NTP_transferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGU7_LEIBR

TriTrypDb:

LbrM.28.2640 , LBRM2903_280033100

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005851	eukaryotic translation initiation factor 2B complex	2	1
GO:0032045	guanyl-nucleotide exchange factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

A4HGU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGU7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	7
GO:0002183	cytoplasmic translational initiation	4	1
GO:0006413	translational initiation	3	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0003676	nucleic acid binding	3	1
GO:0003743	translation initiation factor activity	4	1
GO:0005085	guanyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0045182	translation regulator activity	1	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1
GO:0140678	molecular function inhibitor activity	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0008879	glucose-1-phosphate thymidylyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.517
CLV_C14_Caspase3-7	365	369	PF00656	0.342
CLV_C14_Caspase3-7	453	457	PF00656	0.519
CLV_C14_Caspase3-7	592	596	PF00656	0.538
CLV_NRD_NRD_1	246	248	PF00675	0.619
CLV_NRD_NRD_1	295	297	PF00675	0.592
CLV_NRD_NRD_1	356	358	PF00675	0.416
CLV_NRD_NRD_1	393	395	PF00675	0.500
CLV_PCSK_KEX2_1	230	232	PF00082	0.667
CLV_PCSK_KEX2_1	295	297	PF00082	0.599
CLV_PCSK_KEX2_1	356	358	PF00082	0.416
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.667
CLV_PCSK_PC7_1	226	232	PF00082	0.597
CLV_PCSK_SKI1_1	110	114	PF00082	0.448
CLV_PCSK_SKI1_1	190	194	PF00082	0.331
CLV_PCSK_SKI1_1	33	37	PF00082	0.266
CLV_PCSK_SKI1_1	376	380	PF00082	0.463
CLV_PCSK_SKI1_1	395	399	PF00082	0.417
CLV_PCSK_SKI1_1	57	61	PF00082	0.325
DEG_APCC_DBOX_1	375	383	PF00400	0.458
DEG_SCF_FBW7_2	48	53	PF00400	0.331
DOC_CKS1_1	416	421	PF01111	0.504
DOC_MAPK_FxFP_2	528	531	PF00069	0.463
DOC_MAPK_gen_1	108	115	PF00069	0.427
DOC_MAPK_gen_1	356	362	PF00069	0.422
DOC_MAPK_gen_1	394	400	PF00069	0.501
DOC_MAPK_MEF2A_6	344	351	PF00069	0.470
DOC_PP1_RVXF_1	39	46	PF00149	0.411
DOC_PP2B_LxvP_1	449	452	PF13499	0.584
DOC_PP4_FxxP_1	416	419	PF00568	0.427
DOC_PP4_FxxP_1	528	531	PF00568	0.617
DOC_USP7_MATH_1	122	126	PF00917	0.526
DOC_USP7_MATH_1	160	164	PF00917	0.626
DOC_USP7_MATH_1	276	280	PF00917	0.586
DOC_USP7_MATH_1	308	312	PF00917	0.610
DOC_USP7_MATH_1	494	498	PF00917	0.593
DOC_USP7_MATH_1	511	515	PF00917	0.561
DOC_USP7_MATH_1	558	562	PF00917	0.616
DOC_USP7_UBL2_3	104	108	PF12436	0.402
DOC_WW_Pin1_4	285	290	PF00397	0.587
DOC_WW_Pin1_4	313	318	PF00397	0.732
DOC_WW_Pin1_4	415	420	PF00397	0.507
DOC_WW_Pin1_4	46	51	PF00397	0.405
LIG_14-3-3_CanoR_1	182	189	PF00244	0.497
LIG_14-3-3_CanoR_1	212	218	PF00244	0.501
LIG_14-3-3_CanoR_1	307	313	PF00244	0.584
LIG_14-3-3_CanoR_1	348	352	PF00244	0.437
LIG_14-3-3_CanoR_1	527	531	PF00244	0.475
LIG_14-3-3_CanoR_1	620	627	PF00244	0.443
