Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGS3_LEIBR

TriTrypDb:

LbrM.28.2390 , LBRM2903_280030300

Length:

894

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.541
CLV_C14_Caspase3-7	173	177	PF00656	0.397
CLV_C14_Caspase3-7	205	209	PF00656	0.395
CLV_C14_Caspase3-7	512	516	PF00656	0.568
CLV_NRD_NRD_1	119	121	PF00675	0.518
CLV_NRD_NRD_1	335	337	PF00675	0.701
CLV_NRD_NRD_1	477	479	PF00675	0.740
CLV_NRD_NRD_1	483	485	PF00675	0.672
CLV_NRD_NRD_1	580	582	PF00675	0.524
CLV_NRD_NRD_1	634	636	PF00675	0.682
CLV_NRD_NRD_1	857	859	PF00675	0.673
CLV_PCSK_KEX2_1	119	121	PF00082	0.518
CLV_PCSK_KEX2_1	334	336	PF00082	0.706
CLV_PCSK_KEX2_1	477	479	PF00082	0.740
CLV_PCSK_KEX2_1	634	636	PF00082	0.677
CLV_PCSK_KEX2_1	668	670	PF00082	0.715
CLV_PCSK_KEX2_1	857	859	PF00082	0.673
CLV_PCSK_KEX2_1	93	95	PF00082	0.544
CLV_PCSK_PC1ET2_1	668	670	PF00082	0.715
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.544
CLV_PCSK_PC7_1	115	121	PF00082	0.548
CLV_PCSK_SKI1_1	115	119	PF00082	0.549
CLV_PCSK_SKI1_1	215	219	PF00082	0.556
CLV_PCSK_SKI1_1	310	314	PF00082	0.365
CLV_PCSK_SKI1_1	316	320	PF00082	0.390
CLV_PCSK_SKI1_1	415	419	PF00082	0.555
CLV_PCSK_SKI1_1	422	426	PF00082	0.534
CLV_PCSK_SKI1_1	492	496	PF00082	0.730
CLV_PCSK_SKI1_1	57	61	PF00082	0.374
CLV_PCSK_SKI1_1	614	618	PF00082	0.695
CLV_PCSK_SKI1_1	65	69	PF00082	0.364
CLV_PCSK_SKI1_1	857	861	PF00082	0.679
CLV_Separin_Metazoa	38	42	PF03568	0.552
DEG_APCC_DBOX_1	118	126	PF00400	0.396
DEG_Nend_UBRbox_2	1	3	PF02207	0.569
DEG_SCF_FBW7_1	250	257	PF00400	0.541
DEG_SCF_FBW7_1	656	661	PF00400	0.552
DEG_SCF_FBW7_1	663	670	PF00400	0.540
DEG_SCF_FBW7_1	713	718	PF00400	0.567
DEG_SPOP_SBC_1	265	269	PF00917	0.523
DEG_SPOP_SBC_1	517	521	PF00917	0.559
DEG_SPOP_SBC_1	721	725	PF00917	0.588
DOC_CKS1_1	498	503	PF01111	0.709
DOC_CKS1_1	639	644	PF01111	0.584
DOC_CKS1_1	664	669	PF01111	0.559
DOC_CKS1_1	819	824	PF01111	0.715
DOC_CKS1_1	850	855	PF01111	0.657
DOC_CKS1_1	883	888	PF01111	0.700
DOC_CYCLIN_RxL_1	412	421	PF00134	0.553
DOC_CYCLIN_RxL_1	489	497	PF00134	0.632
DOC_CYCLIN_yCln2_LP_2	549	555	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	603	609	PF00134	0.722
DOC_MAPK_gen_1	186	196	PF00069	0.579
DOC_MAPK_MEF2A_6	310	319	PF00069	0.378
DOC_PP1_RVXF_1	101	107	PF00149	0.537
DOC_PP1_RVXF_1	413	419	PF00149	0.551
DOC_PP2B_LxvP_1	247	250	PF13499	0.808
DOC_PP2B_LxvP_1	326	329	PF13499	0.615
DOC_PP4_FxxP_1	664	667	PF00568	0.554
DOC_PP4_FxxP_1	883	886	PF00568	0.700
DOC_USP7_MATH_1	288	292	PF00917	0.501
DOC_USP7_MATH_1	442	446	PF00917	0.651
DOC_USP7_MATH_1	488	492	PF00917	0.632
DOC_USP7_MATH_1	502	506	PF00917	0.670
DOC_USP7_MATH_1	569	573	PF00917	0.652
