R3H domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

R3H domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGV4_LEIBR

TriTrypDb:

LbrM.28.2720 , LBRM2903_280034100

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGV4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.699
CLV_C14_Caspase3-7	411	415	PF00656	0.507
CLV_NRD_NRD_1	218	220	PF00675	0.440
CLV_NRD_NRD_1	380	382	PF00675	0.685
CLV_NRD_NRD_1	397	399	PF00675	0.498
CLV_NRD_NRD_1	491	493	PF00675	0.627
CLV_NRD_NRD_1	69	71	PF00675	0.486
CLV_PCSK_FUR_1	216	220	PF00082	0.578
CLV_PCSK_KEX2_1	218	220	PF00082	0.440
CLV_PCSK_KEX2_1	378	380	PF00082	0.646
CLV_PCSK_KEX2_1	396	398	PF00082	0.777
CLV_PCSK_KEX2_1	491	493	PF00082	0.626
CLV_PCSK_KEX2_1	69	71	PF00082	0.486
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.646
CLV_PCSK_PC7_1	375	381	PF00082	0.515
CLV_PCSK_SKI1_1	101	105	PF00082	0.289
CLV_PCSK_SKI1_1	154	158	PF00082	0.377
CLV_PCSK_SKI1_1	218	222	PF00082	0.590
CLV_PCSK_SKI1_1	225	229	PF00082	0.574
CLV_PCSK_SKI1_1	28	32	PF00082	0.735
CLV_PCSK_SKI1_1	524	528	PF00082	0.437
CLV_PCSK_SKI1_1	617	621	PF00082	0.452
CLV_PCSK_SKI1_1	8	12	PF00082	0.585
DEG_APCC_DBOX_1	100	108	PF00400	0.535
DEG_Nend_UBRbox_2	1	3	PF02207	0.591
DEG_SPOP_SBC_1	285	289	PF00917	0.712
DEG_SPOP_SBC_1	296	300	PF00917	0.631
DEG_SPOP_SBC_1	543	547	PF00917	0.480
DOC_CKS1_1	496	501	PF01111	0.407
DOC_CKS1_1	52	57	PF01111	0.718
DOC_CYCLIN_RxL_1	521	529	PF00134	0.464
DOC_CYCLIN_RxL_1	97	108	PF00134	0.537
DOC_MAPK_DCC_7	593	602	PF00069	0.459
DOC_MAPK_gen_1	110	117	PF00069	0.414
DOC_MAPK_gen_1	153	159	PF00069	0.613
DOC_MAPK_gen_1	510	519	PF00069	0.399
DOC_MAPK_HePTP_8	507	519	PF00069	0.474
DOC_MAPK_MEF2A_6	510	519	PF00069	0.485
DOC_MAPK_MEF2A_6	593	602	PF00069	0.459
DOC_MAPK_MEF2A_6	97	106	PF00069	0.478
DOC_PP1_RVXF_1	152	159	PF00149	0.608
DOC_PP1_RVXF_1	174	180	PF00149	0.557
DOC_PP2B_LxvP_1	115	118	PF13499	0.431
DOC_PP4_FxxP_1	159	162	PF00568	0.552
DOC_PP4_FxxP_1	531	534	PF00568	0.491
DOC_USP7_MATH_1	14	18	PF00917	0.528
DOC_USP7_MATH_1	270	274	PF00917	0.636
DOC_USP7_MATH_1	285	289	PF00917	0.667
DOC_USP7_MATH_1	296	300	PF00917	0.616
DOC_USP7_MATH_1	497	501	PF00917	0.546
DOC_USP7_MATH_1	56	60	PF00917	0.761
DOC_USP7_MATH_1	621	625	PF00917	0.478
DOC_USP7_MATH_1	632	636	PF00917	0.506
DOC_USP7_MATH_1	88	92	PF00917	0.529
DOC_USP7_UBL2_3	176	180	PF12436	0.568
DOC_USP7_UBL2_3	28	32	PF12436	0.592
DOC_WW_Pin1_4	286	291	PF00397	0.577
DOC_WW_Pin1_4	292	297	PF00397	0.615
DOC_WW_Pin1_4	495	500	PF00397	0.463
DOC_WW_Pin1_4	51	56	PF00397	0.690
DOC_WW_Pin1_4	546	551	PF00397	0.769
DOC_WW_Pin1_4	635	640	PF00397	0.551
LIG_14-3-3_CanoR_1	187	197	PF00244	0.566
LIG_14-3-3_CanoR_1	225	232	PF00244	0.524
LIG_14-3-3_CanoR_1	4	8	PF00244	0.539
LIG_14-3-3_CanoR_1	593	598	PF00244	0.562
LIG_APCC_ABBA_1	324	329	PF00400	0.293
