CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial import receptor subunit ATOM69, putative

Species:

Leishmania braziliensis

UniProt:

A4HGS1_LEIBR

TriTrypDb:

LbrM.28.2370 , LBRM2903_280030100

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0016020	membrane	2	3
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0032991	protein-containing complex	1	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HGS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGS1

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.577
CLV_C14_Caspase3-7	44	48	PF00656	0.568
CLV_C14_Caspase3-7	475	479	PF00656	0.582
CLV_C14_Caspase3-7	560	564	PF00656	0.633
CLV_NRD_NRD_1	489	491	PF00675	0.355
CLV_NRD_NRD_1	585	587	PF00675	0.578
CLV_PCSK_KEX2_1	355	357	PF00082	0.303
CLV_PCSK_KEX2_1	489	491	PF00082	0.346
CLV_PCSK_KEX2_1	89	91	PF00082	0.307
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.365
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.310
CLV_PCSK_SKI1_1	174	178	PF00082	0.503
CLV_PCSK_SKI1_1	236	240	PF00082	0.313
CLV_PCSK_SKI1_1	348	352	PF00082	0.269
CLV_PCSK_SKI1_1	355	359	PF00082	0.264
CLV_PCSK_SKI1_1	380	384	PF00082	0.280
CLV_PCSK_SKI1_1	39	43	PF00082	0.331
CLV_PCSK_SKI1_1	395	399	PF00082	0.257
CLV_PCSK_SKI1_1	507	511	PF00082	0.430
CLV_PCSK_SKI1_1	620	624	PF00082	0.314
CLV_Separin_Metazoa	486	490	PF03568	0.655
CLV_Separin_Metazoa	499	503	PF03568	0.562
DEG_APCC_DBOX_1	120	128	PF00400	0.556
DEG_APCC_KENBOX_2	181	185	PF00400	0.592
DOC_CDC14_PxL_1	635	643	PF14671	0.399
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.317
DOC_MAPK_gen_1	118	126	PF00069	0.579
DOC_MAPK_gen_1	210	216	PF00069	0.540
DOC_MAPK_gen_1	37	45	PF00069	0.495
DOC_MAPK_JIP1_4	37	43	PF00069	0.546
DOC_MAPK_MEF2A_6	37	45	PF00069	0.495
DOC_MAPK_MEF2A_6	489	496	PF00069	0.531
DOC_PP1_RVXF_1	57	64	PF00149	0.632
DOC_PP2B_LxvP_1	65	68	PF13499	0.428
DOC_USP7_MATH_1	251	255	PF00917	0.594
DOC_USP7_MATH_1	429	433	PF00917	0.617
DOC_USP7_MATH_1	479	483	PF00917	0.515
DOC_USP7_MATH_1	529	533	PF00917	0.684
DOC_USP7_MATH_1	535	539	PF00917	0.660
DOC_USP7_MATH_1	557	561	PF00917	0.622
DOC_USP7_MATH_1	562	566	PF00917	0.663
DOC_WW_Pin1_4	343	348	PF00397	0.483
LIG_14-3-3_CanoR_1	118	128	PF00244	0.582
LIG_14-3-3_CanoR_1	250	256	PF00244	0.567
LIG_14-3-3_CanoR_1	414	422	PF00244	0.488
LIG_14-3-3_CanoR_1	575	583	PF00244	0.663
LIG_Actin_WH2_2	398	416	PF00022	0.493
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BRCT_BRCA1_1	449	453	PF00533	0.463
LIG_BRCT_BRCA1_1	594	598	PF00533	0.614
LIG_Clathr_ClatBox_1	213	217	PF01394	0.460
LIG_EH1_1	616	624	PF00400	0.317
