Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HGR9_LEIBR

TriTrypDb:

LbrM.28.2350 , LBRM2903_280029900

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HGR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.742
CLV_NRD_NRD_1	19	21	PF00675	0.604
CLV_NRD_NRD_1	500	502	PF00675	0.503
CLV_NRD_NRD_1	620	622	PF00675	0.626
CLV_NRD_NRD_1	79	81	PF00675	0.838
CLV_NRD_NRD_1	826	828	PF00675	0.588
CLV_PCSK_FUR_1	98	102	PF00082	0.749
CLV_PCSK_KEX2_1	100	102	PF00082	0.746
CLV_PCSK_KEX2_1	18	20	PF00082	0.592
CLV_PCSK_KEX2_1	500	502	PF00082	0.503
CLV_PCSK_KEX2_1	620	622	PF00082	0.442
CLV_PCSK_KEX2_1	762	764	PF00082	0.739
CLV_PCSK_KEX2_1	79	81	PF00082	0.827
CLV_PCSK_KEX2_1	828	830	PF00082	0.645
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.739
CLV_PCSK_PC1ET2_1	828	830	PF00082	0.645
CLV_PCSK_PC7_1	824	830	PF00082	0.594
CLV_PCSK_SKI1_1	113	117	PF00082	0.602
CLV_PCSK_SKI1_1	269	273	PF00082	0.734
CLV_PCSK_SKI1_1	44	48	PF00082	0.721
CLV_PCSK_SKI1_1	488	492	PF00082	0.522
CLV_PCSK_SKI1_1	500	504	PF00082	0.519
CLV_PCSK_SKI1_1	545	549	PF00082	0.731
CLV_PCSK_SKI1_1	591	595	PF00082	0.570
CLV_PCSK_SKI1_1	604	608	PF00082	0.476
CLV_PCSK_SKI1_1	659	663	PF00082	0.607
CLV_PCSK_SKI1_1	714	718	PF00082	0.676
DEG_APCC_DBOX_1	167	175	PF00400	0.430
DEG_APCC_DBOX_1	411	419	PF00400	0.603
DEG_APCC_DBOX_1	470	478	PF00400	0.543
DEG_APCC_DBOX_1	590	598	PF00400	0.581
DEG_APCC_DBOX_1	658	666	PF00400	0.516
DEG_Nend_UBRbox_3	1	3	PF02207	0.670
DEG_SPOP_SBC_1	58	62	PF00917	0.570
DEG_SPOP_SBC_1	67	71	PF00917	0.529
DOC_CDC14_PxL_1	272	280	PF14671	0.667
DOC_CKS1_1	512	517	PF01111	0.649
DOC_CYCLIN_RxL_1	542	551	PF00134	0.519
DOC_MAPK_FxFP_2	47	50	PF00069	0.727
DOC_MAPK_gen_1	269	277	PF00069	0.724
DOC_MAPK_gen_1	483	492	PF00069	0.550
DOC_MAPK_gen_1	589	597	PF00069	0.658
DOC_MAPK_gen_1	762	769	PF00069	0.729
DOC_MAPK_HePTP_8	482	494	PF00069	0.628
DOC_MAPK_MEF2A_6	270	279	PF00069	0.665
DOC_MAPK_MEF2A_6	485	494	PF00069	0.637
DOC_MAPK_MEF2A_6	589	597	PF00069	0.433
DOC_MAPK_MEF2A_6	740	747	PF00069	0.643
DOC_MAPK_MEF2A_6	762	771	PF00069	0.725
DOC_PP1_RVXF_1	543	550	PF00149	0.520
DOC_PP1_RVXF_1	618	625	PF00149	0.563
DOC_PP2B_LxvP_1	220	223	PF13499	0.697
DOC_PP2B_LxvP_1	509	512	PF13499	0.658
DOC_PP4_FxxP_1	328	331	PF00568	0.793
DOC_PP4_FxxP_1	47	50	PF00568	0.727
DOC_USP7_MATH_1	175	179	PF00917	0.562
DOC_USP7_MATH_1	232	236	PF00917	0.637
DOC_USP7_MATH_1	271	275	PF00917	0.700
DOC_USP7_MATH_1	28	32	PF00917	0.663
DOC_USP7_MATH_1	373	377	PF00917	0.581
DOC_USP7_MATH_1	398	402	PF00917	0.577
DOC_USP7_MATH_1	605	609	PF00917	0.440
DOC_USP7_MATH_1	67	71	PF00917	0.645
DOC_USP7_MATH_1	781	785	PF00917	0.668
DOC_USP7_MATH_2	106	112	PF00917	0.565
DOC_WW_Pin1_4	137	142	PF00397	0.644
