Translation initiation factor eIF-2B subunit epsilon

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translation initiation factor eIF-2B subunit epsilon, putative

Species:

Leishmania braziliensis

UniProt:

A4HGT3_LEIBR

TriTrypDb:

LbrM.28.2490 , LBRM2903_280031300

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005851	eukaryotic translation initiation factor 2B complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4HGT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGT3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003743	translation initiation factor activity	4	3
GO:0005085	guanyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	3
GO:0005515	protein binding	2	1
GO:0008135	translation factor activity, RNA binding	3	3
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0031369	translation initiation factor binding	3	1
GO:0045182	translation regulator activity	1	3
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1
GO:0140678	molecular function inhibitor activity	2	1
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.558
CLV_C14_Caspase3-7	808	812	PF00656	0.333
CLV_NRD_NRD_1	125	127	PF00675	0.490
CLV_NRD_NRD_1	175	177	PF00675	0.492
CLV_NRD_NRD_1	370	372	PF00675	0.455
CLV_NRD_NRD_1	459	461	PF00675	0.493
CLV_NRD_NRD_1	585	587	PF00675	0.506
CLV_NRD_NRD_1	7	9	PF00675	0.521
CLV_PCSK_FUR_1	173	177	PF00082	0.298
CLV_PCSK_KEX2_1	125	127	PF00082	0.490
CLV_PCSK_KEX2_1	175	177	PF00082	0.313
CLV_PCSK_KEX2_1	370	372	PF00082	0.455
CLV_PCSK_KEX2_1	459	461	PF00082	0.493
CLV_PCSK_KEX2_1	585	587	PF00082	0.508
CLV_PCSK_KEX2_1	7	9	PF00082	0.554
CLV_PCSK_SKI1_1	126	130	PF00082	0.436
CLV_PCSK_SKI1_1	190	194	PF00082	0.505
CLV_PCSK_SKI1_1	370	374	PF00082	0.405
CLV_PCSK_SKI1_1	460	464	PF00082	0.509
CLV_PCSK_SKI1_1	488	492	PF00082	0.474
CLV_PCSK_SKI1_1	530	534	PF00082	0.557
CLV_PCSK_SKI1_1	652	656	PF00082	0.500
CLV_PCSK_SKI1_1	807	811	PF00082	0.590
DEG_APCC_DBOX_1	487	495	PF00400	0.421
DEG_Nend_UBRbox_2	1	3	PF02207	0.551
DEG_SPOP_SBC_1	284	288	PF00917	0.556
DEG_SPOP_SBC_1	345	349	PF00917	0.309
DEG_SPOP_SBC_1	389	393	PF00917	0.497
DOC_CYCLIN_RxL_1	367	376	PF00134	0.448
DOC_MAPK_FxFP_2	618	621	PF00069	0.456
DOC_MAPK_gen_1	250	257	PF00069	0.493
DOC_PP2B_LxvP_1	150	153	PF13499	0.356
DOC_PP4_FxxP_1	42	45	PF00568	0.349
DOC_PP4_FxxP_1	618	621	PF00568	0.456
DOC_USP7_MATH_1	345	349	PF00917	0.473
DOC_USP7_MATH_1	389	393	PF00917	0.483
DOC_USP7_MATH_1	406	410	PF00917	0.423
DOC_USP7_MATH_1	565	569	PF00917	0.692
DOC_WW_Pin1_4	212	217	PF00397	0.565
DOC_WW_Pin1_4	44	49	PF00397	0.493
