Coatomer subunit gamma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Coatomer subunit gamma

Species:

Leishmania braziliensis

UniProt:

A4HGW5_LEIBR

TriTrypDb:

LbrM.28.2830 , LBRM2903_280035300

Length:

860

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	12
GO:0016020	membrane	2	12
GO:0030117	membrane coat	3	12
GO:0030120	vesicle coat	4	12
GO:0030126	COPI vesicle coat	5	12
GO:0031090	organelle membrane	3	12
GO:0032991	protein-containing complex	1	12
GO:0098588	bounding membrane of organelle	4	12
GO:0098796	membrane protein complex	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HGW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGW5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0009306	protein secretion	4	1
GO:0032940	secretion by cell	3	1
GO:0035592	establishment of protein localization to extracellular region	4	1
GO:0046903	secretion	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0071692	protein localization to extracellular region	5	1
GO:0140352	export from cell	2	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.456
CLV_C14_Caspase3-7	414	418	PF00656	0.418
CLV_C14_Caspase3-7	514	518	PF00656	0.388
CLV_C14_Caspase3-7	628	632	PF00656	0.464
CLV_NRD_NRD_1	173	175	PF00675	0.364
CLV_NRD_NRD_1	504	506	PF00675	0.309
CLV_NRD_NRD_1	84	86	PF00675	0.294
CLV_PCSK_KEX2_1	451	453	PF00082	0.356
CLV_PCSK_KEX2_1	504	506	PF00082	0.309
CLV_PCSK_KEX2_1	512	514	PF00082	0.309
CLV_PCSK_KEX2_1	84	86	PF00082	0.294
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.429
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.329
CLV_PCSK_SKI1_1	175	179	PF00082	0.453
CLV_PCSK_SKI1_1	250	254	PF00082	0.344
CLV_PCSK_SKI1_1	355	359	PF00082	0.329
CLV_PCSK_SKI1_1	45	49	PF00082	0.356
CLV_PCSK_SKI1_1	451	455	PF00082	0.309
CLV_PCSK_SKI1_1	525	529	PF00082	0.309
CLV_PCSK_SKI1_1	531	535	PF00082	0.289
CLV_PCSK_SKI1_1	603	607	PF00082	0.350
CLV_PCSK_SKI1_1	663	667	PF00082	0.238
CLV_PCSK_SKI1_1	777	781	PF00082	0.258
CLV_PCSK_SKI1_1	836	840	PF00082	0.271
CLV_Separin_Metazoa	171	175	PF03568	0.413
CLV_Separin_Metazoa	182	186	PF03568	0.348
DEG_APCC_DBOX_1	602	610	PF00400	0.354
DEG_APCC_DBOX_1	850	858	PF00400	0.512
DEG_SPOP_SBC_1	667	671	PF00917	0.400
DOC_MAPK_gen_1	200	209	PF00069	0.296
DOC_MAPK_gen_1	220	229	PF00069	0.165
DOC_MAPK_gen_1	451	457	PF00069	0.332
DOC_MAPK_gen_1	504	510	PF00069	0.309
DOC_MAPK_MEF2A_6	222	231	PF00069	0.305
DOC_MAPK_MEF2A_6	279	287	PF00069	0.318
DOC_MAPK_MEF2A_6	836	843	PF00069	0.468
DOC_MAPK_NFAT4_5	836	844	PF00069	0.543
DOC_PP4_FxxP_1	590	593	PF00568	0.445
DOC_PP4_FxxP_1	745	748	PF00568	0.458
DOC_USP7_MATH_1	266	270	PF00917	0.447
DOC_USP7_MATH_1	329	333	PF00917	0.317
DOC_USP7_MATH_1	462	466	PF00917	0.429
DOC_USP7_MATH_1	618	622	PF00917	0.468
DOC_USP7_MATH_1	683	687	PF00917	0.577
DOC_USP7_MATH_1	705	709	PF00917	0.400
DOC_USP7_MATH_1	734	738	PF00917	0.473
DOC_USP7_MATH_1	772	776	PF00917	0.500
DOC_WD40_RPTOR_TOS_1	738	744	PF00400	0.560
