Eukaryotic translation initiation factor 3 subunit E

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 3 subunit E

Species:

Leishmania braziliensis

UniProt:

A4HGT5_LEIBR

TriTrypDb:

LbrM.28.2510 , LBRM2903_280031500

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	12
GO:0016282	eukaryotic 43S preinitiation complex	4	11
GO:0032991	protein-containing complex	1	12
GO:0033290	eukaryotic 48S preinitiation complex	4	11
GO:0070993	translation preinitiation complex	3	11
GO:0071540	eukaryotic translation initiation factor 3 complex, eIF3e	3	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGT5

Function

Biological processes
Term	Name	Level	Count
GO:0001732	formation of cytoplasmic translation initiation complex	7	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0022618	ribonucleoprotein complex assembly	6	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0071826	ribonucleoprotein complex subunit organization	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.369
CLV_C14_Caspase3-7	29	33	PF00656	0.504
CLV_C14_Caspase3-7	354	358	PF00656	0.545
CLV_C14_Caspase3-7	398	402	PF00656	0.367
CLV_NRD_NRD_1	181	183	PF00675	0.456
CLV_NRD_NRD_1	238	240	PF00675	0.530
CLV_NRD_NRD_1	307	309	PF00675	0.375
CLV_NRD_NRD_1	94	96	PF00675	0.386
CLV_PCSK_KEX2_1	181	183	PF00082	0.467
CLV_PCSK_KEX2_1	307	309	PF00082	0.374
CLV_PCSK_KEX2_1	328	330	PF00082	0.306
CLV_PCSK_KEX2_1	94	96	PF00082	0.386
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.361
CLV_PCSK_SKI1_1	109	113	PF00082	0.327
CLV_PCSK_SKI1_1	329	333	PF00082	0.304
CLV_PCSK_SKI1_1	69	73	PF00082	0.358
DEG_Nend_UBRbox_2	1	3	PF02207	0.473
DEG_SPOP_SBC_1	195	199	PF00917	0.497
DOC_PP4_FxxP_1	192	195	PF00568	0.602
DOC_PP4_FxxP_1	71	74	PF00568	0.425
DOC_USP7_MATH_1	45	49	PF00917	0.605
DOC_USP7_UBL2_3	371	375	PF12436	0.499
LIG_14-3-3_CanoR_1	239	243	PF00244	0.301
LIG_14-3-3_CanoR_1	94	100	PF00244	0.578
LIG_Actin_WH2_2	238	253	PF00022	0.391
LIG_APCC_ABBA_1	7	12	PF00400	0.511
LIG_BRCT_BRCA1_1	100	104	PF00533	0.561
LIG_FHA_1	110	116	PF00498	0.511
LIG_FHA_1	195	201	PF00498	0.522
LIG_FHA_1	283	289	PF00498	0.511
LIG_FHA_1	38	44	PF00498	0.511
LIG_FHA_1	387	393	PF00498	0.646
LIG_FHA_2	85	91	PF00498	0.511
LIG_FHA_2	94	100	PF00498	0.511
LIG_LIR_Apic_2	189	195	PF02991	0.597
LIG_LIR_Apic_2	70	74	PF02991	0.425
LIG_LIR_Gen_1	146	156	PF02991	0.541
LIG_LIR_Gen_1	262	271	PF02991	0.530
LIG_LIR_Gen_1	333	342	PF02991	0.586
LIG_LIR_Gen_1	394	404	PF02991	0.626
LIG_LIR_Nem_3	146	151	PF02991	0.544
LIG_LIR_Nem_3	155	161	PF02991	0.203
LIG_LIR_Nem_3	262	267	PF02991	0.547
LIG_LIR_Nem_3	333	338	PF02991	0.586
LIG_LIR_Nem_3	394	400	PF02991	0.621
LIG_LYPXL_SIV_4	131	139	PF13949	0.500