LIG_FHA_1	301	307	PF00498	0.515
LIG_FHA_1	332	338	PF00498	0.499
LIG_FHA_1	4	10	PF00498	0.615
LIG_FHA_1	40	46	PF00498	0.482
LIG_FHA_1	547	553	PF00498	0.633
LIG_FHA_1	56	62	PF00498	0.506
LIG_FHA_2	13	19	PF00498	0.558
LIG_FHA_2	175	181	PF00498	0.729
LIG_FHA_2	20	26	PF00498	0.519
LIG_FHA_2	222	228	PF00498	0.602
LIG_FHA_2	229	235	PF00498	0.571
LIG_FHA_2	264	270	PF00498	0.480
LIG_FHA_2	539	545	PF00498	0.644
LIG_FHA_2	574	580	PF00498	0.640
LIG_LIR_LC3C_4	80	85	PF02991	0.517
LIG_LIR_Nem_3	608	613	PF02991	0.289
LIG_MLH1_MIPbox_1	449	453	PF16413	0.477
LIG_MLH1_MIPbox_1	594	598	PF16413	0.520
LIG_NRBOX	164	170	PF00104	0.565
LIG_PCNA_PIPBox_1	405	414	PF02747	0.449
LIG_PCNA_yPIPBox_3	368	380	PF02747	0.532
LIG_PDZ_Class_1	646	651	PF00595	0.483
LIG_Pex14_2	382	386	PF04695	0.449
LIG_Rb_pABgroove_1	369	377	PF01858	0.527
LIG_SH2_CRK	341	345	PF00017	0.509
LIG_SH2_CRK	628	632	PF00017	0.426
LIG_SH2_CRK	66	70	PF00017	0.550
LIG_SH2_NCK_1	613	617	PF00017	0.273
LIG_SH2_NCK_1	628	632	PF00017	0.407
LIG_SH2_NCK_1	66	70	PF00017	0.494
LIG_SH2_SRC	476	479	PF00017	0.626
LIG_SH2_SRC	66	69	PF00017	0.446
LIG_SH2_STAP1	613	617	PF00017	0.259
LIG_SH2_STAT3	391	394	PF00017	0.434
LIG_SH2_STAT5	391	394	PF00017	0.434
LIG_SH2_STAT5	452	455	PF00017	0.486
LIG_SH2_STAT5	476	479	PF00017	0.527
LIG_SH2_STAT5	613	616	PF00017	0.261
LIG_SH3_1	489	495	PF00018	0.561
LIG_SH3_3	122	128	PF00018	0.492
LIG_SH3_3	23	29	PF00018	0.574
LIG_SH3_3	381	387	PF00018	0.460
LIG_SH3_3	489	495	PF00018	0.612
LIG_SH3_3	568	574	PF00018	0.691
LIG_SUMO_SIM_anti_2	78	86	PF11976	0.474
LIG_SUMO_SIM_par_1	212	217	PF11976	0.499
LIG_SUMO_SIM_par_1	40	48	PF11976	0.435
LIG_SUMO_SIM_par_1	78	86	PF11976	0.460
LIG_TRAF2_1	290	293	PF00917	0.521
LIG_TRAF2_1	423	426	PF00917	0.625
LIG_UBA3_1	50	56	PF00899	0.506
MOD_CDK_SPK_2	343	348	PF00069	0.483
MOD_CK1_1	223	229	PF00069	0.615
MOD_CK1_1	254	260	PF00069	0.558
MOD_CK1_1	361	367	PF00069	0.581
MOD_CK1_1	416	422	PF00069	0.560
MOD_CK1_1	519	525	PF00069	0.600
MOD_CK1_1	538	544	PF00069	0.566
MOD_CK1_1	611	617	PF00069	0.386
MOD_CK1_1	629	635	PF00069	0.291
MOD_CK2_1	109	115	PF00069	0.444
MOD_CK2_1	12	18	PF00069	0.539
MOD_CK2_1	174	180	PF00069	0.713
MOD_CK2_1	19	25	PF00069	0.540
MOD_CK2_1	228	234	PF00069	0.600
MOD_CK2_1	254	260	PF00069	0.568
MOD_CK2_1	287	293	PF00069	0.566
MOD_CK2_1	294	300	PF00069	0.530
MOD_CK2_1	420	426	PF00069	0.583
MOD_CK2_1	51	57	PF00069	0.633
MOD_CK2_1	538	544	PF00069	0.619
MOD_CK2_1	573	579	PF00069	0.729
MOD_GlcNHglycan	295	299	PF01048	0.293
MOD_GlcNHglycan	363	366	PF01048	0.311
MOD_GlcNHglycan	449	452	PF01048	0.251
MOD_GlcNHglycan	481	484	PF01048	0.325
