Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGW0_LEIBR

TriTrypDb:

LbrM.28.2780 , LBRM2903_280034800

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.779
CLV_C14_Caspase3-7	129	133	PF00656	0.808
CLV_NRD_NRD_1	10	12	PF00675	0.614
CLV_NRD_NRD_1	125	127	PF00675	0.678
CLV_NRD_NRD_1	91	93	PF00675	0.570
CLV_PCSK_KEX2_1	10	12	PF00082	0.587
CLV_PCSK_KEX2_1	125	127	PF00082	0.719
CLV_PCSK_KEX2_1	93	95	PF00082	0.633
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.804
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.633
CLV_PCSK_PC7_1	121	127	PF00082	0.553
CLV_Separin_Metazoa	205	209	PF03568	0.510
DEG_SCF_SKP2-CKS1_1	70	77	PF00560	0.769
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.527
DOC_MAPK_MEF2A_6	208	216	PF00069	0.498
DOC_PP2B_LxvP_1	134	137	PF13499	0.611
DOC_PP2B_LxvP_1	88	91	PF13499	0.523
DOC_USP7_MATH_1	105	109	PF00917	0.635
DOC_USP7_MATH_1	137	141	PF00917	0.783
DOC_USP7_MATH_1	146	150	PF00917	0.658
DOC_USP7_MATH_1	167	171	PF00917	0.660
DOC_USP7_MATH_1	173	177	PF00917	0.676
DOC_USP7_MATH_1	44	48	PF00917	0.574
DOC_WW_Pin1_4	22	27	PF00397	0.728
DOC_WW_Pin1_4	40	45	PF00397	0.520
DOC_WW_Pin1_4	62	67	PF00397	0.566
DOC_WW_Pin1_4	71	76	PF00397	0.705
LIG_14-3-3_CanoR_1	110	115	PF00244	0.575
LIG_14-3-3_CanoR_1	27	33	PF00244	0.644
LIG_14-3-3_CanoR_1	50	55	PF00244	0.490
LIG_BRCT_BRCA1_1	12	16	PF00533	0.492
LIG_EVH1_1	115	119	PF00568	0.528
LIG_EVH1_2	118	122	PF00568	0.539
LIG_FHA_1	183	189	PF00498	0.648
LIG_FHA_1	199	205	PF00498	0.371
LIG_FHA_1	23	29	PF00498	0.729
LIG_FHA_1	49	55	PF00498	0.679
LIG_FHA_2	71	77	PF00498	0.718
LIG_LIR_Gen_1	187	194	PF02991	0.595
LIG_LIR_Nem_3	187	192	PF02991	0.601
LIG_LIR_Nem_3	8	12	PF02991	0.440
LIG_PDZ_Class_2	221	226	PF00595	0.644
LIG_PDZ_Wminus1_1	224	226	PF00595	0.679
LIG_SH2_CRK	12	16	PF00017	0.613
LIG_SH2_NCK_1	12	16	PF00017	0.613
LIG_SH2_PTP2	189	192	PF00017	0.486
LIG_SH2_STAP1	12	16	PF00017	0.613
LIG_SH2_STAP1	194	198	PF00017	0.516
LIG_SH2_STAT5	189	192	PF00017	0.486
LIG_SH2_STAT5	218	221	PF00017	0.495
LIG_SH3_2	116	121	PF14604	0.536
LIG_SH3_3	113	119	PF00018	0.678
LIG_SH3_CIN85_PxpxPR_1	87	92	PF14604	0.528
LIG_TRAF2_1	95	98	PF00917	0.541
LIG_TYR_ITSM	185	192	PF00017	0.367
LIG_UBA3_1	56	63	PF00899	0.517
LIG_WRC_WIRS_1	6	11	PF05994	0.475
MOD_CDK_SPK_2	22	27	PF00069	0.728
MOD_CDK_SPxK_1	71	77	PF00069	0.768
MOD_CK1_1	106	112	PF00069	0.733
MOD_CK1_1	135	141	PF00069	0.716
MOD_CK1_1	176	182	PF00069	0.684
MOD_CK1_1	197	203	PF00069	0.542
MOD_CK1_1	31	37	PF00069	0.744
MOD_CK1_1	62	68	PF00069	0.466
MOD_CK2_1	70	76	PF00069	0.767
MOD_Cter_Amidation	123	126	PF01082	0.545
MOD_GlcNHglycan	104	108	PF01048	0.799
MOD_GlcNHglycan	134	137	PF01048	0.754
MOD_GlcNHglycan	149	152	PF01048	0.626
MOD_GlcNHglycan	168	172	PF01048	0.481
MOD_GlcNHglycan	46	49	PF01048	0.715
MOD_GSK3_1	105	112	PF00069	0.719
MOD_GSK3_1	128	135	PF00069	0.638
MOD_GSK3_1	138	145	PF00069	0.672
MOD_GSK3_1	194	201	PF00069	0.362
MOD_GSK3_1	31	38	PF00069	0.613
MOD_GSK3_1	40	47	PF00069	0.603
MOD_N-GLC_1	48	53	PF02516	0.496
MOD_NEK2_1	198	203	PF00069	0.435
MOD_NEK2_1	220	225	PF00069	0.520
MOD_NEK2_1	59	64	PF00069	0.419
MOD_NEK2_2	184	189	PF00069	0.557
MOD_PK_1	50	56	PF00069	0.402
MOD_PKA_1	10	16	PF00069	0.587
MOD_PKA_1	126	132	PF00069	0.552
MOD_PKA_2	10	16	PF00069	0.587
MOD_PKA_2	109	115	PF00069	0.546
MOD_PKA_2	49	55	PF00069	0.574
MOD_Plk_1	194	200	PF00069	0.361
MOD_Plk_4	110	116	PF00069	0.546
MOD_Plk_4	184	190	PF00069	0.641
MOD_Plk_4	194	200	PF00069	0.448
MOD_Plk_4	220	226	PF00069	0.536
MOD_Plk_4	77	83	PF00069	0.527
MOD_ProDKin_1	22	28	PF00069	0.727
MOD_ProDKin_1	40	46	PF00069	0.520
MOD_ProDKin_1	62	68	PF00069	0.573
MOD_ProDKin_1	71	77	PF00069	0.707
TRG_ENDOCYTIC_2	12	15	PF00928	0.614
TRG_ENDOCYTIC_2	189	192	PF00928	0.486
TRG_ER_diArg_1	9	11	PF00400	0.613
TRG_ER_diArg_1	91	94	PF00400	0.535
TRG_NLS_MonoExtC_3	91	96	PF00514	0.628
TRG_NLS_MonoExtN_4	91	96	PF00514	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P417	Leptomonas seymouri	45%	100%
A0A3S7X1X0	Leishmania donovani	70%	100%
A4I3Z0	Leishmania infantum	71%	100%
E9B080	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q805	Leishmania major	69%	100%