Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HGW6_LEIBR

TriTrypDb:

LbrM.28.2840 , LBRM2903_280035400

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGW6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.618
CLV_NRD_NRD_1	192	194	PF00675	0.830
CLV_NRD_NRD_1	287	289	PF00675	0.607
CLV_PCSK_KEX2_1	191	193	PF00082	0.835
CLV_PCSK_KEX2_1	216	218	PF00082	0.690
CLV_PCSK_KEX2_1	287	289	PF00082	0.607
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.835
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.785
CLV_PCSK_SKI1_1	455	459	PF00082	0.674
DEG_APCC_DBOX_1	154	162	PF00400	0.596
DEG_SCF_FBW7_1	294	299	PF00400	0.801
DEG_SPOP_SBC_1	231	235	PF00917	0.577
DEG_SPOP_SBC_1	273	277	PF00917	0.611
DEG_SPOP_SBC_1	93	97	PF00917	0.758
DOC_CKS1_1	293	298	PF01111	0.668
DOC_CKS1_1	35	40	PF01111	0.569
DOC_CKS1_1	50	55	PF01111	0.651
DOC_MAPK_DCC_7	300	309	PF00069	0.807
DOC_MAPK_HePTP_8	297	309	PF00069	0.804
DOC_MAPK_MEF2A_6	18	26	PF00069	0.563
DOC_MAPK_MEF2A_6	300	309	PF00069	0.807
DOC_PP2B_LxvP_1	169	172	PF13499	0.637
DOC_PP2B_LxvP_1	241	244	PF13499	0.670
DOC_PP2B_LxvP_1	302	305	PF13499	0.806
DOC_PP4_FxxP_1	293	296	PF00568	0.812
DOC_USP7_MATH_1	127	131	PF00917	0.583
DOC_USP7_MATH_1	172	176	PF00917	0.604
DOC_USP7_MATH_1	180	184	PF00917	0.642
DOC_USP7_MATH_1	208	212	PF00917	0.812
DOC_USP7_MATH_1	223	227	PF00917	0.667
DOC_USP7_MATH_1	93	97	PF00917	0.762
DOC_WW_Pin1_4	18	23	PF00397	0.630
DOC_WW_Pin1_4	292	297	PF00397	0.672
DOC_WW_Pin1_4	31	36	PF00397	0.529
DOC_WW_Pin1_4	366	371	PF00397	0.791
DOC_WW_Pin1_4	385	390	PF00397	0.748
DOC_WW_Pin1_4	393	398	PF00397	0.635
DOC_WW_Pin1_4	49	54	PF00397	0.601
DOC_WW_Pin1_4	59	64	PF00397	0.599
LIG_14-3-3_CanoR_1	155	159	PF00244	0.691
LIG_14-3-3_CanoR_1	209	213	PF00244	0.620
LIG_14-3-3_CanoR_1	269	273	PF00244	0.593
LIG_14-3-3_CanoR_1	324	329	PF00244	0.790
LIG_14-3-3_CanoR_1	363	368	PF00244	0.693
LIG_14-3-3_CanoR_1	57	63	PF00244	0.589
LIG_Actin_WH2_2	181	197	PF00022	0.604
LIG_AP2alpha_2	282	284	PF02296	0.821
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BIR_III_4	463	467	PF00653	0.530
LIG_BRCT_BRCA1_1	444	448	PF00533	0.717
LIG_EVH1_1	241	245	PF00568	0.658
LIG_EVH1_1	50	54	PF00568	0.580
LIG_FHA_1	233	239	PF00498	0.594
LIG_FHA_1	246	252	PF00498	0.560
LIG_FHA_1	297	303	PF00498	0.799
LIG_FHA_1	45	51	PF00498	0.618
LIG_FHA_1	72	78	PF00498	0.780
LIG_FHA_2	346	352	PF00498	0.799
LIG_FHA_2	389	395	PF00498	0.750
LIG_FHA_2	458	464	PF00498	0.762
LIG_Integrin_RGD_1	111	113	PF01839	0.552
LIG_Integrin_RGD_1	5	7	PF01839	0.601
LIG_LIR_Apic_2	103	108	PF02991	0.491
LIG_LIR_Apic_2	87	91	PF02991	0.569
LIG_LIR_Gen_1	118	127	PF02991	0.784
LIG_LIR_Gen_1	96	105	PF02991	0.570
LIG_LIR_Nem_3	118	124	PF02991	0.780
LIG_LIR_Nem_3	210	215	PF02991	0.751
LIG_LIR_Nem_3	386	390	PF02991	0.516
LIG_LIR_Nem_3	7	13	PF02991	0.604
LIG_LIR_Nem_3	96	102	PF02991	0.571
LIG_SH2_CRK	10	14	PF00017	0.604
LIG_SH2_CRK	105	109	PF00017	0.482
LIG_SH2_CRK	387	391	PF00017	0.744
LIG_SH2_CRK	88	92	PF00017	0.569
LIG_SH2_NCK_1	88	92	PF00017	0.569
LIG_SH2_SRC	88	91	PF00017	0.568
LIG_SH2_STAP1	121	125	PF00017	0.807
LIG_SH2_STAT5	105	108	PF00017	0.673
LIG_SH3_2	242	247	PF14604	0.617
LIG_SH3_2	283	288	PF14604	0.596
LIG_SH3_2	35	40	PF14604	0.569
LIG_SH3_3	111	117	PF00018	0.568
LIG_SH3_3	236	242	PF00018	0.589
LIG_SH3_3	248	254	PF00018	0.575
LIG_SH3_3	280	286	PF00018	0.726
