Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGT6_LEIBR

TriTrypDb:

LbrM.28.2520 , LBRM2903_280031600

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.605
CLV_C14_Caspase3-7	571	575	PF00656	0.678
CLV_C14_Caspase3-7	669	673	PF00656	0.717
CLV_C14_Caspase3-7	844	848	PF00656	0.568
CLV_C14_Caspase3-7	861	865	PF00656	0.624
CLV_NRD_NRD_1	114	116	PF00675	0.699
CLV_NRD_NRD_1	149	151	PF00675	0.520
CLV_NRD_NRD_1	339	341	PF00675	0.745
CLV_NRD_NRD_1	37	39	PF00675	0.728
CLV_NRD_NRD_1	381	383	PF00675	0.756
CLV_NRD_NRD_1	415	417	PF00675	0.868
CLV_NRD_NRD_1	430	432	PF00675	0.622
CLV_NRD_NRD_1	467	469	PF00675	0.628
CLV_NRD_NRD_1	474	476	PF00675	0.583
CLV_NRD_NRD_1	617	619	PF00675	0.658
CLV_NRD_NRD_1	662	664	PF00675	0.666
CLV_NRD_NRD_1	9	11	PF00675	0.734
CLV_PCSK_FUR_1	147	151	PF00082	0.664
CLV_PCSK_FUR_1	379	383	PF00082	0.616
CLV_PCSK_FUR_1	465	469	PF00082	0.591
CLV_PCSK_KEX2_1	114	116	PF00082	0.699
CLV_PCSK_KEX2_1	149	151	PF00082	0.663
CLV_PCSK_KEX2_1	339	341	PF00082	0.745
CLV_PCSK_KEX2_1	36	38	PF00082	0.730
CLV_PCSK_KEX2_1	381	383	PF00082	0.751
CLV_PCSK_KEX2_1	415	417	PF00082	0.868
CLV_PCSK_KEX2_1	430	432	PF00082	0.622
CLV_PCSK_KEX2_1	467	469	PF00082	0.624
CLV_PCSK_KEX2_1	474	476	PF00082	0.583
CLV_PCSK_KEX2_1	617	619	PF00082	0.658
CLV_PCSK_KEX2_1	662	664	PF00082	0.666
CLV_PCSK_KEX2_1	9	11	PF00082	0.734
CLV_PCSK_SKI1_1	115	119	PF00082	0.757
CLV_PCSK_SKI1_1	345	349	PF00082	0.673
CLV_PCSK_SKI1_1	460	464	PF00082	0.649
CLV_PCSK_SKI1_1	539	543	PF00082	0.584
CLV_PCSK_SKI1_1	565	569	PF00082	0.602
DEG_SCF_FBW7_2	246	252	PF00400	0.554
DEG_SPOP_SBC_1	583	587	PF00917	0.594
DOC_ANK_TNKS_1	639	646	PF00023	0.592
DOC_CKS1_1	173	178	PF01111	0.655
DOC_CKS1_1	246	251	PF01111	0.554
DOC_CKS1_1	805	810	PF01111	0.583
DOC_CYCLIN_yCln2_LP_2	181	187	PF00134	0.572
DOC_CYCLIN_yCln2_LP_2	577	583	PF00134	0.729
DOC_CYCLIN_yCln2_LP_2	744	747	PF00134	0.548
DOC_PP1_RVXF_1	615	622	PF00149	0.478
DOC_PP2B_LxvP_1	181	184	PF13499	0.577
DOC_PP2B_LxvP_1	577	580	PF13499	0.729
DOC_PP2B_LxvP_1	744	747	PF13499	0.589
DOC_PP4_FxxP_1	929	932	PF00568	0.517
DOC_USP7_MATH_1	11	15	PF00917	0.731
DOC_USP7_MATH_1	188	192	PF00917	0.670
DOC_USP7_MATH_1	25	29	PF00917	0.593
DOC_USP7_MATH_1	323	327	PF00917	0.738
DOC_USP7_MATH_1	329	333	PF00917	0.678
DOC_USP7_MATH_1	41	45	PF00917	0.583
DOC_USP7_MATH_1	651	655	PF00917	0.636
