Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGU5_LEIBR

TriTrypDb:

LbrM.28.2620 , LBRM2903_280032900

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0032991	protein-containing complex	1	2
GO:0045239	tricarboxylic acid cycle enzyme complex	3	2
GO:0045240	dihydrolipoyl dehydrogenase complex	4	2
GO:0045252	oxoglutarate dehydrogenase complex	4	2
GO:1902494	catalytic complex	2	2
GO:1990204	oxidoreductase complex	3	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

A4HGU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGU5

Function

Biological processes
Term	Name	Level	Count
GO:0006099	tricarboxylic acid cycle	3	3
GO:0008152	metabolic process	1	3
GO:0044238	primary metabolic process	2	3
GO:0006082	organic acid metabolic process	3	2
GO:0006084	acetyl-CoA metabolic process	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006520	amino acid metabolic process	3	2
GO:0006553	lysine metabolic process	6	2
GO:0006554	lysine catabolic process	5	2
GO:0006637	acyl-CoA metabolic process	4	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006790	sulfur compound metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0009056	catabolic process	2	2
GO:0009063	amino acid catabolic process	4	2
GO:0009066	aspartate family amino acid metabolic process	5	2
GO:0009068	aspartate family amino acid catabolic process	6	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009150	purine ribonucleotide metabolic process	6	2
GO:0009259	ribonucleotide metabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016054	organic acid catabolic process	4	2
GO:0019474	L-lysine catabolic process to acetyl-CoA	4	2
GO:0019477	L-lysine catabolic process	6	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019693	ribose phosphate metabolic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine	5	2
GO:0033865	nucleoside bisphosphate metabolic process	5	2
GO:0033875	ribonucleoside bisphosphate metabolic process	6	2
GO:0034032	purine nucleoside bisphosphate metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0035383	thioester metabolic process	3	2
GO:0043436	oxoacid metabolic process	4	2
GO:0043603	amide metabolic process	3	2
GO:0043605	amide catabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0046440	L-lysine metabolic process	7	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1901606	alpha-amino acid catabolic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0004149	dihydrolipoyllysine-residue succinyltransferase activity	3	3
GO:0016417	S-acyltransferase activity	5	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3
GO:0016748	succinyltransferase activity	5	3
GO:0016751	S-succinyltransferase activity	6	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.344
CLV_NRD_NRD_1	171	173	PF00675	0.381
CLV_NRD_NRD_1	3	5	PF00675	0.593
CLV_PCSK_KEX2_1	170	172	PF00082	0.381
CLV_PCSK_KEX2_1	211	213	PF00082	0.384
CLV_PCSK_KEX2_1	3	5	PF00082	0.593
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.384
CLV_PCSK_SKI1_1	385	389	PF00082	0.305
DEG_Nend_Nbox_1	1	3	PF02207	0.564
DOC_CKS1_1	258	263	PF01111	0.323
DOC_CKS1_1	318	323	PF01111	0.305
DOC_MAPK_gen_1	211	219	PF00069	0.305
DOC_MAPK_gen_1	348	357	PF00069	0.349
DOC_MAPK_MEF2A_6	211	219	PF00069	0.305
DOC_MAPK_MEF2A_6	23	30	PF00069	0.448
DOC_MAPK_MEF2A_6	348	357	PF00069	0.308
DOC_PP1_RVXF_1	39	46	PF00149	0.305
DOC_PP1_RVXF_1	79	85	PF00149	0.323
DOC_PP2B_LxvP_1	264	267	PF13499	0.305
DOC_USP7_MATH_1	103	107	PF00917	0.658
DOC_USP7_MATH_1	114	118	PF00917	0.583
DOC_USP7_MATH_1	12	16	PF00917	0.465