LIG_SH3_3	307	313	PF00018	0.708
LIG_SH3_3	319	325	PF00018	0.649
LIG_SH3_3	32	38	PF00018	0.589
LIG_SH3_3	48	54	PF00018	0.580
LIG_SH3_3	87	93	PF00018	0.711
LIG_SUMO_SIM_par_1	388	394	PF11976	0.750
LIG_TRAF2_1	347	350	PF00917	0.818
LIG_TYR_ITIM	119	124	PF00017	0.571
LIG_TYR_ITIM	385	390	PF00017	0.634
LIG_WW_3	54	58	PF00397	0.595
MOD_CDC14_SPxK_1	369	372	PF00782	0.556
MOD_CDK_SPxK_1	34	40	PF00069	0.638
MOD_CDK_SPxK_1	366	372	PF00069	0.791
MOD_CK1_1	120	126	PF00069	0.644
MOD_CK1_1	145	151	PF00069	0.814
MOD_CK1_1	154	160	PF00069	0.704
MOD_CK1_1	183	189	PF00069	0.778
MOD_CK1_1	226	232	PF00069	0.606
MOD_CK1_1	271	277	PF00069	0.607
MOD_CK1_1	31	37	PF00069	0.636
MOD_CK1_1	362	368	PF00069	0.775
MOD_CK1_1	388	394	PF00069	0.750
MOD_CK1_1	44	50	PF00069	0.553
MOD_CK1_1	59	65	PF00069	0.679
MOD_CK1_1	95	101	PF00069	0.623
MOD_CK2_1	13	19	PF00069	0.589
MOD_CK2_1	164	170	PF00069	0.803
MOD_CK2_1	272	278	PF00069	0.610
MOD_CK2_1	345	351	PF00069	0.799
MOD_CK2_1	95	101	PF00069	0.572
MOD_GlcNHglycan	129	132	PF01048	0.583
MOD_GlcNHglycan	147	150	PF01048	0.588
MOD_GlcNHglycan	176	179	PF01048	0.607
MOD_GlcNHglycan	185	188	PF01048	0.795
MOD_GlcNHglycan	225	228	PF01048	0.608
MOD_GlcNHglycan	342	345	PF01048	0.747
MOD_GlcNHglycan	411	414	PF01048	0.537
MOD_GlcNHglycan	420	423	PF01048	0.814
MOD_GlcNHglycan	444	447	PF01048	0.686
MOD_GlcNHglycan	7	10	PF01048	0.631
MOD_GSK3_1	145	152	PF00069	0.716
MOD_GSK3_1	179	186	PF00069	0.769
MOD_GSK3_1	226	233	PF00069	0.584
MOD_GSK3_1	268	275	PF00069	0.579
MOD_GSK3_1	292	299	PF00069	0.648
MOD_GSK3_1	357	364	PF00069	0.798
MOD_GSK3_1	436	443	PF00069	0.556
MOD_GSK3_1	58	65	PF00069	0.583
MOD_N-GLC_1	149	154	PF02516	0.708
MOD_NEK2_1	232	237	PF00069	0.598
MOD_NEK2_1	272	277	PF00069	0.668
MOD_NEK2_1	28	33	PF00069	0.647
MOD_NEK2_1	358	363	PF00069	0.568
MOD_NEK2_1	442	447	PF00069	0.668
MOD_PIKK_1	13	19	PF00454	0.603
MOD_PIKK_1	28	34	PF00454	0.569
MOD_PIKK_1	312	318	PF00454	0.758
MOD_PIKK_1	436	442	PF00454	0.791
MOD_PKA_2	145	151	PF00069	0.814
MOD_PKA_2	154	160	PF00069	0.694
MOD_PKA_2	208	214	PF00069	0.622
MOD_PKA_2	268	274	PF00069	0.824
MOD_PKA_2	362	368	PF00069	0.565
MOD_PKA_2	409	415	PF00069	0.533
MOD_PKA_2	56	62	PF00069	0.596
MOD_PKB_1	3	11	PF00069	0.667
MOD_Plk_1	164	170	PF00069	0.596
MOD_Plk_1	180	186	PF00069	0.527
MOD_Plk_1	426	432	PF00069	0.582
MOD_Plk_4	120	126	PF00069	0.761
MOD_Plk_4	268	274	PF00069	0.590
MOD_Plk_4	324	330	PF00069	0.789
MOD_Plk_4	363	369	PF00069	0.797
MOD_Plk_4	95	101	PF00069	0.635
MOD_ProDKin_1	18	24	PF00069	0.631
MOD_ProDKin_1	292	298	PF00069	0.668
MOD_ProDKin_1	31	37	PF00069	0.530
MOD_ProDKin_1	366	372	PF00069	0.791
MOD_ProDKin_1	385	391	PF00069	0.747
MOD_ProDKin_1	393	399	PF00069	0.637
MOD_ProDKin_1	49	55	PF00069	0.601
MOD_ProDKin_1	59	65	PF00069	0.598
TRG_DiLeu_BaEn_1	351	356	PF01217	0.594
TRG_DiLeu_BaEn_1	452	457	PF01217	0.741
TRG_DiLeu_LyEn_5	452	457	PF01217	0.741
TRG_ENDOCYTIC_2	10	13	PF00928	0.606
TRG_ENDOCYTIC_2	121	124	PF00928	0.805
TRG_ENDOCYTIC_2	387	390	PF00928	0.631
TRG_ER_diArg_1	192	195	PF00400	0.832
TRG_ER_diArg_1	286	288	PF00400	0.606
TRG_NLS_MonoExtC_3	190	195	PF00514	0.836
TRG_NLS_MonoExtC_3	215	221	PF00514	0.728
TRG_NLS_MonoExtN_4	213	220	PF00514	0.777
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7K1	Leishmania donovani	56%	100%
E9B086	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
Q4Q7Z9	Leishmania major	55%	100%