LIG_BRCT_BRCA1_1	434	438	PF00533	0.684
LIG_CORNRBOX	170	178	PF00104	0.311
LIG_deltaCOP1_diTrp_1	456	463	PF00928	0.396
LIG_eIF4E_1	232	238	PF01652	0.468
LIG_FHA_1	296	302	PF00498	0.676
LIG_FHA_1	455	461	PF00498	0.395
LIG_FHA_1	466	472	PF00498	0.556
LIG_FHA_1	547	553	PF00498	0.534
LIG_FHA_1	620	626	PF00498	0.553
LIG_FHA_2	34	40	PF00498	0.764
LIG_FHA_2	428	434	PF00498	0.573
LIG_FHA_2	437	443	PF00498	0.392
LIG_FHA_2	496	502	PF00498	0.477
LIG_FHA_2	516	522	PF00498	0.372
LIG_FHA_2	70	76	PF00498	0.672
LIG_LIR_Apic_2	529	534	PF02991	0.477
LIG_LIR_Gen_1	480	489	PF02991	0.349
LIG_LIR_LC3C_4	124	128	PF02991	0.376
LIG_LIR_Nem_3	480	484	PF02991	0.376
LIG_LYPXL_yS_3	572	575	PF13949	0.264
LIG_Pex14_1	459	463	PF04695	0.376
LIG_Pex14_2	477	481	PF04695	0.385
LIG_PTB_Apo_2	525	532	PF02174	0.473
LIG_Rb_LxCxE_1	357	372	PF01857	0.475
LIG_Rb_pABgroove_1	321	329	PF01858	0.325
LIG_RPA_C_Fungi	302	314	PF08784	0.561
LIG_SH2_CRK	493	497	PF00017	0.403
LIG_SH2_CRK	99	103	PF00017	0.435
LIG_SH2_PTP2	506	509	PF00017	0.439
LIG_SH2_SRC	327	330	PF00017	0.394
LIG_SH2_STAP1	113	117	PF00017	0.411
LIG_SH2_STAT3	232	235	PF00017	0.555
LIG_SH2_STAT5	188	191	PF00017	0.618
LIG_SH2_STAT5	352	355	PF00017	0.441
LIG_SH2_STAT5	506	509	PF00017	0.434
LIG_SH3_1	50	56	PF00018	0.513
LIG_SH3_3	493	499	PF00018	0.481
LIG_SH3_3	50	56	PF00018	0.705
LIG_SH3_3	636	642	PF00018	0.489
LIG_TRAF2_1	233	236	PF00917	0.496
LIG_TRAF2_1	402	405	PF00917	0.607
LIG_TRAF2_1	429	432	PF00917	0.745
LIG_TRAF2_1	624	627	PF00917	0.536
LIG_TYR_ITIM	570	575	PF00017	0.251
LIG_UBA3_1	103	112	PF00899	0.385
MOD_CK1_1	138	144	PF00069	0.266
MOD_CK1_1	274	280	PF00069	0.526
MOD_CK1_1	284	290	PF00069	0.672
MOD_CK1_1	295	301	PF00069	0.580
MOD_CK1_1	308	314	PF00069	0.451
MOD_CK1_1	40	46	PF00069	0.752
MOD_CK1_1	424	430	PF00069	0.719
MOD_CK1_1	465	471	PF00069	0.463
MOD_CK1_1	482	488	PF00069	0.433
MOD_CK1_1	635	641	PF00069	0.474
MOD_CK1_1	81	87	PF00069	0.691
MOD_CK2_1	108	114	PF00069	0.288
MOD_CK2_1	127	133	PF00069	0.360
MOD_CK2_1	230	236	PF00069	0.479
MOD_CK2_1	382	388	PF00069	0.683
MOD_CK2_1	425	431	PF00069	0.687
MOD_CK2_1	495	501	PF00069	0.453
MOD_CK2_1	621	627	PF00069	0.514
MOD_CK2_1	84	90	PF00069	0.517
MOD_Cter_Amidation	394	397	PF01082	0.817
MOD_GlcNHglycan	12	15	PF01048	0.664
MOD_GlcNHglycan	140	143	PF01048	0.424
MOD_GlcNHglycan	190	193	PF01048	0.614
MOD_GlcNHglycan	271	276	PF01048	0.525
MOD_GlcNHglycan	283	286	PF01048	0.609
MOD_GlcNHglycan	385	388	PF01048	0.696
MOD_GlcNHglycan	427	430	PF01048	0.734
MOD_GlcNHglycan	451	455	PF01048	0.451
MOD_GlcNHglycan	535	538	PF01048	0.663
MOD_GlcNHglycan	82	86	PF01048	0.590
MOD_GSK3_1	10	17	PF00069	0.670
MOD_GSK3_1	270	277	PF00069	0.694
MOD_GSK3_1	281	288	PF00069	0.614
MOD_GSK3_1	292	299	PF00069	0.592
MOD_GSK3_1	33	40	PF00069	0.645
MOD_GSK3_1	347	354	PF00069	0.347
