Putative leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGW2_LEIBR

TriTrypDb:

LbrM.28.2800 , LBRM2903_280035000

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HGW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGW2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.477
CLV_C14_Caspase3-7	827	831	PF00656	0.538
CLV_NRD_NRD_1	319	321	PF00675	0.504
CLV_NRD_NRD_1	344	346	PF00675	0.659
CLV_NRD_NRD_1	354	356	PF00675	0.604
CLV_NRD_NRD_1	510	512	PF00675	0.708
CLV_NRD_NRD_1	530	532	PF00675	0.533
CLV_NRD_NRD_1	580	582	PF00675	0.532
CLV_NRD_NRD_1	653	655	PF00675	0.300
CLV_NRD_NRD_1	679	681	PF00675	0.550
CLV_NRD_NRD_1	743	745	PF00675	0.484
CLV_PCSK_KEX2_1	319	321	PF00082	0.504
CLV_PCSK_KEX2_1	354	356	PF00082	0.727
CLV_PCSK_KEX2_1	530	532	PF00082	0.531
CLV_PCSK_KEX2_1	580	582	PF00082	0.532
CLV_PCSK_KEX2_1	653	655	PF00082	0.300
CLV_PCSK_KEX2_1	679	681	PF00082	0.714
CLV_PCSK_KEX2_1	835	837	PF00082	0.537
CLV_PCSK_PC1ET2_1	835	837	PF00082	0.537
CLV_PCSK_SKI1_1	111	115	PF00082	0.386
CLV_PCSK_SKI1_1	237	241	PF00082	0.476
CLV_PCSK_SKI1_1	296	300	PF00082	0.412
CLV_PCSK_SKI1_1	543	547	PF00082	0.281
CLV_PCSK_SKI1_1	674	678	PF00082	0.599
CLV_PCSK_SKI1_1	717	721	PF00082	0.531
CLV_PCSK_SKI1_1	728	732	PF00082	0.581
CLV_PCSK_SKI1_1	790	794	PF00082	0.583
CLV_Separin_Metazoa	741	745	PF03568	0.408
DEG_APCC_DBOX_1	163	171	PF00400	0.464
DEG_APCC_DBOX_1	219	227	PF00400	0.439
DEG_APCC_DBOX_1	295	303	PF00400	0.355
DEG_APCC_DBOX_1	334	342	PF00400	0.451
DEG_APCC_DBOX_1	542	550	PF00400	0.465
DEG_APCC_DBOX_1	849	857	PF00400	0.595
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DEG_SPOP_SBC_1	150	154	PF00917	0.642
DOC_ANK_TNKS_1	835	842	PF00023	0.537
DOC_CDC14_PxL_1	189	197	PF14671	0.369
DOC_MAPK_gen_1	111	121	PF00069	0.417
DOC_MAPK_gen_1	17	26	PF00069	0.445
DOC_MAPK_gen_1	319	327	PF00069	0.507
DOC_MAPK_gen_1	530	538	PF00069	0.292
DOC_MAPK_gen_1	650	659	PF00069	0.292
DOC_MAPK_gen_1	860	869	PF00069	0.522
DOC_MAPK_JIP1_4	296	302	PF00069	0.416
DOC_MAPK_MEF2A_6	196	203	PF00069	0.438
DOC_PP1_RVXF_1	115	122	PF00149	0.407
DOC_PP1_RVXF_1	466	473	PF00149	0.507
DOC_PP4_FxxP_1	258	261	PF00568	0.450
DOC_PP4_FxxP_1	777	780	PF00568	0.544
DOC_PP4_MxPP_1	404	407	PF00568	0.527
DOC_USP7_MATH_1	149	153	PF00917	0.622
DOC_USP7_MATH_1	172	176	PF00917	0.549
DOC_USP7_MATH_1	230	234	PF00917	0.402
DOC_USP7_MATH_1	282	286	PF00917	0.492
DOC_USP7_MATH_1	490	494	PF00917	0.685
DOC_USP7_MATH_1	599	603	PF00917	0.691
DOC_USP7_MATH_1	685	689	PF00917	0.575
DOC_USP7_MATH_1	73	77	PF00917	0.325
DOC_USP7_MATH_1	773	777	PF00917	0.614
DOC_WW_Pin1_4	195	200	PF00397	0.311
DOC_WW_Pin1_4	423	428	PF00397	0.670
DOC_WW_Pin1_4	450	455	PF00397	0.767
