2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like

Species:

Leishmania braziliensis

UniProt:

A4HGS6_LEIBR

TriTrypDb:

LbrM.28.2420 , LBRM2903_280030600

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HGS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGS6

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006082	organic acid metabolic process	3	12
GO:0006090	pyruvate metabolic process	7	12
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006096	glycolytic process	5	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006757	obsolete ATP generation from ADP	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009132	nucleoside diphosphate metabolic process	5	12
GO:0009135	purine nucleoside diphosphate metabolic process	6	12
GO:0009141	nucleoside triphosphate metabolic process	5	12
GO:0009144	purine nucleoside triphosphate metabolic process	6	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	12
GO:0009185	ribonucleoside diphosphate metabolic process	6	12
GO:0009199	ribonucleoside triphosphate metabolic process	6	12
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009987	cellular process	1	12
GO:0016052	carbohydrate catabolic process	4	12
GO:0016310	phosphorylation	5	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0032787	monocarboxylic acid metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046031	ADP metabolic process	7	12
GO:0046034	ATP metabolic process	7	12
GO:0046483	heterocycle metabolic process	3	12
GO:0046939	obsolete nucleotide phosphorylation	6	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072521	purine-containing compound metabolic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004619	phosphoglycerate mutase activity	5	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0016868	intramolecular transferase activity, phosphotransferases	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046537	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity	6	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	785	789	PF00656	0.428
CLV_NRD_NRD_1	436	438	PF00675	0.231
CLV_NRD_NRD_1	491	493	PF00675	0.278
CLV_NRD_NRD_1	555	557	PF00675	0.276
CLV_NRD_NRD_1	566	568	PF00675	0.261
CLV_NRD_NRD_1	590	592	PF00675	0.347
CLV_NRD_NRD_1	737	739	PF00675	0.335
CLV_PCSK_KEX2_1	436	438	PF00082	0.232
CLV_PCSK_KEX2_1	491	493	PF00082	0.278
CLV_PCSK_KEX2_1	555	557	PF00082	0.268
CLV_PCSK_KEX2_1	566	568	PF00082	0.262
CLV_PCSK_KEX2_1	737	739	PF00082	0.335
CLV_PCSK_KEX2_1	783	785	PF00082	0.278
CLV_PCSK_KEX2_1	825	827	PF00082	0.382
CLV_PCSK_PC1ET2_1	783	785	PF00082	0.278
CLV_PCSK_PC1ET2_1	825	827	PF00082	0.382
CLV_PCSK_SKI1_1	224	228	PF00082	0.679
CLV_PCSK_SKI1_1	421	425	PF00082	0.331
