Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGT8_LEIBR

TriTrypDb:

LbrM.28.2540 , LBRM2903_280032100

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGT8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.519
CLV_NRD_NRD_1	38	40	PF00675	0.518
CLV_NRD_NRD_1	67	69	PF00675	0.643
CLV_PCSK_FUR_1	39	43	PF00082	0.542
CLV_PCSK_KEX2_1	132	134	PF00082	0.575
CLV_PCSK_KEX2_1	41	43	PF00082	0.539
CLV_PCSK_KEX2_1	67	69	PF00082	0.643
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.677
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.530
CLV_PCSK_PC7_1	63	69	PF00082	0.411
CLV_PCSK_SKI1_1	133	137	PF00082	0.554
CLV_PCSK_SKI1_1	153	157	PF00082	0.501
CLV_PCSK_SKI1_1	96	100	PF00082	0.501
DEG_APCC_DBOX_1	27	35	PF00400	0.564
DEG_Nend_Nbox_1	1	3	PF02207	0.677
DEG_SPOP_SBC_1	272	276	PF00917	0.527
DOC_MAPK_DCC_7	3	11	PF00069	0.703
DOC_MAPK_MEF2A_6	3	11	PF00069	0.670
DOC_PP1_RVXF_1	78	84	PF00149	0.681
DOC_PP4_FxxP_1	4	7	PF00568	0.662
DOC_PP4_FxxP_1	83	86	PF00568	0.571
DOC_SPAK_OSR1_1	3	7	PF12202	0.707
DOC_USP7_MATH_1	243	247	PF00917	0.666
DOC_USP7_UBL2_3	132	136	PF12436	0.649
DOC_USP7_UBL2_3	37	41	PF12436	0.532
DOC_WW_Pin1_4	180	185	PF00397	0.649
DOC_WW_Pin1_4	22	27	PF00397	0.531
DOC_WW_Pin1_4	233	238	PF00397	0.635
DOC_WW_Pin1_4	250	255	PF00397	0.636
LIG_14-3-3_CanoR_1	113	117	PF00244	0.555
LIG_14-3-3_CanoR_1	133	139	PF00244	0.287
LIG_14-3-3_CanoR_1	257	261	PF00244	0.742
LIG_14-3-3_CanoR_1	3	7	PF00244	0.624
LIG_APCC_ABBAyCdc20_2	172	178	PF00400	0.622
LIG_BRCT_BRCA1_1	252	256	PF00533	0.488
LIG_CSL_BTD_1	181	184	PF09270	0.648
LIG_FHA_1	120	126	PF00498	0.574
LIG_FHA_1	257	263	PF00498	0.743
LIG_FHA_1	274	280	PF00498	0.716
LIG_FHA_1	30	36	PF00498	0.547
LIG_FHA_1	68	74	PF00498	0.501
LIG_Integrin_RGD_1	192	194	PF01839	0.659
LIG_LIR_Apic_2	178	184	PF02991	0.642
LIG_LIR_Apic_2	82	86	PF02991	0.444
LIG_LIR_Nem_3	183	188	PF02991	0.540
LIG_LIR_Nem_3	48	53	PF02991	0.612
LIG_LYPXL_yS_3	185	188	PF13949	0.403
LIG_Pex14_1	150	154	PF04695	0.468
LIG_Pex14_1	181	185	PF04695	0.399
LIG_Pex14_2	131	135	PF04695	0.588
LIG_SH2_CRK	105	109	PF00017	0.633
LIG_SH2_NCK_1	105	109	PF00017	0.546
LIG_SH2_PTP2	154	157	PF00017	0.448
LIG_SH2_STAP1	176	180	PF00017	0.534
LIG_SH2_STAT5	154	157	PF00017	0.448
LIG_SH2_STAT5	45	48	PF00017	0.543
LIG_SH2_STAT5	72	75	PF00017	0.550
LIG_SH3_3	211	217	PF00018	0.566
LIG_SH3_3	259	265	PF00018	0.644
LIG_SH3_3	279	285	PF00018	0.517
LIG_SUMO_SIM_par_1	32	38	PF11976	0.556
LIG_TYR_ITIM	152	157	PF00017	0.454
LIG_UBA3_1	156	162	PF00899	0.509
LIG_UBA3_1	33	41	PF00899	0.536
MOD_CDK_SPK_2	233	238	PF00069	0.525
MOD_CDK_SPxK_1	22	28	PF00069	0.531
MOD_CDK_SPxxK_3	250	257	PF00069	0.489
MOD_CK1_1	119	125	PF00069	0.554
MOD_CK1_1	223	229	PF00069	0.639
MOD_CK1_1	232	238	PF00069	0.643
MOD_CK2_1	76	82	PF00069	0.398
MOD_GlcNHglycan	226	229	PF01048	0.670
MOD_GlcNHglycan	231	234	PF01048	0.661
MOD_GlcNHglycan	238	241	PF01048	0.640
MOD_GlcNHglycan	250	253	PF01048	0.704
MOD_GSK3_1	112	119	PF00069	0.480
MOD_GSK3_1	120	127	PF00069	0.411
MOD_GSK3_1	220	227	PF00069	0.746
MOD_GSK3_1	229	236	PF00069	0.745
MOD_N-GLC_1	109	114	PF02516	0.571
MOD_N-GLC_1	272	277	PF02516	0.657
MOD_NEK2_1	120	125	PF00069	0.430
MOD_NEK2_1	2	7	PF00069	0.677
MOD_NEK2_1	220	225	PF00069	0.700
MOD_NEK2_1	256	261	PF00069	0.688
MOD_NEK2_1	29	34	PF00069	0.556
MOD_PIKK_1	45	51	PF00454	0.644
MOD_PKA_1	161	167	PF00069	0.550
MOD_PKA_1	67	73	PF00069	0.608
MOD_PKA_2	112	118	PF00069	0.553
MOD_PKA_2	2	8	PF00069	0.666
MOD_PKA_2	256	262	PF00069	0.713
MOD_PKA_2	67	73	PF00069	0.608
MOD_Plk_1	109	115	PF00069	0.591
MOD_Plk_1	116	122	PF00069	0.526
MOD_Plk_1	29	35	PF00069	0.562
MOD_Plk_4	161	167	PF00069	0.564
MOD_Plk_4	256	262	PF00069	0.491
MOD_Plk_4	29	35	PF00069	0.548
MOD_ProDKin_1	180	186	PF00069	0.649
MOD_ProDKin_1	22	28	PF00069	0.531
MOD_ProDKin_1	233	239	PF00069	0.634
MOD_ProDKin_1	250	256	PF00069	0.487
MOD_SUMO_for_1	139	142	PF00179	0.596
TRG_ENDOCYTIC_2	105	108	PF00928	0.669
TRG_ENDOCYTIC_2	154	157	PF00928	0.448
TRG_ENDOCYTIC_2	185	188	PF00928	0.539
TRG_ER_diArg_1	42	45	PF00400	0.563
TRG_ER_diArg_1	66	68	PF00400	0.671
TRG_NLS_MonoExtC_3	39	44	PF00514	0.522
TRG_NLS_MonoExtN_4	37	44	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ2	Leptomonas seymouri	57%	100%
A0A0S4IRF0	Bodo saltans	45%	100%
A0A1X0NQP5	Trypanosomatidae	46%	100%
A0A3Q8IB55	Leishmania donovani	80%	100%
A4I3W5	Leishmania infantum	80%	100%
D0A933	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B055	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q830	Leishmania major	80%	100%
V5D5Q3	Trypanosoma cruzi	49%	90%