CactinC_cactus domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cactus-binding C-terminus of cactin protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGT7_LEIBR

TriTrypDb:

LbrM.28.2530 , LBRM2903_280032000

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005681	spliceosomal complex	3	1
GO:0005737	cytoplasm	2	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HGT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGT7

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045292	mRNA cis splicing, via spliceosome	9	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.722
CLV_C14_Caspase3-7	277	281	PF00656	0.494
CLV_C14_Caspase3-7	294	298	PF00656	0.495
CLV_C14_Caspase3-7	406	410	PF00656	0.702
CLV_C14_Caspase3-7	721	725	PF00656	0.384
CLV_NRD_NRD_1	11	13	PF00675	0.532
CLV_NRD_NRD_1	384	386	PF00675	0.651
CLV_NRD_NRD_1	68	70	PF00675	0.553
CLV_NRD_NRD_1	748	750	PF00675	0.244
CLV_NRD_NRD_1	756	758	PF00675	0.238
CLV_NRD_NRD_1	99	101	PF00675	0.629
CLV_PCSK_KEX2_1	11	13	PF00082	0.526
CLV_PCSK_KEX2_1	66	68	PF00082	0.596
CLV_PCSK_KEX2_1	710	712	PF00082	0.255
CLV_PCSK_KEX2_1	756	758	PF00082	0.336
CLV_PCSK_KEX2_1	97	99	PF00082	0.540
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.598
CLV_PCSK_PC1ET2_1	710	712	PF00082	0.255
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.540
CLV_PCSK_PC7_1	93	99	PF00082	0.623
CLV_PCSK_SKI1_1	11	15	PF00082	0.440
CLV_PCSK_SKI1_1	151	155	PF00082	0.521
CLV_PCSK_SKI1_1	237	241	PF00082	0.351
CLV_PCSK_SKI1_1	352	356	PF00082	0.610
CLV_PCSK_SKI1_1	714	718	PF00082	0.336
CLV_PCSK_SKI1_1	771	775	PF00082	0.242
DEG_APCC_DBOX_1	10	18	PF00400	0.437
DEG_APCC_DBOX_1	351	359	PF00400	0.613
DEG_SPOP_SBC_1	140	144	PF00917	0.615
DEG_SPOP_SBC_1	186	190	PF00917	0.495
DEG_SPOP_SBC_1	472	476	PF00917	0.714
DOC_CKS1_1	57	62	PF01111	0.447
DOC_CYCLIN_yClb5_NLxxxL_5	549	558	PF00134	0.577
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	701	707	PF00134	0.442
DOC_MAPK_FxFP_2	51	54	PF00069	0.436
DOC_MAPK_gen_1	151	161	PF00069	0.480
DOC_MAPK_gen_1	349	358	PF00069	0.562
DOC_MAPK_gen_1	756	764	PF00069	0.536
DOC_MAPK_MEF2A_6	151	160	PF00069	0.483
DOC_MAPK_MEF2A_6	349	358	PF00069	0.615
DOC_MAPK_MEF2A_6	756	764	PF00069	0.536
DOC_PP1_RVXF_1	759	765	PF00149	0.473
DOC_PP1_RVXF_1	769	775	PF00149	0.411
DOC_PP2B_LxvP_1	194	197	PF13499	0.342
DOC_PP2B_LxvP_1	34	37	PF13499	0.423
DOC_PP2B_LxvP_1	576	579	PF13499	0.611
DOC_PP4_FxxP_1	344	347	PF00568	0.621
DOC_PP4_FxxP_1	40	43	PF00568	0.455
DOC_PP4_FxxP_1	51	54	PF00568	0.422
DOC_USP7_MATH_1	140	144	PF00917	0.591
DOC_USP7_MATH_1	488	492	PF00917	0.748
DOC_USP7_MATH_1	633	637	PF00917	0.674
DOC_USP7_UBL2_3	404	408	PF12436	0.594
DOC_WW_Pin1_4	280	285	PF00397	0.508
DOC_WW_Pin1_4	300	305	PF00397	0.740
DOC_WW_Pin1_4	393	398	PF00397	0.516
DOC_WW_Pin1_4	42	47	PF00397	0.485