LIG_Actin_WH2_2	100	116	PF00022	0.492
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_BRCT_BRCA1_1	74	78	PF00533	0.487
LIG_Clathr_ClatBox_1	201	205	PF01394	0.483
LIG_EVH1_2	599	603	PF00568	0.525
LIG_FHA_1	197	203	PF00498	0.380
LIG_FHA_1	219	225	PF00498	0.482
LIG_FHA_1	261	267	PF00498	0.626
LIG_FHA_1	47	53	PF00498	0.343
LIG_FHA_1	520	526	PF00498	0.768
LIG_FHA_1	603	609	PF00498	0.417
LIG_FHA_1	620	626	PF00498	0.311
LIG_FHA_1	643	649	PF00498	0.395
LIG_FHA_2	26	32	PF00498	0.331
LIG_FHA_2	416	422	PF00498	0.507
LIG_FHA_2	575	581	PF00498	0.631
LIG_FHA_2	96	102	PF00498	0.266
LIG_LIR_Apic_2	413	419	PF02991	0.456
LIG_LIR_Gen_1	211	222	PF02991	0.436
LIG_LIR_Gen_1	58	68	PF02991	0.261
LIG_LIR_Gen_1	82	92	PF02991	0.238
LIG_LIR_Nem_3	211	217	PF02991	0.460
LIG_LIR_Nem_3	482	487	PF02991	0.355
LIG_LIR_Nem_3	529	533	PF02991	0.464
LIG_LIR_Nem_3	53	59	PF02991	0.299
LIG_LIR_Nem_3	65	70	PF02991	0.240
LIG_LIR_Nem_3	75	81	PF02991	0.300
LIG_LIR_Nem_3	82	88	PF02991	0.221
LIG_MAD2	654	662	PF02301	0.368
LIG_MYND_1	531	535	PF01753	0.612
LIG_Pex14_1	377	381	PF04695	0.370
LIG_Pex14_2	56	60	PF04695	0.411
LIG_SH2_CRK	214	218	PF00017	0.385
LIG_SH2_CRK	225	229	PF00017	0.381
LIG_SH2_CRK	484	488	PF00017	0.488
LIG_SH2_CRK	67	71	PF00017	0.281
LIG_SH2_GRB2like	337	340	PF00017	0.457
LIG_SH2_NCK_1	271	275	PF00017	0.463
LIG_SH2_PTP2	85	88	PF00017	0.411
LIG_SH2_SRC	271	274	PF00017	0.318
LIG_SH2_SRC	337	340	PF00017	0.495
LIG_SH2_STAP1	214	218	PF00017	0.454
LIG_SH2_STAT5	106	109	PF00017	0.342
LIG_SH2_STAT5	262	265	PF00017	0.480
LIG_SH2_STAT5	337	340	PF00017	0.469
LIG_SH2_STAT5	372	375	PF00017	0.293
LIG_SH2_STAT5	588	591	PF00017	0.514
LIG_SH2_STAT5	73	76	PF00017	0.281
LIG_SH2_STAT5	85	88	PF00017	0.281
LIG_SH3_3	422	428	PF00018	0.426
LIG_SH3_3	569	575	PF00018	0.525
LIG_SH3_3	594	600	PF00018	0.548
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.378
LIG_SUMO_SIM_par_1	132	139	PF11976	0.470
LIG_SUMO_SIM_par_1	198	205	PF11976	0.434
LIG_SUMO_SIM_par_1	573	580	PF11976	0.622
LIG_TRAF2_1	270	273	PF00917	0.368
LIG_TRFH_1	85	89	PF08558	0.281
LIG_TYR_ITAM	211	228	PF00017	0.408
LIG_WRC_WIRS_1	206	211	PF05994	0.458
LIG_WRC_WIRS_1	56	61	PF05994	0.295
LIG_WRC_WIRS_1	590	595	PF05994	0.455
MOD_CDK_SPxxK_3	415	422	PF00069	0.505
MOD_CK1_1	196	202	PF00069	0.305
MOD_CK1_1	2	8	PF00069	0.544
MOD_CK1_1	216	222	PF00069	0.346
MOD_CK1_1	311	317	PF00069	0.706
MOD_CK1_1	404	410	PF00069	0.339
MOD_CK1_1	439	445	PF00069	0.580
MOD_CK2_1	147	153	PF00069	0.612
MOD_CK2_1	205	211	PF00069	0.522
MOD_CK2_1	25	31	PF00069	0.411
MOD_CK2_1	313	319	PF00069	0.753
MOD_CK2_1	415	421	PF00069	0.494
MOD_CK2_1	460	466	PF00069	0.307
MOD_CK2_1	574	580	PF00069	0.622
MOD_CK2_1	670	676	PF00069	0.546
MOD_GlcNHglycan	124	127	PF01048	0.746
MOD_GlcNHglycan	139	143	PF01048	0.673
MOD_GlcNHglycan	184	187	PF01048	0.587
MOD_GlcNHglycan	235	238	PF01048	0.678
MOD_GlcNHglycan	298	301	PF01048	0.720
