Hd phosphohydrolase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hd phosphohydrolase family protein

Species:

Leishmania braziliensis

UniProt:

A4HGS8_LEIBR

TriTrypDb:

LbrM.28.2440 , LBRM2903_280030800

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGS8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.476
DEG_Nend_Nbox_1	1	3	PF02207	0.434
DEG_SPOP_SBC_1	183	187	PF00917	0.402
DOC_CKS1_1	263	268	PF01111	0.369
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.572
DOC_MAPK_gen_1	163	170	PF00069	0.485
DOC_MAPK_MEF2A_6	202	210	PF00069	0.393
DOC_PP2B_LxvP_1	176	179	PF13499	0.474
DOC_USP7_MATH_1	110	114	PF00917	0.621
DOC_USP7_MATH_1	183	187	PF00917	0.588
DOC_USP7_MATH_1	27	31	PF00917	0.553
DOC_USP7_MATH_1	281	285	PF00917	0.440
DOC_WW_Pin1_4	130	135	PF00397	0.672
DOC_WW_Pin1_4	178	183	PF00397	0.597
DOC_WW_Pin1_4	262	267	PF00397	0.379
DOC_WW_Pin1_4	30	35	PF00397	0.427
LIG_APCC_ABBA_1	206	211	PF00400	0.305
LIG_BRCT_BRCA1_1	132	136	PF00533	0.496
LIG_BRCT_BRCA1_1	54	58	PF00533	0.382
LIG_Clathr_ClatBox_1	142	146	PF01394	0.326
LIG_FHA_1	120	126	PF00498	0.730
LIG_FHA_1	157	163	PF00498	0.384
LIG_FHA_1	38	44	PF00498	0.457
LIG_FHA_1	46	52	PF00498	0.380
LIG_FHA_2	185	191	PF00498	0.539
LIG_FHA_2	278	284	PF00498	0.274
LIG_FHA_2	36	42	PF00498	0.502
LIG_FHA_2	64	70	PF00498	0.438
LIG_Integrin_RGD_1	67	69	PF01839	0.468
LIG_LIR_Gen_1	55	65	PF02991	0.377
LIG_LIR_Gen_1	80	85	PF02991	0.315
LIG_LIR_Nem_3	236	240	PF02991	0.456
LIG_LIR_Nem_3	265	270	PF02991	0.452
LIG_LIR_Nem_3	55	61	PF02991	0.377
LIG_Pex14_1	14	18	PF04695	0.548
LIG_Pex14_2	252	256	PF04695	0.343
LIG_REV1ctd_RIR_1	266	275	PF16727	0.472
LIG_SH2_CRK	263	267	PF00017	0.509
LIG_SH2_STAP1	229	233	PF00017	0.372
LIG_SH2_STAT5	160	163	PF00017	0.397
LIG_SH2_STAT5	267	270	PF00017	0.424
LIG_SH3_2	172	177	PF14604	0.326
LIG_SH3_3	169	175	PF00018	0.456
LIG_SH3_3	176	182	PF00018	0.609
LIG_SH3_3	59	65	PF00018	0.348
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.314
LIG_SUMO_SIM_anti_2	50	55	PF11976	0.358
LIG_SUMO_SIM_par_1	48	55	PF11976	0.402
LIG_TRAF2_1	280	283	PF00917	0.527
MOD_CK1_1	113	119	PF00069	0.619
MOD_CK1_1	135	141	PF00069	0.453
MOD_CK1_1	156	162	PF00069	0.385
MOD_CK1_1	30	36	PF00069	0.486
MOD_CK2_1	178	184	PF00069	0.524
MOD_CK2_1	277	283	PF00069	0.276
MOD_GlcNHglycan	112	115	PF01048	0.494
MOD_GlcNHglycan	116	119	PF01048	0.516
MOD_GlcNHglycan	137	140	PF01048	0.628
MOD_GlcNHglycan	194	197	PF01048	0.491
MOD_GlcNHglycan	29	32	PF01048	0.584
MOD_GlcNHglycan	73	76	PF01048	0.407
MOD_GSK3_1	105	112	PF00069	0.735
MOD_GSK3_1	113	120	PF00069	0.606
MOD_GSK3_1	126	133	PF00069	0.485
MOD_GSK3_1	178	185	PF00069	0.524
MOD_GSK3_1	188	195	PF00069	0.650
MOD_GSK3_1	26	33	PF00069	0.547
MOD_GSK3_1	277	284	PF00069	0.273
MOD_GSK3_1	93	100	PF00069	0.547
MOD_N-GLC_1	71	76	PF02516	0.272
MOD_NEK2_1	26	31	PF00069	0.449
MOD_NEK2_1	52	57	PF00069	0.430
MOD_PIKK_1	126	132	PF00454	0.502
MOD_PK_1	285	291	PF00069	0.285
MOD_PKA_2	153	159	PF00069	0.459
MOD_PKA_2	86	92	PF00069	0.462
MOD_Plk_1	154	160	PF00069	0.250
MOD_Plk_1	183	189	PF00069	0.396
MOD_Plk_1	235	241	PF00069	0.450
MOD_Plk_1	71	77	PF00069	0.363
MOD_Plk_2-3	184	190	PF00069	0.481
MOD_Plk_4	156	162	PF00069	0.399
MOD_Plk_4	188	194	PF00069	0.389
MOD_Plk_4	47	53	PF00069	0.405
MOD_Plk_4	93	99	PF00069	0.382
MOD_ProDKin_1	130	136	PF00069	0.671
MOD_ProDKin_1	178	184	PF00069	0.598
MOD_ProDKin_1	262	268	PF00069	0.379
MOD_ProDKin_1	30	36	PF00069	0.424
MOD_SUMO_rev_2	166	175	PF00179	0.474
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.491
TRG_ER_diArg_1	225	228	PF00400	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I496	Leptomonas seymouri	47%	93%
A0A1X0NQQ5	Trypanosomatidae	31%	96%
A0A3Q8IER6	Leishmania donovani	80%	99%
A0A422N9C9	Trypanosoma rangeli	36%	96%
A4I3V5	Leishmania infantum	80%	99%
D0A923	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B045	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4Q840	Leishmania major	80%	100%
V5D5P4	Trypanosoma cruzi	37%	98%