CLV_PCSK_SKI1_1	555	559	PF00082	0.295
CLV_PCSK_SKI1_1	655	659	PF00082	0.278
CLV_PCSK_SKI1_1	670	674	PF00082	0.178
CLV_PCSK_SKI1_1	727	731	PF00082	0.279
CLV_Separin_Metazoa	734	738	PF03568	0.478
DEG_APCC_DBOX_1	276	284	PF00400	0.442
DEG_APCC_DBOX_1	614	622	PF00400	0.535
DEG_APCC_DBOX_1	669	677	PF00400	0.535
DEG_ODPH_VHL_1	623	634	PF01847	0.535
DEG_SCF_FBW7_1	159	164	PF00400	0.655
DEG_SPOP_SBC_1	161	165	PF00917	0.592
DEG_SPOP_SBC_1	423	427	PF00917	0.435
DOC_CKS1_1	103	108	PF01111	0.189
DOC_CYCLIN_yClb5_NLxxxL_5	727	733	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	346	352	PF00134	0.535
DOC_MAPK_FxFP_2	366	369	PF00069	0.448
DOC_MAPK_FxFP_2	467	470	PF00069	0.535
DOC_MAPK_gen_1	591	599	PF00069	0.500
DOC_MAPK_gen_1	814	823	PF00069	0.351
DOC_MAPK_gen_1	84	91	PF00069	0.425
DOC_MAPK_JIP1_4	256	262	PF00069	0.281
DOC_MAPK_MEF2A_6	727	735	PF00069	0.478
DOC_PP2B_PxIxI_1	332	338	PF00149	0.466
DOC_PP4_FxxP_1	254	257	PF00568	0.564
DOC_PP4_FxxP_1	366	369	PF00568	0.448
DOC_PP4_FxxP_1	467	470	PF00568	0.535
DOC_USP7_MATH_1	113	117	PF00917	0.556
DOC_USP7_MATH_1	161	165	PF00917	0.529
DOC_USP7_MATH_1	287	291	PF00917	0.542
DOC_USP7_MATH_1	297	301	PF00917	0.522
DOC_USP7_MATH_1	352	356	PF00917	0.482
DOC_USP7_MATH_1	496	500	PF00917	0.478
DOC_USP7_MATH_1	51	55	PF00917	0.295
DOC_USP7_MATH_1	581	585	PF00917	0.541
DOC_USP7_MATH_1	691	695	PF00917	0.580
DOC_USP7_MATH_1	760	764	PF00917	0.468
DOC_WW_Pin1_4	102	107	PF00397	0.281
DOC_WW_Pin1_4	155	160	PF00397	0.603
DOC_WW_Pin1_4	240	245	PF00397	0.711
DOC_WW_Pin1_4	275	280	PF00397	0.466
DOC_WW_Pin1_4	292	297	PF00397	0.466
DOC_WW_Pin1_4	329	334	PF00397	0.491
DOC_WW_Pin1_4	761	766	PF00397	0.442
LIG_14-3-3_CanoR_1	120	130	PF00244	0.623
LIG_14-3-3_CanoR_1	162	171	PF00244	0.554
LIG_14-3-3_CanoR_1	36	41	PF00244	0.411
LIG_14-3-3_CanoR_1	784	791	PF00244	0.478
LIG_APCC_ABBA_1	177	182	PF00400	0.678
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_BRCT_BRCA1_1	113	117	PF00533	0.587
LIG_CaM_IQ_9	192	207	PF13499	0.395
LIG_Clathr_ClatBox_1	260	264	PF01394	0.442
LIG_EH1_1	170	178	PF00400	0.398
LIG_EH1_1	340	348	PF00400	0.542
LIG_FHA_1	140	146	PF00498	0.335
LIG_FHA_1	241	247	PF00498	0.475
LIG_FHA_1	330	336	PF00498	0.528
LIG_FHA_1	358	364	PF00498	0.431
LIG_FHA_1	405	411	PF00498	0.451
LIG_FHA_1	511	517	PF00498	0.417
LIG_FHA_1	540	546	PF00498	0.450
LIG_FHA_1	552	558	PF00498	0.431
LIG_FHA_1	609	615	PF00498	0.491
LIG_FHA_1	624	630	PF00498	0.378
LIG_FHA_1	687	693	PF00498	0.570
LIG_FHA_1	753	759	PF00498	0.434
LIG_FHA_2	103	109	PF00498	0.337
LIG_FHA_2	268	274	PF00498	0.447
LIG_FHA_2	276	282	PF00498	0.435
LIG_FHA_2	324	330	PF00498	0.478
LIG_FHA_2	400	406	PF00498	0.540
LIG_FHA_2	509	515	PF00498	0.442
