3_1	498	505	PF00069	0.809
MOD_GSK3_1	562	569	PF00069	0.605
MOD_GSK3_1	592	599	PF00069	0.611
MOD_GSK3_1	6	13	PF00069	0.710
MOD_N-GLC_1	290	295	PF02516	0.555
MOD_N-GLC_1	431	436	PF02516	0.725
MOD_NEK2_1	186	191	PF00069	0.729
MOD_NEK2_1	290	295	PF00069	0.555
MOD_NEK2_1	327	332	PF00069	0.561
MOD_NEK2_1	40	45	PF00069	0.415
MOD_NEK2_2	138	143	PF00069	0.415
MOD_NEK2_2	194	199	PF00069	0.559
MOD_NEK2_2	70	75	PF00069	0.415
MOD_PK_1	496	502	PF00069	0.558
MOD_PKA_1	242	248	PF00069	0.565
MOD_PKA_1	496	502	PF00069	0.723
MOD_PKA_1	95	101	PF00069	0.415
MOD_PKA_2	242	248	PF00069	0.610
MOD_PKA_2	496	502	PF00069	0.723
MOD_PKA_2	613	619	PF00069	0.727
MOD_PKA_2	68	74	PF00069	0.415
MOD_PKA_2	693	699	PF00069	0.669
MOD_PKA_2	95	101	PF00069	0.415
MOD_Plk_1	108	114	PF00069	0.415
MOD_Plk_1	194	200	PF00069	0.567
MOD_Plk_1	431	437	PF00069	0.726
MOD_Plk_1	485	491	PF00069	0.567
MOD_Plk_1	534	540	PF00069	0.544
MOD_Plk_2-3	155	161	PF00069	0.415
MOD_Plk_2-3	256	262	PF00069	0.592
MOD_Plk_4	108	114	PF00069	0.421
MOD_Plk_4	138	144	PF00069	0.490
MOD_Plk_4	24	30	PF00069	0.640
MOD_Plk_4	363	369	PF00069	0.633
MOD_Plk_4	376	382	PF00069	0.687
MOD_Plk_4	392	398	PF00069	0.625
MOD_Plk_4	54	60	PF00069	0.415
MOD_ProDKin_1	220	226	PF00069	0.801
MOD_ProDKin_1	277	283	PF00069	0.568
MOD_ProDKin_1	3	9	PF00069	0.765
MOD_ProDKin_1	328	334	PF00069	0.740
MOD_ProDKin_1	360	366	PF00069	0.544
MOD_ProDKin_1	427	433	PF00069	0.618
MOD_ProDKin_1	514	520	PF00069	0.594
MOD_ProDKin_1	61	67	PF00069	0.434
MOD_ProDKin_1	627	633	PF00069	0.561
MOD_ProDKin_1	731	737	PF00069	0.605
TRG_ENDOCYTIC_2	110	113	PF00928	0.415
TRG_ENDOCYTIC_2	143	146	PF00928	0.523
TRG_ER_diArg_1	106	108	PF00400	0.286
TRG_ER_diArg_1	276	278	PF00400	0.755
TRG_ER_diArg_1	317	319	PF00400	0.704
TRG_ER_diArg_1	433	436	PF00400	0.827
TRG_ER_diArg_1	527	529	PF00400	0.556
TRG_ER_diArg_1	694	697	PF00400	0.674
TRG_ER_diArg_1	736	739	PF00400	0.558
TRG_ER_diArg_1	74	77	PF00400	0.415
TRG_ER_diArg_1	94	97	PF00400	0.415
TRG_NES_CRM1_1	130	144	PF08389	0.415
TRG_NLS_Bipartite_1	601	615	PF00514	0.733
TRG_NLS_MonoCore_2	494	499	PF00514	0.723
TRG_NLS_MonoExtC_3	736	741	PF00514	0.737
TRG_NLS_MonoExtN_4	494	500	PF00514	0.716
TRG_NLS_MonoExtN_4	610	615	PF00514	0.727
TRG_NLS_MonoExtN_4	735	742	PF00514	0.721
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.694
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	529	533	PF00026	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDC7	Leishmania donovani	69%	99%
A4I3Z7	Leishmania infantum	69%	84%
E9B087	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
Q4Q7Z8	Leishmania major	67%	100%