DOC_WW_Pin1_4	496	501	PF00397	0.416
DOC_WW_Pin1_4	62	67	PF00397	0.236
DOC_WW_Pin1_4	640	645	PF00397	0.580
LIG_14-3-3_CanoR_1	125	131	PF00244	0.459
LIG_14-3-3_CanoR_1	198	202	PF00244	0.540
LIG_14-3-3_CanoR_1	252	256	PF00244	0.504
LIG_14-3-3_CanoR_1	545	552	PF00244	0.594
LIG_Actin_WH2_2	23	38	PF00022	0.313
LIG_BRCT_BRCA1_1	553	557	PF00533	0.634
LIG_BRCT_BRCA1_1	614	618	PF00533	0.496
LIG_Clathr_ClatBox_1	151	155	PF01394	0.429
LIG_Clathr_ClatBox_1	729	733	PF01394	0.392
LIG_eIF4E_1	70	76	PF01652	0.350
LIG_FHA_1	252	258	PF00498	0.378
LIG_FHA_1	260	266	PF00498	0.313
LIG_FHA_1	298	304	PF00498	0.252
LIG_FHA_1	324	330	PF00498	0.449
LIG_FHA_1	394	400	PF00498	0.452
LIG_FHA_1	497	503	PF00498	0.474
LIG_FHA_1	526	532	PF00498	0.598
LIG_FHA_1	551	557	PF00498	0.566
LIG_FHA_1	609	615	PF00498	0.471
LIG_FHA_1	626	632	PF00498	0.418
LIG_FHA_1	63	69	PF00498	0.319
LIG_FHA_1	82	88	PF00498	0.317
LIG_FHA_2	127	133	PF00498	0.552
LIG_FHA_2	167	173	PF00498	0.454
LIG_GBD_Chelix_1	193	201	PF00786	0.538
LIG_GBD_Chelix_1	22	30	PF00786	0.428
LIG_Integrin_RGD_1	13	15	PF01839	0.417
LIG_LIR_Apic_2	41	45	PF02991	0.351
LIG_LIR_Apic_2	615	621	PF02991	0.476
LIG_LIR_Apic_2	657	661	PF02991	0.394
LIG_LIR_Gen_1	148	157	PF02991	0.368
LIG_LIR_Gen_1	159	167	PF02991	0.402
LIG_LIR_Gen_1	319	329	PF02991	0.442
LIG_LIR_Gen_1	479	490	PF02991	0.458
LIG_LIR_Gen_1	718	729	PF02991	0.415
LIG_LIR_LC3C_4	499	503	PF02991	0.357
LIG_LIR_Nem_3	148	152	PF02991	0.340
LIG_LIR_Nem_3	159	163	PF02991	0.366
LIG_LIR_Nem_3	319	324	PF02991	0.440
LIG_LIR_Nem_3	333	338	PF02991	0.424
LIG_LIR_Nem_3	479	485	PF02991	0.452
LIG_LIR_Nem_3	718	724	PF02991	0.416
LIG_LYPXL_yS_3	620	623	PF13949	0.448
LIG_PCNA_yPIPBox_3	669	679	PF02747	0.511
LIG_Pex14_1	658	662	PF04695	0.378
LIG_Pex14_2	662	666	PF04695	0.393
LIG_SH2_CRK	321	325	PF00017	0.405
LIG_SH2_CRK	335	339	PF00017	0.490
LIG_SH2_CRK	482	486	PF00017	0.264
LIG_SH2_CRK	721	725	PF00017	0.382
LIG_SH2_NCK_1	482	486	PF00017	0.264
LIG_SH2_STAP1	180	184	PF00017	0.322
LIG_SH2_STAP1	546	550	PF00017	0.576
LIG_SH2_STAT3	699	702	PF00017	0.463
LIG_SH2_STAT5	302	305	PF00017	0.216
LIG_SH2_STAT5	360	363	PF00017	0.364
LIG_SH2_STAT5	398	401	PF00017	0.388
LIG_SH2_STAT5	70	73	PF00017	0.315
LIG_SH2_STAT5	721	724	PF00017	0.388
LIG_SH2_STAT5	746	749	PF00017	0.582
LIG_SH3_1	243	249	PF00018	0.602
LIG_SH3_3	213	219	PF00018	0.655
LIG_SH3_3	243	249	PF00018	0.543
LIG_SH3_3	275	281	PF00018	0.587
LIG_SH3_3	418	424	PF00018	0.407
LIG_SH3_3	42	48	PF00018	0.443
LIG_SH3_3	50	56	PF00018	0.396
LIG_SH3_3	559	565	PF00018	0.686