LIG_FHA_2	526	532	PF00498	0.442
LIG_FHA_2	647	653	PF00498	0.462
LIG_FHA_2	783	789	PF00498	0.558
LIG_Integrin_RGD_1	816	818	PF01839	0.367
LIG_LIR_Apic_2	154	159	PF02991	0.560
LIG_LIR_Apic_2	213	218	PF02991	0.462
LIG_LIR_Apic_2	364	369	PF02991	0.491
LIG_LIR_Gen_1	707	717	PF02991	0.557
LIG_LIR_Gen_1	744	754	PF02991	0.452
LIG_LIR_Gen_1	800	807	PF02991	0.380
LIG_LIR_Nem_3	268	274	PF02991	0.442
LIG_LIR_Nem_3	41	46	PF02991	0.402
LIG_LIR_Nem_3	707	713	PF02991	0.529
LIG_LIR_Nem_3	744	750	PF02991	0.498
LIG_OCRL_FandH_1	611	623	PF00620	0.535
LIG_PCNA_PIPBox_1	824	833	PF02747	0.491
LIG_Pex14_1	608	612	PF04695	0.456
LIG_Pex14_2	396	400	PF04695	0.431
LIG_SH2_CRK	11	15	PF00017	0.227
LIG_SH2_CRK	710	714	PF00017	0.478
LIG_SH2_NCK_1	536	540	PF00017	0.386
LIG_SH2_STAP1	536	540	PF00017	0.439
LIG_SH2_STAP1	541	545	PF00017	0.424
LIG_SH2_STAP1	802	806	PF00017	0.347
LIG_SH2_STAT5	146	149	PF00017	0.334
LIG_SH2_STAT5	432	435	PF00017	0.535
LIG_SH2_STAT5	541	544	PF00017	0.431
LIG_SH2_STAT5	79	82	PF00017	0.189
LIG_SH3_3	241	247	PF00018	0.571
LIG_SH3_3	249	255	PF00018	0.422
LIG_SH3_3	283	289	PF00018	0.428
LIG_SH3_3	44	50	PF00018	0.433
LIG_SH3_3	98	104	PF00018	0.411
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.456
LIG_SUMO_SIM_par_1	105	111	PF11976	0.484
LIG_TRAF2_1	235	238	PF00917	0.713
LIG_TRAF2_1	649	652	PF00917	0.462
LIG_UBA3_1	820	825	PF00899	0.421
LIG_WRC_WIRS_1	400	405	PF05994	0.535
LIG_WRC_WIRS_1	609	614	PF05994	0.478
MOD_CDC14_SPxK_1	295	298	PF00782	0.376
MOD_CDK_SPK_2	157	162	PF00069	0.665
MOD_CDK_SPxK_1	292	298	PF00069	0.376
MOD_CDK_SPxxK_3	155	162	PF00069	0.680
MOD_CK1_1	102	108	PF00069	0.354
MOD_CK1_1	157	163	PF00069	0.739
MOD_CK1_1	169	175	PF00069	0.600
MOD_CK1_1	292	298	PF00069	0.520
MOD_CK1_1	355	361	PF00069	0.470
MOD_CK1_1	425	431	PF00069	0.472
MOD_CK2_1	102	108	PF00069	0.369
MOD_CK2_1	267	273	PF00069	0.447
MOD_CK2_1	275	281	PF00069	0.435
MOD_CK2_1	287	293	PF00069	0.345
MOD_CK2_1	304	310	PF00069	0.547
MOD_CK2_1	323	329	PF00069	0.351
MOD_CK2_1	525	531	PF00069	0.452
MOD_CK2_1	646	652	PF00069	0.513
MOD_GlcNHglycan	113	116	PF01048	0.465
MOD_GlcNHglycan	147	150	PF01048	0.288
MOD_GlcNHglycan	197	200	PF01048	0.523
MOD_GlcNHglycan	299	302	PF01048	0.297
MOD_GlcNHglycan	315	318	PF01048	0.369
MOD_GlcNHglycan	343	346	PF01048	0.251
MOD_GlcNHglycan	427	430	PF01048	0.343
MOD_GlcNHglycan	487	490	PF01048	0.339
MOD_GlcNHglycan	549	552	PF01048	0.320
MOD_GlcNHglycan	583	586	PF01048	0.334
MOD_GlcNHglycan	68	71	PF01048	0.468
MOD_GlcNHglycan	738	741	PF01048	0.348
MOD_GlcNHglycan	747	750	PF01048	0.357
MOD_GlcNHglycan	791	794	PF01048	0.546
MOD_GlcNHglycan	808	811	PF01048	0.559
MOD_GlcNHglycan	81	84	PF01048	0.443
MOD_GSK3_1	120	127	PF00069	0.624
