Vacuolar proton pump subunit B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar proton pump subunit B, putative

Species:

Leishmania braziliensis

UniProt:

A4HGU6_LEIBR

TriTrypDb:

LbrM.28.2630 , LBRM2903_280033000

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain	5	1
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0020022	acidocalcisome	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	11
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	11
GO:0033180	proton-transporting V-type ATPase, V1 domain	4	11
GO:0043226	organelle	2	1

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Expansion

Sequence features

A4HGU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGU6

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	8
GO:0005215	transporter activity	1	11
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015078	proton transmembrane transporter activity	5	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.352
CLV_C14_Caspase3-7	64	68	PF00656	0.368
CLV_NRD_NRD_1	304	306	PF00675	0.352
CLV_NRD_NRD_1	395	397	PF00675	0.455
CLV_NRD_NRD_1	493	495	PF00675	0.655
CLV_NRD_NRD_1	71	73	PF00675	0.277
CLV_PCSK_KEX2_1	203	205	PF00082	0.437
CLV_PCSK_KEX2_1	304	306	PF00082	0.352
CLV_PCSK_KEX2_1	71	73	PF00082	0.369
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.473

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P244	Leptomonas seymouri	27%	95%
A0A0N0P3A9	Leptomonas seymouri	95%	100%
A0A0N1PBM9	Leptomonas seymouri	26%	92%
A0A0S4IQH6	Bodo saltans	28%	90%
A0A0S4IUP5	Bodo saltans	88%	100%
A0A0S4JQS7	Bodo saltans	25%	85%
A0A1X0NJW9	Trypanosomatidae	25%	84%
A0A1X0NM27	Trypanosomatidae	27%	95%
A0A1X0NSC6	Trypanosomatidae	91%	100%
A0A381MM20	Leishmania infantum	27%	94%

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