DOC_WW_Pin1_4	593	598	PF00397	0.570
DOC_WW_Pin1_4	92	97	PF00397	0.350
LIG_14-3-3_CanoR_1	174	184	PF00244	0.388
LIG_14-3-3_CanoR_1	206	210	PF00244	0.297
LIG_14-3-3_CanoR_1	220	230	PF00244	0.304
LIG_14-3-3_CanoR_1	274	283	PF00244	0.389
LIG_14-3-3_CanoR_1	45	54	PF00244	0.381
LIG_14-3-3_CanoR_1	513	522	PF00244	0.435
LIG_14-3-3_CanoR_1	777	786	PF00244	0.401
LIG_Actin_WH2_2	285	302	PF00022	0.309
LIG_Actin_WH2_2	331	348	PF00022	0.311
LIG_Actin_WH2_2	396	414	PF00022	0.438
LIG_Actin_WH2_2	489	506	PF00022	0.309
LIG_Actin_WH2_2	795	812	PF00022	0.543
LIG_APCC_ABBA_1	790	795	PF00400	0.482
LIG_BIR_III_4	588	592	PF00653	0.616
LIG_CSK_EPIYA_1	677	681	PF00017	0.525
LIG_CtBP_PxDLS_1	748	752	PF00389	0.458
LIG_EH1_1	650	658	PF00400	0.560
LIG_eIF4E_1	192	198	PF01652	0.309
LIG_eIF4E_1	853	859	PF01652	0.482
LIG_FHA_1	154	160	PF00498	0.438
LIG_FHA_1	241	247	PF00498	0.404
LIG_FHA_1	251	257	PF00498	0.412
LIG_FHA_1	340	346	PF00498	0.314
LIG_FHA_1	448	454	PF00498	0.442
LIG_FHA_1	46	52	PF00498	0.294
LIG_FHA_1	594	600	PF00498	0.564
LIG_FHA_1	643	649	PF00498	0.406
LIG_FHA_1	669	675	PF00498	0.468
LIG_FHA_1	768	774	PF00498	0.486
LIG_FHA_1	819	825	PF00498	0.456
LIG_FHA_2	140	146	PF00498	0.309
LIG_FHA_2	166	172	PF00498	0.441
LIG_FHA_2	345	351	PF00498	0.294
LIG_FHA_2	374	380	PF00498	0.438
LIG_FHA_2	541	547	PF00498	0.595
LIG_FHA_2	556	562	PF00498	0.395
LIG_FHA_2	59	65	PF00498	0.311
LIG_FHA_2	626	632	PF00498	0.479
LIG_FHA_2	667	673	PF00498	0.560
LIG_FHA_2	758	764	PF00498	0.481
LIG_GBD_Chelix_1	284	292	PF00786	0.438
LIG_IRF3_LxIS_1	416	423	PF10401	0.438
LIG_LIR_Apic_2	587	593	PF02991	0.457
LIG_LIR_Apic_2	677	683	PF02991	0.496
LIG_LIR_Apic_2	743	748	PF02991	0.457
LIG_LIR_Gen_1	133	144	PF02991	0.353
LIG_LIR_Gen_1	391	400	PF02991	0.379
LIG_LIR_Gen_1	443	454	PF02991	0.410
LIG_LIR_Gen_1	78	88	PF02991	0.346
LIG_LIR_Nem_3	247	252	PF02991	0.329
LIG_LIR_Nem_3	391	395	PF02991	0.438
LIG_LIR_Nem_3	443	449	PF02991	0.334
LIG_LIR_Nem_3	691	697	PF02991	0.461
LIG_LIR_Nem_3	78	83	PF02991	0.462
LIG_LIR_Nem_3	788	793	PF02991	0.478
LIG_PCNA_yPIPBox_3	412	420	PF02747	0.438
LIG_PCNA_yPIPBox_3	650	664	PF02747	0.512
LIG_PTB_Apo_2	382	389	PF02174	0.354
LIG_PTB_Apo_2	656	663	PF02174	0.560
LIG_RPA_C_Fungi	329	341	PF08784	0.323
LIG_SH2_CRK	192	196	PF00017	0.261
LIG_SH2_CRK	249	253	PF00017	0.329
LIG_SH2_CRK	529	533	PF00017	0.309
LIG_SH2_CRK	680	684	PF00017	0.384
LIG_SH2_CRK	694	698	PF00017	0.235
LIG_SH2_CRK	80	84	PF00017	0.467
LIG_SH2_NCK_1	475	479	PF00017	0.309
LIG_SH2_PTP2	696	699	PF00017	0.416
LIG_SH2_SRC	305	308	PF00017	0.464
LIG_SH2_SRC	680	683	PF00017	0.329
LIG_SH2_SRC	701	704	PF00017	0.461
LIG_SH2_SRC	793	796	PF00017	0.284
LIG_SH2_STAP1	392	396	PF00017	0.388
LIG_SH2_STAP1	529	533	PF00017	0.309
LIG_SH2_STAT5	291	294	PF00017	0.294
LIG_SH2_STAT5	305	308	PF00017	0.294
LIG_SH2_STAT5	473	476	PF00017	0.404
LIG_SH2_STAT5	52	55	PF00017	0.294
LIG_SH2_STAT5	529	532	PF00017	0.309