MOD_GSK3_1	157	164	PF00069	0.614
MOD_GSK3_1	302	309	PF00069	0.437
MOD_GSK3_1	357	364	PF00069	0.501
MOD_GSK3_1	453	460	PF00069	0.413
MOD_GSK3_1	504	511	PF00069	0.513
MOD_GSK3_1	547	554	PF00069	0.476
MOD_GSK3_1	581	588	PF00069	0.515
MOD_GSK3_1	646	653	PF00069	0.530
MOD_GSK3_1	691	698	PF00069	0.537
MOD_N-GLC_1	453	458	PF02516	0.335
MOD_N-GLC_1	66	71	PF02516	0.320
MOD_NEK2_1	145	150	PF00069	0.268
MOD_NEK2_1	192	197	PF00069	0.693
MOD_NEK2_1	302	307	PF00069	0.422
MOD_NEK2_1	313	318	PF00069	0.460
MOD_NEK2_1	323	328	PF00069	0.421
MOD_NEK2_1	424	429	PF00069	0.508
MOD_NEK2_1	45	50	PF00069	0.235
MOD_NEK2_1	453	458	PF00069	0.481
MOD_NEK2_1	692	697	PF00069	0.532
MOD_NEK2_1	736	741	PF00069	0.547
MOD_NEK2_1	805	810	PF00069	0.447
MOD_NEK2_2	113	118	PF00069	0.482
MOD_NEK2_2	361	366	PF00069	0.501
MOD_NEK2_2	539	544	PF00069	0.535
MOD_NEK2_2	650	655	PF00069	0.535
MOD_PIKK_1	162	168	PF00454	0.416
MOD_PIKK_1	192	198	PF00454	0.417
MOD_PIKK_1	696	702	PF00454	0.376
MOD_PKA_1	783	789	PF00069	0.478
MOD_PKA_2	161	167	PF00069	0.542
MOD_PKA_2	192	198	PF00069	0.601
MOD_PKA_2	297	303	PF00069	0.495
MOD_PKA_2	736	742	PF00069	0.557
MOD_PKA_2	783	789	PF00069	0.542
MOD_PKB_1	118	126	PF00069	0.618
MOD_PKB_1	36	44	PF00069	0.331
MOD_Plk_1	267	273	PF00069	0.477
MOD_Plk_4	172	178	PF00069	0.599
MOD_Plk_4	361	367	PF00069	0.476
MOD_Plk_4	369	375	PF00069	0.573
MOD_Plk_4	608	614	PF00069	0.396
MOD_ProDKin_1	102	108	PF00069	0.281
MOD_ProDKin_1	155	161	PF00069	0.608
MOD_ProDKin_1	240	246	PF00069	0.709
MOD_ProDKin_1	275	281	PF00069	0.466
MOD_ProDKin_1	292	298	PF00069	0.466
MOD_ProDKin_1	329	335	PF00069	0.491
MOD_ProDKin_1	761	767	PF00069	0.442
MOD_SUMO_for_1	731	734	PF00179	0.478
MOD_SUMO_rev_2	413	423	PF00179	0.520
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.484
TRG_ENDOCYTIC_2	11	14	PF00928	0.264
TRG_ENDOCYTIC_2	271	274	PF00928	0.442
TRG_ENDOCYTIC_2	380	383	PF00928	0.485
TRG_ENDOCYTIC_2	43	46	PF00928	0.266
TRG_ENDOCYTIC_2	710	713	PF00928	0.579
TRG_ENDOCYTIC_2	802	805	PF00928	0.339
TRG_ENDOCYTIC_2	831	834	PF00928	0.518
TRG_ER_diArg_1	117	120	PF00400	0.556
TRG_ER_diArg_1	374	377	PF00400	0.442
TRG_ER_diArg_1	491	493	PF00400	0.478
TRG_ER_diArg_1	555	557	PF00400	0.477
TRG_ER_diArg_1	736	738	PF00400	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B9	Leptomonas seymouri	69%	100%
A0A0S4J9H6	Bodo saltans	35%	100%
A0A1X0NQP8	Trypanosomatidae	41%	100%
A0A3S7X1Q9	Leishmania donovani	84%	100%
A0A422MUW5	Trypanosoma rangeli	46%	100%
A4I3V2	Leishmania infantum	84%	100%
D0A920	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B043	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q842	Leishmania major	84%	100%
V5D5P0	Trypanosoma cruzi	44%	100%