DOC_WW_Pin1_4	489	494	PF00397	0.547
DOC_WW_Pin1_4	540	545	PF00397	0.492
DOC_WW_Pin1_4	56	61	PF00397	0.492
DOC_WW_Pin1_4	719	724	PF00397	0.496
LIG_14-3-3_CanoR_1	115	122	PF00244	0.455
LIG_14-3-3_CanoR_1	326	331	PF00244	0.292
LIG_14-3-3_CanoR_1	500	506	PF00244	0.531
LIG_14-3-3_CanoR_1	761	765	PF00244	0.442
LIG_14-3-3_CanoR_1	79	89	PF00244	0.497
LIG_BRCT_BRCA1_1	18	22	PF00533	0.431
LIG_CtBP_PxDLS_1	544	548	PF00389	0.531
LIG_deltaCOP1_diTrp_1	322	330	PF00928	0.466
LIG_deltaCOP1_diTrp_1	694	702	PF00928	0.536
LIG_eIF4E_1	25	31	PF01652	0.417
LIG_eIF4E_1	350	356	PF01652	0.608
LIG_eIF4E_1	454	460	PF01652	0.627
LIG_eIF4E_1	767	773	PF01652	0.496
LIG_EVH1_2	36	40	PF00568	0.424
LIG_EVH1_2	43	47	PF00568	0.405
LIG_FHA_1	186	192	PF00498	0.435
LIG_FHA_1	371	377	PF00498	0.630
LIG_FHA_1	439	445	PF00498	0.624
LIG_FHA_1	474	480	PF00498	0.698
LIG_FHA_1	59	65	PF00498	0.462
LIG_FHA_2	217	223	PF00498	0.508
LIG_FHA_2	224	230	PF00498	0.496
LIG_FHA_2	248	254	PF00498	0.559
LIG_FHA_2	431	437	PF00498	0.669
LIG_FHA_2	541	547	PF00498	0.570
LIG_FHA_2	605	611	PF00498	0.491
LIG_FHA_2	679	685	PF00498	0.442
LIG_FHA_2	707	713	PF00498	0.442
LIG_FHA_2	85	91	PF00498	0.708
LIG_FHA_2	99	105	PF00498	0.525
LIG_Integrin_RGD_1	251	253	PF01839	0.587
LIG_LIR_Apic_2	23	28	PF02991	0.538
LIG_LIR_Apic_2	39	43	PF02991	0.450
LIG_LIR_Apic_2	88	94	PF02991	0.640
LIG_LIR_Gen_1	322	331	PF02991	0.414
LIG_LIR_Gen_1	45	55	PF02991	0.436
LIG_LIR_Gen_1	594	601	PF02991	0.535
LIG_LIR_Gen_1	698	707	PF02991	0.442
LIG_LIR_Gen_1	728	737	PF02991	0.442
LIG_LIR_Nem_3	19	25	PF02991	0.430
LIG_LIR_Nem_3	280	285	PF02991	0.722
LIG_LIR_Nem_3	322	327	PF02991	0.409
LIG_LIR_Nem_3	45	51	PF02991	0.435
LIG_LIR_Nem_3	514	520	PF02991	0.426
LIG_LIR_Nem_3	594	600	PF02991	0.538
LIG_LIR_Nem_3	674	678	PF02991	0.442
LIG_LIR_Nem_3	693	699	PF02991	0.442
LIG_LIR_Nem_3	700	706	PF02991	0.442
LIG_LIR_Nem_3	728	733	PF02991	0.442
LIG_LIR_Nem_3	763	767	PF02991	0.546
LIG_LYPXL_S_1	702	706	PF13949	0.242
LIG_LYPXL_yS_3	703	706	PF13949	0.442
LIG_MLH1_MIPbox_1	22	26	PF16413	0.426
LIG_NRBOX	109	115	PF00104	0.502
LIG_NRBOX	353	359	PF00104	0.483
LIG_NRP_CendR_1	782	783	PF00754	0.242
LIG_Pex14_2	22	26	PF04695	0.426
LIG_Pex14_2	47	51	PF04695	0.439
LIG_PTB_Apo_2	775	782	PF02174	0.442
LIG_PTB_Phospho_1	775	781	PF10480	0.442
LIG_REV1ctd_RIR_1	771	779	PF16727	0.442
LIG_RPA_C_Fungi	518	530	PF08784	0.497
LIG_SH2_CRK	282	286	PF00017	0.674
LIG_SH2_CRK	517	521	PF00017	0.381
LIG_SH2_CRK	730	734	PF00017	0.279
LIG_SH2_NCK_1	741	745	PF00017	0.279
LIG_SH2_SRC	270	273	PF00017	0.610
LIG_SH2_SRC	293	296	PF00017	0.538
LIG_SH2_SRC	741	744	PF00017	0.279
LIG_SH2_STAP1	350	354	PF00017	0.474
LIG_SH2_STAP1	597	601	PF00017	0.476
LIG_SH2_STAP1	697	701	PF00017	0.279
LIG_SH2_STAP1	741	745	PF00017	0.279
LIG_SH2_STAT5	167	170	PF00017	0.341
