Putative histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acetyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HGT1_LEIBR

TriTrypDb:

LbrM.28.2470 , LBRM2903_280031100

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGT1

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	7
GO:0009889	regulation of biosynthetic process	4	7
GO:0010468	regulation of gene expression	5	7
GO:0010556	regulation of macromolecule biosynthetic process	5	7
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	7
GO:0019222	regulation of metabolic process	3	7
GO:0031323	regulation of cellular metabolic process	4	7
GO:0031326	regulation of cellular biosynthetic process	5	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0051171	regulation of nitrogen compound metabolic process	4	7
GO:0051252	regulation of RNA metabolic process	5	7
GO:0060255	regulation of macromolecule metabolic process	4	7
GO:0065007	biological regulation	1	7
GO:0080090	regulation of primary metabolic process	4	7
GO:1903506	regulation of nucleic acid-templated transcription	7	7
GO:2001141	regulation of RNA biosynthetic process	6	7
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004402	histone acetyltransferase activity	4	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0034212	peptide N-acetyltransferase activity	7	7
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:0003712	transcription coregulator activity	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	428	432	PF00656	0.797
CLV_NRD_NRD_1	253	255	PF00675	0.346
CLV_NRD_NRD_1	295	297	PF00675	0.346
CLV_NRD_NRD_1	31	33	PF00675	0.650
CLV_NRD_NRD_1	319	321	PF00675	0.396
CLV_NRD_NRD_1	334	336	PF00675	0.490
CLV_NRD_NRD_1	424	426	PF00675	0.583
CLV_PCSK_FUR_1	29	33	PF00082	0.648
CLV_PCSK_KEX2_1	253	255	PF00082	0.309
CLV_PCSK_KEX2_1	295	297	PF00082	0.346
CLV_PCSK_KEX2_1	31	33	PF00082	0.650
CLV_PCSK_KEX2_1	319	321	PF00082	0.396
CLV_PCSK_KEX2_1	334	336	PF00082	0.490
CLV_PCSK_KEX2_1	352	354	PF00082	0.720
CLV_PCSK_KEX2_1	426	428	PF00082	0.735
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.553
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.735
CLV_PCSK_SKI1_1	121	125	PF00082	0.473
CLV_PCSK_SKI1_1	164	168	PF00082	0.284
CLV_PCSK_SKI1_1	181	185	PF00082	0.313
CLV_PCSK_SKI1_1	188	192	PF00082	0.338
CLV_PCSK_SKI1_1	324	328	PF00082	0.362
CLV_PCSK_SKI1_1	393	397	PF00082	0.538
CLV_PCSK_SKI1_1	513	517	PF00082	0.506
DEG_APCC_DBOX_1	30	38	PF00400	0.626
DEG_APCC_DBOX_1	9	17	PF00400	0.581
DOC_ANK_TNKS_1	149	156	PF00023	0.512
DOC_CKS1_1	299	304	PF01111	0.448
DOC_CKS1_1	61	66	PF01111	0.297
DOC_CYCLIN_RxL_1	176	189	PF00134	0.546
DOC_MAPK_gen_1	334	341	PF00069	0.586
DOC_MAPK_MEF2A_6	498	506	PF00069	0.480
DOC_PP1_RVXF_1	535	542	PF00149	0.479