LIG_SH2_STAT5	544	547	PF00017	0.529
LIG_SH2_STAT5	634	637	PF00017	0.294
LIG_SH2_STAT5	696	699	PF00017	0.366
LIG_SH2_STAT5	793	796	PF00017	0.309
LIG_SH2_STAT5	853	856	PF00017	0.329
LIG_SH2_STAT5	88	91	PF00017	0.309
LIG_SH3_2	170	175	PF14604	0.438
LIG_SH3_3	167	173	PF00018	0.438
LIG_SUMO_SIM_anti_2	506	512	PF11976	0.329
LIG_SUMO_SIM_anti_2	821	826	PF11976	0.329
LIG_SUMO_SIM_par_1	337	342	PF11976	0.309
LIG_SUMO_SIM_par_1	417	423	PF11976	0.321
LIG_SUMO_SIM_par_1	623	629	PF11976	0.486
LIG_TRAF2_1	26	29	PF00917	0.511
LIG_TRAF2_1	760	763	PF00917	0.370
LIG_TYR_ITIM	527	532	PF00017	0.309
LIG_TYR_ITSM	690	697	PF00017	0.354
LIG_UBA3_1	108	115	PF00899	0.329
LIG_UBA3_1	338	346	PF00899	0.338
LIG_UBA3_1	419	424	PF00899	0.359
LIG_UBA3_1	656	664	PF00899	0.370
LIG_UBA3_1	68	74	PF00899	0.329
LIG_WRC_WIRS_1	735	740	PF05994	0.316
MOD_CK1_1	118	124	PF00069	0.392
MOD_CK1_1	153	159	PF00069	0.328
MOD_CK1_1	269	275	PF00069	0.341
MOD_CK1_1	361	367	PF00069	0.388
MOD_CK1_1	391	397	PF00069	0.383
MOD_CK1_1	425	431	PF00069	0.343
MOD_CK1_1	447	453	PF00069	0.438
MOD_CK1_1	499	505	PF00069	0.365
MOD_CK1_1	668	674	PF00069	0.322
MOD_CK1_1	757	763	PF00069	0.278
MOD_CK2_1	139	145	PF00069	0.330
MOD_CK2_1	165	171	PF00069	0.441
MOD_CK2_1	274	280	PF00069	0.309
MOD_CK2_1	344	350	PF00069	0.294
MOD_CK2_1	425	431	PF00069	0.399
MOD_CK2_1	515	521	PF00069	0.312
MOD_CK2_1	540	546	PF00069	0.587
MOD_CK2_1	58	64	PF00069	0.300
MOD_CK2_1	666	672	PF00069	0.386
MOD_CK2_1	757	763	PF00069	0.251
MOD_GlcNHglycan	24	27	PF01048	0.475
MOD_GlcNHglycan	361	364	PF01048	0.355
MOD_GlcNHglycan	408	411	PF01048	0.441
MOD_GlcNHglycan	707	710	PF01048	0.294
MOD_GlcNHglycan	846	849	PF01048	0.343
MOD_GSK3_1	131	138	PF00069	0.308
MOD_GSK3_1	146	153	PF00069	0.350
MOD_GSK3_1	305	312	PF00069	0.247
MOD_GSK3_1	344	351	PF00069	0.303
MOD_GSK3_1	355	362	PF00069	0.375
MOD_GSK3_1	401	408	PF00069	0.285
MOD_GSK3_1	422	429	PF00069	0.412
MOD_GSK3_1	499	506	PF00069	0.333
MOD_GSK3_1	511	518	PF00069	0.329
MOD_GSK3_1	98	105	PF00069	0.388
MOD_N-GLC_1	584	589	PF02516	0.542
MOD_N-GLC_1	764	769	PF02516	0.362
MOD_N-GLC_1	777	782	PF02516	0.231
MOD_NEK2_1	102	107	PF00069	0.294
MOD_NEK2_1	131	136	PF00069	0.329
MOD_NEK2_1	139	144	PF00069	0.165
MOD_NEK2_1	165	170	PF00069	0.418
MOD_NEK2_1	251	256	PF00069	0.344
MOD_NEK2_1	290	295	PF00069	0.334
MOD_NEK2_1	339	344	PF00069	0.299
MOD_NEK2_1	373	378	PF00069	0.445
MOD_NEK2_1	411	416	PF00069	0.377
MOD_NEK2_1	420	425	PF00069	0.388
MOD_NEK2_1	503	508	PF00069	0.327
MOD_NEK2_1	511	516	PF00069	0.322
MOD_NEK2_1	540	545	PF00069	0.584
MOD_NEK2_1	572	577	PF00069	0.768
MOD_NEK2_1	666	671	PF00069	0.468
MOD_NEK2_1	69	74	PF00069	0.388
MOD_NEK2_1	75	80	PF00069	0.392
MOD_NEK2_2	683	688	PF00069	0.491
MOD_NEK2_2	772	777	PF00069	0.356
MOD_PIKK_1	175	181	PF00454	0.328
MOD_PIKK_1	213	219	PF00454	0.213
MOD_PIKK_1	291	297	PF00454	0.384
MOD_PIKK_1	355	361	PF00454	0.354
MOD_PIKK_1	444	450	PF00454	0.388
MOD_PIKK_1	45	51	PF00454	0.329