DOC_USP7_MATH_1	667	671	PF00917	0.599
DOC_USP7_MATH_1	678	682	PF00917	0.657
DOC_USP7_MATH_1	694	698	PF00917	0.608
DOC_USP7_MATH_1	760	764	PF00917	0.669
DOC_USP7_MATH_1	807	811	PF00917	0.573
DOC_USP7_UBL2_3	306	310	PF12436	0.531
DOC_WW_Pin1_4	12	17	PF00397	0.519
DOC_WW_Pin1_4	250	255	PF00397	0.546
DOC_WW_Pin1_4	276	281	PF00397	0.615
DOC_WW_Pin1_4	286	291	PF00397	0.573
DOC_WW_Pin1_4	353	358	PF00397	0.623
DOC_WW_Pin1_4	424	429	PF00397	0.492
DOC_WW_Pin1_4	431	436	PF00397	0.512
DOC_WW_Pin1_4	458	463	PF00397	0.680
DOC_WW_Pin1_4	497	502	PF00397	0.707
DOC_WW_Pin1_4	536	541	PF00397	0.591
DOC_WW_Pin1_4	565	570	PF00397	0.586
DOC_WW_Pin1_4	592	597	PF00397	0.673
DOC_WW_Pin1_4	598	603	PF00397	0.635
DOC_WW_Pin1_4	628	633	PF00397	0.724
DOC_WW_Pin1_4	638	643	PF00397	0.639
DOC_WW_Pin1_4	652	657	PF00397	0.565
DOC_WW_Pin1_4	663	668	PF00397	0.653
DOC_WW_Pin1_4	680	685	PF00397	0.580
DOC_WW_Pin1_4	711	716	PF00397	0.726
DOC_WW_Pin1_4	717	722	PF00397	0.683
DOC_WW_Pin1_4	788	793	PF00397	0.707
DOC_WW_Pin1_4	803	808	PF00397	0.562
DOC_WW_Pin1_4	818	823	PF00397	0.565
DOC_WW_Pin1_4	846	851	PF00397	0.713
DOC_WW_Pin1_4	867	872	PF00397	0.698
DOC_WW_Pin1_4	882	887	PF00397	0.564
LIG_14-3-3_CanoR_1	169	175	PF00244	0.595
LIG_14-3-3_CanoR_1	191	197	PF00244	0.568
LIG_14-3-3_CanoR_1	341	351	PF00244	0.803
LIG_14-3-3_CanoR_1	394	402	PF00244	0.654
LIG_14-3-3_CanoR_1	484	493	PF00244	0.751
LIG_14-3-3_CanoR_1	560	564	PF00244	0.728
LIG_14-3-3_CanoR_1	57	64	PF00244	0.378
LIG_14-3-3_CanoR_1	634	640	PF00244	0.738
LIG_14-3-3_CanoR_1	669	673	PF00244	0.638
LIG_14-3-3_CanoR_1	733	742	PF00244	0.726
LIG_14-3-3_CanoR_1	772	781	PF00244	0.702
LIG_Actin_WH2_2	105	121	PF00022	0.534
LIG_Actin_WH2_2	758	774	PF00022	0.544
LIG_BH_BH3_1	290	306	PF00452	0.544
LIG_BRCT_BRCA1_1	622	626	PF00533	0.558
LIG_BRCT_BRCA1_1	660	664	PF00533	0.712
LIG_BRCT_BRCA1_1	879	883	PF00533	0.714
LIG_CaM_IQ_9	22	38	PF13499	0.388
LIG_Clathr_ClatBox_1	417	421	PF01394	0.565
LIG_CtBP_PxDLS_1	350	354	PF00389	0.533
LIG_FHA_1	13	19	PF00498	0.581
LIG_FHA_1	162	168	PF00498	0.596
LIG_FHA_1	222	228	PF00498	0.419
LIG_FHA_1	266	272	PF00498	0.521
LIG_FHA_1	343	349	PF00498	0.580
LIG_FHA_1	466	472	PF00498	0.547
LIG_FHA_1	488	494	PF00498	0.732
LIG_FHA_1	560	566	PF00498	0.568
LIG_FHA_1	58	64	PF00498	0.377
LIG_FHA_1	655	661	PF00498	0.555
LIG_FHA_1	712	718	PF00498	0.584
LIG_FHA_1	850	856	PF00498	0.599
LIG_FHA_1	99	105	PF00498	0.537
LIG_FHA_2	171	177	PF00498	0.459
LIG_FHA_2	370	376	PF00498	0.394
LIG_FHA_2	484	490	PF00498	0.575
LIG_FHA_2	56	62	PF00498	0.466
LIG_FHA_2	883	889	PF00498	0.697
LIG_LIR_Apic_2	661	667	PF02991	0.556
LIG_LIR_Apic_2	880	886	PF02991	0.706