LIG_SH2_STAT5	25	28	PF00017	0.462
LIG_SH2_STAT5	265	268	PF00017	0.522
LIG_SH2_STAT5	590	593	PF00017	0.482
LIG_SH2_STAT5	623	626	PF00017	0.580
LIG_SH2_STAT5	730	733	PF00017	0.279
LIG_SH3_3	170	176	PF00018	0.315
LIG_SH3_3	298	304	PF00018	0.708
LIG_SH3_3	391	397	PF00018	0.519
LIG_SH3_3	40	46	PF00018	0.429
LIG_SH3_3	467	473	PF00018	0.655
LIG_SH3_3	487	493	PF00018	0.511
LIG_SH3_3	576	582	PF00018	0.608
LIG_SH3_3	624	630	PF00018	0.584
LIG_SH3_3	720	726	PF00018	0.349
LIG_SH3_3	734	740	PF00018	0.209
LIG_SUMO_SIM_anti_2	157	162	PF11976	0.446
LIG_SUMO_SIM_anti_2	353	359	PF11976	0.614
LIG_SUMO_SIM_par_1	462	467	PF11976	0.598
LIG_TRAF2_1	101	104	PF00917	0.586
LIG_TRAF2_1	286	289	PF00917	0.737
LIG_TYR_ITIM	701	706	PF00017	0.279
LIG_WRC_WIRS_1	327	332	PF05994	0.262
LIG_WW_1	347	350	PF00397	0.631
LIG_WW_3	346	350	PF00397	0.621
LIG_WW_3	689	693	PF00397	0.279
MOD_CK1_1	136	142	PF00069	0.686
MOD_CK1_1	213	219	PF00069	0.368
MOD_CK1_1	335	341	PF00069	0.437
MOD_CK1_1	372	378	PF00069	0.654
MOD_CK1_1	396	402	PF00069	0.758
MOD_CK1_1	407	413	PF00069	0.772
MOD_CK1_1	491	497	PF00069	0.664
MOD_CK1_1	540	546	PF00069	0.533
MOD_CK1_1	56	62	PF00069	0.446
MOD_CK1_1	631	637	PF00069	0.660
MOD_CK1_1	638	644	PF00069	0.692
MOD_CK1_1	83	89	PF00069	0.497
MOD_CK2_1	186	192	PF00069	0.506
MOD_CK2_1	223	229	PF00069	0.506
MOD_CK2_1	430	436	PF00069	0.798
MOD_CK2_1	540	546	PF00069	0.542
MOD_CK2_1	604	610	PF00069	0.490
MOD_CK2_1	98	104	PF00069	0.562
MOD_Cter_Amidation	95	98	PF01082	0.623
MOD_DYRK1A_RPxSP_1	300	304	PF00069	0.682
MOD_DYRK1A_RPxSP_1	42	46	PF00069	0.422
MOD_GlcNHglycan	143	146	PF01048	0.669
MOD_GlcNHglycan	18	21	PF01048	0.469
MOD_GlcNHglycan	22	25	PF01048	0.442
MOD_GlcNHglycan	337	340	PF01048	0.439
MOD_GlcNHglycan	381	384	PF01048	0.560
MOD_GlcNHglycan	398	401	PF01048	0.734
MOD_GlcNHglycan	456	459	PF01048	0.602
MOD_GlcNHglycan	484	487	PF01048	0.769
MOD_GlcNHglycan	494	497	PF01048	0.622
MOD_GlcNHglycan	501	504	PF01048	0.443
MOD_GlcNHglycan	539	542	PF01048	0.484
MOD_GlcNHglycan	572	575	PF01048	0.679
MOD_GlcNHglycan	630	633	PF01048	0.689
MOD_GlcNHglycan	650	653	PF01048	0.706
MOD_GlcNHglycan	94	97	PF01048	0.602
MOD_GSK3_1	1	8	PF00069	0.510
MOD_GSK3_1	136	143	PF00069	0.700
MOD_GSK3_1	16	23	PF00069	0.462
MOD_GSK3_1	198	205	PF00069	0.507
MOD_GSK3_1	326	333	PF00069	0.264
MOD_GSK3_1	392	399	PF00069	0.585
MOD_GSK3_1	430	437	PF00069	0.703
MOD_GSK3_1	438	445	PF00069	0.641
MOD_GSK3_1	471	478	PF00069	0.752
MOD_GSK3_1	488	495	PF00069	0.746
MOD_GSK3_1	631	638	PF00069	0.734
MOD_GSK3_1	678	685	PF00069	0.357
MOD_GSK3_1	80	87	PF00069	0.496
MOD_N-GLC_1	263	268	PF02516	0.494
MOD_N-GLC_1	434	439	PF02516	0.614
MOD_N-GLC_1	638	643	PF02516	0.704
MOD_N-GLC_1	678	683	PF02516	0.279
MOD_N-GLC_1	73	78	PF02516	0.512
MOD_NEK2_1	1	6	PF00069	0.437
MOD_NEK2_1	114	119	PF00069	0.382
