Putative glycosomal membrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal membrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGT0_LEIBR

TriTrypDb:

LbrM.28.2460 , LBRM2903_280031000

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	1
GO:0020015	glycosome	7	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGT0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	18
GO:0009987	cellular process	1	18
GO:0016043	cellular component organization	3	18
GO:0016559	peroxisome fission	6	18
GO:0048285	organelle fission	5	18
GO:0071840	cellular component organization or biogenesis	2	18
GO:0032535	regulation of cellular component size	4	1
GO:0044375	regulation of peroxisome size	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0090066	regulation of anatomical structure size	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	155	157	PF00082	0.257
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.289
CLV_PCSK_SKI1_1	128	132	PF00082	0.512
CLV_PCSK_SKI1_1	150	154	PF00082	0.279
CLV_PCSK_SKI1_1	165	169	PF00082	0.257
CLV_PCSK_SKI1_1	6	10	PF00082	0.278
DOC_MAPK_gen_1	164	174	PF00069	0.485
DOC_MAPK_MEF2A_6	176	185	PF00069	0.475
DOC_PP1_RVXF_1	89	96	PF00149	0.517
DOC_USP7_UBL2_3	124	128	PF12436	0.300
DOC_USP7_UBL2_3	164	168	PF12436	0.518
LIG_14-3-3_CanoR_1	117	126	PF00244	0.360
LIG_Actin_WH2_2	136	152	PF00022	0.296
LIG_Actin_WH2_2	178	194	PF00022	0.438
LIG_BH_BH3_1	95	111	PF00452	0.405
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_BRCT_BRCA1_1	88	92	PF00533	0.386
LIG_FHA_1	155	161	PF00498	0.386
LIG_FHA_1	79	85	PF00498	0.467
LIG_LIR_Gen_1	127	135	PF02991	0.288
LIG_LIR_Gen_1	2	11	PF02991	0.441
LIG_LIR_Gen_1	89	99	PF02991	0.515
LIG_LIR_Nem_3	127	132	PF02991	0.302
LIG_LIR_Nem_3	18	24	PF02991	0.442
LIG_LIR_Nem_3	2	7	PF02991	0.574
LIG_LIR_Nem_3	89	95	PF02991	0.500
LIG_LRP6_Inhibitor_1	216	222	PF00058	0.353
LIG_NRBOX	6	12	PF00104	0.540
LIG_Pex14_2	135	139	PF04695	0.293
LIG_Pex14_2	23	27	PF04695	0.480
LIG_Pex14_2	92	96	PF04695	0.556
LIG_PTB_Apo_2	98	105	PF02174	0.331
LIG_PTB_Phospho_1	98	104	PF10480	0.293
LIG_REV1ctd_RIR_1	25	33	PF16727	0.564
LIG_REV1ctd_RIR_1	93	101	PF16727	0.523
LIG_SH2_CRK	129	133	PF00017	0.302
LIG_SH2_CRK	21	25	PF00017	0.470
LIG_SH2_GRB2like	215	218	PF00017	0.464
LIG_SH2_NCK_1	129	133	PF00017	0.186
LIG_SH2_PTP2	46	49	PF00017	0.448
LIG_SH2_STAP1	129	133	PF00017	0.280
LIG_SH2_STAT5	104	107	PF00017	0.269
LIG_SH2_STAT5	190	193	PF00017	0.458
LIG_SH2_STAT5	215	218	PF00017	0.486
LIG_SH2_STAT5	46	49	PF00017	0.448
LIG_SH3_3	191	197	PF00018	0.397
LIG_SUMO_SIM_par_1	170	175	PF11976	0.523
LIG_UBA3_1	59	64	PF00899	0.495
MOD_CK1_1	120	126	PF00069	0.375
MOD_CK1_1	158	164	PF00069	0.410
MOD_CK1_1	198	204	PF00069	0.436
MOD_CK1_1	52	58	PF00069	0.475
MOD_CK2_1	160	166	PF00069	0.449
MOD_GlcNHglycan	197	200	PF01048	0.286
MOD_GlcNHglycan	208	211	PF01048	0.279
MOD_GlcNHglycan	54	57	PF01048	0.311
MOD_GSK3_1	120	127	PF00069	0.238
MOD_GSK3_1	154	161	PF00069	0.451
MOD_GSK3_1	172	179	PF00069	0.572
MOD_GSK3_1	45	52	PF00069	0.446
MOD_GSK3_1	95	102	PF00069	0.454
MOD_NEK2_1	95	100	PF00069	0.497
MOD_PKA_1	155	161	PF00069	0.450
MOD_PKA_2	155	161	PF00069	0.452
MOD_Plk_4	211	217	PF00069	0.477
MOD_Plk_4	99	105	PF00069	0.394
MOD_SUMO_rev_2	120	126	PF00179	0.196
MOD_SUMO_rev_2	163	170	PF00179	0.449
TRG_DiLeu_BaEn_2	87	93	PF01217	0.545
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.220
TRG_ENDOCYTIC_2	129	132	PF00928	0.304
TRG_ENDOCYTIC_2	21	24	PF00928	0.459
TRG_ENDOCYTIC_2	46	49	PF00928	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG1	Leptomonas seymouri	33%	100%
A0A0N1PCA1	Leptomonas seymouri	83%	100%
A0A0S4IU25	Bodo saltans	50%	100%
A0A1X0NR15	Trypanosomatidae	54%	100%
A0A3Q8IB71	Leishmania donovani	25%	100%
A0A3S5H7J8	Leishmania donovani	30%	100%
A0A3S7X1W3	Leishmania donovani	87%	100%
A0A422N9F6	Trypanosoma rangeli	54%	100%
A4HD72	Leishmania braziliensis	24%	100%
A4HGS9	Leishmania braziliensis	29%	100%
A4I3V6	Leishmania infantum	31%	100%
A4I3V7	Leishmania infantum	86%	100%
D0A924	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AH26	Leishmania infantum	25%	100%
E9AWK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B046	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B047	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q838	Leishmania major	84%	100%
Q4Q839	Leishmania major	31%	100%
Q4QAW6	Leishmania major	25%	100%
V5BEE7	Trypanosoma cruzi	59%	100%