MOD_GlcNHglycan	504	510	PF01048	0.425
MOD_GlcNHglycan	518	521	PF01048	0.452
MOD_GlcNHglycan	531	534	PF01048	0.403
MOD_GlcNHglycan	537	540	PF01048	0.365
MOD_GlcNHglycan	568	571	PF01048	0.512
MOD_GlcNHglycan	628	631	PF01048	0.504
MOD_GlcNHglycan	90	93	PF01048	0.382
MOD_GSK3_1	216	223	PF00069	0.602
MOD_GSK3_1	226	233	PF00069	0.619
MOD_GSK3_1	251	258	PF00069	0.528
MOD_GSK3_1	296	303	PF00069	0.568
MOD_GSK3_1	339	346	PF00069	0.484
MOD_GSK3_1	413	420	PF00069	0.473
MOD_GSK3_1	51	58	PF00069	0.551
MOD_GSK3_1	512	519	PF00069	0.692
MOD_GSK3_1	529	536	PF00069	0.625
MOD_GSK3_1	562	569	PF00069	0.680
MOD_N-GLC_1	220	225	PF02516	0.401
MOD_N-GLC_2	247	249	PF02516	0.321
MOD_NEK2_1	109	114	PF00069	0.485
MOD_NEK2_1	119	124	PF00069	0.542
MOD_NEK2_1	263	268	PF00069	0.495
MOD_NEK2_1	358	363	PF00069	0.575
MOD_NEK2_1	413	418	PF00069	0.447
MOD_NEK2_1	466	471	PF00069	0.539
MOD_NEK2_1	51	56	PF00069	0.548
MOD_NEK2_1	566	571	PF00069	0.702
MOD_NEK2_1	626	631	PF00069	0.506
MOD_NEK2_1	641	646	PF00069	0.348
MOD_NEK2_2	605	610	PF00069	0.414
MOD_NEK2_2	646	651	PF00069	0.483
MOD_PIKK_1	119	125	PF00454	0.601
MOD_PIKK_1	12	18	PF00454	0.492
MOD_PIKK_1	251	257	PF00454	0.530
MOD_PIKK_1	263	269	PF00454	0.405
MOD_PIKK_1	339	345	PF00454	0.499
MOD_PKA_1	140	146	PF00069	0.567
MOD_PKA_2	12	18	PF00069	0.509
MOD_PKA_2	413	419	PF00069	0.450
MOD_PKB_1	37	45	PF00069	0.537
MOD_Plk_1	19	25	PF00069	0.539
MOD_Plk_1	216	222	PF00069	0.598
MOD_Plk_1	330	336	PF00069	0.471
MOD_Plk_1	358	364	PF00069	0.522
MOD_Plk_1	39	45	PF00069	0.491
MOD_Plk_1	562	568	PF00069	0.574
MOD_Plk_2-3	287	293	PF00069	0.569
MOD_Plk_4	331	337	PF00069	0.471
MOD_Plk_4	417	423	PF00069	0.516
MOD_Plk_4	605	611	PF00069	0.331
MOD_ProDKin_1	343	349	PF00069	0.479
MOD_SUMO_for_1	195	198	PF00179	0.573
MOD_SUMO_for_1	460	463	PF00179	0.507
MOD_SUMO_rev_2	233	238	PF00179	0.598
MOD_SUMO_rev_2	40	48	PF00179	0.435
MOD_SUMO_rev_2	499	509	PF00179	0.611
TRG_DiLeu_BaEn_1	331	336	PF01217	0.486
TRG_ENDOCYTIC_2	341	344	PF00928	0.482
TRG_ENDOCYTIC_2	628	631	PF00928	0.390
TRG_ENDOCYTIC_2	66	69	PF00928	0.480
TRG_ER_diArg_1	36	39	PF00400	0.587
TRG_ER_diArg_1	488	490	PF00400	0.572
TRG_ER_diArg_1	583	586	PF00400	0.682
TRG_NLS_MonoExtC_3	209	215	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF2	Leptomonas seymouri	72%	100%
A0A0S4IMM1	Bodo saltans	42%	91%
A0A1X0NQQ8	Trypanosomatidae	50%	100%
A0A3Q8IE19	Leishmania donovani	89%	100%
A0A3R7RF21	Trypanosoma rangeli	49%	100%
D0A915	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
E9B038	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q848	Leishmania major	88%	100%
V5BCV7	Trypanosoma cruzi	49%	100%