DOC_USP7_MATH_1	661	665	PF00917	0.678
DOC_USP7_MATH_1	707	711	PF00917	0.607
DOC_USP7_MATH_1	809	813	PF00917	0.618
DOC_USP7_MATH_1	84	88	PF00917	0.600
DOC_USP7_MATH_1	854	858	PF00917	0.689
DOC_USP7_MATH_2	16	22	PF00917	0.576
DOC_USP7_MATH_2	230	236	PF00917	0.569
DOC_WW_Pin1_4	100	105	PF00397	0.750
DOC_WW_Pin1_4	123	128	PF00397	0.571
DOC_WW_Pin1_4	164	169	PF00397	0.722
DOC_WW_Pin1_4	172	177	PF00397	0.640
DOC_WW_Pin1_4	193	198	PF00397	0.623
DOC_WW_Pin1_4	226	231	PF00397	0.782
DOC_WW_Pin1_4	245	250	PF00397	0.619
DOC_WW_Pin1_4	258	263	PF00397	0.710
DOC_WW_Pin1_4	324	329	PF00397	0.663
DOC_WW_Pin1_4	367	372	PF00397	0.662
DOC_WW_Pin1_4	401	406	PF00397	0.745
DOC_WW_Pin1_4	425	430	PF00397	0.718
DOC_WW_Pin1_4	485	490	PF00397	0.712
DOC_WW_Pin1_4	540	545	PF00397	0.641
DOC_WW_Pin1_4	575	580	PF00397	0.586
DOC_WW_Pin1_4	607	612	PF00397	0.690
DOC_WW_Pin1_4	678	683	PF00397	0.587
DOC_WW_Pin1_4	694	699	PF00397	0.654
DOC_WW_Pin1_4	721	726	PF00397	0.696
DOC_WW_Pin1_4	788	793	PF00397	0.578
DOC_WW_Pin1_4	804	809	PF00397	0.648
DOC_WW_Pin1_4	868	873	PF00397	0.585
LIG_14-3-3_CanoR_1	114	124	PF00244	0.585
LIG_14-3-3_CanoR_1	154	160	PF00244	0.713
LIG_14-3-3_CanoR_1	238	247	PF00244	0.566
LIG_14-3-3_CanoR_1	3	8	PF00244	0.722
LIG_14-3-3_CanoR_1	36	45	PF00244	0.570
LIG_14-3-3_CanoR_1	421	429	PF00244	0.646
LIG_14-3-3_CanoR_1	539	544	PF00244	0.723
LIG_14-3-3_CanoR_1	748	753	PF00244	0.805
LIG_14-3-3_CanoR_1	9	19	PF00244	0.683
LIG_BIR_II_1	1	5	PF00653	0.730
LIG_BIR_III_4	484	488	PF00653	0.579
LIG_BRCT_BRCA1_1	58	62	PF00533	0.484
LIG_eIF4E_1	294	300	PF01652	0.610
LIG_FHA_1	584	590	PF00498	0.552
LIG_FHA_1	752	758	PF00498	0.557
LIG_FHA_1	850	856	PF00498	0.743
LIG_FHA_2	422	428	PF00498	0.759
LIG_FHA_2	555	561	PF00498	0.573
LIG_FHA_2	602	608	PF00498	0.552
LIG_FHA_2	665	671	PF00498	0.716
LIG_FHA_2	679	685	PF00498	0.579
LIG_FHA_2	753	759	PF00498	0.538
LIG_FHA_2	919	925	PF00498	0.564
LIG_LIR_Apic_2	927	932	PF02991	0.527
LIG_LIR_Nem_3	263	268	PF02991	0.490
LIG_LIR_Nem_3	43	48	PF02991	0.522
LIG_LIR_Nem_3	684	689	PF02991	0.547
LIG_LIR_Nem_3	897	903	PF02991	0.565
LIG_NRBOX	270	276	PF00104	0.450
LIG_Pex14_1	45	49	PF04695	0.519
LIG_Pex14_2	777	781	PF04695	0.562
LIG_Pex14_2	929	933	PF04695	0.512
LIG_PTAP_UEV_1	223	228	PF05743	0.566
LIG_SH2_CRK	303	307	PF00017	0.761
LIG_SH2_CRK	686	690	PF00017	0.553