LIG_LIR_Gen_1	888	894	PF02991	0.530
LIG_LIR_Nem_3	572	578	PF02991	0.508
LIG_LIR_Nem_3	749	753	PF02991	0.528
LIG_LIR_Nem_3	791	796	PF02991	0.574
LIG_LIR_Nem_3	888	894	PF02991	0.530
LIG_MYND_1	450	454	PF01753	0.681
LIG_MYND_1	602	606	PF01753	0.572
LIG_MYND_3	348	352	PF01753	0.547
LIG_PCNA_yPIPBox_3	360	374	PF02747	0.558
LIG_Pex14_2	543	547	PF04695	0.539
LIG_SH2_NCK_1	743	747	PF00017	0.604
LIG_SH2_SRC	743	746	PF00017	0.532
LIG_SH2_STAP1	283	287	PF00017	0.537
LIG_SH2_STAP1	402	406	PF00017	0.674
LIG_SH2_STAP1	743	747	PF00017	0.604
LIG_SH2_STAT3	542	545	PF00017	0.609
LIG_SH2_STAT5	542	545	PF00017	0.637
LIG_SH3_2	479	484	PF14604	0.578
LIG_SH3_3	476	482	PF00018	0.628
LIG_SH3_3	525	531	PF00018	0.698
LIG_SH3_3	561	567	PF00018	0.624
LIG_SH3_3	603	609	PF00018	0.677
LIG_SH3_3	636	642	PF00018	0.743
LIG_SH3_3	707	713	PF00018	0.649
LIG_SH3_3	819	825	PF00018	0.715
LIG_SH3_3	847	853	PF00018	0.676
LIG_SUMO_SIM_anti_2	20	27	PF11976	0.532
LIG_SUMO_SIM_par_1	349	354	PF11976	0.536
LIG_TRAF2_1	124	127	PF00917	0.570
LIG_TRAF2_1	77	80	PF00917	0.614
LIG_TRAF2_2	739	744	PF00917	0.542
LIG_UBA3_1	416	422	PF00899	0.407
LIG_WRC_WIRS_1	363	368	PF05994	0.562
LIG_WRC_WIRS_1	750	755	PF05994	0.688
LIG_WW_3	481	485	PF00397	0.734
LIG_WW_3	641	645	PF00397	0.579
MOD_CDC14_SPxK_1	631	634	PF00782	0.663
MOD_CDC14_SPxK_1	791	794	PF00782	0.703
MOD_CDK_SPK_2	424	429	PF00069	0.492
MOD_CDK_SPK_2	663	668	PF00069	0.556
MOD_CDK_SPxK_1	433	439	PF00069	0.542
MOD_CDK_SPxK_1	458	464	PF00069	0.692
MOD_CDK_SPxK_1	628	634	PF00069	0.666
MOD_CDK_SPxK_1	638	644	PF00069	0.609
MOD_CDK_SPxK_1	663	669	PF00069	0.684
MOD_CDK_SPxK_1	788	794	PF00069	0.702
MOD_CDK_SPxxK_3	628	635	PF00069	0.729
MOD_CK1_1	135	141	PF00069	0.641
MOD_CK1_1	148	154	PF00069	0.571
MOD_CK1_1	17	23	PF00069	0.569
MOD_CK1_1	342	348	PF00069	0.782
MOD_CK1_1	487	493	PF00069	0.599
MOD_CK1_1	556	562	PF00069	0.690
MOD_CK1_1	621	627	PF00069	0.712
MOD_CK1_1	662	668	PF00069	0.625
MOD_CK1_1	752	758	PF00069	0.666
MOD_CK1_1	763	769	PF00069	0.604
MOD_CK1_1	776	782	PF00069	0.625
MOD_CK2_1	107	113	PF00069	0.386
MOD_CK2_1	340	346	PF00069	0.716
MOD_CK2_1	362	368	PF00069	0.564
MOD_CK2_1	369	375	PF00069	0.475
MOD_CK2_1	483	489	PF00069	0.574
MOD_CK2_1	55	61	PF00069	0.491
MOD_CK2_1	551	557	PF00069	0.575
MOD_CK2_1	67	73	PF00069	0.535
MOD_CK2_1	693	699	PF00069	0.706
MOD_CK2_1	803	809	PF00069	0.734
MOD_CK2_1	882	888	PF00069	0.702
MOD_CK2_1	89	95	PF00069	0.623
MOD_GlcNHglycan	134	137	PF01048	0.620
MOD_GlcNHglycan	147	150	PF01048	0.558
MOD_GlcNHglycan	183	186	PF01048	0.526
MOD_GlcNHglycan	19	22	PF01048	0.552
MOD_GlcNHglycan	261	264	PF01048	0.653