DOC_WW_Pin1_4	153	158	PF00397	0.554
DOC_WW_Pin1_4	176	181	PF00397	0.654
DOC_WW_Pin1_4	384	389	PF00397	0.495
DOC_WW_Pin1_4	511	516	PF00397	0.643
DOC_WW_Pin1_4	555	560	PF00397	0.703
LIG_14-3-3_CanoR_1	213	223	PF00244	0.594
LIG_14-3-3_CanoR_1	259	267	PF00244	0.638
LIG_14-3-3_CanoR_1	310	319	PF00244	0.704
LIG_14-3-3_CanoR_1	381	387	PF00244	0.456
LIG_14-3-3_CanoR_1	447	453	PF00244	0.522
LIG_14-3-3_CanoR_1	501	511	PF00244	0.552
LIG_14-3-3_CanoR_1	545	550	PF00244	0.587
LIG_14-3-3_CanoR_1	59	64	PF00244	0.715
LIG_14-3-3_CanoR_1	620	625	PF00244	0.509
LIG_14-3-3_CanoR_1	808	815	PF00244	0.539
LIG_BRCT_BRCA1_1	160	164	PF00533	0.699
LIG_BRCT_BRCA1_1	324	328	PF00533	0.808
LIG_BRCT_BRCA1_1	379	383	PF00533	0.398
LIG_CaM_NSCaTE_8	432	439	PF13499	0.360
LIG_deltaCOP1_diTrp_1	428	432	PF00928	0.544
LIG_eIF4E_1	417	423	PF01652	0.437
LIG_EVH1_2	444	448	PF00568	0.512
LIG_FHA_1	215	221	PF00498	0.639
LIG_FHA_1	437	443	PF00498	0.371
LIG_FHA_1	503	509	PF00498	0.581
LIG_FHA_2	117	123	PF00498	0.672
LIG_FHA_2	523	529	PF00498	0.692
LIG_FHA_2	67	73	PF00498	0.741
LIG_FHA_2	674	680	PF00498	0.757
LIG_FHA_2	79	85	PF00498	0.728
LIG_Integrin_isoDGR_2	410	412	PF01839	0.632
LIG_LIR_Apic_2	325	331	PF02991	0.797
LIG_LIR_Gen_1	118	128	PF02991	0.661
LIG_LIR_Gen_1	285	295	PF02991	0.375
LIG_LIR_Gen_1	380	390	PF02991	0.447
LIG_LIR_Gen_1	401	409	PF02991	0.468
LIG_LIR_Gen_1	416	425	PF02991	0.446
LIG_LIR_Gen_1	607	614	PF02991	0.606
LIG_LIR_Gen_1	676	686	PF02991	0.559
LIG_LIR_Gen_1	689	699	PF02991	0.590
LIG_LIR_Gen_1	821	830	PF02991	0.553
LIG_LIR_Nem_3	285	290	PF02991	0.366
LIG_LIR_Nem_3	365	370	PF02991	0.483
LIG_LIR_Nem_3	380	386	PF02991	0.406
LIG_LIR_Nem_3	401	405	PF02991	0.500
LIG_LIR_Nem_3	416	420	PF02991	0.462
LIG_LIR_Nem_3	484	490	PF02991	0.459
LIG_LIR_Nem_3	6	12	PF02991	0.673
LIG_LIR_Nem_3	607	613	PF02991	0.591
LIG_LIR_Nem_3	676	681	PF02991	0.724
LIG_LIR_Nem_3	689	694	PF02991	0.606
LIG_LIR_Nem_3	821	825	PF02991	0.497
LIG_NRBOX	111	117	PF00104	0.781
LIG_PCNA_yPIPBox_3	659	670	PF02747	0.523
LIG_PDZ_Class_3	829	834	PF00595	0.510
LIG_Pex14_1	487	491	PF04695	0.501
LIG_REV1ctd_RIR_1	769	778	PF16727	0.720
LIG_SH2_CRK	691	695	PF00017	0.584
LIG_SH2_GRB2like	473	476	PF00017	0.487
LIG_SH2_PTP2	287	290	PF00017	0.361
LIG_SH2_SRC	417	420	PF00017	0.450
LIG_SH2_STAP1	145	149	PF00017	0.391
LIG_SH2_STAP1	683	687	PF00017	0.520
LIG_SH2_STAT3	145	148	PF00017	0.617
LIG_SH2_STAT3	94	97	PF00017	0.582
LIG_SH2_STAT5	145	148	PF00017	0.549
LIG_SH2_STAT5	287	290	PF00017	0.442
LIG_SH2_STAT5	367	370	PF00017	0.627
LIG_SH2_STAT5	404	407	PF00017	0.417
LIG_SH2_STAT5	417	420	PF00017	0.493
LIG_SH2_STAT5	473	476	PF00017	0.496
LIG_SH2_STAT5	94	97	PF00017	0.582
LIG_SH3_3	313	319	PF00018	0.753
LIG_SH3_3	355	361	PF00018	0.413
