Putative eukaryotic translation initiation factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E-3

Species:

Leishmania braziliensis

UniProt:

A4HGV2_LEIBR

TriTrypDb:

LbrM.28.2700 , LBRM2903_280033900

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGV2

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003743	translation initiation factor activity	4	10
GO:0005488	binding	1	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0045182	translation regulator activity	1	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0000339	RNA cap binding	5	1
GO:0000340	RNA 7-methylguanosine cap binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	297	301	PF00656	0.439
CLV_NRD_NRD_1	204	206	PF00675	0.299
CLV_PCSK_SKI1_1	206	210	PF00082	0.358
CLV_PCSK_SKI1_1	238	242	PF00082	0.380
CLV_PCSK_SKI1_1	275	279	PF00082	0.380
CLV_PCSK_SKI1_1	299	303	PF00082	0.259
CLV_PCSK_SKI1_1	64	68	PF00082	0.598
DEG_APCC_DBOX_1	298	306	PF00400	0.497
DEG_MDM2_SWIB_1	182	189	PF02201	0.497
DEG_Nend_UBRbox_3	1	3	PF02207	0.651
DOC_CKS1_1	189	194	PF01111	0.439
DOC_MAPK_gen_1	216	225	PF00069	0.497
DOC_MAPK_gen_1	270	279	PF00069	0.502
DOC_MAPK_HePTP_8	269	281	PF00069	0.580
DOC_MAPK_JIP1_4	275	281	PF00069	0.540
DOC_MAPK_MEF2A_6	218	227	PF00069	0.515
DOC_MAPK_MEF2A_6	272	281	PF00069	0.573
DOC_USP7_MATH_1	10	14	PF00917	0.685
DOC_USP7_MATH_1	132	136	PF00917	0.679
DOC_USP7_MATH_1	157	161	PF00917	0.552
DOC_USP7_MATH_1	19	23	PF00917	0.738
DOC_USP7_MATH_1	190	194	PF00917	0.552
DOC_USP7_MATH_1	325	329	PF00917	0.599
DOC_USP7_MATH_1	77	81	PF00917	0.758
DOC_USP7_UBL2_3	12	16	PF12436	0.771
DOC_USP7_UBL2_3	309	313	PF12436	0.497
DOC_USP7_UBL2_3	334	338	PF12436	0.639
DOC_WW_Pin1_4	158	163	PF00397	0.522
DOC_WW_Pin1_4	17	22	PF00397	0.569
DOC_WW_Pin1_4	188	193	PF00397	0.439
DOC_WW_Pin1_4	337	342	PF00397	0.531
DOC_WW_Pin1_4	54	59	PF00397	0.676
LIG_14-3-3_CanoR_1	232	241	PF00244	0.552
LIG_deltaCOP1_diTrp_1	180	186	PF00928	0.497
LIG_FHA_1	220	226	PF00498	0.499
LIG_FHA_1	276	282	PF00498	0.581
LIG_FHA_1	55	61	PF00498	0.584
LIG_FHA_1	71	77	PF00498	0.591
LIG_LIR_Apic_2	211	215	PF02991	0.580
LIG_LIR_Gen_1	200	208	PF02991	0.499
LIG_LIR_Gen_1	242	253	PF02991	0.499
LIG_LIR_Nem_3	142	146	PF02991	0.517
LIG_LIR_Nem_3	165	171	PF02991	0.573
LIG_LIR_Nem_3	180	185	PF02991	0.467
LIG_LIR_Nem_3	200	204	PF02991	0.405
LIG_PAM2_1	37	49	PF00658	0.631
LIG_Pex14_1	203	207	PF04695	0.439
LIG_Pex14_2	168	172	PF04695	0.543
LIG_Pex14_2	182	186	PF04695	0.449
LIG_SH2_PTP2	207	210	PF00017	0.439
LIG_SH2_STAP1	199	203	PF00017	0.638
LIG_SH2_STAT5	188	191	PF00017	0.515
LIG_SH2_STAT5	199	202	PF00017	0.515
LIG_SH2_STAT5	207	210	PF00017	0.515
LIG_SH3_3	24	30	PF00018	0.783
LIG_SH3_3	42	48	PF00018	0.628
LIG_SH3_3	71	77	PF00018	0.654
LIG_SUMO_SIM_anti_2	222	227	PF11976	0.540
LIG_SUMO_SIM_par_1	222	229	PF11976	0.459
LIG_SxIP_EBH_1	131	143	PF03271	0.540
LIG_WRC_WIRS_1	179	184	PF05994	0.640
MOD_CK1_1	153	159	PF00069	0.571
MOD_CK1_1	160	166	PF00069	0.591
MOD_CK1_1	174	180	PF00069	0.567
MOD_CK1_1	233	239	PF00069	0.591
MOD_CK1_1	80	86	PF00069	0.665
MOD_CK2_1	174	180	PF00069	0.439
MOD_CK2_1	253	259	PF00069	0.497
MOD_CMANNOS	183	186	PF00535	0.297
MOD_GlcNHglycan	113	117	PF01048	0.449
MOD_GlcNHglycan	134	137	PF01048	0.556
MOD_GlcNHglycan	192	195	PF01048	0.340
MOD_GlcNHglycan	231	235	PF01048	0.380
MOD_GlcNHglycan	3	6	PF01048	0.718
MOD_GlcNHglycan	31	34	PF01048	0.797
MOD_GlcNHglycan	39	42	PF01048	0.711
MOD_GlcNHglycan	54	57	PF01048	0.811
MOD_GlcNHglycan	83	86	PF01048	0.738
MOD_GSK3_1	151	158	PF00069	0.583
MOD_GSK3_1	160	167	PF00069	0.585
MOD_GSK3_1	174	181	PF00069	0.572
MOD_GSK3_1	190	197	PF00069	0.528
MOD_GSK3_1	25	32	PF00069	0.740
MOD_GSK3_1	337	344	PF00069	0.506
MOD_GSK3_1	60	67	PF00069	0.756
MOD_GSK3_1	77	84	PF00069	0.733
MOD_N-GLC_1	174	179	PF02516	0.258
MOD_NEK2_1	294	299	PF00069	0.497
MOD_PIKK_1	98	104	PF00454	0.662
MOD_Plk_1	325	331	PF00069	0.442
MOD_Plk_1	98	104	PF00069	0.635
MOD_Plk_4	178	184	PF00069	0.586
MOD_Plk_4	194	200	PF00069	0.442
MOD_ProDKin_1	158	164	PF00069	0.522
MOD_ProDKin_1	17	23	PF00069	0.572
MOD_ProDKin_1	188	194	PF00069	0.439
MOD_ProDKin_1	337	343	PF00069	0.526
MOD_ProDKin_1	54	60	PF00069	0.676
MOD_SUMO_for_1	15	18	PF00179	0.666
MOD_SUMO_for_1	208	211	PF00179	0.552
MOD_SUMO_for_1	91	94	PF00179	0.730
MOD_SUMO_rev_2	68	73	PF00179	0.665
TRG_ENDOCYTIC_2	201	204	PF00928	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S7	Leptomonas seymouri	72%	99%
A0A1X0NR97	Trypanosomatidae	50%	72%
A0A3Q8IDB8	Leishmania donovani	88%	99%
A0A3R7L212	Trypanosoma rangeli	50%	76%
A4I3Y2	Leishmania infantum	88%	99%
D0A951	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	78%
E9B072	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q813	Leishmania major	87%	100%