DOC_PP2B_LxvP_1	151	154	PF13499	0.482
DOC_PP2B_LxvP_1	272	275	PF13499	0.417
DOC_PP2B_LxvP_1	532	535	PF13499	0.479
DOC_PP4_FxxP_1	124	127	PF00568	0.437
DOC_USP7_MATH_1	420	424	PF00917	0.580
DOC_USP7_MATH_1	87	91	PF00917	0.788
DOC_USP7_UBL2_3	348	352	PF12436	0.798
DOC_WW_Pin1_4	18	23	PF00397	0.713
DOC_WW_Pin1_4	270	275	PF00397	0.699
DOC_WW_Pin1_4	298	303	PF00397	0.546
DOC_WW_Pin1_4	44	49	PF00397	0.559
DOC_WW_Pin1_4	475	480	PF00397	0.811
DOC_WW_Pin1_4	60	65	PF00397	0.462
DOC_WW_Pin1_4	95	100	PF00397	0.721
LIG_14-3-3_CanoR_1	131	137	PF00244	0.486
LIG_14-3-3_CanoR_1	253	261	PF00244	0.728
LIG_14-3-3_CanoR_1	3	11	PF00244	0.562
LIG_14-3-3_CanoR_1	446	456	PF00244	0.806
LIG_14-3-3_CanoR_1	46	52	PF00244	0.522
LIG_BRCT_BRCA1_1	201	205	PF00533	0.448
LIG_BRCT_BRCA1_1	564	568	PF00533	0.447
LIG_CtBP_PxDLS_1	461	465	PF00389	0.525
LIG_eIF4E_1	36	42	PF01652	0.596
LIG_eIF4E_1	67	73	PF01652	0.481
LIG_FHA_1	478	484	PF00498	0.580
LIG_FHA_2	432	438	PF00498	0.816
LIG_FHA_2	494	500	PF00498	0.612
LIG_LIR_Apic_2	122	127	PF02991	0.446
LIG_LIR_Apic_2	63	69	PF02991	0.298
LIG_LIR_Gen_1	134	141	PF02991	0.499
LIG_LIR_Nem_3	202	208	PF02991	0.448
LIG_LIR_Nem_3	50	56	PF02991	0.490
LIG_MLH1_MIPbox_1	201	205	PF16413	0.448
LIG_NRBOX	511	517	PF00104	0.497
LIG_Pex14_2	124	128	PF04695	0.434
LIG_Pex14_2	227	231	PF04695	0.504
LIG_PTB_Apo_2	71	78	PF02174	0.632
LIG_PTB_Phospho_1	71	77	PF10480	0.629
LIG_SH2_GRB2like	56	59	PF00017	0.464
LIG_SH2_NCK_1	290	294	PF00017	0.546
LIG_SH2_STAP1	133	137	PF00017	0.599
LIG_SH2_STAP1	290	294	PF00017	0.546
LIG_SH2_STAP1	543	547	PF00017	0.480
LIG_SH2_STAT5	179	182	PF00017	0.512
LIG_SH2_STAT5	204	207	PF00017	0.546
LIG_SH2_STAT5	214	217	PF00017	0.546
LIG_SH2_STAT5	218	221	PF00017	0.546
LIG_SH2_STAT5	226	229	PF00017	0.546
LIG_SH2_STAT5	36	39	PF00017	0.605
LIG_SH2_STAT5	53	56	PF00017	0.486
LIG_SH2_STAT5	538	541	PF00017	0.473
LIG_SH2_STAT5	60	63	PF00017	0.459
LIG_SH3_3	216	222	PF00018	0.530
LIG_SH3_3	243	249	PF00018	0.541
LIG_SH3_3	299	305	PF00018	0.518
LIG_SH3_3	554	560	PF00018	0.431
LIG_SH3_3	58	64	PF00018	0.462
LIG_SH3_3	76	82	PF00018	0.586
LIG_SUMO_SIM_anti_2	384	391	PF11976	0.597
LIG_SUMO_SIM_par_1	284	289	PF11976	0.427
LIG_SUMO_SIM_par_1	384	391	PF11976	0.596
LIG_UBA3_1	183	188	PF00899	0.546
MOD_CDK_SPxK_1	298	304	PF00069	0.546
MOD_CDK_SPxxK_3	95	102	PF00069	0.559
MOD_CK1_1	220	226	PF00069	0.546
MOD_CK1_1	362	368	PF00069	0.757
MOD_CK1_1	470	476	PF00069	0.668
MOD_CK1_1	92	98	PF00069	0.548
MOD_CK2_1	107	113	PF00069	0.532
MOD_CK2_1	186	192	PF00069	0.546
MOD_CK2_1	409	415	PF00069	0.784
MOD_CK2_1	431	437	PF00069	0.813
MOD_Cter_Amidation	251	254	PF01082	0.346
MOD_GlcNHglycan	221	225	PF01048	0.346
MOD_GlcNHglycan	379	382	PF01048	0.601
MOD_GlcNHglycan	405	408	PF01048	0.719