MOD_NEK2_1	141	146	PF00069	0.657
MOD_NEK2_1	168	173	PF00069	0.420
MOD_NEK2_1	210	215	PF00069	0.392
MOD_NEK2_1	29	34	PF00069	0.495
MOD_NEK2_1	313	318	PF00069	0.391
MOD_NEK2_1	330	335	PF00069	0.394
MOD_NEK2_1	464	469	PF00069	0.581
MOD_NEK2_1	55	60	PF00069	0.440
MOD_NEK2_1	673	678	PF00069	0.410
MOD_NEK2_1	706	711	PF00069	0.279
MOD_NEK2_1	733	738	PF00069	0.279
MOD_NEK2_1	774	779	PF00069	0.338
MOD_NEK2_2	697	702	PF00069	0.279
MOD_PIKK_1	133	139	PF00454	0.599
MOD_PIKK_1	673	679	PF00454	0.279
MOD_PIKK_1	73	79	PF00454	0.513
MOD_PKA_1	98	104	PF00069	0.613
MOD_PKA_2	114	120	PF00069	0.378
MOD_PKA_2	499	505	PF00069	0.625
MOD_PKA_2	628	634	PF00069	0.578
MOD_PKA_2	760	766	PF00069	0.279
MOD_PKA_2	774	780	PF00069	0.279
MOD_PKA_2	81	87	PF00069	0.778
MOD_PKA_2	92	98	PF00069	0.704
MOD_Plk_1	168	174	PF00069	0.330
MOD_Plk_1	545	551	PF00069	0.543
MOD_Plk_1	678	684	PF00069	0.279
MOD_Plk_1	697	703	PF00069	0.279
MOD_Plk_4	210	216	PF00069	0.404
MOD_Plk_4	313	319	PF00069	0.365
MOD_Plk_4	326	332	PF00069	0.264
MOD_ProDKin_1	280	286	PF00069	0.508
MOD_ProDKin_1	300	306	PF00069	0.736
MOD_ProDKin_1	393	399	PF00069	0.518
MOD_ProDKin_1	42	48	PF00069	0.489
MOD_ProDKin_1	489	495	PF00069	0.547
MOD_ProDKin_1	540	546	PF00069	0.502
MOD_ProDKin_1	56	62	PF00069	0.495
MOD_ProDKin_1	719	725	PF00069	0.355
MOD_SUMO_for_1	411	414	PF00179	0.736
MOD_SUMO_rev_2	403	410	PF00179	0.654
TRG_DiLeu_BaEn_1	351	356	PF01217	0.557
TRG_DiLeu_BaEn_1	656	661	PF01217	0.201
TRG_DiLeu_BaEn_2	228	234	PF01217	0.477
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.316
TRG_ENDOCYTIC_2	282	285	PF00928	0.724
TRG_ENDOCYTIC_2	517	520	PF00928	0.395
TRG_ENDOCYTIC_2	521	524	PF00928	0.387
TRG_ENDOCYTIC_2	597	600	PF00928	0.482
TRG_ENDOCYTIC_2	703	706	PF00928	0.279
TRG_ENDOCYTIC_2	730	733	PF00928	0.279
TRG_ENDOCYTIC_2	741	744	PF00928	0.279
TRG_ENDOCYTIC_2	770	773	PF00928	0.279
TRG_ER_diArg_1	11	13	PF00400	0.519
TRG_ER_diArg_1	124	127	PF00400	0.413
TRG_ER_diArg_1	67	69	PF00400	0.545
TRG_ER_diArg_1	746	749	PF00400	0.410
TRG_ER_diArg_1	755	757	PF00400	0.410
TRG_ER_diArg_1	781	783	PF00400	0.279
TRG_ER_diArg_1	98	100	PF00400	0.649
TRG_NLS_MonoCore_2	96	101	PF00514	0.655
TRG_NLS_MonoExtC_3	748	754	PF00514	0.410
TRG_NLS_MonoExtC_3	96	102	PF00514	0.561
TRG_NLS_MonoExtN_4	747	753	PF00514	0.410
TRG_NLS_MonoExtN_4	94	101	PF00514	0.605
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	552	556	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P4	Leptomonas seymouri	63%	100%
A0A1X0NRC2	Trypanosomatidae	37%	100%
A0A3S7X1V8	Leishmania donovani	86%	100%
A0A422N9D9	Trypanosoma rangeli	38%	100%
A4I3W4	Leishmania infantum	86%	100%
D0A932	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B054	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q831	Leishmania major	78%	100%
V5APW4	Trypanosoma cruzi	38%	100%