Glycosomal membrane protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal membrane protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HGS9_LEIBR

TriTrypDb:

LbrM.28.2450 , LBRM2903_280030900

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	1
GO:0020015	glycosome	7	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGS9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016559	peroxisome fission	6	12
GO:0032535	regulation of cellular component size	4	1
GO:0044375	regulation of peroxisome size	5	1
GO:0048285	organelle fission	5	12
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090066	regulation of anatomical structure size	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.645
CLV_C14_Caspase3-7	147	151	PF00656	0.435
CLV_NRD_NRD_1	152	154	PF00675	0.561
CLV_NRD_NRD_1	163	165	PF00675	0.531
CLV_NRD_NRD_1	39	41	PF00675	0.372
CLV_NRD_NRD_1	85	87	PF00675	0.409
CLV_PCSK_KEX2_1	39	41	PF00082	0.372
CLV_PCSK_SKI1_1	149	153	PF00082	0.358
CLV_PCSK_SKI1_1	20	24	PF00082	0.342
CLV_PCSK_SKI1_1	48	52	PF00082	0.346
CLV_PCSK_SKI1_1	54	58	PF00082	0.297
CLV_PCSK_SKI1_1	94	98	PF00082	0.317
DEG_Nend_UBRbox_1	1	4	PF02207	0.522
DOC_MAPK_gen_1	20	28	PF00069	0.515
DOC_MAPK_gen_1	58	67	PF00069	0.626
DOC_MAPK_gen_1	86	92	PF00069	0.562
DOC_MAPK_MEF2A_6	154	163	PF00069	0.259
DOC_MAPK_MEF2A_6	20	28	PF00069	0.425
DOC_MAPK_MEF2A_6	61	69	PF00069	0.440
DOC_WW_Pin1_4	194	199	PF00397	0.465
LIG_14-3-3_CanoR_1	126	131	PF00244	0.610
LIG_14-3-3_CanoR_1	42	50	PF00244	0.569
LIG_Actin_WH2_2	135	151	PF00022	0.331
LIG_FHA_1	129	135	PF00498	0.527
LIG_FHA_1	181	187	PF00498	0.379
LIG_FHA_2	93	99	PF00498	0.523
LIG_LIR_Gen_1	95	103	PF02991	0.533
LIG_LIR_Nem_3	95	100	PF02991	0.538
LIG_PDZ_Class_3	216	221	PF00595	0.471
LIG_SH2_CRK	157	161	PF00017	0.416
LIG_SH2_SRC	157	160	PF00017	0.438
LIG_SH2_STAP1	43	47	PF00017	0.541
LIG_SH2_STAT5	214	217	PF00017	0.556
LIG_SUMO_SIM_par_1	71	77	PF11976	0.434
LIG_TRAF2_1	216	219	PF00917	0.453
MOD_CDK_SPK_2	194	199	PF00069	0.369
MOD_CK1_1	33	39	PF00069	0.593
MOD_CK2_1	213	219	PF00069	0.274
MOD_CK2_1	35	41	PF00069	0.648
MOD_CK2_1	68	74	PF00069	0.527
MOD_GlcNHglycan	207	210	PF01048	0.304
MOD_GlcNHglycan	43	46	PF01048	0.398
MOD_GlcNHglycan	6	9	PF01048	0.300
MOD_GSK3_1	205	212	PF00069	0.306
MOD_GSK3_1	213	220	PF00069	0.386
MOD_GSK3_1	27	34	PF00069	0.585
MOD_GSK3_1	48	55	PF00069	0.576
MOD_N-GLC_1	126	131	PF02516	0.323
MOD_NEK2_1	138	143	PF00069	0.416
MOD_NEK2_1	185	190	PF00069	0.352
MOD_NEK2_1	31	36	PF00069	0.622
MOD_NEK2_1	6	11	PF00069	0.661
MOD_NEK2_1	63	68	PF00069	0.631
MOD_NEK2_1	92	97	PF00069	0.549
MOD_NEK2_2	209	214	PF00069	0.450
MOD_PK_1	14	20	PF00069	0.544
MOD_PKA_2	41	47	PF00069	0.550
MOD_PKB_1	124	132	PF00069	0.436
MOD_Plk_1	120	126	PF00069	0.458
MOD_Plk_4	138	144	PF00069	0.435
MOD_Plk_4	177	183	PF00069	0.309
MOD_Plk_4	185	191	PF00069	0.352
MOD_Plk_4	209	215	PF00069	0.336
MOD_Plk_4	68	74	PF00069	0.607
MOD_Plk_4	92	98	PF00069	0.568
MOD_ProDKin_1	194	200	PF00069	0.462
TRG_DiLeu_BaEn_2	84	90	PF01217	0.603
TRG_NLS_Bipartite_1	153	168	PF00514	0.254
TRG_NLS_MonoExtC_3	152	158	PF00514	0.275
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG1	Leptomonas seymouri	45%	100%
A0A0N1PCA1	Leptomonas seymouri	32%	100%
A0A0S4IU25	Bodo saltans	27%	100%
A0A1X0NR15	Trypanosomatidae	32%	100%
A0A3S5H7J8	Leishmania donovani	65%	100%
A0A3S7X1W3	Leishmania donovani	32%	100%
A0A422N9F6	Trypanosoma rangeli	32%	100%
A4HGT0	Leishmania braziliensis	29%	100%
A4I3V6	Leishmania infantum	64%	100%
A4I3V7	Leishmania infantum	32%	100%
D0A924	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B046	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9B047	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q838	Leishmania major	33%	100%
Q4Q839	Leishmania major	63%	100%
V5BEE7	Trypanosoma cruzi	29%	100%