MOD_PIKK_1	689	695	PF00454	0.438
MOD_PK_1	150	156	PF00069	0.438
MOD_PKA_2	205	211	PF00069	0.316
MOD_PKA_2	221	227	PF00069	0.322
MOD_PKA_2	503	509	PF00069	0.294
MOD_PKA_2	58	64	PF00069	0.430
MOD_Plk_1	131	137	PF00069	0.309
MOD_Plk_1	139	145	PF00069	0.165
MOD_Plk_1	349	355	PF00069	0.294
MOD_Plk_1	444	450	PF00069	0.388
MOD_Plk_1	818	824	PF00069	0.399
MOD_Plk_1	98	104	PF00069	0.388
MOD_Plk_2-3	205	211	PF00069	0.438
MOD_Plk_4	131	137	PF00069	0.298
MOD_Plk_4	150	156	PF00069	0.399
MOD_Plk_4	251	257	PF00069	0.338
MOD_Plk_4	283	289	PF00069	0.413
MOD_Plk_4	361	367	PF00069	0.393
MOD_Plk_4	373	379	PF00069	0.428
MOD_Plk_4	391	397	PF00069	0.350
MOD_Plk_4	411	417	PF00069	0.360
MOD_Plk_4	634	640	PF00069	0.299
MOD_Plk_4	818	824	PF00069	0.257
MOD_Plk_4	98	104	PF00069	0.313
MOD_ProDKin_1	593	599	PF00069	0.555
MOD_ProDKin_1	92	98	PF00069	0.350
MOD_SUMO_rev_2	367	376	PF00179	0.209
MOD_SUMO_rev_2	754	760	PF00179	0.320
TRG_DiLeu_BaEn_1	818	823	PF01217	0.438
TRG_DiLeu_BaEn_4	11	17	PF01217	0.601
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.329
TRG_ENDOCYTIC_2	128	131	PF00928	0.388
TRG_ENDOCYTIC_2	136	139	PF00928	0.165
TRG_ENDOCYTIC_2	192	195	PF00928	0.301
TRG_ENDOCYTIC_2	249	252	PF00928	0.332
TRG_ENDOCYTIC_2	392	395	PF00928	0.294
TRG_ENDOCYTIC_2	529	532	PF00928	0.295
TRG_ENDOCYTIC_2	694	697	PF00928	0.299
TRG_ENDOCYTIC_2	80	83	PF00928	0.383
TRG_ENDOCYTIC_2	88	91	PF00928	0.313
TRG_ER_diArg_1	503	505	PF00400	0.309
TRG_ER_diArg_1	83	85	PF00400	0.297
TRG_NES_CRM1_1	49	64	PF08389	0.438
TRG_NES_CRM1_1	784	795	PF08389	0.312
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.294
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	610	614	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	777	781	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q5	Leptomonas seymouri	80%	100%
A0A0S4IV67	Bodo saltans	48%	99%
A0A1X0NR86	Trypanosomatidae	56%	95%
A0A3Q8IEU8	Leishmania donovani	88%	99%
A0A3R7MHH9	Trypanosoma rangeli	56%	99%
A2VE21	Bos taurus	34%	99%
A4I3Z5	Leishmania infantum	88%	99%
D0A965	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
D4ABY2	Rattus norvegicus	35%	100%
E9B085	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
P53620	Bos taurus	35%	98%
P87140	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	95%
Q0WW26	Arabidopsis thaliana	35%	97%
Q22498	Caenorhabditis elegans	33%	99%
Q29AE5	Drosophila pseudoobscura pseudoobscura	33%	98%
Q4AEF8	Rattus norvegicus	35%	98%
Q4Q800	Leishmania major	88%	100%
Q54HL0	Dictyostelium discoideum	34%	96%
Q66JI9	Xenopus tropicalis	34%	99%
Q6DKD7	Xenopus laevis	34%	99%
Q6Z382	Oryza sativa subsp. japonica	34%	97%
Q7PVF6	Anopheles gambiae	33%	99%
Q8H852	Oryza sativa subsp. japonica	34%	97%
Q8I0G5	Drosophila melanogaster	34%	97%
Q9I8E6	Takifugu rubripes	34%	99%
Q9PUE4	Danio rerio	34%	99%
Q9QXK3	Mus musculus	34%	99%
Q9QZE5	Mus musculus	35%	98%
Q9UBF2	Homo sapiens	34%	99%
Q9Y678	Homo sapiens	35%	98%
V5DCV8	Trypanosoma cruzi	58%	99%