LIG_SH3_3	439	445	PF00018	0.373
LIG_SH3_3	487	493	PF00018	0.515
LIG_SH3_3	509	515	PF00018	0.599
LIG_SH3_3	666	672	PF00018	0.696
LIG_SH3_3	700	706	PF00018	0.632
LIG_SUMO_SIM_anti_2	374	380	PF11976	0.564
LIG_SUMO_SIM_anti_2	60	72	PF11976	0.580
LIG_SUMO_SIM_par_1	273	280	PF11976	0.485
LIG_SUMO_SIM_par_1	478	484	PF11976	0.520
LIG_SUMO_SIM_par_1	507	514	PF11976	0.659
LIG_SUMO_SIM_par_1	724	731	PF11976	0.671
LIG_TRAF2_1	31	34	PF00917	0.681
LIG_TYR_ITIM	415	420	PF00017	0.458
LIG_TYR_ITIM	46	51	PF00017	0.794
LIG_TYR_ITIM	681	686	PF00017	0.656
LIG_WRC_WIRS_1	675	680	PF05994	0.612
LIG_WW_3	222	226	PF00397	0.582
LIG_WW_3	444	448	PF00397	0.580
MOD_CK1_1	131	137	PF00069	0.632
MOD_CK1_1	198	204	PF00069	0.518
MOD_CK1_1	246	252	PF00069	0.649
MOD_CK1_1	302	308	PF00069	0.729
MOD_CK1_1	309	315	PF00069	0.764
MOD_CK1_1	376	382	PF00069	0.646
MOD_CK1_1	61	67	PF00069	0.751
MOD_CK1_1	673	679	PF00069	0.633
MOD_CK1_1	68	74	PF00069	0.753
MOD_CK1_1	727	733	PF00069	0.690
MOD_CK1_1	755	761	PF00069	0.685
MOD_CK1_1	96	102	PF00069	0.768
MOD_CK2_1	116	122	PF00069	0.583
MOD_CK2_1	137	143	PF00069	0.445
MOD_CK2_1	28	34	PF00069	0.669
MOD_CK2_1	413	419	PF00069	0.615
MOD_CK2_1	567	573	PF00069	0.829
MOD_CK2_1	67	73	PF00069	0.664
MOD_CK2_1	78	84	PF00069	0.759
MOD_Cter_Amidation	267	270	PF01082	0.690
MOD_Cter_Amidation	77	80	PF01082	0.598
MOD_GlcNHglycan	13	16	PF01048	0.627
MOD_GlcNHglycan	205	208	PF01048	0.550
MOD_GlcNHglycan	304	307	PF01048	0.667
MOD_GlcNHglycan	313	316	PF01048	0.717
MOD_GlcNHglycan	519	522	PF01048	0.796
MOD_GlcNHglycan	569	572	PF01048	0.827
MOD_GlcNHglycan	607	610	PF01048	0.648
MOD_GlcNHglycan	637	640	PF01048	0.673
MOD_GlcNHglycan	757	760	PF01048	0.657
MOD_GlcNHglycan	787	790	PF01048	0.610
MOD_GlcNHglycan	799	802	PF01048	0.659
MOD_GSK3_1	127	134	PF00069	0.651
MOD_GSK3_1	158	165	PF00069	0.611
MOD_GSK3_1	255	262	PF00069	0.749
MOD_GSK3_1	302	309	PF00069	0.760
MOD_GSK3_1	334	341	PF00069	0.657
MOD_GSK3_1	373	380	PF00069	0.507
MOD_GSK3_1	426	433	PF00069	0.494
MOD_GSK3_1	57	64	PF00069	0.704
MOD_GSK3_1	583	590	PF00069	0.696
MOD_GSK3_1	647	654	PF00069	0.662
MOD_GSK3_1	670	677	PF00069	0.632
MOD_GSK3_1	730	737	PF00069	0.708
MOD_GSK3_1	781	788	PF00069	0.662
MOD_GSK3_1	92	99	PF00069	0.763
MOD_N-GLC_1	302	307	PF02516	0.747
MOD_NEK2_1	115	120	PF00069	0.633
MOD_NEK2_1	135	140	PF00069	0.336
MOD_NEK2_1	158	163	PF00069	0.587
MOD_NEK2_1	203	208	PF00069	0.592
MOD_NEK2_1	214	219	PF00069	0.518
MOD_NEK2_1	260	265	PF00069	0.762
MOD_NEK2_1	286	291	PF00069	0.465
MOD_NEK2_1	301	306	PF00069	0.659
MOD_NEK2_1	349	354	PF00069	0.511
MOD_NEK2_1	436	441	PF00069	0.500
MOD_NEK2_1	448	453	PF00069	0.455
MOD_NEK2_1	734	739	PF00069	0.680
MOD_NEK2_1	809	814	PF00069	0.477
MOD_NEK2_1	820	825	PF00069	0.593