MOD_GSK3_1	417	424	PF00069	0.745
MOD_GSK3_1	432	439	PF00069	0.680
MOD_GSK3_1	446	453	PF00069	0.560
MOD_GSK3_1	513	520	PF00069	0.445
MOD_GSK3_1	542	549	PF00069	0.715
MOD_GSK3_1	84	91	PF00069	0.594
MOD_LATS_1	419	425	PF00433	0.600
MOD_LATS_1	67	73	PF00433	0.486
MOD_N-GLC_1	118	123	PF02516	0.403
MOD_N-GLC_1	135	140	PF02516	0.271
MOD_N-GLC_1	573	578	PF02516	0.374
MOD_N-GLC_1	635	640	PF02516	0.468
MOD_NEK2_1	10	15	PF00069	0.645
MOD_NEK2_1	230	235	PF00069	0.610
MOD_NEK2_1	276	281	PF00069	0.533
MOD_NEK2_1	3	8	PF00069	0.595
MOD_NEK2_1	305	310	PF00069	0.670
MOD_NEK2_1	37	42	PF00069	0.648
MOD_NEK2_1	515	520	PF00069	0.473
MOD_NEK2_2	14	19	PF00069	0.618
MOD_NEK2_2	551	556	PF00069	0.452
MOD_NEK2_2	573	578	PF00069	0.359
MOD_PIKK_1	230	236	PF00454	0.479
MOD_PIKK_1	288	294	PF00454	0.783
MOD_PIKK_1	419	425	PF00454	0.633
MOD_PIKK_1	544	550	PF00454	0.483
MOD_PIKK_1	619	625	PF00454	0.498
MOD_PK_1	593	599	PF00069	0.559
MOD_PKA_1	218	224	PF00069	0.572
MOD_PKA_1	69	75	PF00069	0.489
MOD_PKA_2	14	20	PF00069	0.433
MOD_PKA_2	218	224	PF00069	0.466
MOD_PKA_2	3	9	PF00069	0.699
MOD_PKA_2	357	363	PF00069	0.527
MOD_PKA_2	417	423	PF00069	0.646
MOD_PKA_2	424	430	PF00069	0.482
MOD_PKA_2	465	471	PF00069	0.507
MOD_PKA_2	69	75	PF00069	0.695
MOD_PKB_1	216	224	PF00069	0.575
MOD_Plk_1	118	124	PF00069	0.403
MOD_Plk_1	271	277	PF00069	0.581
MOD_Plk_1	513	519	PF00069	0.513
MOD_Plk_1	573	579	PF00069	0.380
MOD_Plk_1	81	87	PF00069	0.629
MOD_Plk_2-3	201	207	PF00069	0.614
MOD_Plk_4	357	363	PF00069	0.414
MOD_Plk_4	573	579	PF00069	0.365
MOD_ProDKin_1	286	292	PF00069	0.579
MOD_ProDKin_1	495	501	PF00069	0.461
MOD_ProDKin_1	51	57	PF00069	0.690
MOD_ProDKin_1	546	552	PF00069	0.766
MOD_ProDKin_1	635	641	PF00069	0.557
MOD_SUMO_for_1	244	247	PF00179	0.565
MOD_SUMO_rev_2	175	184	PF00179	0.500
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.411
TRG_ENDOCYTIC_2	327	330	PF00928	0.418
TRG_ENDOCYTIC_2	493	496	PF00928	0.402
TRG_ENDOCYTIC_2	506	509	PF00928	0.439
TRG_ENDOCYTIC_2	572	575	PF00928	0.299
TRG_ENDOCYTIC_2	99	102	PF00928	0.434
TRG_ER_diArg_1	18	21	PF00400	0.551
TRG_ER_diArg_1	217	219	PF00400	0.449
TRG_ER_diArg_1	337	340	PF00400	0.427
TRG_ER_diArg_1	367	370	PF00400	0.370
TRG_ER_diArg_1	379	381	PF00400	0.662
TRG_ER_diArg_1	396	398	PF00400	0.501
TRG_ER_diArg_1	490	492	PF00400	0.631
TRG_ER_diArg_1	610	613	PF00400	0.514
TRG_ER_diArg_1	68	70	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I070	Leptomonas seymouri	62%	100%
A0A0S4IU96	Bodo saltans	26%	100%
A0A1X0NQY1	Trypanosomatidae	31%	100%
A0A3Q8IE01	Leishmania donovani	79%	100%
A0A3R7KGE8	Trypanosoma rangeli	32%	100%
A4I3Y4	Leishmania infantum	79%	100%
D0A955	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B074	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q811	Leishmania major	81%	100%
V5BGS0	Trypanosoma cruzi	30%	100%