MOD_GlcNHglycan	308	311	PF01048	0.626
MOD_GlcNHglycan	384	387	PF01048	0.421
MOD_GlcNHglycan	438	441	PF01048	0.653
MOD_GlcNHglycan	492	495	PF01048	0.484
MOD_GlcNHglycan	513	516	PF01048	0.614
MOD_GlcNHglycan	560	563	PF01048	0.427
MOD_GSK3_1	117	124	PF00069	0.499
MOD_GSK3_1	134	141	PF00069	0.679
MOD_GSK3_1	147	154	PF00069	0.730
MOD_GSK3_1	260	267	PF00069	0.459
MOD_GSK3_1	283	290	PF00069	0.653
MOD_GSK3_1	296	303	PF00069	0.733
MOD_GSK3_1	306	313	PF00069	0.629
MOD_GSK3_1	401	408	PF00069	0.442
MOD_GSK3_1	490	497	PF00069	0.544
MOD_GSK3_1	589	596	PF00069	0.431
MOD_GSK3_1	638	645	PF00069	0.384
MOD_N-GLC_1	409	414	PF02516	0.499
MOD_N-GLC_1	668	673	PF02516	0.563
MOD_NEK2_1	121	126	PF00069	0.442
MOD_NEK2_1	151	156	PF00069	0.574
MOD_NEK2_1	282	287	PF00069	0.547
MOD_NEK2_1	291	296	PF00069	0.480
MOD_NEK2_1	401	406	PF00069	0.376
MOD_NEK2_1	593	598	PF00069	0.416
MOD_NEK2_2	389	394	PF00069	0.339
MOD_NEK2_2	55	60	PF00069	0.184
MOD_PIKK_1	151	157	PF00454	0.469
MOD_PIKK_1	300	306	PF00454	0.714
MOD_PIKK_1	401	407	PF00454	0.385
MOD_PIKK_1	494	500	PF00454	0.595
MOD_PKA_2	306	312	PF00069	0.504
MOD_PKA_2	347	353	PF00069	0.478
MOD_PKA_2	526	532	PF00069	0.723
MOD_PKA_2	619	625	PF00069	0.351
MOD_Plk_1	117	123	PF00069	0.448
MOD_Plk_1	131	137	PF00069	0.558
MOD_Plk_1	258	264	PF00069	0.620
MOD_Plk_1	358	364	PF00069	0.449
MOD_Plk_1	389	395	PF00069	0.507
MOD_Plk_2-3	205	211	PF00069	0.496
MOD_Plk_4	131	137	PF00069	0.518
MOD_Plk_4	196	202	PF00069	0.305
MOD_Plk_4	205	211	PF00069	0.350
MOD_Plk_4	460	466	PF00069	0.336
MOD_Plk_4	529	535	PF00069	0.770
MOD_Plk_4	566	572	PF00069	0.479
MOD_Plk_4	589	595	PF00069	0.425
MOD_Plk_4	621	627	PF00069	0.370
MOD_Plk_4	638	644	PF00069	0.431
MOD_Plk_4	670	676	PF00069	0.412
MOD_ProDKin_1	285	291	PF00069	0.591
MOD_ProDKin_1	313	319	PF00069	0.732
MOD_ProDKin_1	415	421	PF00069	0.509
MOD_ProDKin_1	46	52	PF00069	0.411
MOD_SUMO_for_1	178	181	PF00179	0.630
MOD_SUMO_rev_2	236	242	PF00179	0.509
TRG_DiLeu_BaEn_4	272	278	PF01217	0.483
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.360
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.440
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.700
TRG_ENDOCYTIC_2	214	217	PF00928	0.370
TRG_ENDOCYTIC_2	225	228	PF00928	0.364
TRG_ENDOCYTIC_2	484	487	PF00928	0.378
TRG_ENDOCYTIC_2	67	70	PF00928	0.281
TRG_ENDOCYTIC_2	85	88	PF00928	0.281
TRG_ER_diArg_1	242	245	PF00400	0.522
TRG_ER_diArg_1	295	297	PF00400	0.606
TRG_ER_diArg_1	356	358	PF00400	0.425
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCH8	Leptomonas seymouri	66%	100%
A0A0S4IV50	Bodo saltans	32%	100%
A0A1X0NS55	Trypanosomatidae	37%	100%
A0A3R7REE6	Trypanosoma rangeli	34%	100%
A0A3S7X1Y8	Leishmania donovani	83%	100%
A4I3X5	Leishmania infantum	83%	100%
D0A943	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B065	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q820	Leishmania major	83%	100%
V5BC43	Trypanosoma cruzi	34%	100%