ADP-ribosylglycohydrolase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylglycohydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGW3_LEIBR

TriTrypDb:

LbrM.28.2810 , LBRM2903_280035100

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGW3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.446
CLV_NRD_NRD_1	201	203	PF00675	0.364
CLV_NRD_NRD_1	325	327	PF00675	0.329
CLV_PCSK_KEX2_1	201	203	PF00082	0.376
CLV_PCSK_KEX2_1	325	327	PF00082	0.414
CLV_PCSK_KEX2_1	64	66	PF00082	0.464
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.464
CLV_PCSK_SKI1_1	303	307	PF00082	0.413
CLV_PCSK_SKI1_1	365	369	PF00082	0.316
CLV_Separin_Metazoa	137	141	PF03568	0.442
DEG_SPOP_SBC_1	112	116	PF00917	0.614
DOC_CKS1_1	186	191	PF01111	0.434
DOC_CKS1_1	7	12	PF01111	0.380
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.335
DOC_MAPK_MEF2A_6	31	39	PF00069	0.384
DOC_MAPK_MEF2A_6	394	403	PF00069	0.498
DOC_USP7_MATH_1	102	106	PF00917	0.717
DOC_USP7_MATH_1	111	115	PF00917	0.663
DOC_USP7_MATH_1	119	123	PF00917	0.586
DOC_USP7_MATH_1	141	145	PF00917	0.405
DOC_USP7_MATH_1	193	197	PF00917	0.428
DOC_USP7_MATH_2	383	389	PF00917	0.569
DOC_WW_Pin1_4	107	112	PF00397	0.614
DOC_WW_Pin1_4	185	190	PF00397	0.386
DOC_WW_Pin1_4	211	216	PF00397	0.487
DOC_WW_Pin1_4	294	299	PF00397	0.654
DOC_WW_Pin1_4	6	11	PF00397	0.579
LIG_14-3-3_CanoR_1	140	149	PF00244	0.383
LIG_14-3-3_CanoR_1	303	312	PF00244	0.527
LIG_14-3-3_CanoR_1	343	349	PF00244	0.205
LIG_eIF4E_1	153	159	PF01652	0.488
LIG_FHA_1	129	135	PF00498	0.347
LIG_FHA_1	186	192	PF00498	0.401
LIG_FHA_1	206	212	PF00498	0.431
LIG_FHA_1	241	247	PF00498	0.420
LIG_FHA_1	270	276	PF00498	0.367
LIG_FHA_1	318	324	PF00498	0.441
LIG_FHA_1	330	336	PF00498	0.308
LIG_FHA_1	396	402	PF00498	0.359
LIG_FHA_2	326	332	PF00498	0.487
LIG_FHA_2	75	81	PF00498	0.587
LIG_LIR_Apic_2	407	411	PF02991	0.401
LIG_LIR_Gen_1	205	215	PF02991	0.366
LIG_LIR_Gen_1	241	251	PF02991	0.334
LIG_LIR_Gen_1	82	93	PF02991	0.515
LIG_LIR_Nem_3	129	135	PF02991	0.294
LIG_LIR_Nem_3	20	25	PF02991	0.410
LIG_LIR_Nem_3	205	210	PF02991	0.352
LIG_LIR_Nem_3	241	247	PF02991	0.335
LIG_LIR_Nem_3	82	88	PF02991	0.498
LIG_PCNA_PIPBox_1	54	63	PF02747	0.405
LIG_PCNA_yPIPBox_3	47	61	PF02747	0.496
LIG_Pex14_2	126	130	PF04695	0.247
LIG_SH2_SRC	203	206	PF00017	0.471
LIG_SH2_STAP1	194	198	PF00017	0.485
LIG_SH2_STAP1	242	246	PF00017	0.332
LIG_SH2_STAT5	135	138	PF00017	0.398
LIG_SH2_STAT5	153	156	PF00017	0.361
LIG_SH2_STAT5	203	206	PF00017	0.496
LIG_SH2_STAT5	242	245	PF00017	0.314