MOD_GlcNHglycan	422	425	PF01048	0.543
MOD_GlcNHglycan	469	472	PF01048	0.783
MOD_GlcNHglycan	523	526	PF01048	0.402
MOD_GlcNHglycan	89	92	PF01048	0.574
MOD_GlcNHglycan	94	97	PF01048	0.566
MOD_GSK3_1	104	111	PF00069	0.497
MOD_GSK3_1	171	178	PF00069	0.546
MOD_GSK3_1	253	260	PF00069	0.685
MOD_GSK3_1	415	422	PF00069	0.664
MOD_GSK3_1	485	492	PF00069	0.641
MOD_GSK3_1	56	63	PF00069	0.294
MOD_GSK3_1	87	94	PF00069	0.567
MOD_N-GLC_1	104	109	PF02516	0.548
MOD_N-GLC_1	171	176	PF02516	0.346
MOD_NEK2_1	24	29	PF00069	0.613
MOD_NEK2_1	326	331	PF00069	0.546
MOD_NEK2_1	346	351	PF00069	0.464
MOD_NEK2_1	562	567	PF00069	0.559
MOD_NEK2_1	568	573	PF00069	0.678
MOD_NEK2_2	12	17	PF00069	0.404
MOD_NEK2_2	543	548	PF00069	0.319
MOD_PIKK_1	171	177	PF00454	0.546
MOD_PIKK_1	24	30	PF00454	0.619
MOD_PIKK_1	447	453	PF00454	0.539
MOD_PIKK_1	489	495	PF00454	0.702
MOD_PK_1	257	263	PF00069	0.514
MOD_PKA_1	253	259	PF00069	0.717
MOD_PKA_1	425	431	PF00069	0.725
MOD_PKA_2	2	8	PF00069	0.425
MOD_PKA_2	252	258	PF00069	0.702
MOD_PKA_2	362	368	PF00069	0.832
MOD_PKA_2	415	421	PF00069	0.700
MOD_PKA_2	493	499	PF00069	0.530
MOD_Plk_1	346	352	PF00069	0.529
MOD_Plk_1	409	415	PF00069	0.572
MOD_Plk_1	442	448	PF00069	0.680
MOD_Plk_1	543	549	PF00069	0.570
MOD_Plk_2-3	431	437	PF00069	0.813
MOD_Plk_4	12	18	PF00069	0.415
MOD_Plk_4	186	192	PF00069	0.546
MOD_Plk_4	199	205	PF00069	0.546
MOD_Plk_4	511	517	PF00069	0.360
MOD_Plk_4	56	62	PF00069	0.458
MOD_ProDKin_1	18	24	PF00069	0.709
MOD_ProDKin_1	270	276	PF00069	0.693
MOD_ProDKin_1	298	304	PF00069	0.546
MOD_ProDKin_1	44	50	PF00069	0.548
MOD_ProDKin_1	475	481	PF00069	0.812
MOD_ProDKin_1	60	66	PF00069	0.462
MOD_ProDKin_1	95	101	PF00069	0.721
MOD_SUMO_for_1	432	435	PF00179	0.837
MOD_SUMO_rev_2	189	196	PF00179	0.546
MOD_SUMO_rev_2	428	434	PF00179	0.829
TRG_DiLeu_BaEn_1	384	389	PF01217	0.390
TRG_DiLeu_BaEn_4	507	513	PF01217	0.491
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.590
TRG_ENDOCYTIC_2	136	139	PF00928	0.489
TRG_ENDOCYTIC_2	204	207	PF00928	0.506
TRG_ENDOCYTIC_2	314	317	PF00928	0.618
TRG_ENDOCYTIC_2	67	70	PF00928	0.459
TRG_ENDOCYTIC_2	77	80	PF00928	0.566
TRG_ER_diArg_1	150	153	PF00400	0.502
TRG_ER_diArg_1	29	32	PF00400	0.648
TRG_ER_diArg_1	294	296	PF00400	0.546
TRG_ER_diArg_1	318	320	PF00400	0.596
TRG_ER_diArg_1	333	335	PF00400	0.473
TRG_ER_diArg_1	427	430	PF00400	0.591
TRG_NES_CRM1_1	161	175	PF08389	0.427
TRG_NLS_MonoExtC_3	424	429	PF00514	0.715
TRG_NLS_MonoExtN_4	425	430	PF00514	0.720
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIW1	Leptomonas seymouri	60%	77%
A0A2D1QVA5	Leishmania donovani	79%	95%
A4I3V8	Leishmania infantum	79%	95%
E9B048	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	74%
Q4Q837	Leishmania major	78%	100%