Serine hydroxymethyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine hydroxymethyltransferase (SHMT-L)

Species:

Leishmania braziliensis

UniProt:

A4HGU0_LEIBR

TriTrypDb:

LbrM.28.2560 , LBRM2903_280032300

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4HGU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGU0

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006544	glycine metabolic process	6	13
GO:0006545	glycine biosynthetic process	7	13
GO:0006563	L-serine metabolic process	6	13
GO:0006565	L-serine catabolic process	5	2
GO:0006575	cellular modified amino acid metabolic process	3	13
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006730	one-carbon metabolic process	3	13
GO:0006760	folic acid-containing compound metabolic process	4	13

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004372	glycine hydroxymethyltransferase activity	5	13
GO:0005488	binding	1	13
GO:0008168	methyltransferase activity	4	9
GO:0008270	zinc ion binding	6	2
GO:0016597	amino acid binding	4	2
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	4	13
GO:0019842	vitamin binding	3	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.186
CLV_NRD_NRD_1	26	28	PF00675	0.233
CLV_NRD_NRD_1	31	33	PF00675	0.235
CLV_NRD_NRD_1	87	89	PF00675	0.303
CLV_PCSK_KEX2_1	147	149	PF00082	0.238
CLV_PCSK_KEX2_1	200	202	PF00082	0.236
CLV_PCSK_KEX2_1	258	260	PF00082	0.324
CLV_PCSK_KEX2_1	31	33	PF00082	0.256
CLV_PCSK_KEX2_1	86	88	PF00082	0.301
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.303

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSI5	Leptomonas seymouri	60%	100%
A0A0N1I2Y4	Leptomonas seymouri	81%	97%
A0A0S4IKW4	Bodo saltans	58%	87%
A0A0S4IVF6	Bodo saltans	71%	99%
A0A0S4JPH2	Bodo saltans	58%	100%
A0A1X0NNF7	Trypanosomatidae	57%	100%
A0A1X0NSD5	Trypanosomatidae	70%	99%
A0A3Q8IA22	Leishmania donovani	60%	100%
A0A3Q8IF07	Leishmania donovani	86%	98%
A0ALM4	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	47%	100%

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