LIG_SH2_CRK	900	904	PF00017	0.568
LIG_SH2_SRC	841	844	PF00017	0.554
LIG_SH2_STAP1	42	46	PF00017	0.530
LIG_SH2_STAT3	142	145	PF00017	0.661
LIG_SH2_STAT3	294	297	PF00017	0.608
LIG_SH2_STAT3	620	623	PF00017	0.634
LIG_SH2_STAT5	48	51	PF00017	0.675
LIG_SH3_2	109	114	PF14604	0.740
LIG_SH3_3	103	109	PF00018	0.732
LIG_SH3_3	121	127	PF00018	0.571
LIG_SH3_3	170	176	PF00018	0.639
LIG_SH3_3	181	187	PF00018	0.687
LIG_SH3_3	19	25	PF00018	0.667
LIG_SH3_3	201	207	PF00018	0.471
LIG_SH3_3	221	227	PF00018	0.587
LIG_SH3_3	243	249	PF00018	0.729
LIG_SH3_3	325	331	PF00018	0.696
LIG_SH3_3	403	409	PF00018	0.713
LIG_SH3_3	458	464	PF00018	0.744
LIG_SH3_3	560	566	PF00018	0.579
LIG_SH3_3	724	730	PF00018	0.701
LIG_SH3_3	732	738	PF00018	0.777
LIG_SH3_3	740	746	PF00018	0.641
LIG_SH3_3	802	808	PF00018	0.674
LIG_SH3_3	857	863	PF00018	0.632
LIG_SH3_CIN85_PxpxPR_1	109	114	PF14604	0.740
LIG_SUMO_SIM_par_1	195	201	PF11976	0.533
LIG_TRAF2_1	469	472	PF00917	0.568
LIG_TRAF2_1	558	561	PF00917	0.664
LIG_WW_3	111	115	PF00397	0.748
LIG_WW_3	745	749	PF00397	0.570
MOD_CDC14_SPxK_1	428	431	PF00782	0.583
MOD_CDK_SPK_2	425	430	PF00069	0.583
MOD_CDK_SPK_2	788	793	PF00069	0.558
MOD_CDK_SPxK_1	425	431	PF00069	0.584
MOD_CDK_SPxxK_3	327	334	PF00069	0.595
MOD_CDK_SPxxK_3	678	685	PF00069	0.539
MOD_CDK_SPxxK_3	788	795	PF00069	0.563
MOD_CK1_1	155	161	PF00069	0.654
MOD_CK1_1	2	8	PF00069	0.723
MOD_CK1_1	327	333	PF00069	0.737
MOD_CK1_1	370	376	PF00069	0.683
MOD_CK1_1	40	46	PF00069	0.701
MOD_CK1_1	404	410	PF00069	0.698
MOD_CK1_1	425	431	PF00069	0.584
MOD_CK1_1	434	440	PF00069	0.556
MOD_CK1_1	636	642	PF00069	0.762
MOD_CK1_1	664	670	PF00069	0.791
MOD_CK1_1	697	703	PF00069	0.774
MOD_CK1_1	785	791	PF00069	0.551
MOD_CK1_1	804	810	PF00069	0.603
MOD_CK1_1	883	889	PF00069	0.696
MOD_CK2_1	155	161	PF00069	0.545
MOD_CK2_1	226	232	PF00069	0.566
MOD_CK2_1	554	560	PF00069	0.639
MOD_CK2_1	664	670	PF00069	0.706
MOD_CK2_1	752	758	PF00069	0.700
MOD_CK2_1	868	874	PF00069	0.578
MOD_CK2_1	918	924	PF00069	0.705
MOD_Cter_Amidation	337	340	PF01082	0.576
MOD_Cter_Amidation	472	475	PF01082	0.572
MOD_GlcNHglycan	13	16	PF01048	0.736
MOD_GlcNHglycan	131	134	PF01048	0.596
MOD_GlcNHglycan	154	157	PF01048	0.542
MOD_GlcNHglycan	176	179	PF01048	0.734
MOD_GlcNHglycan	181	184	PF01048	0.686
MOD_GlcNHglycan	190	193	PF01048	0.565
MOD_GlcNHglycan	224	227	PF01048	0.774