MOD_NEK2_1	90	95	PF00069	0.583
MOD_PIKK_1	533	539	PF00454	0.502
MOD_PIKK_1	561	567	PF00454	0.596
MOD_PIKK_1	625	631	PF00454	0.745
MOD_PIKK_1	718	724	PF00454	0.662
MOD_PIKK_1	93	99	PF00454	0.706
MOD_PK_1	59	65	PF00069	0.756
MOD_PKA_1	620	626	PF00069	0.467
MOD_PKA_2	309	315	PF00069	0.615
MOD_PKA_2	334	340	PF00069	0.505
MOD_PKA_2	51	57	PF00069	0.741
MOD_PKA_2	58	64	PF00069	0.700
MOD_PKA_2	583	589	PF00069	0.644
MOD_PKA_2	620	626	PF00069	0.560
MOD_PKA_2	647	653	PF00069	0.694
MOD_PKA_2	78	84	PF00069	0.685
MOD_Plk_1	107	113	PF00069	0.734
MOD_Plk_1	255	261	PF00069	0.785
MOD_Plk_1	530	536	PF00069	0.737
MOD_Plk_1	730	736	PF00069	0.707
MOD_Plk_1	741	747	PF00069	0.507
MOD_Plk_1	820	826	PF00069	0.656
MOD_Plk_2-3	334	340	PF00069	0.505
MOD_Plk_2-3	391	397	PF00069	0.481
MOD_Plk_2-3	413	419	PF00069	0.471
MOD_Plk_4	116	122	PF00069	0.620
MOD_Plk_4	286	292	PF00069	0.450
MOD_Plk_4	349	355	PF00069	0.534
MOD_Plk_4	362	368	PF00069	0.503
MOD_Plk_4	373	379	PF00069	0.538
MOD_Plk_4	413	419	PF00069	0.565
MOD_Plk_4	426	432	PF00069	0.451
MOD_Plk_4	450	456	PF00069	0.529
MOD_Plk_4	61	67	PF00069	0.583
MOD_Plk_4	724	730	PF00069	0.664
MOD_Plk_4	741	747	PF00069	0.618
MOD_Plk_4	781	787	PF00069	0.678
MOD_ProDKin_1	137	143	PF00069	0.637
MOD_ProDKin_1	153	159	PF00069	0.550
MOD_ProDKin_1	176	182	PF00069	0.657
MOD_ProDKin_1	384	390	PF00069	0.502
MOD_ProDKin_1	511	517	PF00069	0.650
MOD_ProDKin_1	555	561	PF00069	0.705
MOD_SUMO_rev_2	32	41	PF00179	0.797
MOD_SUMO_rev_2	476	484	PF00179	0.366
MOD_SUMO_rev_2	600	606	PF00179	0.638
MOD_SUMO_rev_2	68	77	PF00179	0.581
MOD_SUMO_rev_2	784	794	PF00179	0.591
TRG_DiLeu_BaEn_1	457	462	PF01217	0.556
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.428
TRG_DiLeu_BaLyEn_6	648	653	PF01217	0.521
TRG_ENDOCYTIC_2	121	124	PF00928	0.675
TRG_ENDOCYTIC_2	287	290	PF00928	0.423
TRG_ENDOCYTIC_2	367	370	PF00928	0.563
TRG_ENDOCYTIC_2	417	420	PF00928	0.450
TRG_ENDOCYTIC_2	48	51	PF00928	0.674
TRG_ENDOCYTIC_2	683	686	PF00928	0.699
TRG_ENDOCYTIC_2	691	694	PF00928	0.576
TRG_ENDOCYTIC_2	9	12	PF00928	0.610
TRG_ER_diArg_1	18	20	PF00400	0.596
TRG_ER_diArg_1	22	25	PF00400	0.638
TRG_ER_diArg_1	499	501	PF00400	0.513
TRG_ER_diArg_1	619	621	PF00400	0.445
TRG_ER_diArg_1	827	830	PF00400	0.599
TRG_ER_diArg_1	98	101	PF00400	0.731
TRG_ER_KDEL_1	831	834	PF00810	0.514
TRG_NLS_MonoExtC_3	826	831	PF00514	0.598
TRG_NLS_MonoExtN_4	824	831	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	828	832	PF00026	0.725

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P734	Leptomonas seymouri	47%	97%
A0A1X0NQU7	Trypanosomatidae	31%	100%
A0A3S7X1T8	Leishmania donovani	80%	100%
E9B036	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q850	Leishmania major	80%	100%