DOC_WW_Pin1_4	193	198	PF00397	0.314
DOC_WW_Pin1_4	218	223	PF00397	0.309
DOC_WW_Pin1_4	257	262	PF00397	0.323
DOC_WW_Pin1_4	317	322	PF00397	0.305
LIG_14-3-3_CanoR_1	160	165	PF00244	0.320
LIG_14-3-3_CanoR_1	176	186	PF00244	0.274
LIG_14-3-3_CanoR_1	3	11	PF00244	0.595
LIG_Actin_WH2_2	162	180	PF00022	0.436
LIG_BRCT_BRCA1_1	20	24	PF00533	0.629
LIG_FHA_1	141	147	PF00498	0.493
LIG_FHA_1	159	165	PF00498	0.337
LIG_FHA_1	194	200	PF00498	0.227
LIG_FHA_1	303	309	PF00498	0.331
LIG_FHA_1	318	324	PF00498	0.383
LIG_FHA_1	369	375	PF00498	0.316
LIG_FHA_1	37	43	PF00498	0.317
LIG_FHA_1	44	50	PF00498	0.306
LIG_FHA_1	5	11	PF00498	0.703
LIG_FHA_2	187	193	PF00498	0.305
LIG_FHA_2	295	301	PF00498	0.323
LIG_FHA_2	30	36	PF00498	0.305
LIG_FHA_2	96	102	PF00498	0.499
LIG_LIR_Gen_1	188	198	PF02991	0.305
LIG_LIR_Gen_1	245	256	PF02991	0.313
LIG_LIR_Nem_3	188	193	PF02991	0.305
LIG_LIR_Nem_3	245	251	PF02991	0.310
LIG_LRP6_Inhibitor_1	342	348	PF00058	0.349
LIG_PTB_Apo_2	235	242	PF02174	0.323
LIG_SH2_STAP1	287	291	PF00017	0.436
LIG_SH2_STAP1	359	363	PF00017	0.305
LIG_SH3_3	143	149	PF00018	0.612
LIG_SH3_3	255	261	PF00018	0.305
LIG_SH3_3	68	74	PF00018	0.305
LIG_SUMO_SIM_par_1	386	391	PF11976	0.491
LIG_UBA3_1	198	206	PF00899	0.305
LIG_UBA3_1	330	338	PF00899	0.305
LIG_WRC_WIRS_1	187	192	PF05994	0.305
MOD_CDK_SPK_2	257	262	PF00069	0.305
MOD_CDK_SPxxK_3	218	225	PF00069	0.305
MOD_CK1_1	180	186	PF00069	0.305
MOD_CK1_1	36	42	PF00069	0.305
MOD_CK2_1	186	192	PF00069	0.305
MOD_CK2_1	29	35	PF00069	0.305
MOD_CK2_1	294	300	PF00069	0.323
MOD_CK2_1	95	101	PF00069	0.499
MOD_GlcNHglycan	105	108	PF01048	0.669
MOD_GlcNHglycan	14	17	PF01048	0.677
MOD_GlcNHglycan	226	229	PF01048	0.445
MOD_GlcNHglycan	327	330	PF01048	0.306
MOD_GSK3_1	160	167	PF00069	0.364
MOD_GSK3_1	29	36	PF00069	0.332
MOD_GSK3_1	302	309	PF00069	0.319
MOD_GSK3_1	313	320	PF00069	0.306
MOD_GSK3_1	364	371	PF00069	0.371
MOD_N-GLC_1	18	23	PF02516	0.642
MOD_N-GLC_1	237	242	PF02516	0.305
MOD_N-GLC_1	43	48	PF02516	0.346
MOD_N-GLC_2	182	184	PF02516	0.323
MOD_NEK2_1	177	182	PF00069	0.305
MOD_NEK2_1	186	191	PF00069	0.338
MOD_NEK2_1	306	311	PF00069	0.305
MOD_PIKK_1	177	183	PF00454	0.341
MOD_PK_1	160	166	PF00069	0.349
MOD_PKA_1	3	9	PF00069	0.595
MOD_PKA_2	164	170	PF00069	0.305
MOD_PKA_2	3	9	PF00069	0.595
MOD_Plk_1	18	24	PF00069	0.636
MOD_Plk_1	237	243	PF00069	0.305
MOD_Plk_1	94	100	PF00069	0.295
MOD_Plk_2-3	95	101	PF00069	0.525
MOD_Plk_4	313	319	PF00069	0.305
MOD_Plk_4	368	374	PF00069	0.336
MOD_ProDKin_1	193	199	PF00069	0.314
MOD_ProDKin_1	218	224	PF00069	0.309
MOD_ProDKin_1	257	263	PF00069	0.323
MOD_ProDKin_1	317	323	PF00069	0.305
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.227
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.344
TRG_ENDOCYTIC_2	248	251	PF00928	0.327
TRG_ER_diArg_1	169	172	PF00400	0.335
TRG_ER_diArg_1	2	4	PF00400	0.599
TRG_ER_diArg_1	290	293	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSX4	Leptomonas seymouri	83%	100%
A0A0S4IY01	Bodo saltans	67%	100%
A0A0S4JS90	Bodo saltans	26%	87%
A0A1X0NQZ2	Trypanosomatidae	72%	100%
A0A1X0P2L7	Trypanosomatidae	27%	78%
A0A3Q8IGX8	Leishmania donovani	90%	100%
A0A3R7MEC2	Trypanosoma rangeli	69%	100%
A4I3X3	Leishmania infantum	89%	100%
C9ZPW7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	89%
D0A3J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	87%
D0A940	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AG63	Leishmania infantum	29%	82%
E9B063	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
G0S4X6	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	28%	85%
