Pentatricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGS2_LEIBR

TriTrypDb:

LbrM.28.2380 , LBRM2903_280030200

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGS2

PDB structure(s): 7ane_ap

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.488
CLV_NRD_NRD_1	138	140	PF00675	0.350
CLV_NRD_NRD_1	8	10	PF00675	0.377
CLV_PCSK_KEX2_1	138	140	PF00082	0.405
CLV_PCSK_KEX2_1	8	10	PF00082	0.377
CLV_PCSK_SKI1_1	206	210	PF00082	0.435
CLV_PCSK_SKI1_1	81	85	PF00082	0.296
DEG_APCC_DBOX_1	80	88	PF00400	0.300
DEG_Nend_UBRbox_2	1	3	PF02207	0.480
DEG_SCF_FBW7_2	63	69	PF00400	0.570
DOC_CKS1_1	63	68	PF01111	0.454
DOC_MAPK_HePTP_8	89	101	PF00069	0.385
DOC_MAPK_MEF2A_6	81	89	PF00069	0.302
DOC_MAPK_MEF2A_6	92	101	PF00069	0.353
DOC_PP1_RVXF_1	204	210	PF00149	0.419
DOC_PP2B_LxvP_1	85	88	PF13499	0.302
DOC_USP7_MATH_1	88	92	PF00917	0.470
DOC_WW_Pin1_4	62	67	PF00397	0.441
LIG_14-3-3_CanoR_1	110	115	PF00244	0.491
LIG_14-3-3_CanoR_1	123	128	PF00244	0.366
LIG_14-3-3_CanoR_1	220	224	PF00244	0.483
LIG_deltaCOP1_diTrp_1	160	168	PF00928	0.357
LIG_DLG_GKlike_1	123	131	PF00625	0.325
LIG_FHA_1	93	99	PF00498	0.319
LIG_FHA_2	63	69	PF00498	0.455
LIG_LIR_Gen_1	147	156	PF02991	0.321
LIG_LIR_Gen_1	225	234	PF02991	0.374
LIG_NRBOX	78	84	PF00104	0.442
LIG_PCNA_PIPBox_1	114	123	PF02747	0.468
LIG_Pex14_1	164	168	PF04695	0.363
LIG_Pex14_1	233	237	PF04695	0.396
LIG_Pex14_2	168	172	PF04695	0.431
LIG_SH2_SRC	127	130	PF00017	0.420
LIG_SH2_STAP1	127	131	PF00017	0.424
LIG_SH2_STAT3	154	157	PF00017	0.363
LIG_SH3_1	60	66	PF00018	0.454
LIG_SH3_3	60	66	PF00018	0.430
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.297
LIG_TRAF2_1	44	47	PF00917	0.573
LIG_TRAF2_1	66	69	PF00917	0.546
LIG_WRC_WIRS_1	223	228	PF05994	0.413
MOD_CDK_SPK_2	62	67	PF00069	0.441
MOD_CK1_1	113	119	PF00069	0.355
MOD_CK1_1	222	228	PF00069	0.511
MOD_CK1_1	27	33	PF00069	0.642
MOD_CK2_1	123	129	PF00069	0.327
MOD_CK2_1	172	178	PF00069	0.570
MOD_CK2_1	222	228	PF00069	0.513
MOD_CK2_1	30	36	PF00069	0.652
MOD_CK2_1	62	68	PF00069	0.458
MOD_GlcNHglycan	104	107	PF01048	0.454
MOD_GlcNHglycan	27	30	PF01048	0.499
MOD_GlcNHglycan	32	35	PF01048	0.550
MOD_GSK3_1	215	222	PF00069	0.536
MOD_GSK3_1	24	31	PF00069	0.628
MOD_GSK3_1	88	95	PF00069	0.388
MOD_N-GLC_1	34	39	PF02516	0.592
MOD_NEK2_1	102	107	PF00069	0.458
MOD_NEK2_1	121	126	PF00069	0.319
MOD_NEK2_1	137	142	PF00069	0.557
MOD_NEK2_1	14	19	PF00069	0.483
MOD_NEK2_1	152	157	PF00069	0.313
MOD_NEK2_1	172	177	PF00069	0.470
MOD_PIKK_1	215	221	PF00454	0.580
MOD_PKA_2	137	143	PF00069	0.438
MOD_PKA_2	219	225	PF00069	0.484
MOD_ProDKin_1	62	68	PF00069	0.451
MOD_SUMO_rev_2	193	202	PF00179	0.470
MOD_SUMO_rev_2	36	45	PF00179	0.567
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.283
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.296
TRG_ENDOCYTIC_2	149	152	PF00928	0.322
TRG_ER_diArg_1	137	139	PF00400	0.347
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE2	Leptomonas seymouri	74%	74%
A0A0S4IX75	Bodo saltans	44%	80%
A0A1X0NQT5	Trypanosomatidae	56%	83%
A0A3R7N764	Trypanosoma rangeli	53%	88%
A0A3S7X1T5	Leishmania donovani	90%	100%
A4I3U7	Leishmania infantum	90%	100%
D0A916	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	87%
E9B039	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q847	Leishmania major	89%	100%
V5B8A1	Trypanosoma cruzi	55%	88%