MOD_GlcNHglycan	321	324	PF01048	0.624
MOD_GlcNHglycan	331	334	PF01048	0.665
MOD_GlcNHglycan	336	339	PF01048	0.684
MOD_GlcNHglycan	345	348	PF01048	0.592
MOD_GlcNHglycan	382	385	PF01048	0.597
MOD_GlcNHglycan	39	42	PF01048	0.713
MOD_GlcNHglycan	433	436	PF01048	0.694
MOD_GlcNHglycan	440	443	PF01048	0.649
MOD_GlcNHglycan	477	480	PF01048	0.693
MOD_GlcNHglycan	484	488	PF01048	0.765
MOD_GlcNHglycan	492	495	PF01048	0.695
MOD_GlcNHglycan	641	644	PF01048	0.813
MOD_GlcNHglycan	689	692	PF01048	0.661
MOD_GlcNHglycan	704	708	PF01048	0.614
MOD_GlcNHglycan	769	772	PF01048	0.710
MOD_GlcNHglycan	825	828	PF01048	0.559
MOD_GlcNHglycan	832	835	PF01048	0.651
MOD_GlcNHglycan	86	89	PF01048	0.610
MOD_GlcNHglycan	924	927	PF01048	0.578
MOD_GSK3_1	188	195	PF00069	0.572
MOD_GSK3_1	198	205	PF00069	0.511
MOD_GSK3_1	222	229	PF00069	0.643
MOD_GSK3_1	315	322	PF00069	0.718
MOD_GSK3_1	323	330	PF00069	0.709
MOD_GSK3_1	37	44	PF00069	0.686
MOD_GSK3_1	370	377	PF00069	0.686
MOD_GSK3_1	380	387	PF00069	0.631
MOD_GSK3_1	404	411	PF00069	0.606
MOD_GSK3_1	421	428	PF00069	0.718
MOD_GSK3_1	434	441	PF00069	0.606
MOD_GSK3_1	56	63	PF00069	0.450
MOD_GSK3_1	566	573	PF00069	0.591
MOD_GSK3_1	583	590	PF00069	0.647
MOD_GSK3_1	601	608	PF00069	0.504
MOD_GSK3_1	651	658	PF00069	0.714
MOD_GSK3_1	664	671	PF00069	0.721
MOD_GSK3_1	699	706	PF00069	0.732
MOD_GSK3_1	747	754	PF00069	0.686
MOD_GSK3_1	880	887	PF00069	0.748
MOD_GSK3_1	918	925	PF00069	0.634
MOD_LATS_1	152	158	PF00433	0.537
MOD_N-GLC_1	129	134	PF02516	0.690
MOD_N-GLC_1	238	243	PF02516	0.568
MOD_N-GLC_1	475	480	PF02516	0.595
MOD_N-GLC_1	84	89	PF02516	0.574
MOD_N-GLC_1	922	927	PF02516	0.725
MOD_NEK2_1	162	167	PF00069	0.614
MOD_NEK2_1	198	203	PF00069	0.588
MOD_NEK2_1	501	506	PF00069	0.746
MOD_NEK2_1	554	559	PF00069	0.574
MOD_NEK2_1	56	61	PF00069	0.645
MOD_NEK2_1	582	587	PF00069	0.770
MOD_NEK2_1	64	69	PF00069	0.592
MOD_NEK2_1	703	708	PF00069	0.660
MOD_NEK2_1	767	772	PF00069	0.542
MOD_PIKK_1	141	147	PF00454	0.661
MOD_PIKK_1	260	266	PF00454	0.652
MOD_PIKK_1	422	428	PF00454	0.591
MOD_PIKK_1	48	54	PF00454	0.657
MOD_PK_1	3	9	PF00069	0.566
MOD_PK_1	801	807	PF00069	0.589
MOD_PKA_1	37	43	PF00069	0.716
MOD_PKA_2	2	8	PF00069	0.723
MOD_PKA_2	237	243	PF00069	0.567
MOD_PKA_2	37	43	PF00069	0.716
MOD_PKA_2	380	386	PF00069	0.583
MOD_PKA_2	56	62	PF00069	0.439
MOD_PKA_2	633	639	PF00069	0.752