LIG_PCNA_PIPBox_1	65	74	PF02747	0.561
LIG_PCNA_yPIPBox_3	59	72	PF02747	0.562
LIG_PTB_Apo_2	114	121	PF02174	0.605
LIG_PTB_Phospho_1	114	120	PF10480	0.605
LIG_REV1ctd_RIR_1	212	220	PF16727	0.406
LIG_SH2_CRK	148	152	PF00017	0.561
LIG_SH2_CRK	335	339	PF00017	0.586
LIG_SH2_GRB2like	264	267	PF00017	0.554
LIG_SH2_SRC	278	281	PF00017	0.441
LIG_SH2_STAP1	221	225	PF00017	0.397
LIG_SH2_STAP1	264	268	PF00017	0.552
LIG_SH2_STAP1	280	284	PF00017	0.353
LIG_SH2_STAP1	319	323	PF00017	0.577
LIG_SH2_STAT3	221	224	PF00017	0.511
LIG_SH2_STAT5	124	127	PF00017	0.422
LIG_SH2_STAT5	227	230	PF00017	0.486
LIG_SH2_STAT5	249	252	PF00017	0.362
LIG_SH2_STAT5	314	317	PF00017	0.500
LIG_SH2_STAT5	346	349	PF00017	0.525
LIG_SH3_3	207	213	PF00018	0.395
LIG_SUMO_SIM_anti_2	297	305	PF11976	0.511
LIG_SUMO_SIM_par_1	340	345	PF11976	0.425
LIG_TRAF2_1	186	189	PF00917	0.587
LIG_TYR_ITIM	395	400	PF00017	0.595
LIG_UBA3_1	4	13	PF00899	0.425
MOD_CK1_1	150	156	PF00069	0.460
MOD_CK1_1	262	268	PF00069	0.446
MOD_CK1_1	337	343	PF00069	0.537
MOD_CK1_1	391	397	PF00069	0.637
MOD_CK2_1	266	272	PF00069	0.505
MOD_CK2_1	273	279	PF00069	0.533
MOD_CK2_1	375	381	PF00069	0.525
MOD_CK2_1	84	90	PF00069	0.534
MOD_CK2_1	93	99	PF00069	0.525
MOD_GlcNHglycan	145	148	PF01048	0.507
MOD_GlcNHglycan	171	174	PF01048	0.416
MOD_GlcNHglycan	268	271	PF01048	0.430
MOD_GSK3_1	143	150	PF00069	0.448
MOD_GSK3_1	234	241	PF00069	0.456
MOD_GSK3_1	262	269	PF00069	0.455
MOD_GSK3_1	278	285	PF00069	0.398
MOD_GSK3_1	330	337	PF00069	0.582
MOD_N-GLC_1	184	189	PF02516	0.554
MOD_N-GLC_1	195	200	PF02516	0.512
MOD_NEK2_1	219	224	PF00069	0.481
MOD_NEK2_1	259	264	PF00069	0.503
MOD_NEK2_1	273	278	PF00069	0.494
MOD_NEK2_1	330	335	PF00069	0.541
MOD_NEK2_1	351	356	PF00069	0.525
MOD_NEK2_1	37	42	PF00069	0.579
MOD_NEK2_2	147	152	PF00069	0.338
MOD_NEK2_2	45	50	PF00069	0.586
MOD_PIKK_1	282	288	PF00454	0.368
MOD_PIKK_1	93	99	PF00454	0.586
MOD_PK_1	375	381	PF00069	0.511
MOD_PKA_2	238	244	PF00069	0.449
MOD_PKA_2	262	268	PF00069	0.433
MOD_PKA_2	93	99	PF00069	0.577
MOD_Plk_1	195	201	PF00069	0.541
MOD_Plk_1	234	240	PF00069	0.574
MOD_Plk_1	77	83	PF00069	0.526
MOD_Plk_4	152	158	PF00069	0.451
MOD_Plk_4	273	279	PF00069	0.492
MOD_Plk_4	30	36	PF00069	0.611
MOD_Plk_4	337	343	PF00069	0.539
MOD_Plk_4	391	397	PF00069	0.528
MOD_SUMO_for_1	49	52	PF00179	0.586
MOD_SUMO_rev_2	101	111	PF00179	0.525
TRG_DiLeu_BaEn_4	178	184	PF01217	0.472
TRG_ENDOCYTIC_2	148	151	PF00928	0.516
TRG_ENDOCYTIC_2	227	230	PF00928	0.505
TRG_ENDOCYTIC_2	264	267	PF00928	0.554
TRG_ENDOCYTIC_2	335	338	PF00928	0.564
TRG_ENDOCYTIC_2	397	400	PF00928	0.596
TRG_ER_diArg_1	180	182	PF00400	0.451
TRG_ER_diArg_1	200	203	PF00400	0.497
TRG_ER_diArg_1	261	264	PF00400	0.571
