DUF676 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative serine esterase (DUF676), putative

Species:

Leishmania braziliensis

UniProt:

A4HGU8_LEIBR

TriTrypDb:

LbrM.28.2650 , LBRM2903_280033200

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGU8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.518
CLV_C14_Caspase3-7	380	384	PF00656	0.560
CLV_NRD_NRD_1	161	163	PF00675	0.393
CLV_NRD_NRD_1	54	56	PF00675	0.388
CLV_PCSK_FUR_1	158	162	PF00082	0.427
CLV_PCSK_KEX2_1	160	162	PF00082	0.362
CLV_PCSK_KEX2_1	188	190	PF00082	0.569
CLV_PCSK_KEX2_1	54	56	PF00082	0.388
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.347
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.440
CLV_PCSK_SKI1_1	118	122	PF00082	0.446
CLV_PCSK_SKI1_1	161	165	PF00082	0.362
CLV_PCSK_SKI1_1	371	375	PF00082	0.712
CLV_PCSK_SKI1_1	72	76	PF00082	0.337
DEG_APCC_DBOX_1	160	168	PF00400	0.473
DEG_APCC_DBOX_1	282	290	PF00400	0.360
DEG_APCC_DBOX_1	71	79	PF00400	0.337
DEG_COP1_1	356	364	PF00400	0.429
DEG_Nend_UBRbox_3	1	3	PF02207	0.418
DEG_SCF_FBW7_1	350	357	PF00400	0.393
DOC_CKS1_1	103	108	PF01111	0.393
DOC_CKS1_1	351	356	PF01111	0.401
DOC_CKS1_1	361	366	PF01111	0.342
DOC_CYCLIN_RxL_1	158	166	PF00134	0.301
DOC_CYCLIN_RxL_1	52	60	PF00134	0.257
DOC_MAPK_FxFP_2	333	336	PF00069	0.498
DOC_MAPK_gen_1	158	167	PF00069	0.437
DOC_MAPK_MEF2A_6	158	167	PF00069	0.319
DOC_MAPK_MEF2A_6	270	279	PF00069	0.413
DOC_MAPK_MEF2A_6	312	319	PF00069	0.337
DOC_MAPK_MEF2A_6	72	79	PF00069	0.362
DOC_MAPK_NFAT4_5	312	320	PF00069	0.335
DOC_MAPK_NFAT4_5	72	80	PF00069	0.362
DOC_PP1_RVXF_1	53	60	PF00149	0.462
DOC_PP2B_LxvP_1	252	255	PF13499	0.391
DOC_PP4_FxxP_1	180	183	PF00568	0.399
DOC_PP4_FxxP_1	333	336	PF00568	0.498
DOC_USP7_MATH_1	18	22	PF00917	0.356
DOC_USP7_MATH_1	217	221	PF00917	0.349
DOC_USP7_MATH_1	354	358	PF00917	0.668
DOC_USP7_MATH_1	373	377	PF00917	0.643
DOC_WW_Pin1_4	102	107	PF00397	0.390
DOC_WW_Pin1_4	246	251	PF00397	0.574
DOC_WW_Pin1_4	350	355	PF00397	0.370
DOC_WW_Pin1_4	360	365	PF00397	0.419
DOC_WW_Pin1_4	375	380	PF00397	0.524
DOC_WW_Pin1_4	393	398	PF00397	0.429
LIG_14-3-3_CanoR_1	162	168	PF00244	0.257
LIG_14-3-3_CanoR_1	321	331	PF00244	0.488
LIG_14-3-3_CanoR_1	371	381	PF00244	0.538
LIG_Actin_WH2_2	59	74	PF00022	0.437
LIG_APCC_ABBA_1	93	98	PF00400	0.257
LIG_BRCT_BRCA1_1	176	180	PF00533	0.369
LIG_BRCT_BRCA1_1	89	93	PF00533	0.257
LIG_CSL_BTD_1	252	255	PF09270	0.391
LIG_EH1_1	63	71	PF00400	0.337
LIG_eIF4E_1	345	351	PF01652	0.485
LIG_FHA_1	103	109	PF00498	0.492
LIG_FHA_1	23	29	PF00498	0.472
LIG_FHA_2	288	294	PF00498	0.466
LIG_FHA_2	361	367	PF00498	0.588
LIG_FHA_2	378	384	PF00498	0.496
LIG_FHA_2	83	89	PF00498	0.257
LIG_LIR_Apic_2	177	183	PF02991	0.397
LIG_LIR_Gen_1	56	66	PF02991	0.301
LIG_LIR_Gen_1	98	108	PF02991	0.327
LIG_LIR_Nem_3	334	338	PF02991	0.441
LIG_LIR_Nem_3	56	62	PF02991	0.301