DOC_WW_Pin1_4	473	478	PF00397	0.613
DOC_WW_Pin1_4	679	684	PF00397	0.520
LIG_14-3-3_CanoR_1	164	170	PF00244	0.611
LIG_14-3-3_CanoR_1	237	243	PF00244	0.529
LIG_14-3-3_CanoR_1	259	265	PF00244	0.414
LIG_14-3-3_CanoR_1	354	363	PF00244	0.637
LIG_14-3-3_CanoR_1	511	517	PF00244	0.647
LIG_14-3-3_CanoR_1	606	610	PF00244	0.583
LIG_14-3-3_CanoR_1	679	683	PF00244	0.632
LIG_14-3-3_CanoR_1	728	735	PF00244	0.521
LIG_Actin_WH2_2	222	239	PF00022	0.430
LIG_Actin_WH2_2	56	73	PF00022	0.419
LIG_Actin_WH2_2	85	102	PF00022	0.412
LIG_APCC_ABBA_1	324	329	PF00400	0.522
LIG_BIR_III_4	589	593	PF00653	0.510
LIG_BRCT_BRCA1_1	117	121	PF00533	0.265
LIG_CaM_IQ_9	535	550	PF13499	0.457
LIG_CaM_IQ_9	656	671	PF13499	0.457
LIG_Clathr_ClatBox_1	128	132	PF01394	0.329
LIG_Clathr_ClatBox_1	214	218	PF01394	0.322
LIG_Clathr_ClatBox_1	306	310	PF01394	0.422
LIG_deltaCOP1_diTrp_1	290	301	PF00928	0.450
LIG_EH_1	259	263	PF12763	0.439
LIG_eIF4E_1	123	129	PF01652	0.430
LIG_FHA_1	179	185	PF00498	0.326
LIG_FHA_1	196	202	PF00498	0.364
LIG_FHA_1	238	244	PF00498	0.471
LIG_FHA_1	389	395	PF00498	0.728
LIG_FHA_1	417	423	PF00498	0.541
LIG_FHA_1	444	450	PF00498	0.525
LIG_FHA_1	501	507	PF00498	0.596
LIG_FHA_1	697	703	PF00498	0.568
LIG_FHA_1	824	830	PF00498	0.769
LIG_FHA_2	313	319	PF00498	0.425
LIG_FHA_2	366	372	PF00498	0.407
LIG_FHA_2	427	433	PF00498	0.635
LIG_FHA_2	729	735	PF00498	0.450
LIG_FXI_DFP_1	214	218	PF00024	0.322
LIG_LIR_Apic_2	291	297	PF02991	0.451
LIG_LIR_Apic_2	339	343	PF02991	0.562
LIG_LIR_Apic_2	428	433	PF02991	0.645
LIG_LIR_Apic_2	776	780	PF02991	0.633
LIG_LIR_Gen_1	120	131	PF02991	0.425
LIG_LIR_Gen_1	635	646	PF02991	0.635
LIG_LIR_Gen_1	84	94	PF02991	0.307
LIG_LIR_Nem_3	292	298	PF02991	0.431
LIG_LIR_Nem_3	635	641	PF02991	0.598
LIG_LIR_Nem_3	671	675	PF02991	0.564
LIG_LIR_Nem_3	84	89	PF02991	0.350
LIG_NRBOX	715	721	PF00104	0.542
LIG_PCNA_TLS_4	346	353	PF02747	0.558
LIG_PCNA_yPIPBox_3	628	638	PF02747	0.552
LIG_Pex14_1	294	298	PF04695	0.366
LIG_Pex14_2	258	262	PF04695	0.587
LIG_RPA_C_Fungi	525	537	PF08784	0.440
LIG_SH2_CRK	340	344	PF00017	0.587
LIG_SH2_CRK	672	676	PF00017	0.445
LIG_SH2_GRB2like	340	343	PF00017	0.581
LIG_SH2_SRC	808	811	PF00017	0.527
LIG_SH2_SRC	838	841	PF00017	0.533
LIG_SH2_STAT3	564	567	PF00017	0.521
LIG_SH2_STAT5	352	355	PF00017	0.500
LIG_SH3_1	430	436	PF00018	0.520
LIG_SH3_3	132	138	PF00018	0.452
LIG_SH3_3	430	436	PF00018	0.576
LIG_SH3_3	484	490	PF00018	0.550
LIG_SH3_3	755	761	PF00018	0.523
LIG_SH3_3	837	843	PF00018	0.659
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.444
LIG_SUMO_SIM_anti_2	517	524	PF11976	0.563
LIG_SUMO_SIM_par_1	173	181	PF11976	0.577
LIG_SUMO_SIM_par_1	222	228	PF11976	0.386
LIG_SUMO_SIM_par_1	303	308	PF11976	0.453