MOD_GlcNHglycan	283	286	PF01048	0.518
MOD_GlcNHglycan	290	293	PF01048	0.543
MOD_GlcNHglycan	342	345	PF01048	0.695
MOD_GlcNHglycan	444	447	PF01048	0.543
MOD_GlcNHglycan	486	489	PF01048	0.666
MOD_GlcNHglycan	506	509	PF01048	0.578
MOD_GlcNHglycan	520	523	PF01048	0.679
MOD_GlcNHglycan	553	556	PF01048	0.554
MOD_GlcNHglycan	575	578	PF01048	0.641
MOD_GlcNHglycan	696	699	PF01048	0.735
MOD_GlcNHglycan	717	720	PF01048	0.751
MOD_GlcNHglycan	826	829	PF01048	0.727
MOD_GSK3_1	10	17	PF00069	0.677
MOD_GSK3_1	143	150	PF00069	0.636
MOD_GSK3_1	20	27	PF00069	0.471
MOD_GSK3_1	250	257	PF00069	0.590
MOD_GSK3_1	288	295	PF00069	0.529
MOD_GSK3_1	483	490	PF00069	0.731
MOD_GSK3_1	565	572	PF00069	0.569
MOD_GSK3_1	598	605	PF00069	0.731
MOD_GSK3_1	612	619	PF00069	0.570
MOD_GSK3_1	633	640	PF00069	0.608
MOD_GSK3_1	646	653	PF00069	0.633
MOD_GSK3_1	654	661	PF00069	0.682
MOD_GSK3_1	663	670	PF00069	0.581
MOD_GSK3_1	711	718	PF00069	0.731
MOD_GSK3_1	729	736	PF00069	0.563
MOD_GSK3_1	749	756	PF00069	0.492
MOD_GSK3_1	760	767	PF00069	0.606
MOD_GSK3_1	772	779	PF00069	0.602
MOD_GSK3_1	799	806	PF00069	0.631
MOD_GSK3_1	808	815	PF00069	0.623
MOD_GSK3_1	878	885	PF00069	0.702
MOD_LATS_1	612	618	PF00433	0.689
MOD_N-GLC_1	259	264	PF02516	0.702
MOD_N-GLC_1	31	36	PF02516	0.375
MOD_N-GLC_1	685	690	PF02516	0.595
MOD_NEK2_1	107	112	PF00069	0.337
MOD_NEK2_1	145	150	PF00069	0.535
MOD_NEK2_1	170	175	PF00069	0.592
MOD_NEK2_1	241	246	PF00069	0.674
MOD_NEK2_1	264	269	PF00069	0.545
MOD_NEK2_1	281	286	PF00069	0.612
MOD_NEK2_1	351	356	PF00069	0.577
MOD_NEK2_1	362	367	PF00069	0.539
MOD_NEK2_1	39	44	PF00069	0.401
MOD_NEK2_1	396	401	PF00069	0.675
MOD_NEK2_1	518	523	PF00069	0.628
MOD_NEK2_1	616	621	PF00069	0.712
MOD_NEK2_1	626	631	PF00069	0.623
MOD_NEK2_1	753	758	PF00069	0.665
MOD_NEK2_1	773	778	PF00069	0.518
MOD_NEK2_1	89	94	PF00069	0.537
MOD_NEK2_2	647	652	PF00069	0.590
MOD_PIKK_1	107	113	PF00454	0.523
MOD_PIKK_1	396	402	PF00454	0.555
MOD_PIKK_1	422	428	PF00454	0.601
MOD_PIKK_1	44	50	PF00454	0.388
MOD_PIKK_1	773	779	PF00454	0.568
MOD_PIKK_1	786	792	PF00454	0.533
MOD_PK_1	14	20	PF00069	0.485
MOD_PK_1	668	674	PF00069	0.563
MOD_PKA_1	484	490	PF00069	0.599
MOD_PKA_1	634	640	PF00069	0.681
MOD_PKA_1	668	674	PF00069	0.563
MOD_PKA_2	192	198	PF00069	0.565
MOD_PKA_2	340	346	PF00069	0.692
MOD_PKA_2	483	489	PF00069	0.748
MOD_PKA_2	535	541	PF00069	0.634
MOD_PKA_2	559	565	PF00069	0.689
MOD_PKA_2	633	639	PF00069	0.741
MOD_PKA_2	668	674	PF00069	0.629
MOD_PKB_1	770	778	PF00069	0.566
MOD_Plk_1	265	271	PF00069	0.615
MOD_Plk_1	31	37	PF00069	0.375
MOD_Plk_1	368	374	PF00069	0.389
MOD_Plk_1	488	494	PF00069	0.575
MOD_Plk_1	545	551	PF00069	0.579
MOD_Plk_1	65	71	PF00069	0.433