TRG_ER_diArg_1	306	308	PF00400	0.575
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R0	Leptomonas seymouri	85%	100%
A0A0S4J145	Bodo saltans	36%	100%
A0A1X0NQN6	Trypanosomatidae	55%	100%
A0A3Q8IGX0	Leishmania donovani	95%	100%
A0A3R7MGF4	Trypanosoma rangeli	55%	100%
A1CKN7	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	30%	90%
A1D6T6	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	30%	89%
A4I3W2	Leishmania infantum	95%	100%
A4R796	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	29%	91%
A5AAA4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	31%	90%
A6SM77	Botryotinia fuckeliana (strain B05.10)	29%	90%
A7F3L0	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	29%	90%
A7RWP6	Nematostella vectensis	28%	90%
A8NY27	Brugia malayi	26%	92%
A8XFH3	Caenorhabditis briggsae	29%	100%
A9UQS1	Monosiga brevicollis	27%	84%
B0WAM5	Culex quinquefasciatus	27%	93%
B0XXL3	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	29%	90%
B4MYA1	Drosophila willistoni	30%	93%
B4N3B0	Drosophila willistoni	30%	93%
B5DGH9	Salmo salar	28%	91%
D0A930	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
E9B052	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O61820	Caenorhabditis elegans	26%	94%
O94513	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	81%
P0CN50	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	28%	87%
P0CN51	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	28%	87%
P60228	Homo sapiens	31%	91%
P60229	Mus musculus	31%	91%
Q05AY2	Xenopus laevis	29%	91%
Q0CNR3	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	31%	91%
Q0U0X1	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	28%	93%
Q1E170	Coccidioides immitis (strain RS)	30%	91%
Q1HQY6	Aedes aegypti	27%	93%
Q1LUA8	Danio rerio	30%	91%
Q2F5R8	Bombyx mori	30%	91%
Q2HBQ2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	28%	91%
Q2UKS9	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	90%
Q3B8M3	Xenopus laevis	29%	91%
Q3T102	Bos taurus	31%	91%
Q4PHN4	Ustilago maydis (strain 521 / FGSC 9021)	28%	75%
Q4Q833	Leishmania major	95%	100%
Q4R6G8	Macaca fascicularis	31%	91%
Q4WY08	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	29%	90%
Q54CC5	Dictyostelium discoideum	29%	77%
Q5B973	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	31%	90%
Q5R8K9	Pongo abelii	31%	91%
Q5ZLA5	Gallus gallus	28%	91%
Q641X8	Rattus norvegicus	31%	91%
Q6C0Q2	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	96%
Q6DRI1	Danio rerio	29%	91%
Q6P7L9	Xenopus tropicalis	29%	91%
Q7QIL8	Anopheles gambiae	31%	94%
Q7S519	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	91%
Q9C5Z3	Arabidopsis thaliana	27%	92%
V5BEE1	Trypanosoma cruzi	57%	100%