TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGW4_LEIBR

TriTrypDb:

LbrM.28.2820 , LBRM2903_280035200

Length:

1789

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1638	1642	PF00656	0.414
CLV_C14_Caspase3-7	580	584	PF00656	0.575
CLV_MEL_PAP_1	242	248	PF00089	0.383
CLV_NRD_NRD_1	1000	1002	PF00675	0.502
CLV_NRD_NRD_1	1074	1076	PF00675	0.475
CLV_NRD_NRD_1	1092	1094	PF00675	0.380
CLV_NRD_NRD_1	1115	1117	PF00675	0.419
CLV_NRD_NRD_1	1209	1211	PF00675	0.475
CLV_NRD_NRD_1	1243	1245	PF00675	0.573
CLV_NRD_NRD_1	1255	1257	PF00675	0.401

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV32	Leptomonas seymouri	37%	100%
A0A3S7X1U3	Leishmania donovani	69%	100%
A4I3Z4	Leishmania infantum	69%	100%
E9B084	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q801	Leishmania major	68%	100%

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