O06159	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	99%
O31550	Bacillus subtilis (strain 168)	32%	98%
O94681	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	87%
P09062	Pseudomonas putida	30%	92%
P0AFG6	Escherichia coli (strain K12)	41%	97%
P0AFG7	Escherichia coli O157:H7	41%	97%
P11179	Bos taurus	47%	86%
P11181	Bos taurus	28%	81%
P16263	Bacillus subtilis (strain 168)	39%	94%
P19262	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	84%
P20285	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	85%
P20708	Azotobacter vinelandii	45%	98%
P35489	Acholeplasma laidlawii	32%	72%
P36957	Homo sapiens	49%	86%
P37942	Bacillus subtilis (strain 168)	30%	92%
P45302	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	41%	96%
P47514	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	27%	100%
P65635	Staphylococcus aureus (strain Mu50 / ATCC 700699)	30%	91%
P65636	Staphylococcus aureus (strain N315)	30%	91%
Q01205	Rattus norvegicus	47%	86%
Q19749	Caenorhabditis elegans	31%	77%
Q1RHI5	Rickettsia bellii (strain RML369-C)	45%	98%
Q1RJT3	Rickettsia bellii (strain RML369-C)	30%	94%
Q23571	Caenorhabditis elegans	25%	87%
Q2FH26	Staphylococcus aureus (strain USA300)	36%	93%
Q2FYM2	Staphylococcus aureus (strain NCTC 8325 / PS 47)	36%	93%
Q2YY06	Staphylococcus aureus (strain bovine RF122 / ET3-1)	37%	93%
Q49110	Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)	34%	89%
Q49XM4	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	36%	92%
Q4L6C3	Staphylococcus haemolyticus (strain JCSC1435)	36%	92%
Q4Q822	Leishmania major	89%	98%
Q4UKI7	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	42%	98%
Q4ULG1	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	30%	95%
Q59821	Staphylococcus aureus	30%	91%
Q5HG07	Staphylococcus aureus (strain COL)	36%	93%
Q5HGY9	Staphylococcus aureus (strain COL)	30%	91%
Q5HPC7	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	37%	93%
Q5M729	Arabidopsis thaliana	29%	73%
Q68WK6	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	30%	97%
Q68XI8	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	42%	98%
Q6FYD4	Bartonella quintana (strain Toulouse)	42%	95%
Q6G9E9	Staphylococcus aureus (strain MSSA476)	36%	93%
Q6GAB9	Staphylococcus aureus (strain MSSA476)	30%	91%
Q6GGZ6	Staphylococcus aureus (strain MRSA252)	36%	92%
Q6GHZ0	Staphylococcus aureus (strain MRSA252)	30%	91%
Q7A5N4	Staphylococcus aureus (strain N315)	37%	93%
Q869Y7	Dictyostelium discoideum	50%	89%
Q8BKZ9	Mus musculus	29%	78%
Q8CSL9	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	37%	93%
Q8GCY1	Bartonella vinsonii subsp. berkhoffii	42%	95%
Q8H107	Arabidopsis thaliana	46%	84%
Q8K9N2	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	36%	99%
Q8K9T8	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	25%	97%
Q8NWR7	Staphylococcus aureus (strain MW2)	36%	93%
Q8NX76	Staphylococcus aureus (strain MW2)	30%	91%
Q90512	Takifugu rubripes	49%	96%
Q92HK7	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	30%	95%
Q92J43	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	44%	99%
Q99U75	Staphylococcus aureus (strain Mu50 / ATCC 700699)	37%	93%
Q9D2G2	Mus musculus	47%	86%
Q9FLQ4	Arabidopsis thaliana	48%	84%
Q9I1M0	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	29%	91%
Q9I3D2	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	42%	96%
Q9M7Z1	Arabidopsis thaliana	24%	81%
Q9N0F1	Sus scrofa	48%	86%
Q9ZD20	Rickettsia prowazekii (strain Madrid E)	30%	96%
Q9ZDY4	Rickettsia prowazekii (strain Madrid E)	42%	98%
V5BJF4	Trypanosoma cruzi	27%	89%