MOD_PKA_2	661	667	PF00069	0.661
MOD_PKA_2	747	753	PF00069	0.546
MOD_PKB_1	537	545	PF00069	0.573
MOD_PKB_1	799	807	PF00069	0.588
MOD_Plk_1	17	23	PF00069	0.578
MOD_Plk_1	801	807	PF00069	0.589
MOD_Plk_2-3	918	924	PF00069	0.571
MOD_Plk_4	232	238	PF00069	0.801
MOD_Plk_4	51	57	PF00069	0.641
MOD_Plk_4	748	754	PF00069	0.544
MOD_Plk_4	785	791	PF00069	0.544
MOD_ProDKin_1	100	106	PF00069	0.750
MOD_ProDKin_1	123	129	PF00069	0.565
MOD_ProDKin_1	164	170	PF00069	0.722
MOD_ProDKin_1	172	178	PF00069	0.640
MOD_ProDKin_1	193	199	PF00069	0.623
MOD_ProDKin_1	226	232	PF00069	0.783
MOD_ProDKin_1	245	251	PF00069	0.617
MOD_ProDKin_1	258	264	PF00069	0.705
MOD_ProDKin_1	324	330	PF00069	0.663
MOD_ProDKin_1	367	373	PF00069	0.665
MOD_ProDKin_1	401	407	PF00069	0.747
MOD_ProDKin_1	425	431	PF00069	0.719
MOD_ProDKin_1	485	491	PF00069	0.713
MOD_ProDKin_1	540	546	PF00069	0.639
MOD_ProDKin_1	575	581	PF00069	0.586
MOD_ProDKin_1	607	613	PF00069	0.685
MOD_ProDKin_1	678	684	PF00069	0.587
MOD_ProDKin_1	694	700	PF00069	0.656
MOD_ProDKin_1	721	727	PF00069	0.697
MOD_ProDKin_1	788	794	PF00069	0.580
MOD_ProDKin_1	804	810	PF00069	0.646
MOD_ProDKin_1	868	874	PF00069	0.586
MOD_SUMO_rev_2	229	236	PF00179	0.568
MOD_SUMO_rev_2	924	932	PF00179	0.536
TRG_DiLeu_BaEn_1	295	300	PF01217	0.610
TRG_DiLeu_BaEn_1	652	657	PF01217	0.705
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.538
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.617
TRG_DiLeu_LyEn_5	295	300	PF01217	0.610
TRG_ENDOCYTIC_2	268	271	PF00928	0.464
TRG_ENDOCYTIC_2	303	306	PF00928	0.755
TRG_ENDOCYTIC_2	686	689	PF00928	0.554
TRG_ENDOCYTIC_2	900	903	PF00928	0.567
TRG_ER_diArg_1	113	115	PF00400	0.704
TRG_ER_diArg_1	147	150	PF00400	0.526
TRG_ER_diArg_1	339	341	PF00400	0.613
TRG_ER_diArg_1	36	38	PF00400	0.721
TRG_ER_diArg_1	379	382	PF00400	0.642
TRG_ER_diArg_1	415	417	PF00400	0.803
TRG_ER_diArg_1	429	431	PF00400	0.591
TRG_ER_diArg_1	452	455	PF00400	0.830
TRG_ER_diArg_1	464	467	PF00400	0.667
TRG_ER_diArg_1	474	477	PF00400	0.636
TRG_ER_diArg_1	617	619	PF00400	0.525
TRG_ER_diArg_1	638	641	PF00400	0.695
TRG_ER_diArg_1	9	11	PF00400	0.734
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IE27	Leishmania donovani	60%	100%
A4I3W3	Leishmania infantum	60%	100%
E9B053	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4Q832	Leishmania major	59%	96%