LIG_SUMO_SIM_par_1	48	54	PF11976	0.376
LIG_TRAF2_1	35	38	PF00917	0.487
LIG_TRAF2_1	515	518	PF00917	0.556
LIG_TRAF2_1	552	555	PF00917	0.396
LIG_TRAF2_1	629	632	PF00917	0.604
LIG_TRAF2_1	786	789	PF00917	0.539
LIG_TRAF2_1	807	810	PF00917	0.522
LIG_UBA3_1	109	114	PF00899	0.365
LIG_UBA3_1	369	378	PF00899	0.411
LIG_WRC_WIRS_1	502	507	PF05994	0.554
LIG_WRC_WIRS_1	774	779	PF05994	0.544
LIG_WRPW_2	295	298	PF00400	0.406
LIG_WW_3	405	409	PF00397	0.534
MOD_CK1_1	140	146	PF00069	0.634
MOD_CK1_1	153	159	PF00069	0.599
MOD_CK1_1	175	181	PF00069	0.512
MOD_CK1_1	194	200	PF00069	0.402
MOD_CK1_1	225	231	PF00069	0.333
MOD_CK1_1	426	432	PF00069	0.660
MOD_CK1_1	501	507	PF00069	0.553
MOD_CK1_1	51	57	PF00069	0.487
MOD_CK1_1	594	600	PF00069	0.618
MOD_CK1_1	626	632	PF00069	0.585
MOD_CK1_1	687	693	PF00069	0.516
MOD_CK1_1	76	82	PF00069	0.548
MOD_CK1_1	828	834	PF00069	0.683
MOD_CK2_1	312	318	PF00069	0.418
MOD_CK2_1	333	339	PF00069	0.599
MOD_CK2_1	439	445	PF00069	0.516
MOD_CK2_1	512	518	PF00069	0.562
MOD_CK2_1	549	555	PF00069	0.530
MOD_CK2_1	605	611	PF00069	0.500
MOD_CK2_1	626	632	PF00069	0.598
MOD_CK2_1	773	779	PF00069	0.721
MOD_CK2_1	804	810	PF00069	0.520
MOD_GlcNHglycan	155	158	PF01048	0.714
MOD_GlcNHglycan	161	164	PF01048	0.628
MOD_GlcNHglycan	278	281	PF01048	0.647
MOD_GlcNHglycan	284	287	PF01048	0.719
MOD_GlcNHglycan	3	6	PF01048	0.414
MOD_GlcNHglycan	464	467	PF01048	0.697
MOD_GlcNHglycan	53	56	PF01048	0.353
MOD_GlcNHglycan	601	604	PF01048	0.661
MOD_GlcNHglycan	750	753	PF01048	0.563
MOD_GlcNHglycan	771	774	PF01048	0.622
MOD_GSK3_1	105	112	PF00069	0.440
MOD_GSK3_1	115	122	PF00069	0.445
MOD_GSK3_1	136	143	PF00069	0.620
MOD_GSK3_1	149	156	PF00069	0.576
MOD_GSK3_1	159	166	PF00069	0.651
MOD_GSK3_1	178	185	PF00069	0.317
MOD_GSK3_1	191	198	PF00069	0.299
MOD_GSK3_1	260	267	PF00069	0.587
MOD_GSK3_1	272	279	PF00069	0.532
MOD_GSK3_1	421	428	PF00069	0.594
MOD_GSK3_1	439	446	PF00069	0.481
MOD_GSK3_1	684	691	PF00069	0.627
MOD_GSK3_1	694	701	PF00069	0.512
MOD_GSK3_1	704	711	PF00069	0.462
MOD_GSK3_1	765	772	PF00069	0.630
MOD_GSK3_1	820	827	PF00069	0.686
MOD_GSK3_1	852	859	PF00069	0.624
MOD_N-GLC_1	124	129	PF02516	0.421
MOD_N-GLC_1	159	164	PF02516	0.503
MOD_N-GLC_1	182	187	PF02516	0.392
MOD_N-GLC_1	204	209	PF02516	0.294
MOD_N-GLC_1	42	47	PF02516	0.416
MOD_N-GLC_1	460	465	PF02516	0.518
MOD_N-GLC_1	490	495	PF02516	0.600
MOD_N-GLC_2	864	866	PF02516	0.524
MOD_NEK2_1	1	6	PF00069	0.484
MOD_NEK2_1	109	114	PF00069	0.466
MOD_NEK2_1	131	136	PF00069	0.496
MOD_NEK2_1	165	170	PF00069	0.560
MOD_NEK2_1	177	182	PF00069	0.299
MOD_NEK2_1	204	209	PF00069	0.344
MOD_NEK2_1	248	253	PF00069	0.394
MOD_NEK2_1	264	269	PF00069	0.572
MOD_NEK2_1	289	294	PF00069	0.499