LIG_SH3_3	689	695	PF00018	0.373
LIG_SH3_5	66	70	PF00018	0.348
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.444
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.232
LIG_SUMO_SIM_par_1	793	798	PF11976	0.481
LIG_SUMO_SIM_par_1	81	89	PF11976	0.423
LIG_TRAF2_1	273	276	PF00917	0.456
LIG_TRAF2_1	574	577	PF00917	0.695
LIG_TRAF2_2	565	570	PF00917	0.531
LIG_TRFH_1	149	153	PF08558	0.418
LIG_TYR_ITIM	480	485	PF00017	0.445
LIG_UBA3_1	255	260	PF00899	0.454
LIG_WRC_WIRS_1	157	162	PF05994	0.450
LIG_WRC_WIRS_1	320	325	PF05994	0.433
LIG_WRC_WIRS_1	729	734	PF05994	0.490
MOD_CDK_SPK_2	49	54	PF00069	0.491
MOD_CDK_SPxxK_3	47	54	PF00069	0.491
MOD_CK1_1	212	218	PF00069	0.670
MOD_CK1_1	322	328	PF00069	0.436
MOD_CK1_1	353	359	PF00069	0.359
MOD_CK1_1	445	451	PF00069	0.467
MOD_CK1_1	47	53	PF00069	0.499
MOD_CK1_1	725	731	PF00069	0.459
MOD_CK1_1	771	777	PF00069	0.766
MOD_CK2_1	166	172	PF00069	0.394
MOD_CK2_1	270	276	PF00069	0.437
MOD_CK2_1	308	314	PF00069	0.385
MOD_CK2_1	346	352	PF00069	0.387
MOD_CK2_1	389	395	PF00069	0.496
MOD_CK2_1	571	577	PF00069	0.657
MOD_CK2_1	597	603	PF00069	0.466
MOD_Cter_Amidation	457	460	PF01082	0.450
MOD_GlcNHglycan	222	225	PF01048	0.725
MOD_GlcNHglycan	272	275	PF01048	0.448
MOD_GlcNHglycan	287	290	PF01048	0.520
MOD_GlcNHglycan	355	358	PF01048	0.457
MOD_GlcNHglycan	453	456	PF01048	0.265
MOD_GlcNHglycan	521	524	PF01048	0.526
MOD_GlcNHglycan	535	538	PF01048	0.545
MOD_GlcNHglycan	553	556	PF01048	0.623
MOD_GlcNHglycan	567	570	PF01048	0.616
MOD_GlcNHglycan	615	618	PF01048	0.488
MOD_GlcNHglycan	724	727	PF01048	0.456
MOD_GlcNHglycan	778	781	PF01048	0.574
MOD_GlcNHglycan	90	93	PF01048	0.406
MOD_GSK3_1	205	212	PF00069	0.468
MOD_GSK3_1	227	234	PF00069	0.655
MOD_GSK3_1	259	266	PF00069	0.452
MOD_GSK3_1	26	33	PF00069	0.286
MOD_GSK3_1	285	292	PF00069	0.512
MOD_GSK3_1	319	326	PF00069	0.464
MOD_GSK3_1	346	353	PF00069	0.357
MOD_GSK3_1	389	396	PF00069	0.487
MOD_GSK3_1	419	426	PF00069	0.419
MOD_GSK3_1	492	499	PF00069	0.440
MOD_GSK3_1	551	558	PF00069	0.619
MOD_GSK3_1	597	604	PF00069	0.538
MOD_GSK3_1	608	615	PF00069	0.294
MOD_GSK3_1	762	769	PF00069	0.709
MOD_GSK3_1	770	777	PF00069	0.776
MOD_GSK3_1	88	95	PF00069	0.429
MOD_GSK3_1	97	104	PF00069	0.399
MOD_N-GLC_1	145	150	PF02516	0.475
MOD_N-GLC_1	406	411	PF02516	0.477
MOD_N-GLC_1	496	501	PF02516	0.579
MOD_N-GLC_2	88	90	PF02516	0.293
MOD_NEK2_1	185	190	PF00069	0.433
MOD_NEK2_1	197	202	PF00069	0.485
MOD_NEK2_1	285	290	PF00069	0.478
MOD_NEK2_1	323	328	PF00069	0.434
MOD_NEK2_1	399	404	PF00069	0.424
MOD_NEK2_1	429	434	PF00069	0.443
MOD_NEK2_1	584	589	PF00069	0.493