LIG_SH2_STAT5	60	63	PF00017	0.571
LIG_SH3_3	279	285	PF00018	0.508
LIG_SH3_3	4	10	PF00018	0.391
LIG_TRAF2_1	92	95	PF00917	0.466
LIG_TRAF2_2	217	222	PF00917	0.488
LIG_WRC_WIRS_1	127	132	PF05994	0.306
MOD_CDC14_SPxK_1	297	300	PF00782	0.396
MOD_CDK_SPxK_1	294	300	PF00069	0.405
MOD_CK1_1	291	297	PF00069	0.566
MOD_CK1_1	311	317	PF00069	0.641
MOD_CK1_1	73	79	PF00069	0.594
MOD_CK2_1	224	230	PF00069	0.564
MOD_CK2_1	331	337	PF00069	0.527
MOD_CK2_1	74	80	PF00069	0.598
MOD_GlcNHglycan	121	124	PF01048	0.523
MOD_GlcNHglycan	143	146	PF01048	0.424
MOD_GlcNHglycan	290	293	PF01048	0.649
MOD_GlcNHglycan	314	317	PF01048	0.669
MOD_GlcNHglycan	387	390	PF01048	0.364
MOD_GlcNHglycan	72	75	PF01048	0.666
MOD_GSK3_1	103	110	PF00069	0.700
MOD_GSK3_1	113	120	PF00069	0.701
MOD_GSK3_1	174	181	PF00069	0.433
MOD_GSK3_1	2	9	PF00069	0.584
MOD_GSK3_1	205	212	PF00069	0.475
MOD_GSK3_1	284	291	PF00069	0.477
MOD_GSK3_1	303	310	PF00069	0.656
MOD_GSK3_1	325	332	PF00069	0.447
MOD_GSK3_1	70	77	PF00069	0.565
MOD_NEK2_1	117	122	PF00069	0.692
MOD_NEK2_1	126	131	PF00069	0.488
MOD_NEK2_1	17	22	PF00069	0.486
MOD_NEK2_1	178	183	PF00069	0.416
MOD_NEK2_1	2	7	PF00069	0.586
MOD_NEK2_1	312	317	PF00069	0.595
MOD_NEK2_2	18	23	PF00069	0.386
MOD_PIKK_1	50	56	PF00454	0.508
MOD_PKA_1	325	331	PF00069	0.293
MOD_PKA_2	307	313	PF00069	0.567
MOD_PKA_2	325	331	PF00069	0.513
MOD_Plk_1	240	246	PF00069	0.450
MOD_Plk_1	81	87	PF00069	0.474
MOD_Plk_2-3	103	109	PF00069	0.501
MOD_Plk_2-3	224	230	PF00069	0.651
MOD_Plk_2-3	331	337	PF00069	0.414
MOD_Plk_4	113	119	PF00069	0.748
MOD_Plk_4	174	180	PF00069	0.322
MOD_Plk_4	181	187	PF00069	0.413
MOD_Plk_4	2	8	PF00069	0.439
MOD_Plk_4	56	62	PF00069	0.313
MOD_Plk_4	81	87	PF00069	0.353
MOD_ProDKin_1	107	113	PF00069	0.611
MOD_ProDKin_1	185	191	PF00069	0.388
MOD_ProDKin_1	211	217	PF00069	0.501
MOD_ProDKin_1	294	300	PF00069	0.659
MOD_ProDKin_1	6	12	PF00069	0.577
MOD_SUMO_rev_2	388	396	PF00179	0.515
TRG_DiLeu_BaEn_1	174	179	PF01217	0.324
TRG_ENDOCYTIC_2	135	138	PF00928	0.366
TRG_ER_diArg_1	200	202	PF00400	0.359
TRG_ER_diArg_1	324	326	PF00400	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW3	Leptomonas seymouri	57%	96%
A0A0S4IN38	Bodo saltans	34%	100%
A0A1X0NQK8	Trypanosomatidae	43%	100%
A0A3Q8IF26	Leishmania donovani	82%	99%
A0A3R7KDQ9	Trypanosoma rangeli	46%	100%
A4I3Z3	Leishmania infantum	82%	99%
D0A963	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B083	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4Q802	Leishmania major	81%	100%
V5BC55	Trypanosoma cruzi	43%	100%