MOD_NEK2_1	333	338	PF00069	0.561
MOD_NEK2_1	42	47	PF00069	0.301
MOD_NEK2_1	50	55	PF00069	0.355
MOD_NEK2_1	566	571	PF00069	0.389
MOD_NEK2_1	856	861	PF00069	0.533
MOD_NEK2_1	9	14	PF00069	0.379
MOD_NEK2_2	222	227	PF00069	0.408
MOD_PIKK_1	765	771	PF00454	0.623
MOD_PIKK_1	784	790	PF00454	0.549
MOD_PIKK_1	830	836	PF00454	0.567
MOD_PK_1	356	362	PF00069	0.424
MOD_PKA_1	354	360	PF00069	0.611
MOD_PKA_2	140	146	PF00069	0.641
MOD_PKA_2	163	169	PF00069	0.625
MOD_PKA_2	354	360	PF00069	0.627
MOD_PKA_2	386	392	PF00069	0.735
MOD_PKA_2	416	422	PF00069	0.565
MOD_PKA_2	605	611	PF00069	0.750
MOD_PKA_2	678	684	PF00069	0.703
MOD_PKA_2	748	754	PF00069	0.492
MOD_PKA_2	813	819	PF00069	0.597
MOD_PKB_1	17	25	PF00069	0.333
MOD_PKB_1	850	858	PF00069	0.544
MOD_Plk_1	119	125	PF00069	0.399
MOD_Plk_1	289	295	PF00069	0.480
MOD_Plk_1	444	450	PF00069	0.525
MOD_Plk_1	460	466	PF00069	0.483
MOD_Plk_1	9	15	PF00069	0.400
MOD_Plk_2-3	365	371	PF00069	0.410
MOD_Plk_4	105	111	PF00069	0.364
MOD_Plk_4	124	130	PF00069	0.367
MOD_Plk_4	165	171	PF00069	0.477
MOD_Plk_4	172	178	PF00069	0.374
MOD_Plk_4	238	244	PF00069	0.477
MOD_Plk_4	289	295	PF00069	0.516
MOD_Plk_4	356	362	PF00069	0.513
MOD_Plk_4	365	371	PF00069	0.528
MOD_Plk_4	444	450	PF00069	0.525
MOD_Plk_4	501	507	PF00069	0.568
MOD_Plk_4	605	611	PF00069	0.502
MOD_Plk_4	65	71	PF00069	0.421
MOD_Plk_4	790	796	PF00069	0.526
MOD_Plk_4	841	847	PF00069	0.569
MOD_ProDKin_1	195	201	PF00069	0.307
MOD_ProDKin_1	423	429	PF00069	0.669
MOD_ProDKin_1	450	456	PF00069	0.768
MOD_ProDKin_1	473	479	PF00069	0.612
MOD_ProDKin_1	679	685	PF00069	0.522
TRG_DiLeu_BaEn_1	715	720	PF01217	0.542
TRG_DiLeu_BaEn_2	556	562	PF01217	0.512
TRG_DiLeu_BaEn_4	37	43	PF01217	0.448
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.451
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.444
TRG_ENDOCYTIC_2	123	126	PF00928	0.412
TRG_ENDOCYTIC_2	644	647	PF00928	0.614
TRG_ENDOCYTIC_2	672	675	PF00928	0.560
TRG_ER_diArg_1	319	321	PF00400	0.504
TRG_ER_diArg_1	335	338	PF00400	0.480
TRG_ER_diArg_1	353	355	PF00400	0.721
TRG_ER_diArg_1	407	410	PF00400	0.540
TRG_ER_diArg_1	530	532	PF00400	0.524
TRG_ER_diArg_1	666	669	PF00400	0.311
TRG_ER_diArg_1	849	852	PF00400	0.587
TRG_ER_diArg_1	98	101	PF00400	0.307
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	628	632	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	714	718	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0J5	Leptomonas seymouri	50%	100%
A0A3S7X1U4	Leishmania donovani	65%	98%
A4I3Z2	Leishmania infantum	65%	98%
D0A962	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B082	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	98%
Q4Q803	Leishmania major	66%	100%