MOD_NEK2_1	654	659	PF00069	0.471
MOD_NEK2_1	86	91	PF00069	0.406
MOD_PIKK_1	210	216	PF00454	0.625
MOD_PIKK_1	259	265	PF00454	0.456
MOD_PKA_1	175	181	PF00069	0.477
MOD_PKA_2	175	181	PF00069	0.300
MOD_PKA_2	197	203	PF00069	0.532
MOD_PKA_2	251	257	PF00069	0.424
MOD_PKA_2	376	382	PF00069	0.414
MOD_PKA_2	544	550	PF00069	0.609
MOD_PKA_2	584	590	PF00069	0.482
MOD_PKA_2	744	750	PF00069	0.584
MOD_PKB_1	173	181	PF00069	0.473
MOD_Plk_1	406	412	PF00069	0.514
MOD_Plk_1	419	425	PF00069	0.577
MOD_Plk_1	442	448	PF00069	0.465
MOD_Plk_1	478	484	PF00069	0.397
MOD_Plk_1	512	518	PF00069	0.465
MOD_Plk_1	602	608	PF00069	0.481
MOD_Plk_1	81	87	PF00069	0.425
MOD_Plk_2-3	308	314	PF00069	0.444
MOD_Plk_2-3	572	578	PF00069	0.555
MOD_Plk_2-3	603	609	PF00069	0.479
MOD_Plk_4	145	151	PF00069	0.389
MOD_Plk_4	180	186	PF00069	0.321
MOD_Plk_4	197	203	PF00069	0.441
MOD_Plk_4	251	257	PF00069	0.422
MOD_Plk_4	26	32	PF00069	0.349
MOD_Plk_4	263	269	PF00069	0.393
MOD_Plk_4	308	314	PF00069	0.377
MOD_Plk_4	319	325	PF00069	0.373
MOD_Plk_4	346	352	PF00069	0.359
MOD_Plk_4	38	44	PF00069	0.520
MOD_Plk_4	393	399	PF00069	0.373
MOD_Plk_4	406	412	PF00069	0.436
MOD_Plk_4	429	435	PF00069	0.437
MOD_Plk_4	725	731	PF00069	0.459
MOD_Plk_4	81	87	PF00069	0.403
MOD_ProDKin_1	212	218	PF00069	0.569
MOD_ProDKin_1	44	50	PF00069	0.490
MOD_ProDKin_1	496	502	PF00069	0.414
MOD_ProDKin_1	62	68	PF00069	0.233
MOD_ProDKin_1	640	646	PF00069	0.576
MOD_SUMO_rev_2	784	794	PF00179	0.536
TRG_DiLeu_BaEn_1	308	313	PF01217	0.441
TRG_DiLeu_BaEn_1	790	795	PF01217	0.479
TRG_DiLeu_BaEn_1	82	87	PF01217	0.425
TRG_ENDOCYTIC_2	321	324	PF00928	0.434
TRG_ENDOCYTIC_2	335	338	PF00928	0.503
TRG_ENDOCYTIC_2	482	485	PF00928	0.447
TRG_ENDOCYTIC_2	620	623	PF00928	0.448
TRG_ENDOCYTIC_2	663	666	PF00928	0.460
TRG_ENDOCYTIC_2	721	724	PF00928	0.395
TRG_ENDOCYTIC_2	746	749	PF00928	0.582
TRG_ER_diArg_1	125	127	PF00400	0.491
TRG_ER_diArg_1	173	176	PF00400	0.304
TRG_ER_diArg_1	238	241	PF00400	0.541
TRG_ER_diArg_1	370	372	PF00400	0.455
TRG_ER_diArg_1	584	586	PF00400	0.504
TRG_ER_diArg_1	6	8	PF00400	0.642
TRG_NES_CRM1_1	622	633	PF08389	0.370
TRG_Pf-PMV_PEXEL_1	785	789	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B8	Leptomonas seymouri	67%	97%
A0A0S4IRE8	Bodo saltans	32%	100%
A0A3Q8IDY2	Leishmania donovani	85%	97%
A4I3W0	Leishmania infantum	85%	97%
D0A928	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B050	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
P56287	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	20%	100%
Q4Q835	Leishmania major	85%	100%