Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGV0_LEIBR

TriTrypDb:

LbrM.28.2680 , LBRM2903_280033600

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HGV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.837
CLV_NRD_NRD_1	270	272	PF00675	0.551
CLV_NRD_NRD_1	92	94	PF00675	0.685
CLV_PCSK_KEX2_1	270	272	PF00082	0.549
CLV_PCSK_KEX2_1	288	290	PF00082	0.427
CLV_PCSK_KEX2_1	92	94	PF00082	0.685
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.427
CLV_PCSK_SKI1_1	276	280	PF00082	0.496
DEG_SCF_FBW7_1	57	62	PF00400	0.470
DOC_ANK_TNKS_1	60	67	PF00023	0.467
DOC_MAPK_MEF2A_6	9	17	PF00069	0.455
DOC_MAPK_RevD_3	257	271	PF00069	0.277
DOC_USP7_MATH_1	59	63	PF00917	0.469
DOC_WW_Pin1_4	119	124	PF00397	0.617
DOC_WW_Pin1_4	131	136	PF00397	0.494
DOC_WW_Pin1_4	168	173	PF00397	0.487
DOC_WW_Pin1_4	33	38	PF00397	0.436
DOC_WW_Pin1_4	55	60	PF00397	0.483
DOC_WW_Pin1_4	84	89	PF00397	0.495
LIG_14-3-3_CanoR_1	101	105	PF00244	0.472
LIG_14-3-3_CanoR_1	9	14	PF00244	0.611
LIG_Clathr_ClatBox_1	254	258	PF01394	0.277
LIG_FHA_1	16	22	PF00498	0.505
LIG_FHA_1	203	209	PF00498	0.478
LIG_FHA_1	211	217	PF00498	0.493
LIG_FHA_1	240	246	PF00498	0.288
LIG_FHA_1	65	71	PF00498	0.460
LIG_FHA_1	8	14	PF00498	0.522
LIG_FHA_1	95	101	PF00498	0.578
LIG_FHA_2	201	207	PF00498	0.479
LIG_FHA_2	26	32	PF00498	0.277
LIG_FHA_2	37	43	PF00498	0.559
LIG_Integrin_RGD_1	289	291	PF01839	0.414
LIG_LIR_Nem_3	226	232	PF02991	0.406
LIG_NBox_RRM_1	241	251	PF00076	0.311
LIG_PDZ_Class_2	296	301	PF00595	0.786
LIG_Pex14_2	102	106	PF04695	0.458
LIG_SH2_CRK	229	233	PF00017	0.392
LIG_SH3_1	169	175	PF00018	0.464
LIG_SH3_3	169	175	PF00018	0.464
LIG_SH3_3	205	211	PF00018	0.452
LIG_SUMO_SIM_anti_2	242	247	PF11976	0.277
LIG_SUMO_SIM_par_1	212	220	PF11976	0.443
LIG_SUMO_SIM_par_1	252	258	PF11976	0.444
LIG_WRC_WIRS_1	238	243	PF05994	0.636
MOD_CDK_SPxK_1	55	61	PF00069	0.566
MOD_CDK_SPxxK_3	131	138	PF00069	0.573
MOD_CDK_SPxxK_3	33	40	PF00069	0.531
MOD_CK1_1	171	177	PF00069	0.599
MOD_CK1_1	215	221	PF00069	0.788
MOD_CK1_1	7	13	PF00069	0.494
MOD_CK2_1	200	206	PF00069	0.590
MOD_CK2_1	25	31	PF00069	0.277
MOD_CK2_1	36	42	PF00069	0.703
MOD_DYRK1A_RPxSP_1	119	123	PF00069	0.703
MOD_GlcNHglycan	193	196	PF01048	0.548
MOD_GlcNHglycan	234	237	PF01048	0.427
MOD_GlcNHglycan	28	31	PF01048	0.293
MOD_GlcNHglycan	33	36	PF01048	0.643
MOD_GlcNHglycan	6	9	PF01048	0.701
MOD_GlcNHglycan	61	64	PF01048	0.699
MOD_GSK3_1	138	145	PF00069	0.572
MOD_GSK3_1	196	203	PF00069	0.602
MOD_GSK3_1	212	219	PF00069	0.682
MOD_GSK3_1	36	43	PF00069	0.604
MOD_GSK3_1	51	58	PF00069	0.495
MOD_GSK3_1	64	71	PF00069	0.681
MOD_N-GLC_1	216	221	PF02516	0.639
MOD_NEK2_1	142	147	PF00069	0.578
MOD_NEK2_1	200	205	PF00069	0.552
MOD_NEK2_1	25	30	PF00069	0.530
MOD_NEK2_1	292	297	PF00069	0.764
MOD_PIKK_1	95	101	PF00454	0.797
MOD_PK_1	212	218	PF00069	0.541
MOD_PK_1	9	15	PF00069	0.277
MOD_PKA_2	100	106	PF00069	0.578
MOD_PKA_2	272	278	PF00069	0.584
MOD_PKA_2	292	298	PF00069	0.764
MOD_Plk_1	95	101	PF00069	0.798
MOD_Plk_2-3	160	166	PF00069	0.578
MOD_Plk_4	15	21	PF00069	0.413
MOD_Plk_4	70	76	PF00069	0.553
MOD_ProDKin_1	119	125	PF00069	0.784
MOD_ProDKin_1	131	137	PF00069	0.611
MOD_ProDKin_1	168	174	PF00069	0.600
MOD_ProDKin_1	33	39	PF00069	0.529
MOD_ProDKin_1	55	61	PF00069	0.600
MOD_ProDKin_1	84	90	PF00069	0.611
TRG_DiLeu_BaEn_1	42	47	PF01217	0.525
TRG_DiLeu_LyEn_5	42	47	PF01217	0.525
TRG_ENDOCYTIC_2	229	232	PF00928	0.470
TRG_ER_diArg_1	270	273	PF00400	0.692
TRG_ER_diArg_1	92	94	PF00400	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X1W1	Leishmania donovani	55%	100%
A4I3Y0	Leishmania infantum	55%	100%
E9B070	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	99%
Q4Q815	Leishmania major	51%	100%