MOD_Plk_1	808	814	PF00069	0.579
MOD_Plk_1	861	867	PF00069	0.697
MOD_Plk_1	877	883	PF00069	0.554
MOD_Plk_2-3	369	375	PF00069	0.390
MOD_Plk_2-3	55	61	PF00069	0.377
MOD_Plk_4	198	204	PF00069	0.558
MOD_Plk_4	20	26	PF00069	0.576
MOD_Plk_4	222	228	PF00069	0.419
MOD_Plk_4	242	248	PF00069	0.632
MOD_Plk_4	266	272	PF00069	0.560
MOD_Plk_4	362	368	PF00069	0.407
MOD_Plk_4	448	454	PF00069	0.647
MOD_Plk_4	570	576	PF00069	0.509
MOD_Plk_4	659	665	PF00069	0.569
MOD_Plk_4	808	814	PF00069	0.608
MOD_Plk_4	878	884	PF00069	0.714
MOD_ProDKin_1	12	18	PF00069	0.514
MOD_ProDKin_1	250	256	PF00069	0.546
MOD_ProDKin_1	276	282	PF00069	0.613
MOD_ProDKin_1	286	292	PF00069	0.565
MOD_ProDKin_1	353	359	PF00069	0.616
MOD_ProDKin_1	424	430	PF00069	0.499
MOD_ProDKin_1	431	437	PF00069	0.510
MOD_ProDKin_1	458	464	PF00069	0.681
MOD_ProDKin_1	497	503	PF00069	0.711
MOD_ProDKin_1	536	542	PF00069	0.593
MOD_ProDKin_1	565	571	PF00069	0.582
MOD_ProDKin_1	592	598	PF00069	0.676
MOD_ProDKin_1	602	608	PF00069	0.622
MOD_ProDKin_1	628	634	PF00069	0.726
MOD_ProDKin_1	638	644	PF00069	0.639
MOD_ProDKin_1	652	658	PF00069	0.560
MOD_ProDKin_1	663	669	PF00069	0.655
MOD_ProDKin_1	680	686	PF00069	0.579
MOD_ProDKin_1	711	717	PF00069	0.728
MOD_ProDKin_1	788	794	PF00069	0.711
MOD_ProDKin_1	803	809	PF00069	0.564
MOD_ProDKin_1	818	824	PF00069	0.564
MOD_ProDKin_1	846	852	PF00069	0.707
MOD_ProDKin_1	867	873	PF00069	0.695
MOD_ProDKin_1	882	888	PF00069	0.564
MOD_SUMO_for_1	185	188	PF00179	0.527
MOD_SUMO_for_1	859	862	PF00179	0.682
MOD_SUMO_rev_2	576	583	PF00179	0.658
TRG_DiLeu_BaEn_1	314	319	PF01217	0.547
TRG_DiLeu_BaEn_1	358	363	PF01217	0.579
TRG_DiLeu_BaEn_1	404	409	PF01217	0.492
TRG_DiLeu_BaEn_1	412	417	PF01217	0.514
TRG_DiLeu_BaEn_1	80	85	PF01217	0.525
TRG_DiLeu_BaEn_2	112	118	PF01217	0.540
TRG_DiLeu_BaEn_4	113	119	PF01217	0.544
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.575
TRG_DiLeu_LyEn_5	412	417	PF01217	0.544
TRG_DiLeu_LyEn_5	80	85	PF01217	0.525
TRG_ENDOCYTIC_2	168	171	PF00928	0.453
TRG_ENDOCYTIC_2	283	286	PF00928	0.675
TRG_ER_diArg_1	118	120	PF00400	0.530
TRG_ER_diArg_1	191	194	PF00400	0.575
TRG_ER_diArg_1	334	336	PF00400	0.549
TRG_ER_diArg_1	477	479	PF00400	0.583
TRG_ER_diArg_1	770	773	PF00400	0.642
TRG_ER_diArg_1	81	84	PF00400	0.523
TRG_ER_diArg_1	856	858	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	492	497	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	857	861	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IQR9	Leishmania donovani	68%	98%
A4I3U8	Leishmania infantum	68%	98%
E9B040	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	99%
Q4Q846	Leishmania major	68%	100%