LIG_LIR_Nem_3	98	103	PF02991	0.294
LIG_LYPXL_yS_3	335	338	PF13949	0.542
LIG_MYND_1	250	254	PF01753	0.563
LIG_Pex14_1	331	335	PF04695	0.337
LIG_Pex14_2	93	97	PF04695	0.257
LIG_SH2_STAT3	86	89	PF00017	0.395
LIG_SH2_STAT5	128	131	PF00017	0.286
LIG_SH2_STAT5	223	226	PF00017	0.476
LIG_SH2_STAT5	345	348	PF00017	0.479
LIG_SH3_3	356	362	PF00018	0.592
LIG_SUMO_SIM_par_1	75	80	PF11976	0.257
LIG_TRAF2_1	234	237	PF00917	0.430
LIG_TRAF2_1	363	366	PF00917	0.596
LIG_Vh1_VBS_1	5	23	PF01044	0.318
MOD_CK1_1	141	147	PF00069	0.316
MOD_CK1_1	149	155	PF00069	0.256
MOD_CK1_1	334	340	PF00069	0.318
MOD_CK1_1	372	378	PF00069	0.644
MOD_CK2_1	230	236	PF00069	0.417
MOD_CK2_1	360	366	PF00069	0.596
MOD_CK2_1	387	393	PF00069	0.596
MOD_CK2_1	82	88	PF00069	0.257
MOD_GlcNHglycan	143	146	PF01048	0.385
MOD_GlcNHglycan	20	23	PF01048	0.442
MOD_GlcNHglycan	218	222	PF01048	0.346
MOD_GlcNHglycan	324	327	PF01048	0.388
MOD_GlcNHglycan	35	38	PF01048	0.393
MOD_GlcNHglycan	356	359	PF01048	0.692
MOD_GlcNHglycan	371	374	PF01048	0.688
MOD_GlcNHglycan	375	378	PF01048	0.741
MOD_GlcNHglycan	383	386	PF01048	0.720
MOD_GlcNHglycan	389	392	PF01048	0.685
MOD_GlcNHglycan	59	62	PF01048	0.386
MOD_GSK3_1	137	144	PF00069	0.288
MOD_GSK3_1	18	25	PF00069	0.351
MOD_GSK3_1	199	206	PF00069	0.558
MOD_GSK3_1	288	295	PF00069	0.629
MOD_GSK3_1	350	357	PF00069	0.604
MOD_GSK3_1	369	376	PF00069	0.589
MOD_GSK3_1	377	384	PF00069	0.615
MOD_NEK2_1	114	119	PF00069	0.268
MOD_NEK2_1	137	142	PF00069	0.325
MOD_NEK2_1	174	179	PF00069	0.356
MOD_NEK2_1	230	235	PF00069	0.403
MOD_NEK2_1	322	327	PF00069	0.457
MOD_NEK2_1	33	38	PF00069	0.641
MOD_NEK2_1	57	62	PF00069	0.437
MOD_PK_1	26	32	PF00069	0.410
MOD_PKA_2	149	155	PF00069	0.330
MOD_PKA_2	287	293	PF00069	0.619
MOD_PKA_2	320	326	PF00069	0.404
MOD_Plk_1	169	175	PF00069	0.473
MOD_Plk_1	217	223	PF00069	0.521
MOD_Plk_1	26	32	PF00069	0.561
MOD_Plk_1	87	93	PF00069	0.257
MOD_Plk_4	138	144	PF00069	0.393
MOD_Plk_4	163	169	PF00069	0.443
MOD_Plk_4	176	182	PF00069	0.454
MOD_Plk_4	334	340	PF00069	0.517
MOD_ProDKin_1	102	108	PF00069	0.390
MOD_ProDKin_1	246	252	PF00069	0.568
MOD_ProDKin_1	350	356	PF00069	0.385
MOD_ProDKin_1	360	366	PF00069	0.493
MOD_ProDKin_1	375	381	PF00069	0.566
MOD_ProDKin_1	393	399	PF00069	0.429
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.257
TRG_ENDOCYTIC_2	335	338	PF00928	0.506
TRG_ER_diArg_1	161	163	PF00400	0.393
TRG_ER_diArg_1	282	285	PF00400	0.544
TRG_NES_CRM1_1	349	365	PF08389	0.403
TRG_NLS_MonoExtN_4	158	164	PF00514	0.427
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P6	Leptomonas seymouri	44%	86%
A0A1X0NR47	Trypanosomatidae	31%	100%
A0A3Q8IQU6	Leishmania donovani	55%	82%
A0A3R7K6Z5	Trypanosoma rangeli	30%	100%
A4I3X6	Leishmania infantum	56%	82%
D0A944	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B066	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	81%