Methyltransf_25 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGS0_LEIBR

TriTrypDb:

LbrM.28.2360 , LBRM2903_280030000

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGS0

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0032259	methylation	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008168	methyltransferase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016741	transferase activity, transferring one-carbon groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	160	162	PF00082	0.472
CLV_PCSK_KEX2_1	173	175	PF00082	0.388
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.445
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.499
CLV_PCSK_SKI1_1	173	177	PF00082	0.437
CLV_PCSK_SKI1_1	194	198	PF00082	0.389
CLV_PCSK_SKI1_1	208	212	PF00082	0.323
CLV_PCSK_SKI1_1	30	34	PF00082	0.389
CLV_PCSK_SKI1_1	63	67	PF00082	0.408
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DOC_CKS1_1	167	172	PF01111	0.432
DOC_MAPK_gen_1	173	184	PF00069	0.490
DOC_USP7_MATH_1	3	7	PF00917	0.592
DOC_USP7_MATH_1	37	41	PF00917	0.374
DOC_USP7_UBL2_3	173	177	PF12436	0.477
DOC_WW_Pin1_4	138	143	PF00397	0.486
DOC_WW_Pin1_4	166	171	PF00397	0.432
LIG_14-3-3_CanoR_1	216	221	PF00244	0.436
LIG_14-3-3_CterR_2	224	229	PF00244	0.344
LIG_BRCT_BRCA1_1	118	122	PF00533	0.293
LIG_CaM_IQ_9	152	168	PF13499	0.462
LIG_eIF4E_1	215	221	PF01652	0.450
LIG_FHA_1	167	173	PF00498	0.436
LIG_FHA_1	17	23	PF00498	0.538
LIG_FHA_1	215	221	PF00498	0.475
LIG_FHA_1	49	55	PF00498	0.318
LIG_FHA_2	178	184	PF00498	0.490
LIG_FHA_2	186	192	PF00498	0.458
LIG_FHA_2	66	72	PF00498	0.314
LIG_LIR_Gen_1	110	118	PF02991	0.367
LIG_LIR_Gen_1	119	129	PF02991	0.302
LIG_LIR_Gen_1	71	82	PF02991	0.209
LIG_LIR_Nem_3	11	15	PF02991	0.459
LIG_LIR_Nem_3	110	116	PF02991	0.367
LIG_LIR_Nem_3	119	125	PF02991	0.330
LIG_LIR_Nem_3	181	187	PF02991	0.499
LIG_LIR_Nem_3	26	32	PF02991	0.382
LIG_LIR_Nem_3	71	77	PF02991	0.209
LIG_NBox_RRM_1	193	203	PF00076	0.265
LIG_PDZ_Class_2	224	229	PF00595	0.344
LIG_Pex14_2	118	122	PF04695	0.293
LIG_Pex14_2	154	158	PF04695	0.326
LIG_SH2_PTP2	167	170	PF00017	0.414
LIG_SH2_STAP1	17	21	PF00017	0.435
LIG_SH2_STAP1	189	193	PF00017	0.435
LIG_SH2_STAP1	72	76	PF00017	0.288
LIG_SH2_STAT3	215	218	PF00017	0.499
LIG_SH2_STAT5	117	120	PF00017	0.293
LIG_SH2_STAT5	167	170	PF00017	0.431
LIG_SH2_STAT5	76	79	PF00017	0.318
LIG_SH2_STAT5	8	11	PF00017	0.548
LIG_SH3_3	141	147	PF00018	0.501
LIG_TRAF2_1	196	199	PF00917	0.412
LIG_WRC_WIRS_1	9	14	PF05994	0.380
MOD_CDK_SPxxK_3	138	145	PF00069	0.401
MOD_CDK_SPxxK_3	166	173	PF00069	0.437
MOD_CK1_1	11	17	PF00069	0.581
MOD_CK1_1	23	29	PF00069	0.496
MOD_CK2_1	105	111	PF00069	0.386
MOD_CK2_1	124	130	PF00069	0.209
MOD_GlcNHglycan	118	121	PF01048	0.340
MOD_GlcNHglycan	78	81	PF01048	0.410
MOD_GSK3_1	16	23	PF00069	0.538
MOD_GSK3_1	210	217	PF00069	0.470
MOD_GSK3_1	59	66	PF00069	0.431
MOD_N-GLC_1	105	110	PF02516	0.384
MOD_NEK2_1	116	121	PF00069	0.327
MOD_NEK2_1	65	70	PF00069	0.300
MOD_NEK2_2	8	13	PF00069	0.386
MOD_PIKK_1	152	158	PF00454	0.351
MOD_PIKK_1	214	220	PF00454	0.492
MOD_PKA_1	63	69	PF00069	0.384
MOD_Plk_1	185	191	PF00069	0.461
MOD_Plk_4	118	124	PF00069	0.318
MOD_Plk_4	210	216	PF00069	0.477
MOD_Plk_4	37	43	PF00069	0.385
MOD_Plk_4	49	55	PF00069	0.259
MOD_ProDKin_1	138	144	PF00069	0.483
MOD_ProDKin_1	166	172	PF00069	0.433
MOD_SUMO_for_1	95	98	PF00179	0.257
TRG_DiLeu_BaEn_2	158	164	PF01217	0.482
TRG_ENDOCYTIC_2	29	32	PF00928	0.405
TRG_ER_diArg_1	224	227	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P1	Leptomonas seymouri	77%	99%
A0A0S4IRT5	Bodo saltans	48%	93%
A0A1X0NQR6	Trypanosomatidae	50%	100%
A0A3Q8IGV9	Leishmania donovani	89%	94%
A0A422N7I7	Trypanosoma rangeli	39%	99%
A4I3U5	Leishmania infantum	89%	94%
E9B037	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	94%
Q4Q849	Leishmania major	88%	100%